• proteolysis involved in cellular protein catabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • 蛋白酶解
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000174080 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000083282 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. Dec 1998, 273 (48): 32000–8. PMID 9822672. doi:10.1074/jbc.273.48.32000.
^Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem. Jun 1999, 274 (20): 13800–9. PMID 10318784. doi:10.1074/jbc.274.20.13800.
^Teimoori, Salma; Arimatsu, Yuji; Laha, Thewarach; Kaewkes, Sasithorn; Sereerak, Piya; Tangkawattana, Sirikachorn; Brindley, Paul J; Sripa, Banchob. Immunodiagnosis of opisthorchiasis using parasite cathepsin F. Parasitology Research. December 2015, 114 (12): 4571–4578. ISSN 0932-0113. PMC 4917378. PMID 26344868. doi:10.1007/s00436-015-4703-9（英语）.
^Korkmaz, Huseyin; Findik, Duygu; Ugurluoglu, Ceyha; Terzi, Yuksel. Reliability of stool antigen tests: investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients. Asian Pacific Journal of Cancer Prevention. 2015, 16 (2): 657–660. ISSN 2476-762X. PMID 25684503. doi:10.7314/apjcp.2015.16.2.657.
^Guo, Haobing; Li, Yangping; Zhang, Meiwei; Li, Ruojiao; Li, Wanru; Lou, Jiarun; Bao, Zhenmin; Wang, Yangfan. Expression of Cathepsin F in response to bacterial challenges in Yesso scallop Patinopecten yessoensis. Fish & Shellfish Immunology. September 2018, 80: 141–147 [2022-10-27]. PMID 29879509. S2CID 47014597. doi:10.1016/j.fsi.2018.06.005. （原始内容于2022-08-06） （英语）.
拓展阅读
Nägler DK, Sulea T, Ménard R. Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.. Biochem. Biophys. Res. Commun. 1999, 257 (2): 313–8. PMID 10198209. doi:10.1006/bbrc.1999.0461.
Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700.
Wex T, Wex H, Brömme D. The human cathepsin F gene--a fusion product between an ancestral cathepsin and cystatin gene.. Biol. Chem. 2000, 380 (12): 1439–42. PMID 10661872. S2CID 28469574. doi:10.1515/BC.1999.185.
Shi GP, Bryant RA, Riese R, et al. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.. J. Exp. Med. 2000, 191 (7): 1177–86. PMC 2193169. PMID 10748235. doi:10.1084/jem.191.7.1177.
Deussing J, Tisljar K, Papazoglou A, Peters C. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene.. Gene. 2000, 251 (2): 165–73. PMID 10876093. doi:10.1016/S0378-1119(00)00196-7.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Oörni K, Sneck M, Brömme D, et al. Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.. J. Biol. Chem. 2004, 279 (33): 34776–84. PMID 15184381. doi:10.1074/jbc.M310814200.
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, et al. Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer.. BMC Cancer. 2006, 5 (1): 68. PMC 1175083. PMID 15989693. doi:10.1186/1471-2407-5-68.
Kaakinen R, Lindstedt KA, Sneck M, et al. Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.. Atherosclerosis. 2007, 192 (2): 323–7. PMID 16963053. doi:10.1016/j.atherosclerosis.2006.08.001.
