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维基百科

组织蛋白酶K

行進 31, 2023

组织蛋白酶K（英语：Cathepsin K），是一种在人体中由CTSK基因编码的酶。[7][8]

组织蛋白酶K
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名CTSK；, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD, cathepsin K
外部IDOMIM：601105 MGI：107823 HomoloGene：68053 GeneCards：CTSK
相關疾病
pycnodysostosis[1]
為以下藥物的標靶
odanacatib[2]
基因位置（人类）
染色体1號染色體[3]
基因座1q21.3起始150,794,880 bp[3]
终止150,809,577 bp[3]
RNA表达模式
查阅更多表达数据
直系同源
物種人類小鼠
Entrez

1513

13038

Ensembl

ENSG00000143387

ENSMUSG00000028111

UniProt

P43235

P55097

mRNA​序列

NM_000396

NM_007802

蛋白序列

NP_000387

NP_031828

基因位置​（UCSC）Chr 1: 150.79 – 150.81 MbChr 3: 95.41 – 95.42 Mb
PubMed​查找[5][6]
維基數據
檢視/編輯人類檢視/編輯小鼠

功能

该基因编码的蛋白质是半胱氨酸组织蛋白酶，一种参与骨重塑和再吸收的溶酶体半胱氨酸蛋白酶。这种蛋白质是肽酶C1蛋白质家族的成员，主要在破骨细胞中表达。

组织蛋白酶K是一种蛋白酶，其特征在于其对激肽的高度特异性，与骨吸收有关。该酶分解代谢弹性蛋白、胶原蛋白和明胶的能力使其能够分解骨骼和软骨。这种分解代谢活动也是肺弹性丧失和肺气肿反冲的部分原因。组织蛋白酶K抑制剂在骨质疏松症的治疗中显示出巨大的潜力。在被称为受控组织蛋白酶同类相食的过程中，组织蛋白酶K被组织蛋白酶S降解。

组织蛋白酶K的表达受到组织损伤后释放的炎性细胞因子的刺激。

临床意义

组织蛋白酶K在很大一部分人类乳癌中表达，它可能有助于肿瘤侵袭性。[9]该基因的突变是致密性成骨不全症的原因，这是一种以骨质硬化和身材矮小为特征的常染色体隐性遗传病。[10]组织蛋白酶K也被发现在胶质母细胞瘤中过度表达。[11]

组织蛋白酶K的表达是某些癌症的特征，而其他癌症则没有。[12]组织蛋白酶K抗体已上市销售，用于研究该酶在各种细胞中的表达。[13][14][15]

默克公司在骨质疏松症的III期临床试验中使用了一种组织蛋白酶K抑制剂，奥达那替尼。2016年9月，默克公司在自行评估不良事件后宣布停止开发奥达那替尼，独立评估显示中风风险增加。[16][17]其他组织蛋白酶K抑制剂处于不同的发展阶段。[18][19]截至2017年10月，Medivir公司有一种组织蛋白酶K抑制剂MIV-711（L-006235[20][21][22]），在IIa期临床试验中，作为一种改善骨关节炎的药物。

