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维基百科

SOCS3

十一月 06, 2023

细胞因子信号传导抑制因子3(SOCS3或 SOCS-3)是一种在人体内由 SOCS3基因编码的蛋白。[5][6] 该基因编码 STAT- 诱导的 STAT 抑制子(SSI)，也可称为细胞因子信号转导(SOCS)家族抑制子，的一个成员。 SSI 家族成员是可由细胞因子诱导的细胞因子信号转导负调节因子。

SOCS3
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名SOCS3；, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3
外部IDOMIM：604176 MGI：1201791 HomoloGene：2941 GeneCards：SOCS3
基因位置（人类）
染色体17號染色體[1]
基因座17q25.3起始78,356,778 bp[1]
终止78,360,077 bp[1]
RNA表达模式


查阅更多表达数据
直系同源
物種人類小鼠
Entrez

9021

12702

Ensembl

ENSG00000184557

ENSMUSG00000053113

UniProt

O14543
Q6FI39

O35718

mRNA​序列

NM_003955
​NM_001378932
​NM_001378933

NM_007707

蛋白序列

NP_003946
​NP_001365861
​NP_001365862
NP_003946.3

NP_031733

基因位置​（UCSC）Chr 17: 78.36 – 78.36 MbChr 11: 117.86 – 117.86 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

功能 编辑

SOCS3基因的表达可由多种细胞因子的诱导，包括 IL-6，IL-10，干扰素-γ(IFN-γ)。

在 IL-6，Epo，GCSF 和瘦素的信号传导中，已发现SOCS3在各自的细胞因子受体上的结合对 SOCS3的抑制功能而言是至关重要的。

SOCS3的过表达会抑制脂肪组织和肝脏胰岛素信号转导，但对肌肉则不然。[7] 但是在小鼠骨骼肌中敲除 SOCS3可以保护小鼠免于肥胖相关的胰岛素抵抗。[7]

由于神经酰胺合成的增加，SOCS3会增加瘦素抵抗和胰岛素抵抗。[8] 因此，研究已表明去除 SOCS 基因可以预防肥胖症患者的胰岛素抵抗[7]

对该小鼠中基因的同源基因的研究表明，该基因在胎儿肝脏造血和胎盘发育的负调控中发挥作用。[9]

SOCS3蛋白能与JAK2结合，抑制其活性。

相互作用 编辑

已经证明 SOCS3可以与下列物质相互作用:

调控 编辑

有部分证据表明 SOCS3的表达受小分子核糖核酸 miR-203的调控。[16][17]

参见 编辑

参考文献 编辑

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000184557 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000053113 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun. September 1997, 237 (1): 79–83. PMID 9266833. doi:10.1006/bbrc.1997.7080. 
  6. ^ 6.0 6.1 Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun. November 1997, 239 (2): 439–46. PMID 9344848. doi:10.1006/bbrc.1997.7484. 
  7. ^ 7.0 7.1 7.2 Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes. 2013, 62 (1): 56–64 [2018-11-22]. PMC 3526029  . PMID 22961088. doi:10.2337/db12-0443. （原始内容于2018-11-23）.  引用错误：带有name属性“pmid22961088”的<ref>标签用不同内容定义了多次
  8. ^ Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. American Journal of Physiology. 2009, 297 (1): E211–E224 [2018-11-22]. PMC 2711669  . PMID 19435851. doi:10.1152/ajpendo.91014.2008. （原始内容于2016-08-10）. 
  9. ^ Entrez Gene: SOCS3 suppressor of cytokine signaling 3. （原始内容于2010-03-07）. 
  10. ^ 10.0 10.1 CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. September 2000, 275 (38): 29338–47. PMID 10882725. doi:10.1074/jbc.M003456200. 
  11. ^ A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur. J. Biochem. May 2002, 269 (10): 2516–26. PMID 12027890. doi:10.1046/j.1432-1033.2002.02916.x. 
  12. ^ 12.0 12.1 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J. Biol. Chem. January 2003, 278 (1): 661–71. PMID 12403768. doi:10.1074/jbc.M210552200. 
  13. ^ Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. Biochem. Biophys. Res. Commun. November 2000, 278 (1): 38–43. PMID 11071852. doi:10.1006/bbrc.2000.3762. 
  14. ^ Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. June 1999, 4 (6): 339–51. PMID 10421843. doi:10.1046/j.1365-2443.1999.00263.x. 
  15. ^ Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nat. Cell Biol. May 2001, 3 (5): 460–5. PMID 11331873. doi:10.1038/35074525. 
  16. ^ miR-203 represses 'stemness' by repressing DeltaNp63.. Cell Death Differ. 2008, 15 (7): 1187–95. PMID 18483491. doi:10.1038/cdd.2008.69. 
  17. ^ The expression of microRNA-203 during human skin morphogenesis.. Exp Dermatol. 2010, 19 (9): 854–6. PMID 20698882. doi:10.1111/j.1600-0625.2010.01118.x. 

