· iron ion binding · electron carrier activity · oxidoreductase activity · oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen · enzyme binding · heme binding · demethylase activity · caffeine oxidase activity
· porphyrin-containing compound metabolic process · xenobiotic metabolic process · toxin biosynthetic process · post-embryonic development · alkaloid metabolic process · regulation of gene expression · monoterpenoid metabolic process · drug metabolic process · dibenzo-p-dioxin metabolic process · arachidonic acid metabolic process · epoxygenase P450 pathway · lung development · methylation · response to estradiol · response to lipopolysaccharide · monocarboxylic acid metabolic process · response to immobilization stress · drug catabolic process · exogenous drug catabolic process · small molecule metabolic process · cellular respiration · heterocycle metabolic process · hydrogen peroxide biosynthetic process · oxidation-reduction process · oxidative demethylation · cellular response to cadmium ion · oxidative deethylation
^Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. January 2004, 14 (1): 1–18. PMID 15128046. doi:10.1097/00008571-200401000-00001.
^Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ. Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15. J. Exp. Pathol. 1987, 3 (1): 1–17. PMID 3681487.
延伸閱讀编辑
Meijerman I, Beijnen J, Schellens J. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist. 2006, 11 (7): 742–52. PMID 16880233. doi:10.1634/theoncologist.11-7-742.
Smith G, Stubbins MJ, Harries LW, Wolf CR. Molecular genetics of the human cytochrome P450 monooxygenase superfamily.. Xenobiotica. 1999, 28 (12): 1129–65. PMID 9890157. doi:10.1080/004982598238868.
Landi MT, Sinha R, Lang NP, Kadlubar FF. Human cytochrome P4501A2.. IARC Sci. Publ. 1999, (148): 173–95. PMID 10493258.
Ikeya K, Jaiswal AK, Owens RA; et al. Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.. Mol. Endocrinol. 1990, 3 (9): 1399–408. PMID 2575218. doi:10.1210/mend-3-9-1399.
Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.. Proc. Natl. Acad. Sci. U.S.A. 1989, 86 (20): 7696–700. PMC 298137. PMID 2813353. doi:10.1073/pnas.86.20.7696.
Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.. DNA. 1986, 4 (5): 395–400. PMID 3000715. doi:10.1089/dna.1985.4.395.
Quattrochi LC, Pendurthi UR, Okino ST; et al. Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.. Proc. Natl. Acad. Sci. U.S.A. 1986, 83 (18): 6731–5. PMC 386583. PMID 3462722. doi:10.1073/pnas.83.18.6731.
Wrighton SA, Campanile C, Thomas PE; et al. Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.. Mol. Pharmacol. 1986, 29 (4): 405–10. PMID 3517618.
Eugster HP, Probst M, Würgler FE, Sengstag C. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae.. Drug Metab. Dispos. 1993, 21 (1): 43–9. PMID 8095225.
Schweikl H, Taylor JA, Kitareewan S; et al. Expression of CYP1A1 and CYP1A2 genes in human liver.. Pharmacogenetics. 1994, 3 (5): 239–49. PMID 8287062. doi:10.1097/00008571-199310000-00003.
Yamazaki H, Inoue K, Mimura M; et al. 7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.. Biochem. Pharmacol. 1996, 51 (3): 313–9. PMID 8573198. doi:10.1016/0006-2952(95)02178-7.
Hakkola J, Raunio H, Purkunen R; et al. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy.. Biochem. Pharmacol. 1996, 52 (2): 379–83. PMID 8694864. doi:10.1016/0006-2952(96)00216-X.
Guengerich FP, Johnson WW. Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.. Biochemistry. 1998, 36 (48): 14741–50. PMID 9398194. doi:10.1021/bi9719399.
Wacke R, Kirchner A, Prall F; et al. Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis.. Pancreas. 1998, 16 (4): 521–8. PMID 9598815. doi:10.1097/00006676-199805000-00011.
Macé K, Bowman ED, Vautravers P; et al. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.. Eur. J. Cancer. 1998, 34 (6): 914–20. PMID 9797707. doi:10.1016/S0959-8049(98)00034-3.