参考文献

  1. ^ 與组织蛋白酶K相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 對Cathepsin K起作用的藥物；在維基數據上查看/編輯參考. 
  3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000143387 - Ensembl, May 2017
  4. ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000028111 - Ensembl, May 2017
  5. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  7. ^ Entrez Gene: CTSK cathepsin K. 
  8. ^ Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T. Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone. Biochemical and Biophysical Research Communications. January 1995, 206 (1): 89–96. PMID 7818555. doi:10.1006/bbrc.1995.1013. 
  9. ^ Duong LT, Wesolowski GA, Leung P, Oballa R, Pickarski M. Efficacy of a Cathepsin K Inhibitor in a Preclinical Model for Prevention and Treatment of Breast Cancer Bone Metastasis. Molecular Cancer Therapeutics. 23 September 2014, 13 (12): 2898–909 [2 October 2016]. PMID 25249554. doi:10.1158/1535-7163.MCT-14-0253  . （原始内容于2019-08-24）. 
  10. ^ CTSK cathepsin K [ Homo sapiens (human) ]. NCBI Gene. National Center for Biotechnology Information, U.S. National Library of Medicine. 4 September 2016 [2 October 2016]. （原始内容于2022-10-31）. 
  11. ^ Verbovšek U, Motaln H, Rotter A, Atai NA, Gruden K, Van Noorden CJ, Lah TT. Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma. PLOS ONE. 30 October 2014, 9 (10): e111819. Bibcode:2014PLoSO...9k1819V. PMC 4214761  . PMID 25356585. doi:10.1371/journal.pone.0111819  . 
  12. ^ Argani, Pedram; et al. A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms. American Journal of Clinical Pathology. 1 February 2013, 139 (2): 151–159. PMC 3957187  . PMID 23355199. doi:10.1309/AJCPDTRTO2Z4UEXD. 
  13. ^ Cathepsin K Antibodies. Novus Biologicals online catalog. Novus Biologicals, LLC. 2016 [2 October 2016]. （原始内容于2022-10-31）. 
  14. ^ Anti-Cathepsin K antibody (ab19027). Abcam plc online catalog. Abcam plc. 2016 [2 October 2016]. （原始内容于2022-10-31）. 
  15. ^ Anti-Cathepsin K Antibody (A5871). Antibodies.com online catalog. Antibodies.com Ltd. 2018 [16 January 2018]. （原始内容于2018-01-17）. 
  16. ^ Brömme, Dieter; Lecaille, Fabien. Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opinion on Investigational Drugs. 24 April 2009, 18 (5): 585–600. PMC 3110777  . PMID 19388876. doi:10.1517/13543780902832661. 
  17. ^ Merck Provides Update on Odanacatib Development Program. Merck Sharp & Dohme Corp. 2 September 2016 [1 October 2016]. （原始内容于2016-11-09）. 
  18. ^ Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H,. (2008). Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science, 319(5863), 624-627.
  19. ^ Hussein, H., Ishihara, A., Menendez, M., & Bertone, A. (2014). Pharmacokinetics and bone resorption evaluation of a novel Cathepsin K inhibitor (VEL‐0230) in healthy adult horses. Journal of veterinary pharmacology and therapeutics.
  20. ^ . www.medivir.se. [2017-10-06]. （原始内容存档于6 October 2017） （英语）. 
  21. ^ Burston JJ, Xu L, Mapp PI, Grabowska U, Tunblad K, Lindström E, Chapman V. (PDF). www.medivir.se. April 2016 [6 October 2017]. （原始内容 (PDF)存档于6 October 2017）. 
  22. ^ Data monitoring committee gives "Go Ahead" in the MIV-711 osteoarthritis extension study (PDF). mb.cision.com. 14 September 2017 [2022-10-31]. （原始内容 (PDF)于2022-08-21）. 

