• positive regulation of glucose import • positive regulation of protein phosphorylation • negative regulation of receptor binding • low-density lipoprotein particle clearance • negative regulation of blood pressure • negative regulation of macrophage differentiation • negative regulation of synaptic transmission • generation of precursor metabolites and energy • cellular response to epinephrine stimulus • negative regulation of gluconeogenesis • regulation of glucose metabolic process • 昼夜节律 • fatty acid oxidation • positive regulation of interleukin-8 production • glucose metabolic process • protein heterotrimerization • negative regulation of heterotypic cell-cell adhesion • response to ethanol • negative regulation of inflammatory response • cellular response to cAMP • positive regulation of protein kinase A signaling • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of signal transduction • positive regulation of protein metabolic process • negative regulation of fat cell differentiation • response to linoleic acid • detection of oxidative stress • glucose homeostasis • adiponectin-activated signaling pathway • response to tumor necrosis factor • positive regulation of blood pressure • response to nutrient levels • positive regulation of cholesterol efflux • negative regulation of MAP kinase activity • cellular response to insulin stimulus • positive regulation of peptidyl-tyrosine phosphorylation • fatty acid beta-oxidation • 腫瘤壞死因子產生的負調控 • protein localization to plasma membrane • negative regulation of hormone secretion • protein homooligomerization • response to sucrose • positive regulation of metanephric glomerular visceral epithelial cell development • positive regulation of renal albumin absorption • negative regulation of granulocyte differentiation • response to nutrient • negative regulation of protein autophosphorylation • negative regulation of intracellular protein transport • membrane depolarization • response to glucose • positive regulation of myeloid cell apoptotic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of metanephric mesenchymal cell migration • negative regulation of cell migration • positive regulation of fatty acid metabolic process • brown fat cell differentiation • positive regulation of cAMP-dependent protein kinase activity • positive regulation of glycogen (starch) synthase activity • negative regulation of transcription, DNA-templated • negative regulation of DNA biosynthetic process • positive regulation of protein kinase activity • response to hypoxia • negative regulation of phagocytosis • membrane hyperpolarization • negative regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of monocyte chemotactic protein-1 production • response to glucocorticoid • response to activity • negative regulation of platelet-derived growth factor receptor-alpha signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of ERK1 and ERK2 cascade • negative regulation of macrophage derived foam cell differentiation • regulation of fatty acid biosynthetic process • regulation of signaling receptor activity • negative regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell migration • response to bacterium • positive regulation of cold-induced thermogenesis • negative regulation of cold-induced thermogenesis • 訊息傳遞
These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin. The receptors affect the downstream target AMP kinase（英语：AMP-activated protein kinase）, an important cellular metabolic rate control point. Expression of the receptors is correlated with insulin levels, as well as reduced in mouse models of diabetes, particularly in 骨骼肌 and adipose tissue.[9][10]
参考文献编辑
^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000181092 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000022878 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. April 1996, 221 (2): 286–9. PMID 8619847. doi:10.1006/bbrc.1996.0587.
^Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. March 1998, 8 (6): 335–8. PMID 9512423. doi:10.1016/S0960-9822(98)70133-2.