Huang JD, Guo WC, Lai MD; et al. Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.. Drug Metab. Dispos. 1999, 27 (1): 98–101. PMID 9884316.
Tatemichi M, Nomura S, Ogura T; et al. Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.. Cancer Res. 1999, 59 (16): 3893–8. PMID 10463577.
十月 25, 2023
cyp1a2, 细胞色素p450, 英語, cytochrome, p450, 缩写为, 是细胞色素p450混合功能氧化酶家族的一员, 参与体内异生物质的代谢, 酶由人类基因编码, cytochrome, p450, family, subfamily, polypeptide, 2pdb根据2hi4所绘制的渲染图有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表2hi4标识代号, cp12, p450, 扩展标识遗传学, 124060, 鼠基因, 88589, 同源基因, 68082, ch. 细胞色素P450 1A2 英語 Cytochrome P450 1A2 缩写为CYP1A2 是细胞色素P450混合功能氧化酶家族的一员 参与体内异生物质的代谢 1 CYP1A2酶由人类CYP1A2基因编码 2 Cytochrome P450 family 1 subfamily A polypeptide 2PDB根据2hi4所绘制的渲染图有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表2HI4标识代号CYP1A2 CP12 P3 450 P450 PA 扩展标识遗传学 124060 鼠基因 88589 同源基因 68082 ChEMBL 3356 GeneCards CYP1A2 GeneEC編號1 14 14 1基因本体论描述分子功能 monooxygenase activity iron ion binding electron carrier activity oxidoreductase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen enzyme binding heme binding demethylase activity caffeine oxidase activity aromatase activity细胞成分 endoplasmic reticulum membrane intracellular membrane bounded organelle生物过程 steroid catabolic process porphyrin containing compound metabolic process xenobiotic metabolic process toxin biosynthetic process post embryonic development alkaloid metabolic process regulation of gene expression monoterpenoid metabolic process drug metabolic process dibenzo p dioxin metabolic process arachidonic acid metabolic process epoxygenase P450 pathway lung development methylation response to estradiol response to lipopolysaccharide monocarboxylic acid metabolic process response to immobilization stress drug catabolic process exogenous drug catabolic process small molecule metabolic process cellular respiration heterocycle metabolic process hydrogen peroxide biosynthetic process oxidation reduction process oxidative demethylation cellular response to cadmium ion oxidative deethylation omega hydroxylase P450 pathwaySources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez154413077EnsemblENSG00000140505ENSMUSG00000032310UniProtP05177P00186mRNA序列NM 000761NM 009993蛋白序列NP 000752NP 034123基因位置Chr 15 74 75 74 76 MbChr 9 57 68 57 68 MbPubMed查询 1 2 查论编引用 编辑 Nelson DR Zeldin DC Hoffman SM Maltais LJ Wain HM Nebert DW Comparison of cytochrome P450 CYP genes from the mouse and human genomes including nomenclature recommendations for genes pseudogenes and alternative splice variants Pharmacogenetics January 2004 14 1 1 18 PMID 15128046 doi 10 1097 00008571 200401000 00001 Jaiswal AK Nebert DW McBride OW Gonzalez FJ Human P 3 450 cDNA and complete protein sequence repetitive Alu sequences in the 3 nontranslated region and localization of gene to chromosome 15 J Exp Pathol 1987 3 1 1 17 PMID 3681487 延伸閱讀 编辑Meijerman I Beijnen J Schellens J Herb drug interactions in oncology focus on mechanisms of induction Oncologist 2006 11 7 742 52 PMID 16880233 doi 10 1634 theoncologist 11 7 742 Smith G Stubbins MJ Harries LW Wolf CR Molecular genetics of the human cytochrome P450 monooxygenase superfamily Xenobiotica 1999 28 12 1129 65 PMID 9890157 doi 10 1080 004982598238868 Landi MT Sinha R Lang NP Kadlubar FF