阅读

  • Motyckova G, Fisher DE. Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease.. Current Molecular Medicine. 2003, 2 (5): 407–21. PMID 12125807. doi:10.2174/1566524023362401. 
  • Troen BR. The regulation of cathepsin K gene expression.. Annals of the New York Academy of Sciences. 2006, 1068 (1): 165–72. Bibcode:2006NYASA1068..165T. PMID 16831915. S2CID 8117602. doi:10.1196/annals.1346.018. 
  • Del Nery E, Chagas JR, Juliano MA, et al. Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.. The Biochemical Journal. 1996, 312 (1): 233–8. PMC 1136249  . PMID 7492318. doi:10.1042/bj3120233. 
  • Brömme D, Okamoto K. Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.. Biological Chemistry Hoppe-Seyler. 1995, 376 (6): 379–84. PMID 7576232. doi:10.1515/bchm3.1995.376.6.379. 
  • Gelb BD, Edelson JG, Desnick RJ. Linkage of pycnodysostosis to chromosome 1q21 by homozygosity mapping.. Nature Genetics. 1995, 10 (2): 235–7. PMID 7663521. S2CID 24297764. doi:10.1038/ng0695-235. 
  • Polymeropoulos MH, Ortiz De Luna RI, Ide SE, et al. The gene for pycnodysostosis maps to human chromosome 1cen-q21.. Nature Genetics. 1995, 10 (2): 238–9 [2022-10-31]. PMID 7663522. S2CID 11723845. doi:10.1038/ng0695-238. （原始内容于2022-10-31）. 
  • Shi GP, Chapman HA, Bhairi SM, et al. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. (PDF). FEBS Letters. 1995, 357 (2): 129–34. PMID 7805878. S2CID 28099876. doi:10.1016/0014-5793(94)01349-6  . 
  • Inaoka T, Bilbe G, Ishibashi O, et al. Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.. Biochemical and Biophysical Research Communications. 1995, 206 (1): 89–96. PMID 7818555. doi:10.1006/bbrc.1995.1013. 
  • Velasco G, Ferrando AA, Puente XS, et al. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.. The Journal of Biological Chemistry. 1994, 269 (43): 27136–42. PMID 7929457. doi:10.1016/S0021-9258(18)47135-9  . 
  • Li YP, Alexander M, Wucherpfennig AL, et al. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.. Journal of Bone and Mineral Research. 1996, 10 (8): 1197–202. PMID 8585423. S2CID 41832979. doi:10.1002/jbmr.5650100809. 
  • Bossard MJ, Tomaszek TA, Thompson SK, et al. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification.. Journal of Biological Chemistry. 1996, 271 (21): 12517–24. PMID 8647860. doi:10.1074/jbc.271.21.12517  . 
  • Gelb BD, Shi GP, Chapman HA, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.. Science. 1996, 273 (5279): 1236–8. Bibcode:1996Sci...273.1236G. PMID 8703060. S2CID 7188076. doi:10.1126/science.273.5279.1236. 
  • Johnson MR, Polymeropoulos MH, Vos HL, et al. A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis.. Genome Research. 1997, 6 (11): 1050–5. PMID 8938428. doi:10.1101/gr.6.11.1050  . 
  • Littlewood-Evans A, Kokubo T, Ishibashi O, et al. Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry.. Bone. 1997, 20 (2): 81–6. PMID 9028530. doi:10.1016/S8756-3282(96)00351-1. 
  • McGrath ME, Klaus JL, Barnes MG, Brömme D. Crystal structure of human cathepsin K complexed with a potent inhibitor.. Nature Structural Biology. 1997, 4 (2): 105–9. PMID 9033587. S2CID 22175354. doi:10.1038/nsb0297-105. 
  • Rood JA, Van Horn S, Drake FH, et al. Genomic organization and chromosome localization of the human cathepsin K gene (CTSK).. Genomics. 1997, 41 (2): 169–76. PMID 9143491. doi:10.1006/geno.1997.4614. 
  • Gelb BD, Shi GP, Heller M, et al. Structure and chromosomal assignment of the human cathepsin K gene.. Genomics. 1997, 41 (2): 258–62. PMID 9143502. doi:10.1006/geno.1997.4631. 
  • Gomes RA, Juliano L, Chagas JR, Hial V. Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.. Canadian Journal of Physiology and Pharmacology. 1997, 75 (6): 757–61. PMID 9276160. doi:10.1139/cjpp-75-6-757. 
  • Thompson SK, Halbert SM, Bossard MJ, et al. Design of potent and selective human cathepsin K inhibitors that span the active site.. Proceedings of the National Academy of Sciences. 1998, 94 (26): 14249–54. PMC 24926  . PMID 9405598. doi:10.1073/pnas.94.26.14249  . 
  • Gelb BD, Willner JP, Dunn TM, et al. Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis.. The American Journal of Human Genetics. 1998, 62 (4): 848–54. PMC 1377035  . PMID 9529353. doi:10.1086/301795. 

