^Farid NR, Szkudlinski MW. Minireview: structural and functional evolution of the thyrotropin receptor. Endocrinology. 2004, 145 (9): 4048–57. PMID 15231707. doi:10.1210/en.2004-0437.
^Calebiro D, Nikolaev VO, Lohse MJ. Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. J. Mol. Endocrinol. July 2010, 45 (1): 1–8. PMID 20378719. doi:10.1677/JME-10-0014.
延伸阅读编辑
Führer D, Wonerow P, Willgerodt H, Paschke R. Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.. J. Clin. Endocrinol. Metab. 1998, 82 (12): 4234–8. PMID 9398746. doi:10.1210/jc.82.12.4234.
Farid NR, Kascur V, Balazs C. The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.. Eur. J. Endocrinol. 2000, 143 (1): 25–30. PMID 10870027. doi:10.1530/eje.0.1430025.
Tonacchera M, Vitti P, De Servi M; et al. Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.. J. Endocrinol. Invest. 2004, 26 (2 Suppl): 2–6. PMID 12762632. 引文格式1维护：显式使用等标签 (link)
Arturi F, Scarpelli D, Coco A; et al. Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.. Thyroid. 2004, 13 (4): 341–3. PMID 12804102. doi:10.1089/105072503321669811. 引文格式1维护：显式使用等标签 (link)
Vaidya B, Campbell V, Tripp JH; et al. Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.. Clin. Endocrinol. (Oxf). 2004, 60 (6): 711–8. PMID 15163335. doi:10.1111/j.1365-2265.2004.02040.x. 引文格式1维护：显式使用等标签 (link)
Takeshita A, Nagayama Y, Fujiyama K; et al. Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.. Biochem. Biophys. Res. Commun. 1992, 188 (3): 1214–9. PMID 1445355. doi:10.1016/0006-291X(92)91360-3. 引文格式1维护：显式使用等标签 (link)
Graves PN, Tomer Y, Davies TF. Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.. Biochem. Biophys. Res. Commun. 1992, 187 (2): 1135–43. PMID 1530609. doi:10.1016/0006-291X(92)91315-H.
Loosfelt H, Pichon C, Jolivet A; et al. Two-subunit structure of the human thyrotropin receptor. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (9): 3765–9. PMC 525571. PMID 1570295. doi:10.1073/pnas.89.9.3765. 引文格式1维护：显式使用等标签 (link)
Nagayama Y, Russo D, Wadsworth HL; et al. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J. Biol. Chem. 1991, 266 (23): 14926–30. PMID 1651314. 引文格式1维护：显式使用等标签 (link)
Murakami M, Mori M. Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease. Biochem. Biophys. Res. Commun. 1990, 171 (1): 512–8. PMID 1697467. doi:10.1016/0006-291X(90)91423-P.
Heldin NE, Gustavsson B, Westermark K, Westermark B. A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism. J. Clin. Endocrinol. Metab. 1992, 73 (6): 1374–6. PMID 1955520. doi:10.1210/jcem-73-6-1374.
Libert F, Passage E, Lefort A; et al. Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization. Cytogenet. Cell Genet. 1991, 54 (1–2): 82–3. PMID 2249482. doi:10.1159/000132964. 引文格式1维护：显式使用等标签 (link)
Frazier AL, Robbins LS, Stork PJ; et al. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol. Endocrinol. 1991, 4 (8): 1264–76. PMID 2293030. doi:10.1210/mend-4-8-1264. 引文格式1维护：显式使用等标签 (link)
Misrahi M, Loosfelt H, Atger M; et al. Cloning, sequencing and expression of human TSH receptor. Biochem. Biophys. Res. Commun. 1990, 166 (1): 394–403. PMID 2302212. doi:10.1016/0006-291X(90)91958-U. 引文格式1维护：显式使用等标签 (link)
Nagayama Y, Kaufman KD, Seto P, Rapoport B. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 1990, 165 (3): 1184–90. PMID 2558651. doi:10.1016/0006-291X(89)92727-7.
Libert F, Lefort A, Gerard C; et al. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 1990, 165 (3): 1250–5. PMID 2610690. doi:10.1016/0006-291X(89)92736-8. 引文格式1维护：显式使用等标签 (link)
Cuddihy RM, Bryant WP, Bahn RS. Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor. Thyroid. 1996, 5 (4): 255–7. PMID 7488864. doi:10.1089/thy.1995.5.255.
