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维基百科

周期蛋白D1

二月 05, 2023

参见：周期蛋白D

G1/S-特异性周期蛋白-D1是一个由人类CCND1基因所编码的蛋白质[1][2]。

周期蛋白D1
Rendering based on PDB 2W96.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 CCND1; BCL1; D11S287E; PRAD1; U21B31
扩展标识 遗传学：168461 鼠基因：88313 同源基因：1334 ChEMBL: 3610 GeneCards: CCND1 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 595 12443
Ensembl ENSG00000110092 ENSMUSG00000070348
UniProt P24385 P25322
mRNA序列 NM_053056 NM_007631
蛋白序列 NP_444284 NP_031657
基因位置 Chr 11:
69.46 – 69.47 Mb		 Chr 7:
144.93 – 144.94 Mb
PubMed查询 [1] [2]

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G1到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生[3]。

套细胞淋巴瘤中对周期蛋白D1进行染色的显微图

使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。

另见

  • 甲状旁腺腺瘤
  • 套细胞淋巴瘤

参考文献

  1. ^ Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0. 
  2. ^ Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W. 
  3. ^ Entrez Gene: CCND1 cyclin D1. （原始内容于2009-05-11）. 

深入阅读

  • Akita H. [Prognostic importance of altered expression of cell cycle regulators in lung cancer]. Nippon Rinsho. 2003,. 60 Suppl 5: 267–71. PMID 12101670. 
  • Chung DC. Cyclin D1 in human neuroendocrine: tumorigenesis. Ann. N. Y. Acad. Sci. 2004, 1014: 209–17. PMID 15153436. doi:10.1196/annals.1294.022. 
  • Jain S, Khuri FR, Shin DM. Prevention of head and neck cancer: current status and future prospects. Current Problems in Cancer. 2004, 28 (5): 265–86. PMID 15375804. doi:10.1016/j.currproblcancer.2004.05.003. 
  • Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J. Cell. Biochem. 2006, 96 (5): 906–13. PMID 16163738. doi:10.1002/jcb.20613. 
  • Walker JL, Assoian RK. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev. 2006, 24 (3): 383–93. PMID 16258726. doi:10.1007/s10555-005-5130-7. 
  • Gautschi O, Ratschiller D, Gugger M; et al. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer. 2007, 55 (1): 1–14. PMID 17070615. doi:10.1016/j.lungcan.2006.09.024. 
  • Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle. 2007, 5 (21): 2440–2. PMID 17106256. 
  • Tao Zhang, Breslin MB, Lan MS. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest. J. Biol. Chem. 2009, 284 (9): 5574–81. PMC 2645817  . PMID 19124461. doi:10.1074/jbc.M808843200. 
  • Inaba T, Matsushime H, Valentine M; et al. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics. 1992, 13 (3): 565–74. PMID 1386335. doi:10.1016/0888-7543(92)90126-D. 
  • Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene. 1992, 7 (2): 355–61. PMID 1532244. 
  • Seto M, Yamamoto K, Iida S; et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene. 1992, 7 (7): 1401–6. PMID 1535701. 
  • Rosenberg CL, Wong E, Petty EM; et al. PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc. Natl. Acad. Sci. U.S.A. 1991, 88 (21): 9638–42. PMC 52773  . PMID 1682919. doi:10.1073/pnas.88.21.9638. 
  • Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell. 1991, 65 (4): 691–9. PMID 1827756. doi:10.1016/0092-8674(91)90100-D. 
  • Withers DA, Harvey RC, Faust JB; et al. Characterization of a candidate bcl-1 gene. Mol. Cell. Biol. 1991, 11 (10): 4846–53. PMC 361453  . PMID 1833629. 
  • Tsujimoto Y, Yunis J, Onorato-Showe L; et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science. 1984, 224 (4656): 1403–6. PMID 6610211. doi:10.1126/science.6610211. 
  • Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene. 1995, 11 (8): 1581–8. PMID 7478582. 
  • Tassan JP, Jaquenoud M, Léopold P; et al. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (19): 8871–5. PMC 41069  . PMID 7568034. doi:10.1073/pnas.92.19.8871. 
  • Fornaro M, Dell'Arciprete R, Stella M; et al. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer. 1995, 62 (5): 610–8. PMID 7665234. doi:10.1002/ijc.2910620520. 
  • Motokura T, Arnold A. PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosomes Cancer. 1993, 7 (2): 89–95. PMID 7687458. doi:10.1002/gcc.2870070205. 