扩展阅读 编辑

  • Yasukawa H, Sasaki A, Yoshimura A (2000). "Negative regulation of cytokine signaling pathways". Annu. Rev. Immunol. 18: 143–64. doi:10.1146/annurev.immunol.18.1.143. PMID 10837055（页面存档备份，存于互联网档案馆）.
  • Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 1276535（页面存档备份，存于互联网档案馆）.
  • Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BJ, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M (1999). "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2071–6. doi:10.1073/pnas.96.5.2071. PMC 26738. PMID 10051596（页面存档备份，存于互联网档案馆）.
  • Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A (1999). "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. 4 (6): 339–51. doi:10.1046/j.1365-2443.1999.00263.x. PMID 10421843（页面存档备份，存于互联网档案馆）.
  • Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN (1999). "SOCS3 is essential in the regulation of fetal liver erythropoiesis". Cell. 98 (5): 617–27. doi:10.1016/S0092-8674(00)80049-5. PMID 10490101（页面存档备份，存于互联网档案馆）.
  • Schmitz J, Weissenbach M, Haan S, Heinrich PC, Schaper F (2000). "SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130". J. Biol. Chem. 275 (17): 12848–56. doi:10.1074/jbc.275.17.12848. PMID 10777583（页面存档备份，存于互联网档案馆）.
  • Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430（页面存档备份，存于互联网档案馆）.
  • Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A (2000). "CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2". J. Biol. Chem. 275 (38): 29338–47. doi:10.1074/jbc.M003456200. PMID 10882725（页面存档备份，存于互联网档案馆）.
  • Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F (2000). "Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation". J. Immunol. 165 (5): 2535–43. doi:10.4049/jimmunol.165.5.2535. PMID 10946280（页面存档备份，存于互联网档案馆）.
  • Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, Flier JS, Myers MG (2001). "SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985". J. Biol. Chem. 275 (51): 40649–57. doi:10.1074/jbc.M007577200. PMID 11018044（页面存档备份，存于互联网档案馆）.
  • Shen X, Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Lett. 480 (2–3): 132–6. doi:10.1016/S0014-5793(00)01905-0. PMID 11034314（页面存档备份，存于互联网档案馆）.
  • Dey BR, Furlanetto RW, Nissley P (2001). "Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor". Biochem. Biophys. Res. Commun. 278 (1): 38–43. doi:10.1006/bbrc.2000.3762. PMID 11071852（页面存档备份，存于互联网档案馆）.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" （页面存档备份，存于互联网档案馆）. Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 （页面存档备份，存于互联网档案馆）. PMID 11076863（页面存档备份，存于互联网档案馆）.
  • Cookson WO, Ubhi B, Lawrence R, Abecasis GR, Walley AJ, Cox HE, Coleman R, Leaves NI, Trembath RC, Moffatt MF, Harper JI (2001). "Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci". Nat. Genet. 27 (4): 372–3. doi:10.1038/86867. PMID 11279517（页面存档备份，存于互联网档案馆）.
  • Cacalano NA, Sanden D, Johnston JA (2001). "Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras". Nat. Cell Biol. 3 (5): 460–5. doi:10.1038/35074525. PMID 11331873（页面存档备份，存于互联网档案馆）.
  • Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, Hilton DJ, Alexander WS (2001). "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9324–9. doi:10.1073/pnas.161271798. PMC 55419. PMID 11481489（页面存档备份，存于互联网档案馆）.
  • Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology. 142 (12): 5286–93. doi:10.1210/endo.142.12.8549. PMIDPMID 11713228（页面存档备份，存于互联网档案馆）.
  • Bode JG, Ludwig S, Freitas CA, Schaper F, Ruhl M, Melmed S, Heinrich PC, Häussinger D (2002). "The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription". Biol. Chem. 382 (10): 1447–53. doi:10.1515/BC.2001.178. PMID 11727828（页面存档备份，存于互联网档案馆）.

