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维基百科

主要碱性蛋白

二月 01, 2023

主要碱性蛋白（英語：Major basic protein，MBP），全称为嗜酸性粒细胞主要碱性蛋白（英語：Eosinophil Major basic protein），也称为蛋白多糖2（Proteoglycan 2，PRG2），是一种由人类基因PRG2编码的蛋白质[5]。

主要碱性蛋白
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名PRG2；, BMPG, MBP, MBP1, proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein), proMBP, proteoglycan 2, pro eosinophil major basic protein
外部IDOMIM：605601 MGI：103294 HomoloGene：2044 GeneCards：PRG2
基因位置（人类）
染色体11號染色體[1]
基因座11q12.1起始57,386,780 bp[1]
终止57,390,650 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物種人類小鼠
Entrez

5553

19074

Ensembl

ENSG00000186652

ENSMUSG00000027073

UniProt

P13727

Q61878

mRNA​序列

NM_002728
​NM_001243245
​NM_001302926
​NM_001302927

NM_008920

蛋白序列

NP_001230174
​NP_001289855
​NP_001289856
​NP_002719

NP_032946

基因位置​（UCSC）Chr 11: 57.39 – 57.39 MbChr 2: 84.81 – 84.81 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

MBP在结构上类似于凝集素（糖结合蛋白），特别是与C-型凝集素在折叠上相似。但与C-型凝集素不同（C-型凝集素在钙的存在下会结合各种碳水化合物），MBP既不与钙结合也不与这些糖类结合，而是识别並結合硫酸乙酰肝素（heparan sulfate）。MBP的两种晶体结构已被测定。[6][7]

相互作用

主要碱性蛋白已知可与妊娠相关血浆蛋白A发生蛋白質交互作用。[8][9][10]

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000186652 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000027073 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein). （原始内容于2008-11-02）. 
  6. ^ PDB 1h8u; Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR. Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity. J. Biol. Chem. July 2001, 276 (28): 26197–26203. PMID 11319227. doi:10.1074/jbc.M100848200. 
  7. ^ PDB 2brs; Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR. Eosinophil-granule major basic protein, a C-type lectin, binds heparin. Biochemistry. November 2005, 44 (43): 14152–14158. PMID 16245931. doi:10.1021/bi051112b. 
  8. ^ Overgaard, M T; Haaning J; Boldt H B; Olsen I M; Laursen L S; Christiansen M; Gleich G J; Sottrup-Jensen L; Conover C A; Oxvig C. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J. Biol. Chem. (UNITED STATES). October 2000, 275 (40): 31128–31133. ISSN 0021-9258. PMID 10913121. doi:10.1074/jbc.M001384200. 
  9. ^ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. J. Biol. Chem. (United States). January 2003, 278 (4): 2106–2117. ISSN 0021-9258. PMID 12421832. doi:10.1074/jbc.M208777200. 
  10. ^ Oxvig, C; Sand O; Kristensen T; Gleich G J; Sottrup-Jensen L. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J. Biol. Chem. (UNITED STATES). June 1993, 268 (17): 12243–6. ISSN 0021-9258. PMID 7685339. 

