· G-protein coupled receptor signaling pathway · G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger · activation of adenylate cyclase activity · phospholipase C-activating G-protein coupled receptor signaling pathway · spermatogenesis · male gonad development · male genitalia development · positive regulation of inositol trisphosphate biosynthetic process · positive regulation of cAMP-mediated signaling · development of secondary male sexual characteristics · uterus development · cellular response to gonadotropin stimulus · seminiferous tubule development
· regulation of steroid hormone biosynthetic process
^Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. 1997, 18 (6): 739–73. PMID 9408742. doi:10.1210/er.18.6.739.
^Hirakawa, Takashi; Galet Colette, Kishi Mikiko, Ascoli Mario. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. J. Biol. Chem. (United States). Dec 2003, 278 (49): 49348–57. ISSN 0021-9258. PMID 14507927. doi:10.1074/jbc.M306557200.引文使用过时参数coauthors (帮助)
延伸阅读
Ji TH, Ryu KS, Gilchrist R, Ji I. Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor.. Recent Prog. Horm. Res. 1997, 52: 431–53; discussion 454. PMID 9238862.
Fanelli F, Puett D. Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis. Endocrine. 2003, 18 (3): 285–93. PMID 12450321. doi:10.1385/ENDO:18:3:285.
Latronico AC, Segaloff DL. Insights Learned from L457(3.43)R, an Activating Mutant of the Human Lutropin Receptor. Mol. Cell. Endocrinol. 2007,. 260-262: 287–93. PMC 1785107. PMID 17055147. doi:10.1016/j.mce.2005.11.053.
Nagayama Y; Russo D; Wadsworth HL; et al. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J. Biol. Chem. 1991, 266 (23): 14926–30. PMID 1651314.已忽略未知参数|author-separator= (帮助)
Jia XC; Oikawa M; Bo M; et al. Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species. Mol. Endocrinol. 1991, 5 (6): 759–68. PMID 1922095. doi:10.1210/mend-5-6-759.已忽略未知参数|author-separator= (帮助)
Minegishi T; Nakamura K; Takakura Y; et al. Cloning and sequencing of human LH/hCG receptor cDNA. Biochem. Biophys. Res. Commun. 1990, 172 (3): 1049–54. PMID 2244890. doi:10.1016/0006-291X(90)91552-4.已忽略未知参数|author-separator= (帮助)
Rousseau-Merck MF; Misrahi M; Atger M; et al. Localization of the human luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21. Cytogenet. Cell Genet. 1991, 54 (1–2): 77–9. PMID 2249480. doi:10.1159/000132962.已忽略未知参数|author-separator= (帮助)
Xie YB, Wang H, Segaloff DL. Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J. Biol. Chem. 1991, 265 (35): 21411–4. PMID 2254302.
Frazier AL; Robbins LS; Stork PJ; et al. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol. Endocrinol. 1991, 4 (8): 1264–76. PMID 2293030. doi:10.1210/mend-4-8-1264.已忽略未知参数|author-separator= (帮助)
Keutmann HT; Charlesworth MC; Mason KA; et al. A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (7): 2038–42. PMC 304579. PMID 3470775. doi:10.1073/pnas.84.7.2038.已忽略未知参数|author-separator= (帮助)
Jiang X, Dreano M, Buckler DR; et al. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 1996, 3 (12): 1341–53. PMID 8747461. doi:10.1016/S0969-2126(01)00272-6. 引文格式1维护：显式使用等标签 (link)
Atger M; Misrahi M; Sar S; et al. Structure of the human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5' non-coding regions. Mol. Cell. Endocrinol. 1995, 111 (2): 113–23. PMID 7556872. doi:10.1016/0303-7207(95)03557-N.已忽略未知参数|author-separator= (帮助)
Latronico AC; Anasti J; Arnhold IJ; et al. A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty. J. Clin. Endocrinol. Metab. 1995, 80 (8): 2490–4. PMID 7629248. doi:10.1210/jc.80.8.2490.已忽略未知参数|author-separator= (帮助)
Shenker A; Laue L; Kosugi S; et al. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature. 1993, 365 (6447): 652–4. PMID 7692306. doi:10.1038/365652a0.已忽略未知参数|author-separator= (帮助)
Yano K; Saji M; Hidaka A; et al. A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty. J. Clin. Endocrinol. Metab. 1995, 80 (4): 1162–8. PMID 7714085. doi:10.1210/jc.80.4.1162.已忽略未知参数|author-separator= (帮助)