Bahn RS, Dutton CM, Heufelder AE, Sarkar G. A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy. J. Clin. Endocrinol. Metab. 1994, 78 (2): 256–60. PMID 7508946. doi:10.1210/jc.78.2.256.
Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S. Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene. N. Engl. J. Med. 1995, 332 (3): 155–60. PMID 7528344. doi:10.1056/NEJM199501193320305.
外部链接编辑
Glycoprotein Hormone Receptors: TSH. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容于2013-11-01）.
促甲状腺激素受体, 提示, 此条目的主题不是促甲状腺激素释放激素或促甲状腺激素释放激素受体, 英語, thyrotropin, receptor, receptor, tshr, 又称甲促素受体, 是一种接受促甲状腺激素, 甲促素, thyrotropin, 信号, 刺激细胞生成甲状腺激素, 和三碘甲状腺激素, 的跨膜受体, tshr是整合膜蛋白中g蛋白偶联受体超家族的一员, 与gs蛋白偶合, thyroid, stimulating, hormone, receptorrendering, based, 1xum. 提示 此条目的主题不是促甲状腺激素释放激素或促甲状腺激素释放激素受体 促甲状腺激素受体 英語 thyrotropin receptor TSH receptor TSHR 又称甲促素受体 是一种接受促甲状腺激素 甲促素 thyrotropin 信号 刺激细胞生成甲状腺激素 T4 和三碘甲状腺激素 T3 的跨膜受体 TSHR是整合膜蛋白中G蛋白偶联受体超家族的一员 1 与Gs蛋白偶合 2 Thyroid stimulating hormone receptor促甲状腺激素受体Rendering based on PDB 1XUM 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表2XWT 3G04标识代号TSHR CHNG1 LGR3 hTSHR I扩展标识遗传学 603372 鼠基因 98849 同源基因 315 IUPHAR TSH ChEMBL 1963 GeneCards TSHR Gene基因本体论描述分子功能 thyroid stimulating hormone receptor activity protein binding细胞成分 plasma membrane integral to plasma membrane生物过程 G protein coupled receptor signaling pathway G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger cell cell signaling positive regulation of cell proliferationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez725322095EnsemblENSG00000165409ENSMUSG00000020963UniProtP16473P47750mRNA序列NM 000369NM 001113404蛋白序列NP 000360NP 001106875基因位置Chr 14 81 42 81 61 MbChr 12 91 4 91 54 MbPubMed查询 1 2 查论编该受体主要出现在甲状腺上皮细胞 英语 thyroid epithelial cell 的表面 目录 1 功能 2 另见 3 参考文献 4 延伸阅读 5 外部链接功能 编辑在结合血循的TSH后 G蛋白信号级联反应会激活腺苷酸环化酶 adenylyl cyclase 进而使胞内环腺苷酸 cAMP 浓度升高 环腺苷酸可活化甲状腺细胞各功能层面 包括 碘泵运 甲状腺球蛋白的合成 碘化 胞吞和蛋白酶解 甲狀腺过氧化物酶活性 以及甲狀腺激素释放 另见 编辑弥漫性毒性甲状腺肿参考文献 编辑 Farid NR Szkudlinski MW Minireview structural and functional evolution of the thyrotropin receptor Endocrinology 2004 145 9 4048 57 PMID 15231707 doi 10 1210 en 2004 0437 Calebiro D Nikolaev VO Lohse MJ Imaging of persistent cAMP signaling by internalized G protein coupled receptors J Mol Endocrinol July 2010 45 1 1 8 PMID 20378719 doi 10 1677 JME 10 0014 延伸阅读 编辑Fuhrer D Wonerow P Willgerodt H Paschke R Identification of a new thyrotropin receptor germline mutation Leu629Phe in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism J Clin Endocrinol Metab 1998 82 12 4234 8 PMID 9398746 doi 10 1210 jc 82 12 4234 Farid NR Kascur V Balazs C The human thyrotropin receptor is highly mutable a review of gain of function mutations Eur J Endocrinol 2000 143 1 25 30 PMID 10870027 doi 10 1530 eje 0 1430025 Szkudlinski MW Fremont V Ronin C Weintraub BD Thyroid stimulating hormone and thyroid stimulating hormone receptor structure function relationships Physiol Rev 2002 82 2 473 502 PMID 11917095 doi 10 1152 physrev 00031 2001 Tonacchera M Vitti P De Servi M et al Gain of function TSH receptor mutations and iodine deficiency implications in iodine prophylaxis J Endocrinol Invest 2004 26 2 Suppl 2 6 PMID 12762632 引文格式1维护 显式使用等标签 link Arturi F Scarpelli D Coco A et al Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery unresolved questions Thyroid 2004 13 4 341 3 PMID 12804102 doi 10 1089 105072503321669811 引文格式1维护 显式使用等标签 link