图集

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    Osteoclast

外部链接

行進 31, 2023
组织蛋白酶k, 英语, cathepsin, 是一种在人体中由ctsk基因编码的酶, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1mem, 3kwb, 3kx1, 4x6j, 1ayw, 3kw9, 1yt7, 1au2, 4x6h, 1q6k, 1yk7, 1atk, 3c9e, 1ayv, 1bgo, 4n8w, 7pck, 4dmx, 4x6i, 1nl6, 1tu6, 3o0u, 1au4, 3ovz, 3kwz, 2ato, 3o1g, 1au0, 1by8, 1snk, 2auz. 组织蛋白酶K 英语 Cathepsin K 是一种在人体中由CTSK基因编码的酶 7 8 组织蛋白酶K已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1MEM 3KWB 3KX1 4X6J 1AYW 3KW9 1YT7 1AU2 4X6H 1Q6K 1YK7 1ATK 3C9E 1AYV 1BGO 4N8W 7PCK 4DMX 4X6I 1NL6 1TU6 3O0U 1AU4 3OVZ 3KWZ 2ATO 3O1G 1AU0 1BY8 1SNK 2AUZ 4DMY 4N79 1AYU 1U9X 1YK8 1AU3 1U9V 2BDL 1VSN 1U9W 2AUX 2R6N 3H7D 1NLJ 5J94 4YVA 4YV8識別號别名CTSK CTS02 CTSO CTSO1 CTSO2 PKND PYCD cathepsin K外部IDOMIM 601105 MGI 107823 HomoloGene 68053 GeneCards CTSK相關疾病pycnodysostosis 1 為以下藥物的標靶odanacatib 2 基因位置 人类 染色体1號染色體 3 基因座1q21 3起始150 794 880 bp 3 终止150 809 577 bp 3 基因位置 小鼠 染色体小鼠3号染色体 4 基因座3 F2 1 3 40 74 cM起始95 406 567 bp 4 终止95 416 673 bp 4 RNA表达模式查阅更多表达数据基因本體分子功能 fibronectin binding 半胱氨酸型肽酶活性 collagen binding 肽酶活性 血浆蛋白结合 cysteine type endopeptidase activity 水解酶活性 proteoglycan binding serine type endopeptidase activity細胞組分 細胞質 細胞外區域 endolysosome lumen 溶酶体 細胞外空間 核质 細胞內膜結合細胞器 lysosomal lumen生物學過程 膜内成骨 positive regulation of protein targeting to mitochondrion extracellular matrix disassembly 骨质吸收 蛋白酶解 toll like receptor signaling pathway regulation of autophagy of mitochondrion collagen catabolic process proteolysis involved in cellular protein catabolic process regulation of keratinocyte differentiationSources Amigo QuickGO直系同源物種人類小鼠Entrez151313038EnsemblENSG00000143387ENSMUSG00000028111UniProtP43235P55097mRNA 序列NM 000396NM 007802蛋白序列NP 000387NP 031828基因位置 UCSC Chr 1 150 79 150 81 MbChr 3 95 41 95 42 MbPubMed 查找 5 6 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 功能 2 临床意义 3 参考文献 4 阅读 5 图集 6 外部链接功能 编辑该基因编码的蛋白质是半胱氨酸组织蛋白酶 一种参与骨重塑和再吸收的溶酶体半胱氨酸蛋白酶 这种蛋白质是肽酶C1蛋白质家族的成员 主要在破骨细胞中表达 组织蛋白酶K是一种蛋白酶 其特征在于其对激肽的高度特异性 与骨吸收有关 该酶分解代谢弹性蛋白 胶原蛋白和明胶的能力使其能够分解骨骼和软骨 这种分解代谢活动也是肺弹性丧失和肺气肿反冲的部分原因 组织蛋白酶K抑制剂在骨质疏松症的治疗中显示出巨大的潜力 在被称为受控组织蛋白酶同类相食的过程中 组织蛋白酶K被组织蛋白酶S降解 组织蛋白酶K的表达受到组织损伤后释放的炎性细胞因子的刺激 临床意义 编辑组织蛋白酶K在很大一部分人类乳癌中表达 它可能有助于肿瘤侵袭性 9 该基因的突变是致密性成骨不全症的原因 这是一种以骨质硬化和身材矮小为特征的常染色体隐性遗传病 10 组织蛋白酶K也被发现在胶质母细胞瘤中过度表达 11 组织蛋白酶K的表达是某些癌症的特征 而其他癌症则没有 12 组织蛋白酶K抗体已上市销售 用于研究该酶在各种细胞中的表达 13 14 15 默克公司在骨质疏松症的III期临床试验中使用了一种组织蛋白酶K抑制剂 奥达那替尼 2016年9月 默克公司在自行评估不良事件后宣布停止开发奥达那替尼 独立评估显示中风风险增加 16 17 其他组织蛋白酶K抑制剂处于不同的发展阶段 18 19 截至2017年10月 Medivir公司有一种组织蛋白酶K抑制剂MIV 711 L 006235 20 21 22 在IIa期临床试验中 作为一种改善骨关节炎的药物 参考文献 编辑 與组织蛋白酶K相關的疾病 在維基數據上查看 編輯參考 對Cathepsin K起作用的藥物 在維基數據上查看 編輯參考 3 0 