十一月 06, 2023
socs3, 细胞因子信号传导抑制因子3, socs, 是一种在人体内由, 基因编码的蛋白, 该基因编码, stat, 诱导的, stat, 抑制子, 也可称为细胞因子信号转导, socs, 家族抑制子, 的一个成员, 家族成员是可由细胞因子诱导的细胞因子信号转导负调节因子, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表2bbu, 2hmh, 2jz3, 4gl9識別號别名, atod4, cis3, cish3, socs, ssi3, suppressor, cytokine, signa. 细胞因子信号传导抑制因子3 SOCS3或 SOCS 3 是一种在人体内由 SOCS3基因编码的蛋白 5 6 该基因编码 STAT 诱导的 STAT 抑制子 SSI 也可称为细胞因子信号转导 SOCS 家族抑制子 的一个成员 SSI 家族成员是可由细胞因子诱导的细胞因子信号转导负调节因子 SOCS3已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2BBU 2HMH 2JZ3 4GL9識別號别名SOCS3 ATOD4 CIS3 Cish3 SOCS 3 SSI 3 SSI3 suppressor of cytokine signaling 3外部IDOMIM 604176 MGI 1201791 HomoloGene 2941 GeneCards SOCS3基因位置 人类 染色体17號染色體 1 基因座17q25 3起始78 356 778 bp 1 终止78 360 077 bp 1 基因位置 小鼠 染色体小鼠11号染色体 2 基因座11 11 E2起始117 856 905 bp 2 终止117 860 873 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 protein kinase inhibitor activity 血浆蛋白结合 phosphotyrosine residue binding 1 phosphatidylinositol 3 kinase regulator activity細胞組分 细胞质基质 細胞質 phosphatidylinositol 3 kinase complex 胞內生物學過程 regulation of protein phosphorylation trophoblast giant cell differentiation intracellular signal transduction spongiotrophoblast differentiation placenta blood vessel development negative regulation of apoptotic process negative regulation of insulin receptor signaling pathway regulation of interferon gamma mediated signaling pathway branching involved in labyrinthine layer morphogenesis protein ubiquitination positive regulation of cell differentiation regulation of cell differentiation regulation of growth negative regulation of signal transduction negative regulation of inflammatory response negative regulation of protein kinase activity negative regulation of receptor signaling pathway via JAK STAT negative regulation of tyrosine phosphorylation of STAT protein 翻译后修饰 cellular response to leukemia inhibitory factor positive regulation of tyrosine phosphorylation of STAT protein receptor signaling pathway via JAK STAT cytokine mediated signaling pathway interleukin 6 mediated signaling pathway regulation of phosphatidylinositol 3 kinase activity phosphatidylinositol phosphate biosynthetic processSources Amigo QuickGO直系同源物種人類小鼠Entrez902112702EnsemblENSG00000184557ENSMUSG00000053113UniProtO14543Q6FI39O35718mRNA 序列NM 003955 NM 001378932 NM 001378933NM 007707蛋白序列NP 003946 NP 001365861 NP 001365862NP 003946 3NP 031733基因位置 UCSC Chr 17 78 36 78 36 MbChr 11 117 86 117 86 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 功能 2 相互作用 3 调控 4 参见 5 参考文献 6 扩展阅读功能 编辑SOCS3基因的表达可由多种细胞因子的诱导 包括 IL 6 IL 10 干扰素 g IFN g 在 IL 6 Epo GCSF 和瘦素的信号传导中 已发现SOCS3在各自的细胞因子受体上的结合对 SOCS3的抑制功能而言是至关重要的 SOCS3的过表达会抑制脂肪组织和肝脏胰岛素信号转导 但对肌肉则不然 7 但是在小鼠骨骼肌中敲除 SOCS3可以保护小鼠免于肥胖相关的胰岛素抵抗 7 由于神经酰胺合成的增加 SOCS3会增加瘦素抵抗和胰岛素抵抗 8 因此 研究已表明去除 SOCS 基因可以预防肥胖症患者的胰岛素抵抗 7 对该小鼠中基因的同源基因的研究表明 该基因在胎儿肝脏造血和胎盘发育的负调控中发挥作用 9 SOCS3蛋白能与JAK2结合 抑制其活性 相互作用 编辑已经证明 SOCS3可以与下列物质相互作用 促红细胞生成素受体 10 11 糖蛋白130 12 胰岛素样生长因子1受体 13 JAK2 6 10 14 PTPN11 12 RAS p21蛋白激活因子1 15 调控 编辑有部分证据表明 SOCS3的表达受小分子核糖核酸 miR 203的调控 16 17 参见 编辑SOCS JAK STAT信号通路参考文献 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000184557 