Human cytochrome P4501A2 IARC Sci Publ 1999 148 173 95 PMID 10493258 Ikeya K Jaiswal AK Owens RA et al Human CYP1A2 sequence gene structure comparison with the mouse and rat orthologous gene and differences in liver 1A2 mRNA expression Mol Endocrinol 1990 3 9 1399 408 PMID 2575218 doi 10 1210 mend 3 9 1399 Butler MA Iwasaki M Guengerich FP Kadlubar FF Human cytochrome P 450PA P 450IA2 the phenacetin O deethylase is primarily responsible for the hepatic 3 demethylation of caffeine and N oxidation of carcinogenic arylamines Proc Natl Acad Sci U S A 1989 86 20 7696 700 PMC 298137 nbsp PMID 2813353 doi 10 1073 pnas 86 20 7696 Quattrochi LC Okino ST Pendurthi UR Tukey RH Cloning and isolation of human cytochrome P 450 cDNAs homologous to dioxin inducible rabbit mRNAs encoding P 450 4 and P 450 6 DNA 1986 4 5 395 400 PMID 3000715 doi 10 1089 dna 1985 4 395 Quattrochi LC Pendurthi UR Okino ST et al Human cytochrome P 450 4 mRNA and gene part of a multigene family that contains Alu sequences in its mRNA Proc Natl Acad Sci U S A 1986 83 18 6731 5 PMC 386583 nbsp PMID 3462722 doi 10 1073 pnas 83 18 6731 Wrighton SA Campanile C Thomas PE et al Identification of a human liver cytochrome P 450 homologous to the major isosafrole inducible cytochrome P 450 in the rat Mol Pharmacol 1986 29 4 405 10 PMID 3517618 Jaiswal AK Nebert DW Gonzalez FJ Human P3 450 cDNA and complete amino acid sequence Nucleic Acids Res 1986 14 16 6773 4 PMC 311685 nbsp PMID 3755823 doi 10 1093 nar 14 16 6773 Eugster HP Probst M Wurgler FE Sengstag C Caffeine estradiol and progesterone interact with human CYP1A1 and CYP1A2 Evidence from cDNA directed expression in Saccharomyces cerevisiae Drug Metab Dispos 1993 21 1 43 9 PMID 8095225 Schweikl H Taylor JA Kitareewan S et al Expression of CYP1A1 and CYP1A2 genes in human liver Pharmacogenetics 1994 3 5 239 49 PMID 8287062 doi 10 1097 00008571 199310000 00003 Yamazaki H Inoue K Mimura M et al 7 Ethoxycoumarin O deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes Biochem Pharmacol 1996 51 3 313 9 PMID 8573198 doi 10 1016 0006 2952 95 02178 7 Hakkola J Raunio H Purkunen R et al Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy Biochem Pharmacol 1996 52 2 379 83 PMID 8694864 doi 10 1016 0006 2952 96 00216 X Guengerich FP Johnson WW Kinetics of ferric cytochrome P450 reduction by NADPH cytochrome P450 reductase rapid reduction in the absence of substrate and variations among cytochrome P450 systems Biochemistry 1998 36 48 14741 50 PMID 9398194 doi 10 1021 bi9719399 Wacke R Kirchner A Prall F et al Up regulation of cytochrome P450 1A2 2C9 and 2E1 in chronic pancreatitis Pancreas 1998 16 4 521 8 PMID 9598815 doi 10 1097 00006676 199805000 00011 Mace K Bowman ED Vautravers P et al Characterisation of xenobiotic metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues Eur J Cancer 1998 34 6 914 20 PMID 9797707 doi 10 1016 S0959 8049 98 00034 3 Huang JD Guo WC Lai MD et al Detection of a novel cytochrome P 450 1A2 polymorphism F21L in Chinese Drug Metab Dispos 1999 27 1 98 101 PMID 9884316 Tatemichi M Nomura S Ogura T et al Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia Cancer Res 1999 59 16 3893 8 PMID 10463577 取自 https zh wikipedia org w index php title CYP1A2 amp oldid 56261489, 维基百科，wiki，书籍，书籍，图书馆，
