• iron ion binding • 金屬離子結合 • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • cholesterol monooxygenase (side-chain-cleaving) activity • 血浆蛋白结合
細胞組分
• 膜 • 线粒体基质 • 線粒體 • mitochondrial inner membrane
生物學過程
• vitamin D metabolic process • C21-steroid hormone metabolic process • 脂質代謝 • cholesterol metabolic process • C21-steroid hormone biosynthetic process • sterol metabolic process • steroid biosynthetic process • steroid metabolic process • glucocorticoid biosynthetic process • cellular response to peptide hormone stimulus • cortisol metabolic process
^ 3.03.13.2GRCh38: Ensembl release 89: ENSG00000140459、ENSG00000288362 - Ensembl, May 2017
^ 4.04.14.2GRCm38: Ensembl release 89: ENSMUSG00000032323 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.
^Entrez Gene: CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1.
延伸阅读
Helmberg A. Twin genes and endocrine disease: CYP21 and CYP11B genes. Acta Endocrinologica. August 1993, 129 (2): 97–108. PMID 8372604. doi:10.1530/acta.0.1290097.
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids. January 1997, 62 (1): 21–8. PMID 9029710. doi:10.1016/S0039-128X(96)00154-7.
Stocco DM. Intramitochondrial cholesterol transfer. Biochimica et Biophysica Acta. June 2000, 1486 (1): 184–97. PMID 10856721. doi:10.1016/S1388-1981(00)00056-1.
Kristensen VN, Kure EH, Erikstein B, Harada N, Børresen-Dale A. Genetic susceptibility and environmental estrogen-like compounds. Mutation Research. October 2001, 482 (1–2): 77–82. PMID 11535251. doi:10.1016/S0027-5107(01)00212-3.
Strauss JF. Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome. Annals of the New York Academy of Sciences. November 2003, 997 (1): 42–8. PMID 14644808. doi:10.1196/annals.1290.005.
Wada A, Waterman MR. Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding. The Journal of Biological Chemistry. November 1992, 267 (32): 22877–82. PMID 1429635.
Hu MC, Guo IC, Lin JH, Chung BC. Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. The Biochemical Journal. March 1991, 274 (Pt 3): 813–7. PMC 1149983. PMID 1849407. doi:10.1042/bj2740813.
Sparkes RS, Klisak I, Miller WL. Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25. DNA and Cell Biology. June 1991, 10 (5): 359–65. PMID 1863359. doi:10.1089/dna.1991.10.359.
Coghlan VM, Vickery LE. Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc. The Journal of Biological Chemistry. October 1991, 266 (28): 18606–12. PMID 1917982.
Matteson KJ, Chung BC, Urdea MS, Miller WL. Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450scc oligodeoxyribonucleotide probes. Endocrinology. April 1986, 118 (4): 1296–305. PMID 2419119. doi:10.1210/endo-118-4-1296.
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Proceedings of the National Academy of Sciences of the United States of America. December 1986, 83 (23): 8962–6. PMC 387054. PMID 3024157. doi:10.1073/pnas.83.23.8962.
Morohashi K, Sogawa K, Omura T, Fujii-Kuriyama Y. Gene structure of human cytochrome P-450(SCC), cholesterol desmolase. Journal of Biochemistry. April 1987, 101 (4): 879–87. PMID 3038854.
Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. January 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Gharani N, Waterworth DM, Batty S, White D, Gilling-Smith C, Conway GS, McCarthy M, Franks S, Williamson R. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Human Molecular Genetics. March 1997, 6 (3): 397–402. PMID 9147642. doi:10.1093/hmg/6.3.397.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. October 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Hukkanen J, Mäntylä M, Kangas L, Wirta P, Hakkola J, Paakki P, Evisalmi S, Pelkonen O, Raunio H. Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. Pharmacology & Toxicology. February 1998, 82 (2): 93–7. PMID 9498238. doi:10.1111/j.1600-0773.1998.tb01404.x.
Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW. Prominent sex steroid metabolism in human lymphocytes. Molecular and Cellular Endocrinology. March 1998, 138 (1–2): 61–9. PMID 9685215. doi:10.1016/S0303-7207(98)00052-5.