Vaidya B Campbell V Tripp JH et al Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation Clin Endocrinol Oxf 2004 60 6 711 8 PMID 15163335 doi 10 1111 j 1365 2265 2004 02040 x 引文格式1维护 显式使用等标签 link Takeshita A Nagayama Y Fujiyama K et al Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript Biochem Biophys Res Commun 1992 188 3 1214 9 PMID 1445355 doi 10 1016 0006 291X 92 91360 3 引文格式1维护 显式使用等标签 link Graves PN Tomer Y Davies TF Cloning and sequencing of a 1 3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain Biochem Biophys Res Commun 1992 187 2 1135 43 PMID 1530609 doi 10 1016 0006 291X 92 91315 H Loosfelt H Pichon C Jolivet A et al Two subunit structure of the human thyrotropin receptor Proc Natl Acad Sci U S A 1992 89 9 3765 9 PMC 525571 nbsp PMID 1570295 doi 10 1073 pnas 89 9 3765 引文格式1维护 显式使用等标签 link Nagayama Y Russo D Wadsworth HL et al Eleven amino acids Lys 201 to Lys 211 and 9 amino acids Gly 222 to Leu 230 in the human thyrotropin receptor are involved in ligand binding J Biol Chem 1991 266 23 14926 30 PMID 1651314 引文格式1维护 显式使用等标签 link Murakami M Mori M Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves disease Biochem Biophys Res Commun 1990 171 1 512 8 PMID 1697467 doi 10 1016 0006 291X 90 91423 P Heldin NE Gustavsson B Westermark K Westermark B A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism J Clin Endocrinol Metab 1992 73 6 1374 6 PMID 1955520 doi 10 1210 jcem 73 6 1374 Libert F Passage E Lefort A et al Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization Cytogenet Cell Genet 1991 54 1 2 82 3 PMID 2249482 doi 10 1159 000132964 引文格式1维护 显式使用等标签 link Frazier AL Robbins LS Stork PJ et al Isolation of TSH and LH CG receptor cDNAs from human thyroid regulation by tissue specific splicing Mol Endocrinol 1991 4 8 1264 76 PMID 2293030 doi 10 1210 mend 4 8 1264 引文格式1维护 显式使用等标签 link Misrahi M Loosfelt H Atger M et al Cloning sequencing and expression of human TSH receptor Biochem Biophys Res Commun 1990 166 1 394 403 PMID 2302212 doi 10 1016 0006 291X 90 91958 U 引文格式1维护 显式使用等标签 link Nagayama Y Kaufman KD Seto P Rapoport B Molecular cloning sequence and functional expression of the cDNA for the human thyrotropin receptor Biochem Biophys Res Commun 1990 165 3 1184 90 PMID 2558651 doi 10 1016 0006 291X 89 92727 7 Libert F Lefort A Gerard C et al Cloning sequencing and expression of the human thyrotropin TSH receptor evidence for binding of autoantibodies Biochem Biophys Res Commun 1990 165 3 1250 5 PMID 2610690 doi 10 1016 0006 291X 89 92736 8 引文格式1维护 显式使用等标签 link Cuddihy RM Bryant WP Bahn RS Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor Thyroid 1996 5 4 255 7 PMID 7488864 doi 10 1089 thy 1995 5 255 Bahn RS Dutton CM Heufelder AE Sarkar G A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves ophthalmopathy J Clin Endocrinol Metab 1994 78 2 256 60 PMID 7508946 doi 10 1210 jc 78 2 256 Sunthornthepvarakui T Gottschalk ME Hayashi Y Refetoff S Brief report resistance to thyrotropin caused by mutations in the thyrotropin receptor gene N Engl J Med 1995 332 3 155 60 PMID 7528344 doi 10 1056 NEJM199501193320305 外部链接 编辑Glycoprotein Hormone Receptors TSH IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology 原始内容存档于2013 11 01 醫學主題詞表 MeSH Thyrotropin Receptors GRIS Glycoprotein hormone Receptor Information System 取自 https zh wikipedia org w index php title 促甲状腺激素受体 amp oldid 68261613, 维基百科，wiki，书籍，书籍，图书馆，
