· endothelial cell proliferation · wound healing involved in inflammatory response · negative regulation of leukocyte migration · porphyrin-containing compound metabolic process · heme oxidation · cellular iron ion homeostasis · response to oxidative stress · intracellular protein kinase cascade · small GTPase mediated signal transduction · excretion · regulation of blood pressure · cell death · intrinsic apoptotic signaling pathway in response to DNA damage · smooth muscle hyperplasia · cellular response to nutrient · negative regulation of mast cell cytokine production · erythrocyte homeostasis · low-density lipoprotein particle clearance · response to nicotine · heme catabolic process · response to hydrogen peroxide · negative regulation of apoptotic process · positive regulation of I-kappaB kinase/NF-kappaB cascade · negative regulation of mast cell degranulation · negative regulation of DNA binding · negative regulation of sequence-specific DNA binding transcription factor activity · negative regulation of neuron apoptotic process · regulation of transcription from RNA polymerase II promoter in response to oxidative stress · response to estrogen stimulus · small molecule metabolic process · positive regulation of chemokine biosynthetic process · regulation of angiogenesis · positive regulation of angiogenesis · positive regulation of vasodilation · positive regulation of smooth muscle cell proliferation · negative regulation of smooth muscle cell proliferation · regulation of sequence-specific DNA binding transcription factor activity · protein homooligomerization · iron ion homeostasis · transmembrane transport · cellular response to cadmium ion
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一月 13, 2023
hmox1, 血红素加氧酶1, 英語, heme, oxygenase, 缩写或ho, 是一种血红素加氧酶, 是血红素代谢过程中的重要酶, 它将血红素转化为胆绿素, heme, oxygenase, decycling, 1血红素加氧酶1, 脱环, rendering, based, 1n3u, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1n3u, 1n45, 1ni6, 1oyk, 1oyl, 1oze, 1ozl, 1ozr, 1ozw, 1s13, 1s8c, 1t5p, 1tw. 血红素加氧酶1 英語 heme oxygenase 1 缩写HMOX1或HO 1 是一种血红素加氧酶 EC 1 14 99 3 是血红素代谢过程中的重要酶 它将血红素转化为胆绿素 Heme oxygenase decycling 1血红素加氧酶1 脱环 PDB rendering based on 1n3u 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM标识代号HMOX1 HMOX1D HO 1 HSP32 bK286B10扩展标识遗传学 141250 鼠基因 96163 同源基因 31075 ChEMBL 2823 GeneCards HMOX1 GeneEC編號1 14 99 3基因本体论描述分子功能 heme oxygenase decyclizing activity phospholipase D activity signal transducer activity enzyme binding heme binding protein homodimerization activity metal ion binding细胞成分 extracellular space nucleus nucleolus endoplasmic reticulum endoplasmic reticulum membrane cytosol caveola membrane生物过程 angiogenesis endothelial cell proliferation wound healing involved in inflammatory response negative regulation of leukocyte migration porphyrin containing compound metabolic process heme oxidation cellular iron ion homeostasis response to oxidative stress intracellular protein kinase cascade small GTPase mediated signal transduction excretion regulation of blood pressure cell death intrinsic apoptotic signaling pathway in response to DNA damage smooth muscle hyperplasia cellular response to nutrient negative regulation of mast cell cytokine production erythrocyte homeostasis low density lipoprotein particle clearance response to nicotine heme catabolic process response to hydrogen peroxide negative regulation of apoptotic process positive regulation of I kappaB kinase NF kappaB cascade negative regulation of mast cell degranulation negative regulation of DNA binding negative regulation of sequence specific DNA binding transcription factor activity negative regulation of neuron apoptotic process regulation of transcription from RNA polymerase II promoter in response to oxidative stress response to estrogen stimulus small molecule metabolic process positive regulation of chemokine biosynthetic process regulation of angiogenesis positive regulation of angiogenesis positive regulation of vasodilation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of sequence specific DNA binding transcription factor activity protein homooligomerization iron ion homeostasis transmembrane transport cellular response to cadmium ion cellular response to hypoxiaSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez316215368EnsemblENSG00000100292ENSMUSG00000005413UniProtP09601P14901mRNA序列NM 002133NM 010442蛋白序列NP 002124NP 034572基因位置Chr 22 35 78 35 79 MbChr 8 75 09 75 1 MbPubMed查询 1 2 查论编另见 编辑HMOX2参考文献 编辑延伸阅读 编辑Yachie A Niida Y Wada T Igarashi N Kaneda H Toma T Ohta K Kasahara Y Koizumi S Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase 1 deficiency J Clin Invest 1999 103 1 129 35 PMC 407858 PMID 9884342 doi 10 1172 JCI4165 Wang J Dore S Heme oxygenase 1 exacerbates early brain injury after intracerebral haemorrhage Brain 2007 130 6 1643 52 PMC 2291147 PMID 17525142 doi 10 1093 brain awm095 Soares MP Brouard S Smith RN Bach FH Heme oxygenase 1 a protective gene that prevents the rejection of transplanted organs Immunol Rev 2002 184 275 85 PMID 12086318 doi 10 1034 j 1600 065x 2001 1840124 x Morse D Choi AM Heme oxygenase 1 the emerging molecule has arrived Am J Respir Cell Mol Biol 2002 27 1 8 16 PMID 12091240 doi 10 1165 ajrcmb 27 1 4862 Buelow R Tullius SG Volk HD Protection of grafts by hemoxygenase 1 and its toxic product carbon monoxide Am J Transplant 2002 1 4 313 5 PMID 12099373 doi 10 1034 j 1600 6143 2001 10404 x Ishikawa K Heme oxygenase 1 against vascular insufficiency roles of atherosclerotic disorders Curr Pharm Des 2003 9 30 2489 97 PMID 14529548 doi 10 2174 1381612033453767 Exner M Minar E Wagner O Schillinger M The role of heme oxygenase 1 promoter polymorphisms in human disease Free Radic Biol Med 2005 37 8 1097 104 PMID 15451051 doi 10 1016 j freeradbiomed 2004 07 008 Ozono R New biotechnological methods to reduce oxidative stress in the cardiovascular system focusing on the Bach1 heme oxygenase 1 pathway Current pharmaceutical biotechnology 2006 7 2 87 93 PMID 16724942 doi 10 2174 138920106776597630 Tracz MJ Alam J Nath KA Physiology and pathophysiology of heme implications for kidney disease J Am Soc Nephrol 2007 18 2 414 20 PMID 17229906 doi 10 1681 ASN 2006080894 Hill Kapturczak N Agarwal A Haem oxygenase 1 a culprit in vascular and renal damage Nephrol Dial Transplant 2007 22 6 1495 9 PMID 17389623 doi 10 1093 ndt gfm093 取自 https zh wikipedia org w index php title HMOX1 amp oldid 31868005, 维基百科，wiki，书籍，书籍，图书馆，