外部链接
The MEROPS online database for peptidases and their inhibitors: C01.018
组织蛋白酶f, 英文, cathepsin, 是一种在人体中由ctsf基因编码的蛋白质, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1m6d識別號别名ctsf, catsf, cln13, cathepsin, f外部idomim, 603539, 1861434, homologene, 31194, genecards, ctsf相關疾病neuronal, ceroid, lipofuscinosis, adult, neuronal, ceroid, lipofuscinosis, 基. 组织蛋白酶F 英文 Cathepsin F 是一种在人体中由CTSF基因编码的蛋白质 6 7 8 组织蛋白酶F已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1M6D識別號别名CTSF CATSF CLN13 cathepsin F外部IDOMIM 603539 MGI 1861434 HomoloGene 31194 GeneCards CTSF相關疾病neuronal ceroid lipofuscinosis 13 adult neuronal ceroid lipofuscinosis 1 基因位置 人类 染色体11號染色體 2 基因座11q13 2起始66 563 464 bp 2 终止66 568 879 bp 2 基因位置 小鼠 染色体小鼠19号染色体 3 基因座19 19 A起始4 905 158 bp 3 终止4 910 946 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 肽酶活性 半胱氨酸型肽酶活性 水解酶活性 cysteine type endopeptidase activity細胞組分 細胞外囊泡 溶酶体 lysosomal lumen 外排體 細胞外空間 collagen containing extracellular matrix生物學過程 proteolysis involved in cellular protein catabolic process antigen processing and presentation of exogenous peptide antigen via MHC class II 蛋白酶解Sources Amigo QuickGO直系同源物種人類小鼠Entrez872256464EnsemblENSG00000174080ENSMUSG00000083282UniProtQ9UBX1Q9R013mRNA 序列 NM 003793NM 019861蛋白序列NP 003784NP 063914基因位置 UCSC Chr 11 66 56 66 57 MbChr 19 4 91 4 91 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠木瓜样蛋白酶是半胱氨酸蛋白酶家族 代表溶酶体蛋白水解系统的主要成分 通常 组织蛋白酶包含一个信号肽 然后是一个前肽 再然后是一个催化活性成熟区 组织蛋白酶F前体非常长的 251个氨基酸残基 前区包含一个与组织蛋白酶L样酶的前段相似的C端结构域 一个50个残基的柔性连接肽和N端结构域预计采用胱抑素样折叠组织蛋白酶F前区在木瓜蛋白酶家族半胱氨酸蛋白酶中是独一无二的 因为它包含这个额外的N端片段 预计与胱抑素超家族的半胱氨酸蛋白酶抑制剂具有结构相似性 这种胱抑素样结构域包含一些已知对抑制活性很重要的元素 CTSF编码预测的484个氨基酸的蛋白质 其中包含19个残基信号肽 组织蛋白酶F含有五个潜在的N 连接糖基化位点 它可能通过甘露糖6 磷酸受体途径靶向内体 溶酶体区室 组织蛋白酶F基因普遍表达 它定位于染色体11q13 接近编码组织蛋白酶W的基因 8 目录 1 泰国肝吸虫的免疫诊断 2 组织蛋白酶F在虾夷盘扇贝中的表达 3 参考文献 4 拓展阅读 5 外部链接泰国肝吸虫的免疫诊断 编辑组织蛋白酶F可用作测试泰国肝吸虫造成的疾病的替代方法 9 近年来 泰国肝吸虫的诊断一直通过大便检查来完成 被认为是 金标准 方法 然而 基于粪便的诊断可能是不可靠的 10 尽管它是一种非侵入性方法 进行的实验表明 通过使用重组DNA技术和组织蛋白酶F半胱氨酸蛋白酶 可以产生更可靠的结果 组织蛋白酶F在虾夷盘扇贝中的表达 编辑最近的实验表明在虾夷盘扇贝中发现了组织蛋白酶F 11 在虾夷盘扇贝的各个胚胎发育阶段鉴定组织蛋白酶F基因具有重要意义 组织蛋白酶F基因在先天免疫反应中具有重要作用 虾夷盘扇贝一直因细菌性疾病而遭受高死亡率 组织蛋白酶F的发现可以领导进一步的研究和解决虾夷盘扇贝死亡率问题的方法 参考文献 编辑 與组织蛋白酶F相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000174080 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000083282 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wang B Shi GP Yao PM Li Z Chapman HA Bromme D Human cathepsin F Molecular cloning functional expression tissue localization and enzymatic characterization J Biol Chem Dec 1998 273 48 32000 8 PMID 9822672 doi 10 1074 jbc 273 48 32000 Santamaria I Velasco G Pendas AM Paz A Lopez Otin C Molecular cloning and structural and functional characterization of human cathepsin F a new cysteine proteinase of the papain family with a long propeptide domain J Biol Chem Jun 1999 274 20 13800 9 PMID 10318784 doi 10 1074 jbc 274 20 13800 8 0 8 1 Entrez Gene CTSF cathepsin F Teimoori Salma Arimatsu Yuji Laha Thewarach Kaewkes Sasithorn Sereerak Piya Tangkawattana Sirikachorn