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维基百科

γ-干扰素

一月 11, 2024

干扰素-γ（Interferon gamma、Interferon-γ、IFNG、IFNγ）是水溶性二聚体的细胞因子[2]。是II型干扰素的唯一成员[3]曾被称为巨噬细胞活化因子。

干扰素-γ
γ-干擾素晶體結構線狀表示[1]
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 IFNG; IFG; IFI
扩展标识 遗传学：147570 鼠基因：107656 同源基因：55526 GeneCards: IFNG Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 3458 15978
Ensembl ENSG00000111537 ENSMUSG00000055170
UniProt P01579 P01580
mRNA序列 NM_000619 NM_008337
蛋白序列 NP_000610 NP_032363
基因位置 Chr 12:
68.55 – 68.55 Mb		 Chr 10:
118.44 – 118.45 Mb
PubMed查询 [1] [2]
IFN-γ
Crystal structure of a biologically active single chain mutant of human interferon gamma
鑑定
標誌?
PfamPF00714（旧版）
Pfam宗系CL0053（旧版）
InterPro（英语：InterPro）IPR002069
SCOP（英语：Structural Classification of Proteins）1rfb / SUPFAM
現有可用的蛋白結構：
Pfam結構（旧版） / ECOD
PDBRCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）結構概要
Γ-干扰素
臨床資料
商品名（英语：Drug nomenclature）Actimmune
AHFS/Drugs.comMonograph
MedlinePlusa601152
ATC碼
识别信息
  • Human interferon gamma-1b
CAS号82115-62-6  Y
98059-61-1
DrugBank
  • DB00033 N
ChemSpider
  • NA Y
ChEMBL
  • ChEMBL1201564 N
化学信息
化学式C761H1206N214O225S6
摩尔质量17145.6 g/mol

结构 编辑

干扰素-γ的单体是由六个α螺旋组成一个核心[4]和在C端区延伸展开的片断序列。

生物活性的二聚体是由两个反平行相互锁定的单体形成。

生物活性 编辑

所有的细胞都可以产生干扰素-α（英语：Interferon alfa）和干扰素-β， 而干扰素-γ只由自然杀伤细胞（NK细胞）和活化的T细胞产生。I型干扰素对酸稳定，而干扰素-γ则遇酸变性。

干扰素-γ具有抗病毒、免疫调节及抗肿瘤特性[5]。干扰素-γ可以与干扰素伽玛受体（英语：Interferon-gamma receptor）(IFNGR)结合，进而调节JAK-STAT通路。干扰素-γ激活抗原提呈细胞，通过上调转录因子T-bet而促进I型辅助T细胞(Th1细胞)的分化。

干扰素-γ是I型辅助T细胞(Th1细胞)的标志性的细胞因子。II型辅助T细胞(Th2细胞)释放白细胞介素-4（IL-4）和白细胞介素-13（IL-13）。自然杀伤细胞和CD8+T细胞也产生干扰素-γ。干扰素-γ通过迅速降解RANK-RANKL信号通路的TRAF6而抑制破骨细胞形成。

治疗用途 编辑

干扰素可以用来治疗传染病，但也能促成自體免疫。在接受干扰素伽玛治疗的病人中，多达19%的病人会有自體免疫.

干擾素IFNγ用於豬生殖與呼吸道綜合症PRRSV的治療上，有試驗發現干擾素IFNγ能活化先天免疫細胞，進而達到抑制病毒數量的效果。[6]

A型流感的治療上，也有小鼠試驗表現出當缺失干擾素後，流感感染小鼠死亡率大幅提升且體內病毒數量維持高濃度水平；相較之下，體內有干擾素存在的小鼠，流感病毒數量隨著干擾素的生成而逐漸下降。[7]