外部链接

延伸阅读

  • Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 2000, 346 (3): 561–76. PMC 1220886  . PMID 10698680. doi:10.1042/0264-6021:3460561. 
  • Yoshimatsu K, Ohya Y, Shikata Y, et al. Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. Mol. Immunol. 1992, 29 (4): 537–546. PMID 1565101. doi:10.1016/0161-5890(92)90012-M. 
  • Barker RL, Loegering DA, Arakawa KC, et al. Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. Gene. 1990, 86 (2): 285–289. PMID 2323577. doi:10.1016/0378-1119(90)90292-Y. 
  • Gabay JE, Scott RW, Campanelli D, et al. Antibiotic proteins of human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. U.S.A. 1989, 86 (14): 5610–5614. Bibcode:1989PNAS...86.5610G. PMC 297672  . PMID 2501794. doi:10.1073/pnas.86.14.5610. 
  • Wasmoen TL, McKean DJ, Benirschke K, et al. Evidence of eosinophil granule major basic protein in human placenta. J. Exp. Med. 1990, 170 (6): 2051–2063. PMC 2189540  . PMID 2584934. doi:10.1084/jem.170.6.2051. 
  • Barker RL, Gleich GJ, Pease LR. Acidic precursor revealed in human eosinophil granule major basic protein cDNA. J. Exp. Med. 1988, 168 (4): 1493–1498. PMC 2189086  . PMID 3171483. doi:10.1084/jem.168.4.1493. 
  • McGrogan M, Simonsen C, Scott R, et al. Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein. J. Exp. Med. 1989, 168 (6): 2295–2308. PMC 2189145  . PMID 3199069. doi:10.1084/jem.168.6.2295. 
  • Wasmoen TL, Bell MP, Loegering DA, et al. Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein. J. Biol. Chem. 1988, 263 (25): 12559–63. PMID 3410852. 
  • Weller PF, Ackerman SJ, Smith JA. Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase. J. Leukoc. Biol. 1988, 43 (1): 1–4. PMID 3422083. 
  • Kristensen T, Oxvig C, Sand O, et al. Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA. Biochemistry. 1994, 33 (6): 1592–1598. PMID 7508748. doi:10.1021/bi00172a040. 
  • Oxvig C, Haaning J, Højrup P, Sottrup-Jensen L. Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum. Biochem. Mol. Biol. Int. 1994, 33 (2): 329–36. PMID 7524900. 
  • Bonno M, Oxvig C, Kephart GM, et al. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. Lab. Invest. 1994, 71 (4): 560–6. PMID 7526035. 
  • Li MS, Sun L, Satoh T, et al. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. Biochem. J. 1995, 305 (3): 921–7. PMC 1136346  . PMID 7531438. 
  • Oxvig C, Haaning J, Kristensen L, et al. Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. J. Biol. Chem. 1995, 270 (23): 13645–13651. PMID 7539791. doi:10.1074/jbc.270.23.13645. 
  • Oxvig C, Sand O, Kristensen T, et al. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J. Biol. Chem. 1993, 268 (17): 12243–6. PMID 7685339. 
  • Levi-Schaffer F, Lacy P, Severs NJ, et al. Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils. Blood. 1995, 85 (9): 2579–86. PMID 7727786. 
  • Oxvig C, Gleich GJ, Sottrup-Jensen L. Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein. FEBS Lett. 1994, 341 (2–3): 213–217. PMID 8137941. doi:10.1016/0014-5793(94)80459-1. 
  • Shikata Y, Hayashi Y, Yoshimatsu K, et al. Pro-major basic protein has three types of sugar chains at the pro-portion. Biochim. Biophys. Acta. 1993, 1163 (3): 243–9. PMID 8507662. doi:10.1016/0167-4838(93)90158-N. 
  • Nittoh T, Watanabe M, Okayama H, et al. Cloning of cDNA for rat eosinophil major basic protein. Biochim. Biophys. Acta. 1996, 1264 (3): 261–4. PMID 8547309. doi:10.1016/0167-4781(95)00183-2. 
  • Delcommenne M, Tan C, Gray V, et al. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (19): 11211–11216. Bibcode:1998PNAS...9511211D. PMC 21621  . PMID 9736715. doi:10.1073/pnas.95.19.11211. 

