· osteoblast differentiation · osteoblast development · cell adhesion · cell aging · response to mechanical stimulus · response to gravity · response to zinc ion · response to activity · bone mineralization · regulation of bone mineralization · response to vitamin K · response to vitamin D · response to testosterone stimulus · response to hydroxyisoflavone · odontogenesis · response to drug · response to estrogen stimulus · regulation of bone resorption · response to ethanol · regulation of osteoclast differentiation · response to glucocorticoid stimulus · bone development · cellular response to vitamin D
^ 4.04.1Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G. 骨骼对能量代谢的内分泌调节（Endocrine regulation of energy metabolism by the skeleton）. Cell. August 2007, 130 (3): 456–69. PMC 2013746. PMID 17693256. doi:10.1016/j.cell.2007.05.047.
^Franck Oury, Grzegorz Sumara, Olga Sumara, Mathieu Ferron, Haixin Chang, Charles E. Smith, Louis Hermo, Susan Suarez, Bryan L. Roth, Patricia Ducy et al.骨骼对男性生育力的内分泌调节 （Endocrine Regulation of Male Fertility by the Skeleton）. Cell, 17 February 2011 doi:10.1016/j.cell.2011.02.004
^Pi M, Wu Y, Quarles DL. GPRC6A介导体外beta细胞和体内胰腺对骨钙蛋白的反应（GPRC6A mediates responses to osteocalcin in beta-cells in vitro and pancreas in vivo）. JBMR. July 2011, 26 (7): 1680–1683. PMID 21425331. doi:10.1002/jbmr.390.
^Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell. July 2010, 142 (2): 309–19. PMC 2925155. PMID 20655471. doi:10.1016/j.cell.2010.06.002.
^Bharadwaj S, Naidu AG, Betageri GV, Prasadarao NV, Naidu AS. Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women. Osteoporos Int. September 2009, 20 (9): 1603–11. PMID 19172341. doi:10.1007/s00198-009-0839-8.
延伸阅读
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Lin GT, Tseng HF, Chang CK; et al. SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.. Chin J Physiol. 2008, 51 (1): 32–41. PMID 18551993. 引文格式1维护：显式使用等标签 (link)
Lumachi F, Camozzi V, Tombolan V, Luisetto G. Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus.. Annals of the New York Academy of Sciences. 2009,. 1173 Suppl 1: E64–7. PMID 19751417. doi:10.1111/j.1749-6632.2009.04955.x.
Kanazawa I, Yamaguchi T, Yamamoto M; et al. Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes.. Calcif. Tissue Int. 2009, 85 (3): 228–34. PMID 19641839. doi:10.1007/s00223-009-9272-4. 引文格式1维护：显式使用等标签 (link)
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Desbois C, Karsenty G. Osteocalcin cluster: implications for functional studies.. J. Cell. Biochem. 1995, 57 (3): 379–83. PMID 7768973. doi:10.1002/jcb.240570302.
Salem AM, Zohny SF, Abd El-Wahab MM, Hamdy R. Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer.. Clin. Biochem. 2007, 40 (16-17): 1201–8. PMID 17889845. doi:10.1016/j.clinbiochem.2007.07.006.
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Hwang YC, Jeong IK, Ahn KJ, Chung HY. The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects.. Diabetes Metab. Res. Rev. 2009, 25 (8): 768–72. PMID 19877133. doi:10.1002/dmrr.1045.
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French D, Hamilton LH, Mattano LA; et al. A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.. Blood. 2008, 111 (9): 4496–9. PMC 2343589. PMID 18285546. doi:10.1182/blood-2007-11-123885. 引文格式1维护：显式使用等标签 (link)
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骨钙蛋白, 也被称为骨含伽马羧酸蛋白, bglap, 是一种非胶原蛋白质, 可见于骨或牙本质之中, 因其含, 伽马羧酸基团, 所以其合成是维生素k依赖性的, 在人体, 是由bglap, 基因编码的, 其受体是, gprc6a, bone, gamma, carboxyglutamate, protein骨含伽马羧酸蛋白pdb, rendering, based, 1q8h, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1q3m, 1q8h标识代号bglap, ocn扩展标识遗传学, 11. 