参考文献 编辑

  1. ^ PDB 1FG9; Thiel DJ, le Du MH, Walter RL, D'Arcy A, Chène C, Fountoulakis M, Garotta G, Winkler FK, Ealick SE. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. September 2000, 8 (9): 927–36. PMID 10986460. doi:10.1016/S0969-2126(00)00184-2. 
  2. ^ Gray PW, Goeddel DV. Structure of the human immune interferon gene. Nature. 1982 Aug 26;298(5877):859-63.
  3. ^ Gray PW, Goeddel DV. Structure of the human immune interferon gene. Nature. August 1982, 298 (5877): 859–63. PMID 6180322. doi:10.1038/298859a0. 
  4. ^ Ealick SE, et al., Three-dimensional structure of recombinant human interferon-gamma. Science. 1991 May 3;252(5006):698-702.
  5. ^ Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004 Feb;75(2):163-89.
  6. ^ Bautista, E. M.; Molitor, T. W. IFNγ inhibits porcine reproductive and respiratory syndrome virus replication in macrophages. Archives of Virology. 1999-06, 144 (6): 1191–1200. ISSN 0304-8608. doi:10.1007/s007050050578. 
  7. ^ Hoshino, Akinori; Takenaka, Hiroshi; Mizukoshi, Osamu; Imanishi, Jiro; Kishida, Tsunataro; Tovey, Michael G. Effect of anti-interferon serum of influenza virus infection in mice. Antiviral Research. 1983-03, 3 (1): 59–65. ISSN 0166-3542. doi:10.1016/0166-3542(83)90015-3. 

延伸閱讀 编辑

  • Hall, Stephen K. A commotion in the blood: life, death, and the immune system. New York: Henry Holt. 1997. ISBN 0-8050-5841-9. 
  • Ikeda H, Old LJ, Schreiber RD. The roles of IFN gamma in protection against tumor development and cancer immunoediting.. Cytokine Growth Factor Rev. 2002, 13 (2): 95–109. PMID 11900986. doi:10.1016/S1359-6101(01)00038-7. 
  • Chesler DA, Reiss CS. The role of IFN-gamma in immune responses to viral infections of the central nervous system.. Cytokine Growth Factor Rev. 2003, 13 (6): 441–54. PMID 12401479. doi:10.1016/S1359-6101(02)00044-8. 
  • Dessein A, Kouriba B, Eboumbou C, Dessein H, Argiro L, Marquet S, Elwali NE, Rodrigues V, Li Y, Doumbo O, Chevillard C. Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis.. Immunol. Rev. 2005, 201: 180–90. PMID 15361241. doi:10.1111/j.0105-2896.2004.00195.x. 
  • Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection.. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013. 
  • Copeland KF. Modulation of HIV-1 transcription by cytokines and chemokines.. Mini reviews in medicinal chemistry. 2006, 5 (12): 1093–101. PMID 16375755. doi:10.2174/138955705774933383. 
  • Chiba H, Kojima T, Osanai M, Sawada N. The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease.. Sci. STKE. 2006, 2006 (316): pe1. PMID 16391178. doi:10.1126/stke.3162006pe1. 
  • Tellides G, Pober JS. Interferon-gamma axis in graft arteriosclerosis.. Circ. Res. 2007, 100 (5): 622–32. PMID 17363708. doi:10.1161/01.RES.0000258861.72279.29. 

