• G protein-coupled receptor signaling pathway • body fluid secretion • prolactin secretion • mRNA stabilization • positive regulation of cell population proliferation • 先天免疫系統 • positive regulation of protein catabolic process • regulation of protein localization • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of signaling receptor activity • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of endothelial cell proliferation • learning or memory • positive regulation of epinephrine secretion • negative regulation of apoptotic process • negative regulation of potassium ion transport • epinephrine secretion • 平滑肌細胞增殖的負調控 • regulation of sensory perception of pain • positive regulation of penile erection • phospholipase C-activating G protein-coupled receptor signaling pathway
^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000146469 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000019772 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Umetsu Y, Tenno T, Goda N, Shirakawa M, Ikegami T, Hiroaki H. Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments. Biochimica et Biophysica Acta. May 2011, 1814 (5): 724–30. PMID 21439408. doi:10.1016/j.bbapap.2011.03.009.
^Juhász T, Helgadottir SL, Tamás A, Reglődi D, Zákány R. PACAP and VIP signaling in chondrogenesis and osteogenesis. Peptides. April 2015, 66: 51–7. PMID 25701761. doi:10.1016/j.peptides.2015.02.001.
^Delgado M, Ganea D. Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions. Amino Acids. July 2013, 45 (1): 25–39. PMC 3883350. PMID 22139413. doi:10.1007/s00726-011-1184-8.
^Fahrenkrug J. VIP and PACAP. Results and Problems in Cell Differentiation. 2010-01-01, 50: 221–34. PMID 19859678. doi:10.1007/400_2009_24.
^Hahm SH, Eiden LE. Cis-regulatory elements controlling basal and inducible VIP gene transcription. Annals of the New York Academy of Sciences. December 1998, 865: 10–26. PMID 9927992.
^Henning RJ, Sawmiller DR. Vasoactive intestinal peptide: cardiovascular effects. Cardiovascular Research. January 2001, 49 (1): 27–37. PMID 11121793.
延伸閱讀
Watanabe J. Subchapter 18E - Vasoactive Intestinal Peptide. Handbook of Hormones (Academic Press). 1 January 2016: 150–e18E–10. doi:10.1016/b978-0-12-801028-0.00146-x.
Fahrenkrug J. Gut/brain peptides in the genital tract: VIP and PACAP. Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum. 2001, 234: 35–9. PMID 11713978.
Delgado M, Pozo D, Ganea D. The significance of vasoactive intestinal peptide in immunomodulation. Pharmacological Reviews. June 2004, 56 (2): 249–90. PMID 15169929. doi:10.1124/pr.56.2.7.
Conconi MT, Spinazzi R, Nussdorfer GG. Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland. International Review of Cytology. 2006, 249: 1–51. ISBN 978-0-12-364653-8. PMID 16697281. doi:10.1016/S0074-7696(06)49001-X.
Hill JM. Vasoactive intestinal peptide in neurodevelopmental disorders: therapeutic potential. Current Pharmaceutical Design. 2007, 13 (11): 1079–89. PMID 17430171. doi:10.2174/138161207780618975.
Gonzalez-Rey E, Varela N, Chorny A, Delgado M. Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator. Current Pharmaceutical Design. 2007, 13 (11): 1113–39. PMID 17430175. doi:10.2174/138161207780618966.
Glowa JR, Panlilio LV, Brenneman DE, Gozes I, Fridkin M, Hill JM. Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist. Brain Research. January 1992, 570 (1-2): 49–53. PMID 1617429. doi:10.1016/0006-8993(92)90562-n.
Theriault Y, Boulanger Y, St-Pierre S. Structural determination of the vasoactive intestinal peptide by two-dimensional H-NMR spectroscopy. Biopolymers. March 1991, 31 (4): 459–64. PMID 1863695. doi:10.1002/bip.360310411.
Gozes I, Giladi E, Shani Y. Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level. Journal of Neurochemistry. April 1987, 48 (4): 1136–41. PMID 2434617. doi:10.1111/j.1471-4159.1987.tb05638.x.
Yamagami T, Ohsawa K, Nishizawa M, Inoue C, Gotoh E, Yanaihara N, Yamamoto H, Okamoto H. Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter. Annals of the New York Academy of Sciences. 1988, 527: 87–102. PMID 2839091. doi:10.1111/j.1749-6632.1988.tb26975.x.
DeLamarter JF, Buell GN, Kawashima E, Polak JM, Bloom SR. Vasoactive intestinal peptide: expression of the prohormone in bacterial cells. Peptides. 1985,. 6 Suppl 1 (Suppl 1): 95–102. PMID 2995945. doi:10.1016/0196-9781(85)90016-6.
