• iron ion binding • 金屬離子結合 • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • sterol 14-demethylase activity
細胞組分
• integral component of membrane • organelle membrane • endoplasmic reticulum membrane • 膜 • 細胞內膜結合細胞器 • 细胞膜 • 内质网
生物學過程
• steroid metabolic process • sterol biosynthetic process • 脂質代謝 • cholesterol metabolic process • cholesterol biosynthetic process via 24,25-dihydrolanosterol • sterol metabolic process • cholesterol biosynthetic process • steroid biosynthetic process • 脱甲基化 • regulation of cholesterol biosynthetic process • negative regulation of protein catabolic process • negative regulation of protein secretion • negative regulation of amyloid-beta clearance
^對Cytochrome P450 family 51 subfamily A member 1起作用的藥物;在維基數據上查看/編輯參考.
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000001630 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000001467 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Metabocard for 4,4-Dimethylcholesta-8,14,24-trienol (HMDB01023). Human Metabolome Database. February 2014 [2020-04-18]. (原始内容于2017-12-26).
^Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochimica et Biophysica Acta. March 2007, 1770 (3): 467–77. PMC 2324071. PMID 16963187. doi:10.1016/j.bbagen.2006.07.018.
^Lepesheva GI, Waterman MR. CYP51--the omnipotent P450. Molecular and Cellular Endocrinology. February 2004, 215 (1–2): 165–70. PMID 15026190. doi:10.1016/j.mce.2003.11.016.
^Becher R, Wirsel SG. Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens. Applied Microbiology and Biotechnology. August 2012, 95 (4): 825–40. PMID 22684327. doi:10.1007/s00253-012-4195-9.
^Lepesheva GI, Waterman MR. Structural basis for conservation in the CYP51 family. Biochimica et Biophysica Acta. January 2011, 1814 (1): 88–93. PMC 2962772. PMID 20547249. doi:10.1016/j.bbapap.2010.06.006.