参看 编辑

外部链接 编辑

一月 11, 2024
干扰素, 干扰素, interferon, gamma, interferon, ifng, ifnγ, 是水溶性二聚体的细胞因子, 是ii型干扰素的唯一成员, 曾被称为巨噬细胞活化因子, 干扰素, γγ, 干擾素晶體結構線狀表示, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1eku, 1fg9, 1fyh, 1hig, 3bes标识代号ifng, ifi扩展标识遗传学, 147570, 鼠基因, 107656, 同源基因, 55526, genecards, ifng, gene基因. 干扰素 g Interferon gamma Interferon g IFNG IFNg 是水溶性二聚体的细胞因子 2 是II型干扰素的唯一成员 3 曾被称为巨噬细胞活化因子 干扰素 gg 干擾素晶體結構線狀表示 1 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1EKU 1FG9 1FYH 1HIG 3BES标识代号IFNG IFG IFI扩展标识遗传学 147570 鼠基因 107656 同源基因 55526 GeneCards IFNG Gene基因本体论描述分子功能 cytokine activity interferon gamma receptor binding细胞成分 extracellular region extracellular space external side of plasma membrane生物过程 protein import into nucleus translocation negative regulation of transcription from RNA polymerase II promoter neutrophil apoptotic process regulation of the force of heart contraction positive regulation of mesenchymal cell proliferation adaptive immune response CD8 positive alpha beta T cell differentiation involved in immune response negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis apoptotic process cellular component movement humoral immune response cell cycle arrest cell surface receptor signaling pathway response to virus cytokine mediated signaling pathway antigen processing and presentation neutrophil chemotaxis endoplasmic reticulum unfolded protein response negative regulation of myelination positive regulation of synaptic transmission cholinergic negative regulation of interleukin 17 production positive regulation of interleukin 12 production positive regulation of interleukin 23 production positive regulation of tumor necrosis factor production positive regulation of peptidyl serine phosphorylation of STAT protein positive regulation of smooth muscle cell apoptotic process positive regulation of T cell proliferation response to drug positive regulation of tyrosine phosphorylation of Stat1 protein defense response to bacterium defense response to protozoan negative regulation of growth of symbiont in host positive regulation of chemokine biosynthetic process positive regulation of interleukin 12 biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of interleukin 6 biosynthetic process positive regulation of nitric oxide biosynthetic process positive regulation of neuron differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgG isotypes negative regulation of smooth muscle cell proliferation positive regulation of interleukin 1 beta secretion regulation of insulin secretion positive regulation of membrane protein ectodomain proteolysis defense response to virus positive regulation of killing of cells of other organism interferon gamma mediated signaling pathway regulation of interferon gamma mediated signaling pathway positive regulation of fructose 1 6 bisphosphate 1 phosphatase activity positive regulation of fructose 1 6 bisphosphate metabolic process positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1 monooxygenase activity cellular response to lipopolysaccharide cellular response to interleukin 18 negative regulation of metanephric nephron tubule epithelial cell differentiation positive regulation of tumor necrosis factor ligand superfamily member 11 productionSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez345815978EnsemblENSG00000111537ENSMUSG00000055170UniProtP01579P01580mRNA序列NM 000619NM 008337蛋白序列NP 000610NP 032363基因位置Chr 12 68 55 68 55 MbChr 10 118 44 118 45 MbPubMed查询 1 2 查论编IFN gCrystal structure of a biologically active single chain mutant of human interferon gamma鑑定標誌 PfamPF00714 旧版 Pfam宗系CL0053 旧版 InterPro 英语 InterPro IPR002069SCOP 英语 Structural Classification of Proteins 1rfb SUPFAM現有可用的蛋白結構 Pfam結構 旧版 ECODPDBRCSB PDB PDBe PDBjPDBsum 英语 PDBsum 結構概要G 干扰素臨床資料商品名 英语 Drug nomenclature ActimmuneAHFS Drugs comMonographMedlinePlusa601152ATC碼L03AB03 WHO 识别信息IUPAC命名法 