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孕酮受体, 英語, progesterone, receptor, 缩写pr, 也被称为nr3c3, nuclear, receptor, subfamily, group, member, 即核受体第三亚族c组成员3, 是一种细胞内蛋白质, 由甾体激素孕酮激活, progesterone, receptorpdb, rendering, based, 1a28, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1a28, 1e3k, 1sqn, 1sr7, 1zuc, 2c7a, 2ovh. 孕酮受体 英語 progesterone receptor 缩写PR 也被称为NR3C3 nuclear receptor subfamily 3 group C member 3 即核受体第三亚族C组成员3 是一种细胞内蛋白质 由甾体激素孕酮激活 Progesterone receptor孕酮受体PDB rendering based on 1a28 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU标识代号PGR NR3C3 PR扩展标识遗传学 607311 鼠基因 97567 同源基因 713 IUPHAR ChEMBL 208 GeneCards PGR Gene基因本体论描述分子功能 DNA binding steroid hormone receptor activity ligand activated sequence specific DNA binding RNA polymerase II transcription factor activity receptor binding steroid binding protein binding zinc ion binding enzyme binding sequence specific DNA binding细胞成分 nucleus nucleoplasm nucleolus cytoplasm intracellular membrane bounded organelle生物过程 ovulation from ovarian follicle epithelial cell maturation transcription initiation from RNA polymerase II promoter signal transduction cell cell signaling gene expression negative regulation of gene expression regulation of epithelial cell proliferation progesterone receptor signaling pathway tertiary branching involved in mammary gland duct morphogenesisSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez524118667EnsemblENSG00000082175ENSMUSG00000031870UniProtP06401n amRNA序列NM 000926NM 008829蛋白序列NP 000917NP 032855基因位置Chr 11 100 9 101 MbChr 9 8 9 8 97 MbPubMed查询 1 2 查论编在人体中 孕酮受体由基因PGR 编码 位于11号染色体长臂22区 1 2 3 能通过选择性剪接形成两种蛋白异形体A和B 有着各自不同的分子量 4 5 6 目录 1 功能 2 结构 3 交互作用 4 另见 5 参考文献 6 延伸阅读 7 外部链接功能 编辑孕酮是引起孕酮受体反应的配体 在孕酮受体的C端未结合该激素时 与其相关的DNA片段的转录处于抑制状态 在与激素结合后 孕酮受体会变构并开始起作用 而孕酮受体的受体拮抗剂会阻止这种结构改变 在孕酮与其受体结合后 孕酮受体变构并发生二聚化 紧接着以复合体形式进入细胞核与相关的DNA结合 从而使其开始转录 合成mRNA 并表达为相关蛋白质 结构 编辑Progesterone receptor N terminal鑑定標誌Progest rcpt NPfamPF02161InterPro 英语 InterPro IPR000128現有可用的蛋白結構 Pfam結構 ECODPDBRCSB PDB PDBe PDBjPDBsum 英语 PDBsum 結構概要和其它甾体激素受体类似 孕酮受体的N端有一个调控结构域 一个DNA结合结构域 英语 DNA binding domain 以及一个铰链区 在C端有一个配体结合结构域 异形体B比异形体A多一个TAF 3区域 交互作用 编辑孕酮受体能与下列蛋白質发生交互作用 KLF9 英语 KLF9 7 Nuclear receptor co repressor 2 英语 Nuclear receptor co repressor 2 8 UBE3A 英语 UBE3A 9 另见 编辑Selective progesterone receptor modulator 英语 Selective progesterone receptor modulator 参考文献 编辑 Misrahi M Atger M d Auriol L Loosfelt H Meriel C Fridlansky F Guiochon Mantel A Galibert F Milgrom E Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA Biochem Biophys Res Commun March 1987 143 2 740 8 PMID 3551956 doi 10 1016 0006 291X 87 91416 1 Law ML Kao FT Wei Q Hartz JA Greene GL Zarucki Schulz T Conneely OM Jones C Puck TT O Malley BW The progesterone receptor gene maps to human chromosome band 11q13 the site of the mammary oncogene int 2 Proc Natl Acad Sci U S A May 1987 84 9 2877 81 PMC 304763 PMID 3472240 doi 10 1073 pnas 84 9 2877 ensembl org Gene ESR1 ENSG00000091831 2014 06 28 原始内容存档于2022 01 05 Gadkar Sable S Shah C Rosario G Sachdeva G Puri C Progesterone receptors various forms and functions in reproductive tissues Front Biosci 2005 10 2118 30 PMID 15970482 doi 10 2741 1685 Kase Nathan G Speroff Leon Glass Robert L Clinical gynecologic endocrinology and infertility Hagerstown MD Lippincott Williams amp Wilkins 1999 ISBN 0 683 30379 1 Fritz Marc A Speroff Leon Clinical gynecologic endocrinology and infertility Hagerstown MD Lippincott Williams amp Wilkins 2005 ISBN 0 7817 4795 3 Zhang XL Zhang D Michel FJ Blum JL Simmen FA Simmen RC Selective interactions of Kruppel like factor 9 basic transcription element binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone responsive genes in endometrial epithelial cells J Biol Chem June 2003 278 24 21474 82 PMID 12672823 doi 10 1074 jbc M212098200 Giangrande PH Kimbrel EA Edwards DP McDonnell DP The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding Mol Cell Biol May 2000 20 9 3102 15 PMC 85605 PMID 10757795 doi 10 1128 MCB 20 9 3102 3115 2000 Nawaz Z Lonard DM Smith CL Lev Lehman E Tsai SY Tsai MJ O Malley BW The Angelman syndrome associated protein E6 AP is a coactivator for the nuclear