骨钙蛋白 也被称为骨含伽马羧酸蛋白 BGLAP 是一种非胶原蛋白质 可见于骨或牙本质之中 因其含 伽马羧酸基团 所以其合成是维生素K依赖性的 在人体 骨钙蛋白是由BGLAP 基因编码的 1 2 其受体是 GPRC6A 3 Bone gamma carboxyglutamate gla protein骨含伽马羧酸蛋白PDB rendering based on 1q8h 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1q3m 1q8h标识代号BGLAP BGP OC OCN扩展标识遗传学 112260 鼠基因 88156 同源基因 104130 GeneCards BGLAP Gene基因本体论描述分子功能 structural molecule activity calcium ion binding structural constituent of bone hydroxyapatite binding细胞成分 extracellular region extracellular space rough endoplasmic reticulum Golgi apparatus dendrite membrane bounded vesicle perikaryon生物过程 skeletal system development osteoblast differentiation osteoblast development cell adhesion cell aging response to mechanical stimulus response to gravity response to zinc ion response to activity bone mineralization regulation of bone mineralization response to vitamin K response to vitamin D response to testosterone stimulus response to hydroxyisoflavone odontogenesis response to drug response to estrogen stimulus regulation of bone resorption response to ethanol regulation of osteoclast differentiation response to glucocorticoid stimulus bone development cellular response to vitamin D cellular response to growth factor stimulusSources Amigo QuickGO直系同源体物种人类小鼠Entrez63212095EnsemblENSG00000242252ENSMUSG00000074489UniProtP02818P54615mRNA序列NM 199173NM 031368 4蛋白序列NP 954642NP 112736 3基因位置Chr 1 156 21 156 21 MbChr 3 88 37 88 37 MbPubMed查询 1 2 查论编提示 此条目的主题不是骨粘连蛋白或骨桥蛋白 目录 1 功能 2 用做成骨过程的生化标记 3 引用 4 延伸阅读 5 外部链接功能 编辑骨钙蛋白仅由成骨细胞分泌 它在人体代谢调节方面有一定作用 并具有 促成骨 作用 4 它也涉及骨矿化和钙离子动态平衡 骨钙蛋白在人体内也是一种荷尔蒙 它可促使胰腺的beta细胞释放更多的胰岛素 并同时指示脂肪细胞 释放荷尔蒙脂联素来提高对胰岛素的敏感性 4 当前的数据暗示骨钙蛋白在男性生育能力方面扮演的一种可能的角色 5 来自哥伦比亚大学医学中心的研究提出骨钙蛋白可能增强睾酮的分泌 6 虽然这些研究只由单独的一家实验室进行 但至少有其它两个团体曾独立确认了骨钙蛋白在胰岛素分泌方面的作用 7 8 用做成骨过程的生化标记 编辑由于骨钙蛋白是由成骨细胞产生 所以它常常被用作成骨过程标记 在使用针对成骨细胞的成骨促进药物 如 特立帕肽 Teriparatide 的治疗过程当中 曾观察到较高的血浆骨钙蛋白水平与骨矿物质密度 BMD 之间有较高的相关性 在许多研究当中 骨钙蛋白被用作一种指示某种药物骨形成效应的基本的生化标记 例如 一项针对一种叫做乳铁蛋白 lactoferrin 的糖蛋白对成骨过程效用的研究就使用了骨钙蛋白作为成骨细胞活跃度的度量指标 9 引用 编辑 Puchacz E Lian JB Stein GS Wozney J Huebner K Croce C 人类骨钙蛋白基因染色体定位 Endocrinology May 1989 124 5 2648 50 PMID 2785029 doi 10 1210 endo 124 5 2648 Cancela L Hsieh CL Francke U Price PA 分子结构 染色体分配 以及人类基质Gla的蛋白质基因的启动子的组织 J Biol Chem 1990 九月 265 25 15040 8 PMID 2394711 请检查 date 中的日期值 帮助 存档副本 2014 10 18 原始内容存档于2014 10 18 4 0 4 1 Lee NK Sowa H Hinoi E Ferron M Ahn JD Confavreux C Dacquin R Mee PJ McKee MD Jung DY Zhang Z Kim JK Mauvais Jarvis F Ducy P Karsenty G 骨骼对能量代谢的内分泌调节 Endocrine regulation of energy metabolism by the skeleton Cell August 2007 130 3 456 69 PMC 2013746 PMID 17693256 doi 10 1016 j cell 2007 05 047 Franck Oury Grzegorz Sumara Olga Sumara Mathieu Ferron Haixin Chang Charles E Smith Louis Hermo Susan Suarez Bryan L Roth Patricia Ducy et al 骨骼对男性生育力的内分泌调节 Endocrine Regulation of Male Fertility by the Skeleton Cell 17 February 2011 doi 10 1016 j cell 2011 02 004 睾酮 Pi M Wu Y Quarles DL GPRC6A介导体外beta细胞和体内胰腺对骨钙蛋白的反应 GPRC6A mediates responses to osteocalcin in beta cells in vitro and pancreas in vivo JBMR July 2011 26 7 1680 1683 PMID 21425331 doi 10 1002 jbmr 390 Fulzele K Riddle RC DiGirolamo DJ Cao X Wan C Chen D Faugere MC Aja S Hussain MA Bruning JC Clemens TL Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition Cell July 2010 142 2 309 19 PMC 2925155 PMID 20655471 doi 10 1016 j cell 2010 06 002 Bharadwaj S Naidu AG Betageri GV Prasadarao NV Naidu AS Milk ribonuclease enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women Osteoporos Int September 2009 20 9 1603 11 PMID 19172341 doi 10 1007 s00198 009 0839 8 延伸阅读 编辑Kamdem LK Hamilton L Cheng C et al Genetic predictors of glucocorticoid induced hypertension in children with acute lymphoblastic leukemia Pharmacogenet Genomics 2008 18 6 507 14 PMID 18496130 doi 10 1097 FPC 0b013e3282fc5801 引文格式1维护 显式使用等标签 link Lin GT Tseng HF Chang CK et al SNP combinations in chromosome wide genes are associated with bone mineral density in Taiwanese women Chin J Physiol 2008 51 1 32 41 PMID 18551993 引文格式1维护 显式使用等标签 link Lumachi F Camozzi V Tombolan V Luisetto G Bone mineral density osteocalcin and bone specific alkaline phosphatase in patients with insulin dependent diabetes mellitus Annals