Human interferon gamma 1bCAS号82115 62 6 Y98059 61 1DrugBankDB00033 NChemSpiderNA YChEMBLChEMBL1201564 N化学信息化学式C 761H 1206N 214O 225S 6摩尔质量17145 6 g mol 目录 1 结构 2 生物活性 3 治疗用途 4 参考文献 5 延伸閱讀 6 参看 7 外部链接结构 编辑干扰素 g的单体是由六个a螺旋组成一个核心 4 和在C端区延伸展开的片断序列 生物活性的二聚体是由两个反平行相互锁定的单体形成 生物活性 编辑所有的细胞都可以产生干扰素 a 英语 Interferon alfa 和干扰素 b 而干扰素 g只由自然杀伤细胞 NK细胞 和活化的T细胞产生 I型干扰素对酸稳定 而干扰素 g则遇酸变性 干扰素 g具有抗病毒 免疫调节及抗肿瘤特性 5 干扰素 g可以与干扰素伽玛受体 英语 Interferon gamma receptor IFNGR 结合 进而调节JAK STAT通路 干扰素 g激活抗原提呈细胞 通过上调转录因子T bet而促进I型辅助T细胞 Th1细胞 的分化 干扰素 g是I型辅助T细胞 Th1细胞 的标志性的细胞因子 II型辅助T细胞 Th2细胞 释放白细胞介素 4 IL 4 和白细胞介素 13 IL 13 自然杀伤细胞和CD8 T细胞也产生干扰素 g 干扰素 g通过迅速降解RANK RANKL信号通路的TRAF6而抑制破骨细胞形成 治疗用途 编辑干扰素可以用来治疗传染病 但也能促成自體免疫 在接受干扰素伽玛治疗的病人中 多达19 的病人会有自體免疫 干擾素IFNg用於豬生殖與呼吸道綜合症PRRSV的治療上 有試驗發現干擾素IFNg能活化先天免疫細胞 進而達到抑制病毒數量的效果 6 A型流感的治療上 也有小鼠試驗表現出當缺失干擾素後 流感感染小鼠死亡率大幅提升且體內病毒數量維持高濃度水平 相較之下 體內有干擾素存在的小鼠 流感病毒數量隨著干擾素的生成而逐漸下降 7 参考文献 编辑 PDB 1FG9 Thiel DJ le Du MH Walter RL D Arcy A Chene C Fountoulakis M Garotta G Winkler FK Ealick SE Observation of an unexpected third receptor molecule in the crystal structure of human interferon gamma receptor complex Structure September 2000 8 9 927 36 PMID 10986460 doi 10 1016 S0969 2126 00 00184 2 Gray PW Goeddel DV Structure of the human immune interferon gene Nature 1982 Aug 26 298 5877 859 63 Gray PW Goeddel DV Structure of the human immune interferon gene Nature August 1982 298 5877 859 63 PMID 6180322 doi 10 1038 298859a0 Ealick SE et al Three dimensional structure of recombinant human interferon gamma Science 1991 May 3 252 5006 698 702 Schroder K Hertzog PJ Ravasi T Hume DA Interferon gamma an overview of signals mechanisms and functions J Leukoc Biol 2004 Feb 75 2 163 89 Bautista E M Molitor T W IFNg inhibits porcine reproductive and respiratory syndrome virus replication in macrophages Archives of Virology 1999 06 144 6 1191 1200 ISSN 0304 8608 doi 10 1007 s007050050578 Hoshino Akinori Takenaka Hiroshi Mizukoshi Osamu Imanishi Jiro Kishida Tsunataro Tovey Michael G Effect of anti interferon serum of influenza virus infection in mice Antiviral Research 1983 03 3 1 59 65 ISSN 0166 3542 doi 10 1016 0166 3542 83 90015 3 延伸閱讀 编辑Hall Stephen K A commotion in the blood life death and the immune system New York Henry Holt 1997 ISBN 0 8050 5841 9 Ikeda H Old LJ Schreiber RD The roles of IFN gamma in protection against tumor development and cancer immunoediting Cytokine Growth Factor Rev 2002 13 2 95 109 PMID 11900986 doi 10 1016 S1359 6101 01 00038 7 Chesler DA Reiss CS The role of IFN gamma in immune responses to viral infections of the central nervous system Cytokine Growth Factor Rev 2003 13 6 441 54 PMID 12401479 doi 10 1016 S1359 6101 02 00044 8 Dessein A Kouriba B Eboumbou C Dessein H Argiro L Marquet S Elwali NE Rodrigues V Li Y Doumbo O Chevillard C Interleukin 13 in the skin and interferon gamma in the liver are key players in immune protection in human schistosomiasis Immunol Rev 2005 201 180 90 PMID 15361241 doi 10 1111 j 0105 2896 2004 00195 x Joseph AM Kumar M Mitra D Nef necessary and enforcing factor in HIV infection Curr HIV Res 2005 3 1 87 94 PMID 15638726 doi 10 2174 1570162052773013 Copeland KF Modulation of HIV 1 transcription by cytokines and chemokines Mini reviews in medicinal chemistry 2006 5 12 1093 101 PMID 16375755 doi 10 2174 138955705774933383 Chiba H Kojima T Osanai M Sawada N The significance of interferon gamma triggered internalization of tight junction proteins in inflammatory bowel disease Sci STKE 2006 2006 316 pe1 PMID 16391178 doi 10 1126 stke 3162006pe1 Tellides G Pober JS Interferon gamma axis in graft arteriosclerosis Circ Res 2007 100 5 622 32 PMID 17363708 doi 10 1161 01 RES 0000258861 72279 29 参看 编辑T细胞 辅助T细胞 II型干扰素 细胞因子外部链接 编辑MeSH Interferon Type II 页面存档备份 存于互联网档案馆 取自 https zh wikipedia org w index php title G 干扰素 amp oldid 75886226, 维基百科，wiki，书籍，书籍，图书馆，

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