Linder S, Barkhem T, Norberg A, Persson H, Schalling M, Hökfelt T, Magnusson G. Structure and expression of the gene encoding the vasoactive intestinal peptide precursor. Proceedings of the National Academy of Sciences of the United States of America. January 1987, 84 (2): 605–9. PMC 304259. PMID 3025882. doi:10.1073/pnas.84.2.605.
Gozes I, Bodner M, Shani Y, Fridkin M. Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor. Peptides. 1986,. 7 Suppl 1 (Suppl 1): 1–6. PMID 3748844. doi:10.1016/0196-9781(86)90156-7.
Tsukada T, Horovitch SJ, Montminy MR, Mandel G, Goodman RH. Structure of the human vasoactive intestinal polypeptide gene. Dna. August 1985, 4 (4): 293–300. PMID 3899557. doi:10.1089/dna.1985.4.293.
Heinz-Erian P, Dey RD, Flux M, Said SI. Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients. Science. September 1985, 229 (4720): 1407–8. PMID 4035357. doi:10.1126/science.4035357.
血管活性腸肽, vasoactive, intestinal, peptide, 常簡稱vip, 屬於一種可促進腸道血管活性, 英语, vasoactive, 的肽类激素, 由28個氨基酸殘基組成, 本蛋白屬於升糖素, 胰泌素超家族, 英语, protein, superfamily, 為第二型g蛋白偶联受体的配體, vip在許多脊椎動物身上皆存在, 包含腸, 英语, zoology, 胰脏, 以及下視丘視上核, 英语, suprachiasmatic, nuclei, vip能刺激心臟收縮力, 英语, contr. 血管活性腸肽 Vasoactive intestinal peptide 常簡稱VIP 屬於一種可促進腸道血管活性 英语 vasoactive 的肽类激素 由28個氨基酸殘基組成 本蛋白屬於升糖素 胰泌素超家族 英语 protein superfamily 為第二型G蛋白偶联受体的配體 5 VIP在許多脊椎動物身上皆存在 包含腸 英语 Gut zoology 胰脏 以及下視丘視上核 英语 suprachiasmatic nuclei 6 7 8 VIP能刺激心臟收縮力 英语 contractility 血管舒張 增加糖原分解 降低動脈血壓 以及促進氣管 胃 膽囊平滑肌舒張 在人類體內 該蛋白的編碼基因為 VIP 9 血管活性腸肽已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2RRI 2RRH識別號别名VIP vasoactive intestinal peptide PHM27外部IDOMIM 192320 MGI 98933 HomoloGene 2539 GeneCards VIP基因位置 人类 染色体6號染色體 1 基因座6q25 2起始152 750 797 bp 1 终止152 759 765 bp 1 基因位置 小鼠 染色体小鼠10号染色体 2 基因座10 10 A1起始5 589 218 bp 2 终止5 597 617 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 hormone activity 血浆蛋白结合 neuropeptide hormone activity peptide hormone receptor binding細胞組分 細胞外區域 胞內 neuron projection 細胞本體生物學過程 G protein coupled receptor signaling pathway body fluid secretion prolactin secretion mRNA stabilization positive regulation of cell population proliferation 先天免疫系統 positive regulation of protein catabolic process regulation of protein localization antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity adenylate cyclase activating G protein coupled receptor signaling pathway positive regulation of endothelial cell proliferation learning or memory positive regulation of epinephrine secretion negative regulation of apoptotic process negative regulation of potassium ion transport epinephrine secretion 平滑肌細胞增殖的負調控 regulation of sensory perception of pain positive regulation of penile erection phospholipase C activating G protein coupled receptor signaling pathwaySources Amigo QuickGO直系同源物種人類小鼠Entrez743222353EnsemblENSG00000146469ENSMUSG00000019772UniProtP01282P32648mRNA 序列 NM 003381 NM 194435NM 011702 NM 001313969蛋白序列NP 003372 NP 919416NP 001300898 NP 035832 NP 001394459 NP 001394460 NP 001394461 NP 001394462 NP 001394463基因位置 UCSC Chr 6 152 75 152 76 MbChr 10 5 59 5 6 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠VIP在血中的半衰期 t 約兩分鐘 10 目录 1 參考文獻 2 參考文獻 3 延伸閱讀 4 外部連結參考文獻 编辑血管活性腸肽受體 英语 Vasoactive intestinal peptide receptor VPAC1 英语 VIPR1 VPAC2 英语 VIPR2 參考文獻 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000146469 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000019772 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Umetsu Y Tenno T Goda N Shirakawa M Ikegami T Hiroaki H Structural difference of vasoactive intestinal peptide in two distinct membrane mimicking environments Biochimica et Biophysica Acta May 2011 1814 5 724 30 PMID 21439408 doi 10 1016 j bbapap 2011 03 009 Juhasz T Helgadottir SL Tamas A Reglodi D Zakany R PACAP and VIP signaling in chondrogenesis and osteogenesis Peptides April 2015 66 51 7 PMID 25701761 doi 10 1016 j peptides 2015 02 001 Delgado M Ganea D Vasoactive intestinal peptide a