of the New York Academy of Sciences 2009 1173 Suppl 1 E64 7 PMID 19751417 doi 10 1111 j 1749 6632 2009 04955 x Kanazawa I Yamaguchi T Yamamoto M et al Serum osteocalcin bone specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes Calcif Tissue Int 2009 85 3 228 34 PMID 19641839 doi 10 1007 s00223 009 9272 4 引文格式1维护 显式使用等标签 link Makita N Suzuki M Asami S et al Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells Gene 2008 413 1 2 8 17 PMID 18321663 doi 10 1016 j gene 2007 12 025 引文格式1维护 显式使用等标签 link Desbois C Karsenty G Osteocalcin cluster implications for functional studies J Cell Biochem 1995 57 3 379 83 PMID 7768973 doi 10 1002 jcb 240570302 Salem AM Zohny SF Abd El Wahab MM Hamdy R Predictive value of osteocalcin and beta CrossLaps in metastatic breast cancer Clin Biochem 2007 40 16 17 1201 8 PMID 17889845 doi 10 1016 j clinbiochem 2007 07 006 Im JA Yu BP Jeon JY Kim SH Relationship between osteocalcin and glucose metabolism in postmenopausal women Clin Chim Acta 2008 396 1 2 66 9 PMID 18657532 doi 10 1016 j cca 2008 07 001 Ba Y Huang H Yang Y et al The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People s Republic of China Ecotoxicol Environ Saf 2009 72 8 2158 61 PMID 19767102 doi 10 1016 j ecoenv 2009 08 014 引文格式1维护 显式使用等标签 link Hwang YC Jeong IK Ahn KJ Chung HY The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta cell function in middle aged male subjects Diabetes Metab Res Rev 2009 25 8 768 72 PMID 19877133 doi 10 1002 dmrr 1045 Yerges LM Klei L Cauley JA et al High density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men J Bone Miner Res 2009 24 12 2039 49 PMC 2791518 PMID 19453261 doi 10 1359 jbmr 090524 引文格式1维护 显式使用等标签 link Yu S Jiang Y Galson DL et al General transcription factor IIA gamma increases osteoblast specific osteocalcin gene expression via activating transcription factor 4 and runt related transcription factor 2 J Biol Chem 2008 283 9 5542 53 PMC 2736298 PMID 18171674 doi 10 1074 jbc M705653200 引文格式1维护 显式使用等标签 link Kayed H Bekasi S Keleg S et al BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion Mol Cancer 2007 6 83 PMC 2245975 PMID 18163903 doi 10 1186 1476 4598 6 83 引文格式1维护 显式使用等标签 link French D Hamilton LH Mattano LA et al A PAI 1 SERPINE1 polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia a report from the Children s Oncology Group Blood 2008 111 9 4496 9 PMC 2343589 PMID 18285546 doi 10 1182 blood 2007 11 123885 引文格式1维护 显式使用等标签 link Pittas AG Harris SS Eliades M et al Association between serum osteocalcin and markers of metabolic phenotype J Clin Endocrinol Metab 2009 94 3 827 32 PMC 2681283 PMID 19088165 doi 10 1210 jc 2008 1422 引文格式1维护 显式使用等标签 link Kindblom JM Ohlsson C Ljunggren O et al Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men J Bone Miner Res 2009 24 5 785 91 PMID 19063687 doi 10 1359 jbmr 081234 引文格式1维护 显式使用等标签 link Wahlgren CM Zheng W Shaalan W et al Human carotid plaque calcification and vulnerability Relationship between degree of plaque calcification fibrous cap inflammatory gene expression and symptomatology Cerebrovasc Dis 2009 27 2 193 200 PMID 19136823 doi 10 1159 000189204 引文格式1维护 显式使用等标签 link Lumachi F Ermani M Camozzi V et al Changes of bone formation markers osteocalcin and bone specific alkaline phosphatase in postmenopausal women with osteoporosis Annals of the New York Academy of Sciences 2009 1173 Suppl 1 E60 3 PMID 19751416 doi 10 1111 j 1749 6632 2009 04953 x 引文格式1维护 显式使用等标签 link Born AK Rottmar M Lischer S et al Correlating cell architecture with osteogenesis first steps towards live single cell monitoring Eur Cell Mater 2009 18 49 60 61 2 discussion 60 PMID 19856264 引文格式1维护 显式使用等标签 link Fujisawa R Recent advances in research on bone matrix proteins Nippon Rinsho 2002 60 Suppl 3 72 8 PMID 11979972 外部链接 编辑醫學主題詞表 MeSH Osteocalcin 取自 https zh wikipedia org w index php title 骨钙蛋白 amp oldid 70541030, 维基百科，wiki，书籍，书籍，图书馆，
