FTO基因全稱脂肪和肥胖相关基因（Fat mass and obesity-associated），在人類基因組中位於16號染色體，此基因編碼的FTO蛋白屬AlkB家族（英语：AlkB）（即與細菌的AlkB蛋白同源[6][7]），為α-酮戊二酸依赖性羟化酶（英语：alpha-ketoglutarate-dependent hydroxylase）[6]。此基因可能與肥胖症有關[8][9]。2011年何川實驗室發現FTO蛋白可將mRNA上的N6-甲基腺苷（m6A）去甲基化成腺苷（A），為第一個被發現的mRNA去甲基酶[10][11]。
• regulation of multicellular organism growth • regulation of respiratory system process • regulation of white fat cell proliferation • cellular response to DNA damage stimulus • oxidative demethylation • oxidative single-stranded RNA demethylation • regulation of lipid storage • RNA repair • adipose tissue development • DNA去甲基化 • regulation of brown fat cell differentiation • temperature homeostasis • oxidative single-stranded DNA demethylation • DNA修復 • DNA dealkylation involved in DNA repair
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000140718 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000055932 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ 6.06.1Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. November 2007, 318 (5855): 1469–72. Bibcode:2007Sci...318.1469G. PMC 2668859. PMID 17991826. doi:10.1126/science.1151710.
^Sanchez-Pulido L, Andrade-Navarro MA. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochemistry. November 2007, 8: 23. PMC 2241624. PMID 17996046. doi:10.1186/1471-2091-8-23.
^Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. January 2014, 10 (1): 51–61. PMC 4188449. PMID 24247219. doi:10.1038/nrendo.2013.227.
^Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, et al. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. The New England Journal of Medicine. September 2015, 373 (10): 895–907. PMC 4959911. PMID 26287746. doi:10.1056/NEJMoa1502214.
^Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology. October 2011, 7 (12): 885–7. PMC 3218240. PMID 22002720. doi:10.1038/nchembio.687.
^Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. June 2012, 149 (7): 1635–46. PMC 3383396. PMID 22608085. doi:10.1016/j.cell.2012.05.003.
十月 31, 2023
fto基因, 全稱脂肪和肥胖相关基因, mass, obesity, associated, 在人類基因組中位於16號染色體, 此基因編碼的fto蛋白屬alkb家族, 英语, alkb, 即與細菌的alkb蛋白同源, 為α, 酮戊二酸依赖性羟化酶, 英语, alpha, ketoglutarate, dependent, hydroxylase, 此基因可能與肥胖症有關, 2011年何川實驗室發現fto蛋白可將mrna上的n6, 甲基腺苷, 去甲基化成腺苷, 為第一個被發現的mrna去甲基酶, 肥胖基因已知的結構p. FTO基因全稱脂肪和肥胖相关基因 Fat mass and obesity associated 在人類基因組中位於16號染色體 此基因編碼的FTO蛋白屬AlkB家族 英语 AlkB 即與細菌的AlkB蛋白同源 6 7 為a 酮戊二酸依赖性羟化酶 英语 alpha ketoglutarate dependent hydroxylase 6 此基因可能與肥胖症有關 8 9 2011年何川實驗室發現FTO蛋白可將mRNA上的N6 甲基腺苷 m6A 去甲基化成腺苷 A 為第一個被發現的mRNA去甲基酶 10 11 肥胖基因已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表3LFM 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7 4CXW 4CXX 4CXY 4QHO 4QKN 4ZS3 4ZS2識別號别名FTO ALKBH9 GDFD BMIQ14 fat mass and obesity associated alpha ketoglutarate dependent dioxygenase外部IDOMIM 610966 MGI 1347093 HomoloGene 8053 GeneCards FTO相關疾病2型糖尿病 肥胖症 morbid obesity 黑色素瘤 退化性關節炎 代謝疾病 慢性阻塞性肺病 lethal polymalformative syndrome Boissel type 1 基因位置 人类 染色体16號染色體 2 基因座16q12 2起始53 701 692 bp 2 终止54 158 512 bp 2 基因位置 小鼠 染色体小鼠8号染色体 3 基因座8 C5 8 44 34 cM起始92 040 153 bp 3 终止92 395 067 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 