^Hug, C; Wang, J; Ahmad, NS; Bogan, JS; Tsao, TS; Lodish, HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (28): 10308–13. PMC 478568. PMID 15210937. doi:10.1073/pnas.0403382101.已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^Fang, X; Sweeney, G. Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes. Biochem. Soc. Trans. 2006, 34 (Pt 5): 798–801. PMID 17052201. doi:10.1042/BST0340798.已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^Bonnard, C; Durand, A; Vidal, H; Rieusset, J. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Diabetes Metab. 2008, 34 (1): 52–61. PMID 18222103. doi:10.1016/j.diabet.2007.09.006.已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
一月 18, 2024
脂联素, 此條目翻譯品質不佳, 2019年1月23日, 翻譯者可能不熟悉中文或原文語言, 也可能使用了機器翻譯, 請協助翻譯本條目或重新編寫, 并注意避免翻译腔的问题, 明顯拙劣的翻譯請改掛, href, template, html, class, redirect, title, template, href, wikipedia, html, class, redirect, title, wikipedia, 提交刪除, 脂连蛋白, 英語, adiponectin, 亦称为, 是一种主要由脂肪细胞分泌的蛋白. 此條目翻譯品質不佳 2019年1月23日 翻譯者可能不熟悉中文或原文語言 也可能使用了機器翻譯 請協助翻譯本條目或重新編寫 并注意避免翻译腔的问题 明顯拙劣的翻譯請改掛 a href Template D html class mw redirect title Template D d a a href Wikipedia CSD html G13 class mw redirect title Wikipedia CSD G13 a 提交刪除 脂连蛋白 英語 adiponectin 亦称为脂联素 是一种主要由脂肪细胞分泌的蛋白质激素 由ADIPOQ基因所编码 5 含244个氨基酸 成人体内的脂联素水平与脂肪储量负相关 來源請求 脂联素已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4DOU識別號别名ADIPOQ ACDC ACRP30 ADIPQTL1 ADPN APM 1 APM1 GBP28 adiponectin C1Q and collagen domain containing Adiponectin外部IDOMIM 605441 MGI 106675 HomoloGene 3525 GeneCards ADIPOQ基因位置 人类 染色体3號染色體 1 基因座3q27 3起始186 842 704 bp 1 终止186 858 463 bp 1 基因位置 小鼠 染色体小鼠16号染色体 2 基因座16 B1 16 13 96 cM起始22 965 286 bp 2 终止22 976 778 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 hormone activity signaling receptor binding 細胞因子活性 sialic acid binding protein homodimerization activity 血浆蛋白结合 相同蛋白质结合 extracellular matrix structural constituent細胞組分 cell surface 内质网 膠原蛋白 細胞外空間 細胞外區域 大分子复合体 collagen containing extracellular matrix生物學過程 positive regulation of glucose import positive regulation of protein phosphorylation negative regulation of receptor binding low density lipoprotein particle clearance negative regulation of blood pressure negative regulation of macrophage differentiation negative regulation of synaptic transmission generation of precursor metabolites and energy cellular response to epinephrine stimulus negative regulation of gluconeogenesis regulation of glucose metabolic process 昼夜节律 fatty acid oxidation positive regulation of interleukin 8 production glucose metabolic process protein heterotrimerization negative regulation of heterotypic cell cell adhesion response to ethanol negative regulation of inflammatory response cellular response to cAMP positive regulation of protein kinase A signaling negative regulation of platelet derived growth factor receptor signaling pathway positive regulation of signal transduction positive regulation of protein metabolic process negative regulation of fat cell differentiation response to linoleic acid detection of oxidative stress glucose homeostasis adiponectin activated signaling pathway response to tumor necrosis factor positive regulation of blood pressure response to nutrient levels positive regulation of cholesterol efflux negative regulation of MAP kinase activity cellular response to insulin stimulus positive regulation of peptidyl tyrosine phosphorylation fatty acid beta oxidation 腫瘤壞死因子產生的負調控 protein localization to plasma membrane negative regulation of hormone secretion protein homooligomerization response to sucrose positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of renal albumin absorption negative regulation of granulocyte differentiation response to nutrient negative regulation of protein autophosphorylation negative regulation of intracellular protein transport membrane depolarization response to glucose positive regulation of myeloid cell apoptotic process negative regulation of I kappaB kinase NF kappaB signaling