neuropeptide with pleiotropic immune functions Amino Acids July 2013 45 1 25 39 PMC 3883350 PMID 22139413 doi 10 1007 s00726 011 1184 8 Fahrenkrug J VIP and PACAP Results and Problems in Cell Differentiation 2010 01 01 50 221 34 PMID 19859678 doi 10 1007 400 2009 24 Hahm SH Eiden LE Cis regulatory elements controlling basal and inducible VIP gene transcription Annals of the New York Academy of Sciences December 1998 865 10 26 PMID 9927992 Henning RJ Sawmiller DR Vasoactive intestinal peptide cardiovascular effects Cardiovascular Research January 2001 49 1 27 37 PMID 11121793 延伸閱讀 编辑Watanabe J Subchapter 18E Vasoactive Intestinal Peptide Handbook of Hormones Academic Press 1 January 2016 150 e18E 10 doi 10 1016 b978 0 12 801028 0 00146 x Fahrenkrug J Gut brain peptides in the genital tract VIP and PACAP Scandinavian Journal of Clinical and Laboratory Investigation Supplementum 2001 234 35 9 PMID 11713978 Delgado M Pozo D Ganea D The significance of vasoactive intestinal peptide in immunomodulation Pharmacological Reviews June 2004 56 2 249 90 PMID 15169929 doi 10 1124 pr 56 2 7 Conconi MT Spinazzi R Nussdorfer GG Endogenous ligands of PACAP VIP receptors in the autocrine paracrine regulation of the adrenal gland International Review of Cytology 2006 249 1 51 ISBN 978 0 12 364653 8 PMID 16697281 doi 10 1016 S0074 7696 06 49001 X Hill JM Vasoactive intestinal peptide in neurodevelopmental disorders therapeutic potential Current Pharmaceutical Design 2007 13 11 1079 89 PMID 17430171 doi 10 2174 138161207780618975 Gonzalez Rey E Varela N Chorny A Delgado M Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator Current Pharmaceutical Design 2007 13 11 1113 39 PMID 17430175 doi 10 2174 138161207780618966 Glowa JR Panlilio LV Brenneman DE Gozes I Fridkin M Hill JM Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist Brain Research January 1992 570 1 2 49 53 PMID 1617429 doi 10 1016 0006 8993 92 90562 n Theriault Y Boulanger Y St Pierre S Structural determination of the vasoactive intestinal peptide by two dimensional H NMR spectroscopy Biopolymers March 1991 31 4 459 64 PMID 1863695 doi 10 1002 bip 360310411 Gozes I Giladi E Shani Y Vasoactive intestinal peptide gene putative mechanism of information storage at the RNA level Journal of Neurochemistry April 1987 48 4 1136 41 PMID 2434617 doi 10 1111 j 1471 4159 1987 tb05638 x Yamagami T Ohsawa K Nishizawa M Inoue C Gotoh E Yanaihara N Yamamoto H Okamoto H Complete nucleotide sequence of human vasoactive intestinal peptide PHM 27 gene and its inducible promoter Annals of the New York Academy of Sciences 1988 527 87 102 PMID 2839091 doi 10 1111 j 1749 6632 1988 tb26975 x DeLamarter JF Buell GN Kawashima E Polak JM Bloom SR Vasoactive intestinal peptide expression of the prohormone in bacterial cells Peptides 1985 6 Suppl 1 Suppl 1 95 102 PMID 2995945 doi 10 1016 0196 9781 85 90016 6 Linder S Barkhem T Norberg A Persson H Schalling M Hokfelt T Magnusson G Structure and expression of the gene encoding the vasoactive intestinal peptide precursor Proceedings of the National Academy of Sciences of the United States of America January 1987 84 2 605 9 PMC 304259 PMID 3025882 doi 10 1073 pnas 84 2 605 Gozes I Bodner M Shani Y Fridkin M Structure and expression of the vasoactive intestinal peptide VIP gene in a human tumor Peptides 1986 7 Suppl 1 Suppl 1 1 6 PMID 3748844 doi 10 1016 0196 9781 86 90156 7 Tsukada T Horovitch SJ Montminy MR Mandel G Goodman RH Structure of the human vasoactive intestinal polypeptide gene Dna August 1985 4 4 293 300 PMID 3899557 doi 10 1089 dna 1985 4 293 Heinz Erian P Dey RD Flux M Said SI Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients Science September 1985 229 4720 1407 8 PMID 4035357 doi 10 1126 science 4035357 外部連結 编辑Pathway at biocarta com 页面存档备份 存于互联网档案馆 MCG生理学 6 6ch2 s6ch2 34 取自 https zh wikipedia org w index php title 血管活性腸肽 amp oldid 67765083, 维基百科，wiki，书籍，书籍，图书馆，