oxidative DNA demethylase activity dioxygenase activity 金屬離子結合 DNA N1 methyladenine dioxygenase activity oxidoreductase activity ferrous iron binding mRNA N6 methyladenosine dioxygenase activity oxidative RNA demethylase activity細胞組分 nuclear speck 细胞核 核质生物學過程 regulation of multicellular organism growth regulation of respiratory system process regulation of white fat cell proliferation cellular response to DNA damage stimulus oxidative demethylation oxidative single stranded RNA demethylation regulation of lipid storage RNA repair adipose tissue development DNA去甲基化 regulation of brown fat cell differentiation temperature homeostasis oxidative single stranded DNA demethylation DNA修復 DNA dealkylation involved in DNA repairSources Amigo QuickGO直系同源物種人類小鼠Entrez7906826383EnsemblENSG00000140718ENSMUSG00000055932UniProtQ9C0B1Q8BGW1mRNA 序列 NM 001080432NM 011936蛋白序列NP 001073901 NP 001350820 NP 001350823 NP 001350825 NP 001350826 NP 001350827 NP 001350828 NP 001350829 NP 001350830 NP 001350832 NP 001350834 NP 001350917NP 036066基因位置 UCSC Chr 16 53 7 54 16 MbChr 8 92 04 92 4 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠參考文獻 编辑 nbsp 分子与细胞生物学主题 與肥胖基因相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000140718 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000055932 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine 6 0 6 1 Gerken T Girard CA Tung YC Webby CJ Saudek V Hewitson KS Yeo GS McDonough MA Cunliffe S McNeill LA Galvanovskis J Rorsman P Robins P Prieur X Coll AP Ma M Jovanovic Z Farooqi IS Sedgwick B Barroso I Lindahl T Ponting CP Ashcroft FM O Rahilly S Schofield CJ The obesity associated FTO gene encodes a 2 oxoglutarate dependent nucleic acid demethylase Science November 2007 318 5855 1469 72 Bibcode 2007Sci 318 1469G PMC 2668859 nbsp PMID 17991826 doi 10 1126 science 1151710 Sanchez Pulido L Andrade Navarro MA The FTO fat mass and obesity associated gene codes for a novel member of the non heme dioxygenase superfamily BMC Biochemistry November 2007 8 23 PMC 2241624 nbsp PMID 17996046 doi 10 1186 1471 2091 8 23 Loos RJ Yeo GS The bigger picture of FTO the first GWAS identified obesity gene Nature Reviews Endocrinology January 2014 10 1 51 61 PMC 4188449 nbsp PMID 24247219 doi 10 1038 nrendo 2013 227 Claussnitzer M Dankel SN Kim KH Quon G Meuleman W Haugen C et al FTO Obesity Variant Circuitry and Adipocyte Browning in Humans The New England Journal of Medicine September 2015 373 10 895 907 PMC 4959911 nbsp PMID 26287746 doi 10 1056 NEJMoa1502214 Jia G Fu Y Zhao X Dai Q Zheng G Yang Y Yi C Lindahl T Pan T Yang YG He C N6 methyladenosine in nuclear RNA is a major substrate of the obesity associated FTO Nature Chemical Biology October 2011 7 12 885 7 PMC 3218240 nbsp PMID 22002720 doi 10 1038 nchembio 687 Meyer KD Saletore Y Zumbo P Elemento O Mason CE Jaffrey SR Comprehensive analysis of mRNA methylation reveals enrichment in 3 UTRs and near stop codons Cell June 2012 149 7 1635 46 PMC 3383396 nbsp PMID 22608085 doi 10 1016 j cell 2012 05 003 取自 https zh wikipedia org w index php title FTO基因 amp oldid 69793027, 维基百科，wiki，书籍，书籍，图书馆，