Kremer H; Kraaij R; Toledo SP; et al. Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat. Genet. 1995, 9 (2): 160–4. PMID 7719343. doi:10.1038/ng0295-160.已忽略未知参数|author-separator= (帮助)
Kosugi S; Van Dop C; Geffner ME; et al. Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. Hum. Mol. Genet. 1995, 4 (2): 183–8. PMID 7757065. doi:10.1093/hmg/4.2.183.已忽略未知参数|author-separator= (帮助)
Kremer H; Mariman E; Otten BJ; et al. Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. Hum. Mol. Genet. 1994, 2 (11): 1779–83. PMID 8281137. doi:10.1093/hmg/2.11.1779.已忽略未知参数|author-separator= (帮助)
外部链接
Glycoprotein Hormone Receptors: LH. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
黄体生成素, 绒毛膜促性腺激素受体, 英語, luteinizing, hormone, choriogonadotropin, receptor, 缩写lhcgr也作, lutropin, choriogonadotropin, receptor, lcgr或luteinizing, hormone, receptor, 是一种主要出现在卵巢和睾丸的跨膜受体, 但在一些性腺外的器官如子宫和乳房也有表达, 该受体是g蛋白偶联受体, gpcr, 的一种, 既能与黄体生成素, 互作也能与绒毛膜促性腺激素, 如人类的hc. 黄体生成素 绒毛膜促性腺激素受体 英語 luteinizing hormone choriogonadotropin receptor 缩写LHCGR也作 lutropin choriogonadotropin receptor LCGR或luteinizing hormone receptor LHR 是一种主要出现在卵巢和睾丸的跨膜受体 但在一些性腺外的器官如子宫和乳房也有表达 该受体是G蛋白偶联受体 GPCR 的一种 既能与黄体生成素 LH 互作也能与绒毛膜促性腺激素 如人类的hCG 其激活是在繁殖期间的荷尔蒙运作所需的 Luteinizing hormone choriogonadotropin receptor黄体生成素 绒毛膜促性腺激素受体有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1LUT 1XUL标识代号LHCGR HHG LCGR LGR2 LH CG R LH CGR LHR LHRHR LSH R ULG5扩展标识遗传学 152790 鼠基因 96783 同源基因 37276 IUPHAR LH ChEMBL 1854 GeneCards LHCGR Gene基因本体论描述分子功能 luteinizing hormone receptor activity choriogonadotropin hormone receptor activity choriogonadotropin hormone binding细胞成分 endosome plasma membrane integral to plasma membrane生物过程 ovarian follicle development G protein coupled receptor signaling pathway G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger activation of adenylate cyclase activity phospholipase C activating G protein coupled receptor signaling pathway spermatogenesis male gonad development male genitalia development positive regulation of inositol trisphosphate biosynthetic process positive regulation of cAMP mediated signaling development of secondary male sexual characteristics uterus development cellular response to gonadotropin stimulus seminiferous tubule development regulation of steroid hormone biosynthetic processSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez397316867EnsemblENSG00000138039ENSMUSG00000024107UniProtP22888P30730mRNA序列NM 000233NM 013582蛋白序列NP 000224NP 038610基因位置Chr 2 48 86 48 98 MbChr 17 88 74 88 79 MbPubMed查询 1 2 查论编 目录 1 LHCGR基因 2 历史 3 相互作用 4 参考文献 5 延伸阅读 6 外部链接LHCGR基因 编辑LHCGR位于人类基因组上的2號染色體p21区 接近类似的促卵泡激素受体 FSHR 基因 长约70Kbp FSHR为54Kpb 1 除了与FSHR相似外 还类似于促甲状腺激素受体 TSHR 历史 编辑馬丁 羅德貝爾与艾爾佛列 古曼 吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖 相互作用 编辑黄体生成素 绒毛膜促性腺激素受体与GIPC1能进行相互作用 2 参考文献 编辑 Simoni M Gromoll J Nieschlag E The follicle stimulating hormone receptor biochemistry molecular biology physiology and pathophysiology Endocr Rev 1997 18 6 739 73 PMID 9408742 doi 10 1210 er 18 6 739 Hirakawa Takashi Galet Colette Kishi Mikiko Ascoli Mario GIPC binds to the human lutropin receptor hLHR through an unusual PDZ domain binding motif and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR J Biol Chem United States Dec 2003 278 49 49348 57 ISSN 0021 9258 PMID 14507927 doi 10 1074 jbc M306557200 引文使用过时参数coauthors 帮助 延伸阅读 编辑Ji TH Ryu KS Gilchrist R Ji I Interaction signal generation signal divergence and signal transduction of LH CG and the receptor Recent Prog Horm Res 1997 52 431 53 discussion 454 PMID 9238862 Dufau ML The luteinizing hormone receptor Annu Rev Physiol 1998 60 461 96 PMID 9558473 doi 10 1146 annurev physiol 60 1 461 Ascoli M Fanelli F Segaloff DL The lutropin choriogonadotropin receptor a 2002 perspective Endocr Rev 2002 23 2 141 74 PMID 11943741 doi 10 1210 er 23 2 141 Amsterdam A Hanoch T Dantes A et al Mechanisms of gonadotropin desensitization Mol Cell Endocrinol 2003 187 1 2 69 74 PMID 11988313 doi 10 1016 S0303 7207 01 00701 8 已忽略未知参数 author separator 帮助 Fanelli F Puett D Structural aspects of luteinizing hormone receptor information