CXCL10

CXCL10（英語：C-X-C motif chemokine 10）是一小分子的细胞因子属于CXC趋化因子家族^[5]，又被称作“干扰素伽玛诱导的10千道尔顿蛋白”（10 kDa interferon-gamma-induced protein，IP-10）^[6] 。干扰素伽玛可以在多种细胞（如巨噬细胞^[7] ，单核细胞^[7] ，内皮细胞^[8]和成纤维细胞）中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用^[9][10]，促进T细胞黏附于内皮细胞^[8]，抗肿瘤^[11]，及血管新生^[8]。人类的CXCL10基因与CXCL9，CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用^[9][10] 。

CXCL10
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1O80、​1LV9、​1O7Y、​1O7Z
識別號
别名	CXCL10；, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
外部ID	OMIM：147310 MGI：1352450 HomoloGene：1203 GeneCards：CXCL10
基因位置（人类） 染色体 4號染色體^[1] 基因座 4q21.1 起始 76,021,118 bp^[1] 终止 76,023,497 bp^[1]
基因位置（小鼠） 染色体 小鼠5号染色体^[2] 基因座 5 E2|5 46.57 cM 起始 92,494,497 bp^[2] 终止 92,496,748 bp^[2]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • 細胞因子活性 • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • 血浆蛋白结合 • cAMP-dependent protein kinase regulator activity • signaling receptor binding • chemoattractant activity 細胞組分 • 細胞外區域 • external side of plasma membrane • 細胞外空間 • 胞內 生物學過程 • regulation of endothelial tube morphogenesis • negative regulation of myoblast differentiation • cellular response to heat • response to vitamin D • positive regulation of cell migration • T cell chemotaxis • chemokine-mediated signaling pathway • cell-cell signaling • response to virus • muscle organ development • positive regulation of monocyte chemotaxis • positive regulation of release of sequestered calcium ion into cytosol • endothelial cell activation • positive regulation of cAMP-mediated signaling • regulation of T cell chemotaxis • blood circulation • 趨化性 • positive regulation of leukocyte chemotaxis • cell surface receptor signaling pathway • response to lipopolysaccharide • negative regulation of myoblast fusion • defense response to virus • regulation of cell population proliferation • 免疫反应 • positive regulation of cell population proliferation • response to auditory stimulus • negative regulation of angiogenesis • response to cold • cellular response to lipopolysaccharide • response to gamma radiation • positive regulation of T cell migration • 訊息傳遞 • positive regulation of transcription by RNA polymerase II • regulation of protein kinase activity • defense response • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • cytokine-mediated signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to bacterium • neutrophil chemotaxis • leukocyte chemotaxis • positive chemotaxis • regulation of apoptotic process Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3627	15945
Ensembl	ENSG00000169245	ENSMUSG00000034855
UniProt	P02778	P17515
mRNA​序列	NM_001565	NM_021274
蛋白序列	NP_001556	NP_067249
基因位置​（UCSC）	Chr 4: 76.02 – 76.02 Mb	Chr 5: 92.49 – 92.5 Mb
PubMed​查找	^[3]	^[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

参见

• 趋化因子
• CXCR3
• CXCL9
• CXCL11

参考文献

1. GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
6. Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
7. Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
8. Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
9. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
10. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
11. Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部链接

• Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）