3 1 3 2 GRCh38 Ensembl release 89 ENSG00000143387 Ensembl May 2017 4 0 4 1 4 2 GRCm38 Ensembl release 89 ENSMUSG00000028111 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene CTSK cathepsin K Inaoka T Bilbe G Ishibashi O Tezuka K Kumegawa M Kokubo T Molecular cloning of human cDNA for cathepsin K novel cysteine proteinase predominantly expressed in bone Biochemical and Biophysical Research Communications January 1995 206 1 89 96 PMID 7818555 doi 10 1006 bbrc 1995 1013 Duong LT Wesolowski GA Leung P Oballa R Pickarski M Efficacy of a Cathepsin K Inhibitor in a Preclinical Model for Prevention and Treatment of Breast Cancer Bone Metastasis Molecular Cancer Therapeutics 23 September 2014 13 12 2898 909 2 October 2016 PMID 25249554 doi 10 1158 1535 7163 MCT 14 0253 原始内容存档于2019 08 24 CTSK cathepsin K Homo sapiens human NCBI Gene National Center for Biotechnology Information U S National Library of Medicine 4 September 2016 2 October 2016 原始内容存档于2022 10 31 Verbovsek U Motaln H Rotter A Atai NA Gruden K Van Noorden CJ Lah TT Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma PLOS ONE 30 October 2014 9 10 e111819 Bibcode 2014PLoSO 9k1819V PMC 4214761 PMID 25356585 doi 10 1371 journal pone 0111819 Argani Pedram et al A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms American Journal of Clinical Pathology 1 February 2013 139 2 151 159 PMC 3957187 PMID 23355199 doi 10 1309 AJCPDTRTO2Z4UEXD Cathepsin K Antibodies Novus Biologicals online catalog Novus Biologicals LLC 2016 2 October 2016 原始内容存档于2022 10 31 Anti Cathepsin K antibody ab19027 Abcam plc online catalog Abcam plc 2016 2 October 2016 原始内容存档于2022 10 31 Anti Cathepsin K Antibody A5871 Antibodies com online catalog Antibodies com Ltd 2018 16 January 2018 原始内容存档于2018 01 17 Bromme Dieter Lecaille Fabien Cathepsin K inhibitors for osteoporosis and potential off target effects Expert Opinion on Investigational Drugs 24 April 2009 18 5 585 600 PMC 3110777 PMID 19388876 doi 10 1517 13543780902832661 Merck Provides Update on Odanacatib Development Program Merck Sharp amp Dohme Corp 2 September 2016 1 October 2016 原始内容存档于2016 11 09 Asagiri M Hirai T Kunigami T Kamano S Gober HJ Okamoto K Nishikawa K Latz E Golenbock DT Aoki K Ohya K Imai Y Morishita Y Miyazono K Kato S Saftig P Takayanagi H 2008 Cathepsin K dependent toll like receptor 9 signaling revealed in experimental arthritis Science 319 5863 624 627 Hussein H Ishihara A Menendez M amp Bertone A 2014 Pharmacokinetics and bone resorption evaluation of a novel Cathepsin K inhibitor VEL 0230 in healthy adult horses Journal of veterinary pharmacology and therapeutics