二月 01, 2023
主要碱性蛋白, 英語, major, basic, protein, 全称为嗜酸性粒细胞, 英語, eosinophil, major, basic, protein, 也称为蛋白多糖2, proteoglycan, prg2, 是一种由人类基因prg2编码的蛋白质, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1h8u, 2brs, 4qxx識別號别名prg2, bmpg, mbp1, proteoglycan, bone, marrow, natural, killer, cell, ac. 主要碱性蛋白 英語 Major basic protein MBP 全称为嗜酸性粒细胞主要碱性蛋白 英語 Eosinophil Major basic protein 也称为蛋白多糖2 Proteoglycan 2 PRG2 是一种由人类基因PRG2编码的蛋白质 5 主要碱性蛋白已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1H8U 2BRS 4QXX識別號别名PRG2 BMPG MBP MBP1 proteoglycan 2 bone marrow natural killer cell activator eosinophil granule major basic protein proMBP proteoglycan 2 pro eosinophil major basic protein外部IDOMIM 605601 MGI 103294 HomoloGene 2044 GeneCards PRG2基因位置 人类 染色体11號染色體 1 基因座11q12 1起始57 386 780 bp 1 终止57 390 650 bp 1 基因位置 小鼠 染色体小鼠2号染色体 2 基因座2 D 2 49 45 cM起始84 810 805 bp 2 终止84 813 976 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 heparin binding carbohydrate binding extracellular matrix structural constituent conferring compression resistance細胞組分 細胞外區域 transport vesicle cytoplasmic vesicle 外排體 ficolin 1 rich granule lumen collagen containing extracellular matrix生物學過程 defense response to bacterium immune system process defense response to nematode negative regulation of interleukin 10 production positive regulation of interleukin 4 production 免疫反应 neutrophil degranulationSources Amigo QuickGO直系同源物種人類小鼠Entrez555319074EnsemblENSG00000186652ENSMUSG00000027073UniProtP13727Q61878mRNA 序列NM 002728 NM 001243245 NM 001302926 NM 001302927NM 008920蛋白序列NP 001230174 NP 001289855 NP 001289856 NP 002719NP 032946基因位置 UCSC Chr 11 57 39 57 39 MbChr 2 84 81 84 81 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠MBP在结构上类似于凝集素 糖结合蛋白 特别是与C 型凝集素在折叠上相似 但与C 型凝集素不同 C 型凝集素在钙的存在下会结合各种碳水化合物 MBP既不与钙结合也不与这些糖类结合 而是识别並結合硫酸乙酰肝素 heparan sulfate MBP的两种晶体结构已被测定 6 7 目录 1 相互作用 2 参考文献 3 外部链接 4 延伸阅读相互作用 编辑主要碱性蛋白已知可与妊娠相关血浆蛋白A发生蛋白質交互作用 8 9 10 参考文献 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000186652 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000027073 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PRG2 proteoglycan 2 bone marrow natural killer cell activator eosinophil granule major basic protein 原始内容存档于2008 11 02 PDB 1h8u Swaminathan GJ Weaver AJ Loegering DA Checkel JL Leonidas DD Gleich GJ Acharya KR Crystal structure of the eosinophil major basic protein at 1 8 A An atypical lectin with a paradigm shift in specificity J Biol Chem July 2001 276 28 26197 26203 PMID 11319227 doi 10 1074 jbc M100848200 PDB 2brs Swaminathan GJ Myszka DG Katsamba PS Ohnuki LE Gleich GJ Acharya KR Eosinophil granule major basic protein a C type lectin binds heparin Biochemistry November 2005 44 43 14152 14158 PMID 16245931 doi 10 1021 bi051112b Overgaard M T Haaning J Boldt H B Olsen I M Laursen L S Christiansen M Gleich G J Sottrup Jensen L Conover C A Oxvig C Expression of recombinant human pregnancy associated plasma protein A and identification of the proform of eosinophil major basic protein as its physiological inhibitor J Biol Chem UNITED STATES October 2000 275 40 31128 31133 ISSN 0021 9258 PMID 10913121 doi 10 1074 jbc M001384200 Overgaard MT Sorensen ES Stachowiak D Boldt HB Kristensen L Sottrup Jensen L Oxvig C Complex of pregnancy associated plasma protein A and the proform of eosinophil major basic protein Disulfide structure and carbohydrate attachment J Biol Chem United States January 2003 278 4 2106 2117 ISSN 0021 9258 PMID 12421832 doi 10 1074 jbc M208777200 Oxvig C Sand O Kristensen T Gleich G J Sottrup Jensen L Circulating human pregnancy associated plasma protein A is disulfide bridged to the proform of eosinophil major basic protein J Biol Chem UNITED STATES June 1993 268 17 12243 6 ISSN 0021 9258 PMID 7685339 外部链接 编辑醫學主題詞表 MeSH Eosinophil Major Basic Protein延伸阅读 编辑Vanhaesebroeck B Alessi DR The PI3K PDK1 connection more than just a road to PKB Biochem J 2000 346 3 561 76 PMC 1220886 