from molecular modeling and mutagenesis Endocrine 2003 18 3 285 93 PMID 12450321 doi 10 1385 ENDO 18 3 285 Latronico AC Segaloff DL Insights Learned from L457 3 43 R an Activating Mutant of the Human Lutropin Receptor Mol Cell Endocrinol 2007 260 262 287 93 PMC 1785107 PMID 17055147 doi 10 1016 j mce 2005 11 053 Nagayama Y Russo D Wadsworth HL et al Eleven amino acids Lys 201 to Lys 211 and 9 amino acids Gly 222 to Leu 230 in the human thyrotropin receptor are involved in ligand binding J Biol Chem 1991 266 23 14926 30 PMID 1651314 已忽略未知参数 author separator 帮助 Jia XC Oikawa M Bo M et al Expression of human luteinizing hormone LH receptor interaction with LH and chorionic gonadotropin from human but not equine rat and ovine species Mol Endocrinol 1991 5 6 759 68 PMID 1922095 doi 10 1210 mend 5 6 759 已忽略未知参数 author separator 帮助 Minegishi T Nakamura K Takakura Y et al Cloning and sequencing of human LH hCG receptor cDNA Biochem Biophys Res Commun 1990 172 3 1049 54 PMID 2244890 doi 10 1016 0006 291X 90 91552 4 已忽略未知参数 author separator 帮助 Rousseau Merck MF Misrahi M Atger M et al Localization of the human luteinizing hormone choriogonadotropin receptor gene LHCGR to chromosome 2p21 Cytogenet Cell Genet 1991 54 1 2 77 9 PMID 2249480 doi 10 1159 000132962 已忽略未知参数 author separator 帮助 Xie YB Wang H Segaloff DL Extracellular domain of lutropin choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity J Biol Chem 1991 265 35 21411 4 PMID 2254302 Frazier AL Robbins LS Stork PJ et al Isolation of TSH and LH CG receptor cDNAs from human thyroid regulation by tissue specific splicing Mol Endocrinol 1991 4 8 1264 76 PMID 2293030 doi 10 1210 mend 4 8 1264 已忽略未知参数 author separator 帮助 Keutmann HT Charlesworth MC Mason KA et al A receptor binding region in human choriogonadotropin lutropin beta subunit Proc Natl Acad Sci U S A 1987 84 7 2038 42 PMC 304579 PMID 3470775 doi 10 1073 pnas 84 7 2038 已忽略未知参数 author separator 帮助 Jiang X Dreano M Buckler DR et al Structural predictions for the ligand binding region of glycoprotein hormone receptors and the nature of hormone receptor interactions Structure 1996 3 12 1341 53 PMID 8747461 doi 10 1016 S0969 2126 01 00272 6 引文格式1维护 显式使用等标签 link Atger M Misrahi M Sar S et al Structure of the human luteinizing hormone choriogonadotropin receptor gene unusual promoter and 5 non coding regions Mol Cell Endocrinol 1995 111 2 113 23 PMID 7556872 doi 10 1016 0303 7207 95 03557 N 已忽略未知参数 author separator 帮助 Latronico AC Anasti J Arnhold IJ et al A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin independent precocious puberty J Clin Endocrinol Metab 1995 80 8 2490 4 PMID 7629248 doi 10 1210 jc 80 8 2490 已忽略未知参数 author separator 帮助 Shenker A Laue L Kosugi S et al A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty Nature 1993 365 6447 652 4 PMID 7692306 doi 10 1038 365652a0 已忽略未知参数 author separator 帮助 Yano K Saji M Hidaka A et al A new constitutively activating point mutation in the luteinizing hormone choriogonadotropin receptor gene in cases of male limited precocious puberty J Clin Endocrinol Metab 1995 80 4 1162 8 PMID 7714085 doi 10 1210 jc 80 4 1162 已忽略未知参数 author separator 帮助 Kremer H Kraaij R Toledo SP et al Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene Nat Genet 1995 9 2 160 4 PMID 7719343 doi 10 1038 ng0295 160 已忽略未知参数 author separator 帮助 Kosugi S Van Dop C Geffner ME et al Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty Hum Mol Genet 1995 4 2 183 8 PMID 7757065 doi 10 1093 hmg 4 2 183 已忽略未知参数 author separator 帮助 Kremer H Mariman E Otten BJ et al Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male limited precocious puberty Hum Mol Genet 1994 2 11 1779 83 PMID 8281137 doi 10 1093 hmg 2 11 1779 已忽略未知参数 author separator 帮助 外部链接 编辑Glycoprotein Hormone Receptors LH IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology GRIS Glycoprotein hormone Receptor Information System 醫學主題詞表 MeSH LH hCG Receptors 取自 https zh wikipedia org w index php title 黄体生成素 绒毛膜促性腺激素受体 amp oldid 70688148, 维基百科，wiki，书籍，书籍，图书馆，