MIV 711 for the treatment of ostheoarthritis www medivir se 2017 10 06 原始内容存档于6 October 2017 英语 Burston JJ Xu L Mapp PI Grabowska U Tunblad K Lindstrom E Chapman V The Cathepsin K Inhibitor L 006235 Demonstrates Both Disease Modification and Attenuation of Pain Behaviour in the in the Mia Model of Osteoarthritis PDF www medivir se April 2016 6 October 2017 原始内容 PDF 存档于6 October 2017 Data monitoring committee gives Go Ahead in the MIV 711 osteoarthritis extension study PDF mb cision com 14 September 2017 2022 10 31 原始内容存档 PDF 于2022 08 21 阅读 编辑Motyckova G Fisher DE Pycnodysostosis role and regulation of cathepsin K in osteoclast function and human disease Current Molecular Medicine 2003 2 5 407 21 PMID 12125807 doi 10 2174 1566524023362401 Troen BR The regulation of cathepsin K gene expression Annals of the New York Academy of Sciences 2006 1068 1 165 72 Bibcode 2006NYASA1068 165T PMID 16831915 S2CID 8117602 doi 10 1196 annals 1346 018 Del Nery E Chagas JR Juliano MA et al Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments The Biochemical Journal 1996 312 1 233 8 PMC 1136249 PMID 7492318 doi 10 1042 bj3120233 Bromme D Okamoto K Human cathepsin O2 a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning sequencing and tissue distribution Biological Chemistry Hoppe Seyler 1995 376 6 379 84 PMID 7576232 doi 10 1515 bchm3 1995 376 6 379 Gelb BD Edelson JG Desnick RJ Linkage of pycnodysostosis to chromosome 1q21 by homozygosity mapping Nature Genetics 1995 10 2 235 7 PMID 7663521 S2CID 24297764 doi 10 1038 ng0695 235 Polymeropoulos MH Ortiz De Luna RI Ide SE et al The gene for pycnodysostosis maps to human chromosome 1cen q21 Nature Genetics 1995 10 2 238 9 2022 10 31 PMID 7663522 S2CID 11723845 doi 10 1038 ng0695 238 原始内容存档于2022 10 31 Shi GP Chapman HA Bhairi SM et al Molecular cloning of human cathepsin O a novel endoproteinase and homologue of rabbit OC2 PDF FEBS Letters 1995 357 2 129 34 PMID 7805878 S2CID 28099876 doi 10 1016 0014 5793 94 01349 6 Inaoka T Bilbe G Ishibashi O et al Molecular cloning of human cDNA for cathepsin K novel cysteine proteinase predominantly expressed in bone Biochemical and Biophysical Research Communications 1995 206 1 89 96 PMID 7818555 doi 10 1006 bbrc 1995 1013 Velasco G Ferrando AA Puente XS et al Human cathepsin O Molecular cloning from a breast carcinoma production of the active enzyme in Escherichia coli and expression analysis in human tissues The Journal of Biological Chemistry 1994 269 43 27136 42 PMID 7929457 doi 10 1016 S0021 9258 18 47135 9 Li YP Alexander M Wucherpfennig AL 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