PMID 10698680 doi 10 1042 0264 6021 3460561 Yoshimatsu K Ohya Y Shikata Y et al Purification and cDNA cloning of a novel factor produced by a human T cell hybridoma sequence homology with animal lectins Mol Immunol 1992 29 4 537 546 PMID 1565101 doi 10 1016 0161 5890 92 90012 M Barker RL Loegering DA Arakawa KC et al Cloning and sequence analysis of the human gene encoding eosinophil major basic protein Gene 1990 86 2 285 289 PMID 2323577 doi 10 1016 0378 1119 90 90292 Y Gabay JE Scott RW Campanelli D et al Antibiotic proteins of human polymorphonuclear leukocytes Proc Natl Acad Sci U S A 1989 86 14 5610 5614 Bibcode 1989PNAS 86 5610G PMC 297672 PMID 2501794 doi 10 1073 pnas 86 14 5610 Wasmoen TL McKean DJ Benirschke K et al Evidence of eosinophil granule major basic protein in human placenta J Exp Med 1990 170 6 2051 2063 PMC 2189540 PMID 2584934 doi 10 1084 jem 170 6 2051 Barker RL Gleich GJ Pease LR Acidic precursor revealed in human eosinophil granule major basic protein cDNA J Exp Med 1988 168 4 1493 1498 PMC 2189086 PMID 3171483 doi 10 1084 jem 168 4 1493 McGrogan M Simonsen C Scott R et al Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein J Exp Med 1989 168 6 2295 2308 PMC 2189145 PMID 3199069 doi 10 1084 jem 168 6 2295 Wasmoen TL Bell MP Loegering DA et al Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein J Biol Chem 1988 263 25 12559 63 PMID 3410852 Weller PF Ackerman SJ Smith JA Eosinophil granule cationic proteins major basic protein is distinct from the smaller subunit of eosinophil peroxidase J Leukoc Biol 1988 43 1 1 4 PMID 3422083 Kristensen T Oxvig C Sand O et al Amino acid sequence of human pregnancy associated plasma protein A derived from cloned cDNA Biochemistry 1994 33 6 1592 1598 PMID 7508748 doi 10 1021 bi00172a040 Oxvig C Haaning J Hojrup P Sottrup Jensen L Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum Biochem Mol Biol Int 1994 33 2 329 36 PMID 7524900 Bonno M Oxvig C Kephart GM et al Localization of pregnancy associated plasma protein A and colocalization of pregnancy associated plasma protein A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta Lab Invest 1994 71 4 560 6 PMID 7526035 Li MS Sun L Satoh T et al Human eosinophil major basic protein a mediator of allergic inflammation is expressed by alternative splicing from two promoters Biochem J 1995 305 3 921 7 PMC 1136346 PMID 7531438 Oxvig C Haaning J Kristensen L et al Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma J Biol Chem 1995 270 23 13645 13651 PMID 7539791 doi 10 1074 jbc 270 23 13645 Oxvig C Sand O Kristensen T et al Circulating human pregnancy associated plasma protein A is disulfide bridged to the proform of eosinophil major basic protein J Biol Chem 1993 268 17 12243 6 PMID 7685339 Levi Schaffer F Lacy P Severs NJ et al Association of granulocyte macrophage colony stimulating factor with the crystalloid granules of human eosinophils Blood 1995 85 9 2579 86 PMID 7727786 Oxvig C Gleich GJ Sottrup Jensen L Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein FEBS Lett 1994 341 2 3 213 217 PMID 8137941 doi 10 1016 0014 5793 94 80459 1 Shikata Y Hayashi Y Yoshimatsu K et al Pro major basic protein has three types of sugar chains at the pro portion Biochim Biophys Acta 1993 1163 3 243 9 PMID 8507662 doi 10 1016 0167 4838 93 90158 N Nittoh T Watanabe M Okayama H et al Cloning of cDNA for rat eosinophil major basic protein Biochim Biophys Acta 1996 1264 3 261 4 PMID 8547309 doi 10 1016 0167 4781 95 00183 2 Delcommenne M Tan C Gray V et al Phosphoinositide 3 OH kinase dependent regulation of glycogen synthase kinase 3 and protein kinase B AKT by the integrin linked kinase Proc Natl Acad Sci U S A 1998 95 19 11211 11216 Bibcode 1998PNAS 9511211D PMC 21621 PMID 9736715 doi 10 1073 pnas 95 19 11211 取自 https zh wikipedia org w index php title 主要碱性蛋白 amp oldid 71197512, 维基百科，wiki，书籍，书籍，图书馆，

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