Brindley Paul J Sripa Banchob Immunodiagnosis of opisthorchiasis using parasite cathepsin F Parasitology Research December 2015 114 12 4571 4578 ISSN 0932 0113 PMC 4917378 PMID 26344868 doi 10 1007 s00436 015 4703 9 英语 Korkmaz Huseyin Findik Duygu Ugurluoglu Ceyha Terzi Yuksel Reliability of stool antigen tests investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients Asian Pacific Journal of Cancer Prevention 2015 16 2 657 660 ISSN 2476 762X PMID 25684503 doi 10 7314 apjcp 2015 16 2 657 Guo Haobing Li Yangping Zhang Meiwei Li Ruojiao Li Wanru Lou Jiarun Bao Zhenmin Wang Yangfan Expression of Cathepsin F in response to bacterial challenges in Yesso scallop Patinopecten yessoensis Fish amp Shellfish Immunology September 2018 80 141 147 2022 10 27 PMID 29879509 S2CID 47014597 doi 10 1016 j fsi 2018 06 005 原始内容存档于2022 08 06 英语 拓展阅读 编辑Nagler DK Sulea T Menard R Full length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N terminus of the cysteine protease zymogen Biochem Biophys Res Commun 1999 257 2 313 8 PMID 10198209 doi 10 1006 bbrc 1999 0461 Wex T Levy B Wex H Bromme D Human cathepsins F and W A new subgroup of cathepsins Biochem Biophys Res Commun 1999 259 2 401 7 PMID 10362521 doi 10 1006 bbrc 1999 0700 Wex T Wex H Bromme D The human cathepsin F gene a fusion product between an ancestral cathepsin and cystatin gene Biol Chem 2000 380 12 1439 42 PMID 10661872 S2CID 28469574 doi 10 1515 BC 1999 185 Shi GP Bryant RA Riese R et al Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages J Exp Med 2000 191 7 1177 86 PMC 2193169 PMID 10748235 doi 10 1084 jem 191 7 1177 Deussing J Tisljar K Papazoglou A Peters C Mouse cathepsin F cDNA cloning genomic organization and chromosomal assignment of the gene Gene 2000 251 2 165 73 PMID 10876093 doi 10 1016 S0378 1119 00 00196 7 Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 Bibcode 2002PNAS 9916899M PMC 139241 PMID 12477932 doi 10 1073 pnas 242603899 Oorni K Sneck M Bromme D et al Cysteine protease cathepsin F is expressed in human atherosclerotic lesions is secreted by cultured macrophages and modifies low density lipoprotein particles in vitro J Biol Chem 2004 279 33 34776 84 PMID 15184381 doi 10 1074 jbc M310814200 Gerhard DS Wagner L Feingold EA et al The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 PMID 15489334 doi 10 1101 gr 2596504 Vazquez Ortiz G Pina Sanchez P Vazquez K et al Overexpression of cathepsin F matrix metalloproteinases 11 and 12 in cervical cancer BMC Cancer 2006 5 1 68 PMC 1175083 PMID 15989693 doi 10 1186 1471 2407 5 68 Kaakinen R Lindstedt KA Sneck M et al Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte derived macrophages an angiotensin II type 2 receptor mediated effect Atherosclerosis 2007 192 2 323 7 PMID 16963053 doi 10 1016 j atherosclerosis 2006 08 001 外部链接 编辑The MEROPS online database for peptidases and their inhibitors C01 018 生物学主题 取自 https zh wikipedia org w index php title 组织蛋白酶F amp oldid 75000530, 维基百科，wiki，书籍，书籍，图书馆，