二月 12, 2023
胆固醇侧链裂解酶, 英語, cholesterol, side, chain, cleavage, enzyme, cyp11a1或p450scc, 其中, side, chain, 侧链, cleavage, 裂解, 的缩写, 是一种将胆固醇转化为孕烯醇酮的线粒体酶, 这是所有哺乳动物中由胆固醇生成各种甾类激素的第一步反应, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表3na1, 3n9y, 3n9z, 3na0識別號别名cyp11a1, cyp11a, cypxia1, p450scc, . 胆固醇侧链裂解酶 英語 Cholesterol side chain cleavage enzyme CYP11A1或P450scc 其中 scc 是 side chain 侧链 cleavage 裂解 的缩写 是一种将胆固醇转化为孕烯醇酮的线粒体酶 这是所有哺乳动物中由胆固醇生成各种甾类激素的第一步反应 7 胆固醇侧链裂解酶已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表3NA1 3N9Y 3N9Z 3NA0識別號别名CYP11A1 CYP11A CYPXIA1 P450SCC cytochrome P450 family 11 subfamily A member 1外部IDOMIM 118485 MGI 88582 HomoloGene 37347 GeneCards CYP11A1相關疾病congenital adrenal insufficiency 1 為以下藥物的標靶米托坦 2 基因位置 人类 染色体15號染色體 3 基因座15q24 1起始74 337 759 bp 3 终止74 367 646 bp 3 基因位置 小鼠 染色体小鼠9号染色体 4 基因座9 B 9 31 63 cM起始57 913 694 bp 4 终止57 934 306 bp 4 RNA表达模式查阅更多表达数据基因本體分子功能 iron ion binding 金屬離子結合 monooxygenase activity heme binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen oxidoreductase activity cholesterol monooxygenase side chain cleaving activity 血浆蛋白结合細胞組分 膜 线粒体基质 線粒體 mitochondrial inner membrane生物學過程 vitamin D metabolic process C21 steroid hormone metabolic process 脂質代謝 cholesterol metabolic process C21 steroid hormone biosynthetic process sterol metabolic process steroid biosynthetic process steroid metabolic process glucocorticoid biosynthetic process cellular response to peptide hormone stimulus cortisol metabolic processSources Amigo QuickGO直系同源物種人類小鼠Entrez158313070EnsemblENSG00000140459 ENSG00000288362ENSMUSG00000032323UniProtP05108Q9QZ82mRNA 序列NM 001099773 NM 000781NM 019779 NM 001346787蛋白序列NP 000772 NP 001093243NP 001333716 NP 062753基因位置 UCSC Chr 15 74 34 74 37 MbChr 9 57 91 57 93 MbPubMed 查找 5 6 維基數據檢視 編輯人類檢視 編輯小鼠 胆固醇 3 NADPH 3 H 3 O2 孕烯醇酮 4 甲基戊醛 3 NADP 3 H2O P450scc 是细胞色素P450氧化酶超家族的一员 家族11亚家族A多肽1 基因名为 CYP11A1 8 另见 编辑类固醇生成酶 细胞色素P450参考文献 编辑 與胆固醇侧链裂解酶相關的疾病 在維基數據上查看 編輯參考 對胆固醇侧链裂解酶起作用的藥物 在維基數據上查看 編輯參考 3 0 3 1 3 2 GRCh38 Ensembl release 89 ENSG00000140459 ENSG00000288362 Ensembl May 2017 4 0 4 1 4 2 GRCm38 Ensembl release 89 ENSMUSG00000032323 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Hanukoglu I Steroidogenic enzymes structure function and role in regulation of steroid hormone biosynthesis The Journal of Steroid Biochemistry and Molecular Biology December 1992 43 8 779 804 PMID 22217824 doi 10 1016 0960 0760 92 90307 5 Entrez Gene CYP11A1 cytochrome P450 family 11 subfamily A polypeptide 1 延伸阅读 编辑Helmberg A Twin genes and endocrine disease CYP21 and CYP11B genes Acta Endocrinologica August 1993 129 2 97 108 PMID 8372604 doi 10 1530 acta 0 1290097 Papadopoulos V Amri H Boujrad N Cascio C Culty M Garnier M Hardwick M Li H Vidic B Brown AS Reversa JL Bernassau JM Drieu K Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis Steroids January 1997 62 1 21 8 PMID 9029710 doi 10 1016 S0039 128X 96 00154 7 Stocco DM Intramitochondrial cholesterol transfer Biochimica et Biophysica Acta June 2000 1486 1 184 97 PMID 10856721 doi 10 1016 S1388 1981 00 00056 1 Kristensen VN Kure EH Erikstein B Harada N Borresen Dale A Genetic susceptibility and environmental estrogen like