hormone receptor superfamily Mol Cell Biol February 1999 19 2 1182 9 PMC 116047 PMID 9891052 延伸阅读 编辑Butnor KJ Burchette JL Robboy SJ Progesterone receptor activity in leiomyomatosis peritonealis disseminata Int J Gynecol Pathol 2002 18 3 259 64 PMID 12090595 doi 10 1097 00004347 199907000 00012 Leonhardt SA Boonyaratanakornkit V Edwards DP Progesterone receptor transcription and non transcription signaling mechanisms Steroids 2004 68 10 13 761 70 PMID 14667966 doi 10 1016 S0039 128X 03 00129 6 Conneely OM Mulac Jericevic B Lydon JP Progesterone dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms Steroids 2004 68 10 13 771 8 PMID 14667967 doi 10 1016 S0039 128X 03 00126 0 Bagchi MK Tsai SY Tsai MJ O Malley BW Ligand and DNA dependent phosphorylation of human progesterone receptor in vitro Proc Natl Acad Sci U S A 1992 89 7 2664 8 PMC 48722 PMID 1557371 doi 10 1073 pnas 89 7 2664 Kastner P Krust A Turcotte B et al Two distinct estrogen regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B EMBO J 1990 9 5 1603 14 PMC 551856 PMID 2328727 引文格式1维护 显式使用等标签 link Guiochon Mantel A Loosfelt H Lescop P et al Mechanisms of nuclear localization of the progesterone receptor evidence for interaction between monomers Cell 1989 57 7 1147 54 PMID 2736623 doi 10 1016 0092 8674 89 90052 4 引文格式1维护 显式使用等标签 link Fernandez MD Carter GD Palmer TN The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol British Journal of Clinical Pharmacology 1983 15 1 95 101 PMC 1427833 PMID 6849751 doi 10 1111 j 1365 2125 1983 tb01470 x Onate SA Tsai SY Tsai MJ O Malley BW Sequence and characterization of a coactivator for the steroid hormone receptor superfamily Science 1995 270 5240 1354 7 PMID 7481822 doi 10 1126 science 270 5240 1354 Zhang Y Beck CA Poletti A et al Identification of phosphorylation sites unique to the B form of human progesterone receptor In vitro phosphorylation by casein kinase II J Biol Chem 1995 269 49 31034 40 PMID 7983041 引文格式1维护 显式使用等标签 link Mansour I Reznikoff Etievant MF Netter A No evidence for the expression of the progesterone receptor on peripheral blood lymphocytes during pregnancy Hum Reprod 1995 9 8 1546 9 PMID 7989520 Kalkhoven E Wissink S van der Saag PT van der Burg B Negative interaction between the RelA p65 subunit of NF kappaB and the progesterone receptor J Biol Chem 1996 271 11 6217 24 PMID 8626413 doi 10 1074 jbc 271 11 6217 Wang JD Zhu JB Fu Y et al Progesterone receptor immunoreactivity at the maternofetal interface of first trimester pregnancy a study of the trophoblast population Hum Reprod 1996 11 2 413 9 PMID 8671234 doi 10 1093 humrep 11 2 413 引文格式1维护 显式使用等标签 link Thenot S Henriquet C Rochefort H Cavailles V Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 J Biol Chem 1997 272 18 12062 8 PMID 9115274 doi 10 1074 jbc 272 18 12062 Jenster G Spencer TE Burcin MM et al Steroid receptor induction of gene transcription a two step model Proc Natl Acad Sci U S A 1997 94 15 7879 84 PMC 21523 PMID 9223281 doi 10 1073 pnas 94 15 7879 引文格式1维护 显式使用等标签 link Shanker YG Sharma SC Rao AJ Expression of progesterone receptor mRNA in the first trimester human placenta Biochem Mol Biol Int 1997 42 6 1235 40 PMID 9305541 Richer JK Lange CA Wierman AM et al Progesterone receptor variants found in breast cells repress transcription by wild type receptors Breast Cancer Res Treat 1998 48 3 231 41 PMID 9598870 doi 10 1023 A 1005941117247 引文格式1维护 显式使用等标签 link Williams SP Sigler PB Atomic structure of progesterone complexed with its receptor Nature 1998 393 6683 392 6 PMID 9620806 doi 10 1038 30775 Boonyaratanakornkit V Melvin V Prendergast P et al High mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells Mol Cell Biol 1998 18 8 4471 87 PMC 109033 PMID 9671457 引文格式1维护 显式使用等标签 link Nawaz Z Lonard DM Smith CL et al The Angelman syndrome associated protein E6 AP is a coactivator for the nuclear hormone receptor superfamily Mol Cell Biol 1999 19 2 1182 9 PMC 116047 PMID 9891052 引文格式1维护 显式使用等标签 link 外部链接 编辑醫學主題詞表 MeSH Progesterone Receptors此条目包含有源于Pfam以及InterPro的属于公有领域的文本 IPR000342 取自 https zh wikipedia org w index php title 孕酮受体 amp oldid 70676411, 维基百科，wiki，书籍，书籍，图书馆，