negative regulation of metanephric mesenchymal cell migration negative regulation of cell migration positive regulation of fatty acid metabolic process brown fat cell differentiation positive regulation of cAMP dependent protein kinase activity positive regulation of glycogen starch synthase activity negative regulation of transcription DNA templated negative regulation of DNA biosynthetic process positive regulation of protein kinase activity response to hypoxia negative regulation of phagocytosis membrane hyperpolarization negative regulation of tumor necrosis factor mediated signaling pathway positive regulation of monocyte chemotactic protein 1 production response to glucocorticoid response to activity negative regulation of platelet derived growth factor receptor alpha signaling pathway positive regulation of I kappaB kinase NF kappaB signaling negative regulation of ERK1 and ERK2 cascade negative regulation of macrophage derived foam cell differentiation regulation of fatty acid biosynthetic process regulation of signaling receptor activity negative regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration response to bacterium positive regulation of cold induced thermogenesis negative regulation of cold induced thermogenesis 訊息傳遞Sources Amigo QuickGO直系同源物種人類小鼠Entrez937011450EnsemblENSG00000181092ENSMUSG00000022878UniProtQ15848Q60994mRNA 序列NM 001177800 NM 004797NM 009605蛋白序列NP 001171271 NP 004788NP 033735基因位置 UCSC Chr 3 186 84 186 86 MbChr 16 22 97 22 98 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠结构 编辑脂联素包含244个氨基酸 可分为4个结构域 从其N端起算 第一个是使其定位于细胞外的信号序列 第二个区域较短且在物种间高度变异 第三个65个氨基酸的区域与膠原蛋白相似 最后一个是脂联素的球状结构域 总的上看 这一蛋白与补体片段C1q 英语 C1q 相似 其中球状结构域的三维结构已经测定 结构上与TNFa非常相似 但在氨基酸序列上却差异巨大 6 受体 编辑脂联素可与几种受体结合 两种受体与G蛋白偶联受体有同源性 一种属于钙粘蛋白家族 7 8 脂联素受体1 ADIPOR1 脂联素受体2 ADIPOR2 T cadherin CDH13 英语 T cadherin These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin The receptors affect the downstream target AMP kinase 英语 AMP activated protein kinase an important cellular metabolic rate control point Expression of the receptors is correlated with insulin levels as well as reduced in mouse models of diabetes particularly in 骨骼肌 and adipose tissue 9 10 参考文献 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000181092 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000022878 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Maeda K Okubo K Shimomura I Funahashi T Matsuzawa Y Matsubara K cDNA cloning and expression of a novel adipose specific collagen like factor apM1 AdiPose Most abundant Gene transcript 1 Biochem Biophys Res Commun April 1996 221 2 286 9 PMID 8619847 doi 10 1006 bbrc 1996 0587 Shapiro L Scherer PE The crystal structure of a complement 1q family protein suggests an evolutionary link to tumor necrosis factor Curr Biol March 1998 8 6 335 8 PMID 9512423 doi 10 1016 S0960 9822 98 70133 2 Yamauchi T Kamon J Ito Y Tsuchida A Yokomizo T Kita S et al Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 2003 423 6941 762 9 PMID 12802337 doi 10 1038 nature01705 已忽略未知参数 author name separator 帮助 已忽略未知参数 author separator 帮助 Hug C Wang J Ahmad NS Bogan JS Tsao TS Lodish HF T cadherin is a receptor for hexameric and high molecular weight forms of Acrp30 adiponectin Proc Natl Acad Sci U S A 2004 101 28 10308 13 PMC 478568 nbsp PMID 15210937 doi 10 1073 pnas 0403382101 已忽略未知参数 author name separator 帮助 已忽略未知参数 author separator 帮助 Fang X Sweeney G Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes Biochem Soc Trans 2006 34 Pt 5 798 801 PMID 17052201 doi 10 1042 BST0340798 已忽略未知参数 author separator 帮助 已忽略未知参数 author name separator 帮助 Bonnard C Durand A Vidal H Rieusset J Changes in adiponectin its receptors and AMPK activity in tissues of diet induced diabetic mice Diabetes Metab 2008 34 1 52 61 PMID 18222103 doi 10 1016 j diabet 2007 09 006 已忽略未知参数 author name separator 帮助 已忽略未知参数 author separator 帮助 取自 https zh wikipedia org w index php title 脂联素 amp oldid 53867243, 维基百科，wiki，书籍，书籍，图书馆，