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000053113 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cloning and functional analysis of new members of STAT induced STAT inhibitor SSI family SSI 2 and SSI 3 Biochem Biophys Res Commun September 1997 237 1 79 83 PMID 9266833 doi 10 1006 bbrc 1997 7080 6 0 6 1 Cloning and characterization of novel CIS family genes Biochem Biophys Res Commun November 1997 239 2 439 46 PMID 9344848 doi 10 1006 bbrc 1997 7484 7 0 7 1 7 2 Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity Diabetes 2013 62 1 56 64 2018 11 22 PMC 3526029 nbsp PMID 22961088 doi 10 2337 db12 0443 原始内容存档于2018 11 23 引用错误 带有name属性 pmid22961088 的 lt ref gt 标签用不同内容定义了多次 Central role of ceramide biosynthesis in body weight regulation energy metabolism and the metabolic syndrome American Journal of Physiology 2009 297 1 E211 E224 2018 11 22 PMC 2711669 nbsp PMID 19435851 doi 10 1152 ajpendo 91014 2008 原始内容存档于2016 08 10 Entrez Gene SOCS3 suppressor of cytokine signaling 3 原始内容存档于2010 03 07 10 0 10 1 CIS3 SOCS 3 suppresses erythropoietin EPO signaling by binding the EPO receptor and JAK2 J Biol Chem September 2000 275 38 29338 47 PMID 10882725 doi 10 1074 jbc M003456200 A new high affinity binding site for suppressor of cytokine signaling 3 on the erythropoietin receptor Eur J Biochem May 2002 269 10 2516 26 PMID 12027890 doi 10 1046 j 1432 1033 2002 02916 x 12 0 12 1 SHP2 and SOCS3 contribute to Tyr 759 dependent attenuation of interleukin 6 signaling through gp130 J Biol Chem January 2003 278 1 661 71 PMID 12403768 doi 10 1074 jbc M210552200 Suppressor of cytokine signaling SOCS 3 protein interacts with the insulin like growth factor I receptor Biochem Biophys Res Commun November 2000 278 1 38 43 PMID 11071852 doi 10 1006 bbrc 2000 3762 Cytokine inducible SH2 protein 3 CIS3 SOCS3 inhibits Janus tyrosine kinase by binding through the N terminal kinase inhibitory region as well as SH2 domain Genes Cells June 1999 4 6 339 51 PMID 10421843 doi 10 1046 j 1365 2443 1999 00263 x Tyrosine phosphorylated SOCS 3 inhibits STAT activation but binds to p120 RasGAP and activates Ras Nat Cell Biol May 2001 3 5 460 5 PMID 11331873 doi 10 1038 35074525 miR 203 represses stemness by repressing DeltaNp63 Cell Death Differ 2008 15 7 1187 95 PMID 18483491 doi 10 1038 cdd 2008 69 The expression of microRNA 203 during human skin morphogenesis Exp Dermatol 2010 19 9 854 6 PMID 20698882 doi 10 1111 j 1600 0625 2010 01118 x 扩展阅读 编辑Yasukawa H Sasaki A Yoshimura A 2000 Negative regulation of cytokine signaling pathways Annu Rev Immunol 18 143 64 doi 10 1146 annurev immunol 18 1 143 PMID 10837055 页面存档备份 存于互联网档案馆 Kile BT Schulman BA Alexander WS Nicola NA Martin HM Hilton DJ 2002 The SOCS box a tale of destruction and degradation Trends Biochem Sci 27 5 235 41 doi 10 1016 S0968 0004 02 02085 6 PMID 1276535 页面存档备份 存于互联网档案馆 Zhang JG Farley A Nicholson SE Willson TA Zugaro LM Simpson RJ Moritz RL Cary D Richardson R Hausmann G Kile BJ Kent SB Alexander WS Metcalf D Hilton DJ Nicola NA Baca M 1999 The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Proc