视黄酸受体α

视黄酸受体α（英語：Retinoic acid receptor alpha，RAR-α），也称为NR1B1（核受体第一亚族B组成员1，nuclear receptor subfamily 1, group B, member 1）是一个核受体，在人类基因组中由 RARA 基因编码。^[6][7]

视黄酸受体α
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1DKF、​1DSZ、​3A9E、​3KMR、​3KMZ、​4DQM、​5K13
識別號
别名	RARA；, NR1B1, RAR, retinoic acid receptor alpha, RARalpha
外部ID	OMIM：180240 MGI：97856 HomoloGene：20262 GeneCards：RARA
為以下藥物的標靶
阿达帕林、​alitretinoin、​tamibarotene、​tazarotene、​維A酸^[1]
基因位置（人类） 染色体 17號染色體^[2] 基因座 17q21.2 起始 40,309,180 bp^[2] 终止 40,357,643 bp^[2]
基因位置（小鼠） 染色体 小鼠11号染色体^[3] 基因座 11 D|11 62.76 cM 起始 98,818,644 bp^[3] 终止 98,865,768 bp^[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • retinoic acid binding • transcription corepressor activity • protein domain specific binding • DNA结合转录因子活性 • nuclear receptor activity • mRNA 5'-UTR binding • signaling receptor binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • retinoic acid-responsive element binding • 转录因子结合 • 金屬離子結合 • steroid hormone receptor activity • 酶结合 • 鋅離子結合 • 血浆蛋白结合 • DNA结合 • sequence-specific DNA binding • 转录共激活因子活性 • protein kinase A binding • protein kinase B binding • translation repressor activity, mRNA regulatory element binding • alpha-actinin binding • protein heterodimerization activity • chromatin DNA binding • DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding • transcription cis-regulatory region binding • nuclear receptor coactivator activity • signaling receptor activity 細胞組分 • 細胞質 • actin cytoskeleton • 细胞质的核周区域 • neuron projection • 细胞核 • cell surface • 核质 • neuronal cell body • 树突 • 细胞质基质 • RNA polymerase II transcription regulator complex 生物學過程 • growth plate cartilage development • germ cell development • cellular response to retinoic acid • ureteric bud development • positive regulation of interleukin-5 production • prostate gland development • limb development • apoptotic cell clearance • chondroblast differentiation • regulation of granulocyte differentiation • protein phosphorylation • response to vitamin A • face development • 精子发生 • response to ethanol • negative regulation of cell population proliferation • steroid hormone mediated signaling pathway • regulation of apoptotic process • response to cytokine • negative regulation of translation • regulation of transcription, DNA-templated • negative regulation of cell differentiation • negative regulation of gene expression • transcription, DNA-templated • cellular response to estrogen stimulus • positive regulation of transcription, DNA-templated • positive regulation of cell cycle • regulation of myelination • positive regulation of neuron differentiation • 腫瘤壞死因子產生的負調控 • transcription initiation from RNA polymerase II promoter • trachea cartilage development • glandular epithelial cell development • male gonad development • negative regulation of cartilage development • response to retinoic acid • negative regulation of granulocyte differentiation • multicellular organism growth • female pregnancy • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • positive regulation of interleukin-4 production • regulation of synaptic plasticity • outflow tract septum morphogenesis • negative regulation of transcription, DNA-templated • negative regulation of interferon-gamma production • response to estradiol • negative regulation of translational initiation • embryonic camera-type eye development • positive regulation of interleukin-13 production • neural tube closure • positive regulation of binding • retinoic acid receptor signaling pathway • positive regulation of gene expression • Sertoli cell fate commitment • positive regulation of cell population proliferation • positive regulation of T-helper 2 cell differentiation • ventricular cardiac muscle cell differentiation • liver development • cellular response to lipopolysaccharide • bone development • hippocampus development • 訊息傳遞 • positive regulation of transcription by RNA polymerase II • multicellular organism development • hormone-mediated signaling pathway • 细胞分化 • response to lipid • gland development • bone morphogenesis • epithelium development Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	5914	19401
Ensembl	ENSG00000131759	ENSMUSG00000037992
UniProt	P10276 Q6I9R7	P11416
mRNA​序列	​NM_000964 ​NM_001024809 ​NM_001033603 ​NM_001145301 ​NM_001145302	NM_001176528 ​NM_001177302 ​NM_001177303 ​NM_009024 ​NM_001361954
蛋白序列	NP_000955 ​NP_001019980 ​NP_001138773 ​NP_001138774 NP_000955.1 ​NP_001138773.1	NP_001169999 ​NP_001170773 ​NP_001170774 ​NP_033050 ​NP_001348883
基因位置​（UCSC）	Chr 17: 40.31 – 40.36 Mb	Chr 11: 98.82 – 98.87 Mb
PubMed​查找	^[4]	^[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

相互作用

视黄酸受体α可以与下列蛋白質发生进行交互作用：

• BAG1,^[8]
• CLOCK,^[9]
• CCND3,^[10]
• NCOA6,^[11][12][13]
• NCOR1,^[14][15]
• NCOR2,^[16][17]
• NPAS2,^[9]
• NRIP1,^[18][19][20]
• NR0B2,^[21][22]
• NR4A2,^[23]
• PML^[24]
• RXRA.^[25][26]
• Src,^[27][28]
• TADA3L,^[29]
• ZBTB16.^[30]

参考文献

1. 對retinoic acid receptor alpha起作用的藥物；在維基數據上查看/編輯參考. 
2. GRCh38: Ensembl release 89: ENSG00000131759 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000037992 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
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延伸阅读

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