compounds Mutation Research October 2001 482 1 2 77 82 PMID 11535251 doi 10 1016 S0027 5107 01 00212 3 Strauss JF Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome Annals of the New York Academy of Sciences November 2003 997 1 42 8 PMID 14644808 doi 10 1196 annals 1290 005 Wada A Waterman MR Identification by site directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding The Journal of Biological Chemistry November 1992 267 32 22877 82 PMID 1429635 Hu MC Guo IC Lin JH Chung BC Regulated expression of cytochrome P 450scc cholesterol side chain cleavage enzyme in cultured cell lines detected by antibody against bacterially expressed human protein The Biochemical Journal March 1991 274 Pt 3 813 7 PMC 1149983 PMID 1849407 doi 10 1042 bj2740813 Sparkes RS Klisak I Miller WL Regional mapping of genes encoding human steroidogenic enzymes P450scc to 15q23 q24 adrenodoxin to 11q22 adrenodoxin reductase to 17q24 q25 and P450c17 to 10q24 q25 DNA and Cell Biology June 1991 10 5 359 65 PMID 1863359 doi 10 1089 dna 1991 10 359 Coghlan VM Vickery LE Site specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc The Journal of Biological Chemistry October 1991 266 28 18606 12 PMID 1917982 Matteson KJ Chung BC Urdea MS Miller WL Study of cholesterol side chain cleavage 20 22 desmolase deficiency causing congenital lipoid adrenal hyperplasia using bovine sequence P450scc oligodeoxyribonucleotide probes Endocrinology April 1986 118 4 1296 305 PMID 2419119 doi 10 1210 endo 118 4 1296 Chung BC Matteson KJ Voutilainen R Mohandas TK Miller WL Human cholesterol side chain cleavage enzyme P450scc cDNA cloning assignment of the gene to chromosome 15 and expression in the placenta Proceedings of the National Academy of Sciences of the United States of America December 1986 83 23 8962 6 PMC 387054 PMID 3024157 doi 10 1073 pnas 83 23 8962 Morohashi K Sogawa K Omura T Fujii Kuriyama Y Gene structure of human cytochrome P 450 SCC cholesterol desmolase Journal of Biochemistry April 1987 101 4 879 87 PMID 3038854 Maruyama K Sugano S Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene January 1994 138 1 2 171 4 PMID 8125298 doi 10 1016 0378 1119 94 90802 8 Gharani N Waterworth DM Batty S White D Gilling Smith C Conway GS McCarthy M Franks S Williamson R Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism Human Molecular Genetics March 1997 6 3 397 402 PMID 9147642 doi 10 1093 hmg 6 3 397 Suzuki Y Yoshitomo Nakagawa K Maruyama K Suyama A Sugano S Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene October 1997 200 1 2 149 56 PMID 9373149 doi 10 1016 S0378 1119 97 00411 3 Hukkanen J Mantyla M Kangas L Wirta P Hakkola J Paakki P Evisalmi S Pelkonen O Raunio H Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium Pharmacology amp Toxicology February 1998 82 2 93 7 PMID 9498238 doi 10 1111 j 1600 0773 1998 tb01404 x Zhou Z Shackleton CH Pahwa S White PC Speiser PW Prominent sex steroid metabolism in human lymphocytes Molecular and Cellular Endocrinology March 1998 138 1 2 61 9 PMID 9685215 doi 10 1016 S0303 7207 98 00052 5 取自 https zh wikipedia org w index php title 胆固醇侧链裂解酶 amp oldid 70678749, 维基百科，wiki，书籍，书籍，图书馆，