Natl Acad Sci U S A 96 5 2071 6 doi 10 1073 pnas 96 5 2071 PMC 26738 PMID 10051596 页面存档备份 存于互联网档案馆 Sasaki A Yasukawa H Suzuki A Kamizono S Syoda T Kinjyo I Sasaki M Johnston JA Yoshimura A 1999 Cytokine inducible SH2 protein 3 CIS3 SOCS3 inhibits Janus tyrosine kinase by binding through the N terminal kinase inhibitory region as well as SH2 domain Genes Cells 4 6 339 51 doi 10 1046 j 1365 2443 1999 00263 x PMID 10421843 页面存档备份 存于互联网档案馆 Marine JC McKay C Wang D Topham DJ Parganas E Nakajima H Pendeville H Yasukawa H Sasaki A Yoshimura A Ihle JN 1999 SOCS3 is essential in the regulation of fetal liver erythropoiesis Cell 98 5 617 27 doi 10 1016 S0092 8674 00 80049 5 PMID 10490101 页面存档备份 存于互联网档案馆 Schmitz J Weissenbach M Haan S Heinrich PC Schaper F 2000 SOCS3 exerts its inhibitory function on interleukin 6 signal transduction through the SHP2 recruitment site of gp130 J Biol Chem 275 17 12848 56 doi 10 1074 jbc 275 17 12848 PMID 10777583 页面存档备份 存于互联网档案馆 Ram PA Waxman DJ 2000 SOCS CIS protein inhibition of growth hormone stimulated STAT5 signaling by multiple mechanisms J Biol Chem 274 50 35553 61 doi 10 1074 jbc 274 50 35553 PMID 10585430 页面存档备份 存于互联网档案馆 Sasaki A Yasukawa H Shouda T Kitamura T Dikic I Yoshimura A 2000 CIS3 SOCS 3 suppresses erythropoietin EPO signaling by binding the EPO receptor and JAK2 J Biol Chem 275 38 29338 47 doi 10 1074 jbc M003456200 PMID 10882725 页面存档备份 存于互联网档案馆 Anhuf D Weissenbach M Schmitz J Sobota R Hermanns HM Radtke S Linnemann S Behrmann I Heinrich PC Schaper F 2000 Signal transduction of IL 6 leukemia inhibitory factor and oncostatin M structural receptor requirements for signal attenuation J Immunol 165 5 2535 43 doi 10 4049 jimmunol 165 5 2535 PMID 10946280 页面存档备份 存于互联网档案馆 Bjorbak C Lavery HJ Bates SH Olson RK Davis SM Flier JS Myers MG 2001 SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985 J Biol Chem 275 51 40649 57 doi 10 1074 jbc M007577200 PMID 11018044 页面存档备份 存于互联网档案馆 Shen X Hong F Nguyen VA Gao B 2000 IL 10 attenuates IFN alpha activated STAT1 in the liver involvement of SOCS2 and SOCS3 FEBS Lett 480 2 3 132 6 doi 10 1016 S0014 5793 00 01905 0 PMID 11034314 页面存档备份 存于互联网档案馆 Dey BR Furlanetto RW Nissley P 2001 Suppressor of cytokine signaling SOCS 3 protein interacts with the insulin like growth factor I receptor Biochem Biophys Res Commun 278 1 38 43 doi 10 1006 bbrc 2000 3762 PMID 11071852 页面存档备份 存于互联网档案馆 Hartley JL Temple GF Brasch MA 2001 DNA cloning using in vitro site specific recombination 页面存档备份 存于互联网档案馆 Genome Res 10 11 1788 95 doi 10 1101 gr 143000 PMC 310948 页面存档备份 存于互联网档案馆 PMID 11076863 页面存档备份 存于互联网档案馆 Cookson 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JG Ludwig S Freitas CA Schaper F Ruhl M Melmed S Heinrich PC Haussinger D 2002 The MKK6 p38 mitogen activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL 6 induced transcription Biol Chem 382 10 1447 53 doi 10 1515 BC 2001 178 PMID 11727828 页面存档备份 存于互联网档案馆 取自 https zh wikipedia org w index php title SOCS3 amp oldid 71674587, 维基百科，wiki，书籍，书籍，图书馆，

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