去甲腎上腺素轉運體(英語:Norepinephrine_transporter,NET),也被稱為溶質載體家族6成員2(英語:solute carrier family 6 member 2,SLC6A2),是由SLC6A2基因編碼的蛋白質。[6]。NET是一种單胺轉運體(英语:monoamine transporter),負責依賴Na+/Cl−的胞外去甲腎上腺素再攝取。NET也可轉運多巴胺。對這兩種神经递质的再吸收是調控突觸間隙(英语:synaptic cleft)傳導物濃度的重要機制。
• integral component of membrane • 细胞膜 • 膜 • 脂筏模型 • neuron projection • cell surface • integral component of plasma membrane • neuronal cell body membrane • presynaptic membrane
生物學過程
• dopamine uptake involved in synaptic transmission • neurotransmitter transport • response to pain • monoamine transport • 化学性突触传递 • norepinephrine transport • transmembrane transport • sodium ion transmembrane transport • norepinephrine uptake • neuron cellular homeostasis • 再攝取
^對Solute carrier family 6 member 2起作用的藥物;在維基數據上查看/編輯參考.
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.
^Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.
^Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.