二月 05, 2023
周期蛋白d1, 参见, 周期蛋白d, 特异性周期蛋白, d1是一个由人类ccnd1基因所编码的蛋白质, rendering, based, 2w96, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表2w96, 2w99, 2w9f, 2w9z标识代号ccnd1, bcl1, d11s287e, prad1, u21b31扩展标识遗传学, 168461, 鼠基因, 88313, 同源基因, 1334, chembl, 3610, genecards, ccnd1, gene基因本体论描述分子. 参见 周期蛋白D G1 S 特异性周期蛋白 D1是一个由人类CCND1基因所编码的蛋白质 1 2 周期蛋白D1Rendering based on PDB 2W96 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表2W96 2W99 2W9F 2W9Z标识代号CCND1 BCL1 D11S287E PRAD1 U21B31扩展标识遗传学 168461 鼠基因 88313 同源基因 1334 ChEMBL 3610 GeneCards CCND1 Gene基因本体论描述分子功能 protein kinase activity protein binding cyclin dependent protein serine threonine kinase regulator activity enzyme binding protein kinase binding protein complex binding细胞成分 cyclin dependent protein kinase holoenzyme complex intracellular nucleus nucleoplasm cytosol tight junction membrane生物过程 G1 phase of mitotic cell cycle G1 S transition of mitotic cell cycle S phase of mitotic cell cycle mitotic cell cycle re entry into mitotic cell cycle liver development positive regulation of protein phosphorylation response to DNA damage stimulus lactation response to iron ion response to X ray response to organic nitrogen negative regulation of Wnt receptor signaling pathway negative regulation of epithelial cell differentiation endoplasmic reticulum unfolded protein response organ regeneration mitotic G1 DNA damage checkpoint response to magnesium ion response to vitamin E Leydig cell differentiation mammary gland epithelial cell proliferation positive regulation of mammary gland epithelial cell proliferation response to drug response to estrogen stimulus fat cell differentiation response to ethanol positive regulation of cyclin dependent protein kinase activity cell division response to corticosterone stimulus response to calcium ion canonical Wnt receptor signaling pathway mammary gland alveolus development response to UV A regulation of G1 S transition of mitotic cell cycleSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez59512443EnsemblENSG00000110092ENSMUSG00000070348UniProtP24385P25322mRNA序列NM 053056NM 007631蛋白序列NP 444284NP 031657基因位置Chr 11 69 46 69 47 MbChr 7 144 93 144 94 MbPubMed查询 1 2 查论编该基因编码的蛋白质属于高度保守的周期蛋白家族 该家族成员的显著特征是贯穿细胞周期 其蛋白质丰度周期性地急剧改变 周期蛋白作为CDK 周期蛋白依赖性激酶 的调节因子 不同的周期蛋白表现出各自独特的表达及降解特性 这有助于每个有丝分裂事件在时间上的协调性 周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基 这两种周期蛋白依赖性激酶对于G1到S期的转变来说是不可或缺的 该蛋白表现出与抑癌基因Rb有着相互作用 且此基因的表达受Rb的正向调控 周期蛋白D1发生突变 扩增及过表达将会改变细胞周期进程 这些现象常发生在多种肿瘤中并可能导致肿瘤发生 3 套细胞淋巴瘤中对周期蛋白D1进行染色的显微图 使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤 另见 编辑甲状旁腺腺瘤 套细胞淋巴瘤参考文献 编辑 Motokura T Bloom T Kim HG Juppner H Ruderman JV Kronenberg HM Arnold A A novel cyclin encoded by a bcl1 linked candidate oncogene Nature May 1991 350 6318 512 5 PMID 1826542 doi 10 1038 350512a0 Lew DJ Dulic V Reed SI Isolation of three novel human cyclins by rescue of G1 cyclin Cln function in yeast Cell October 1991 66 6 1197 206 PMID 1833066 doi 10 1016 0092 8674 91 90042 W Entrez Gene CCND1 cyclin D1 原始内容存档于2009 05 11 深入阅读 编辑Akita H Prognostic importance of altered expression of cell cycle regulators in lung cancer Nippon Rinsho 2003 60 Suppl 5 267 71 PMID 12101670 Chung DC Cyclin D1 in human neuroendocrine tumorigenesis Ann N Y Acad Sci 2004 1014 209 17 PMID 15153436 doi 10 1196 annals 1294 022 Jain S Khuri FR Shin DM Prevention of head and neck cancer current status and future prospects Current Problems in Cancer 2004 28 5 265 86 PMID 15375804 doi 10 1016 j currproblcancer 2004 05 003 Gladden AB Diehl JA Location location location the role of cyclin D1 nuclear localization in cancer J Cell Biochem 2006 96 5 906 13 PMID 16163738 doi 10 1002 jcb 20613 Walker JL Assoian RK Integrin dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression Cancer Metastasis Rev 2006 24 3 383 93 PMID 16258726 doi 10 1007 s10555 005 5130 7 Gautschi O Ratschiller D Gugger M et al Cyclin D1 in non small cell lung cancer a key driver of malignant transformation Lung Cancer 2007 55 1 1 14 PMID 17070615 doi 10 1016 j lungcan 2006 09 024 引文格式1维护 显式使用等标签 link Li Z Wang C Prendergast GC Pestell RG Cyclin D1 functions in cell migration Cell Cycle 2007 5 21 2440 2 PMID 17106256 Tao Zhang Breslin MB Lan MS Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest J Biol Chem 2009 284 9 5574 81 PMC 2645817 PMID 19124461 doi 10 1074 jbc M808843200 Inaba T Matsushime H Valentine M et al Genomic organization chromosomal localization and independent expression of human cyclin D genes Genomics 1992 13 3 565 74 PMID 1386335 doi 10 1016 0888 7543 92 90126 D 引文格式1维护 显式使用等标签 link Schuuring E Verhoeven E Mooi WJ Michalides RJ Identification and cloning of two overexpressed genes U21B31 PRAD1 and EMS1 within the amplified chromosome 11q13 region in human carcinomas Oncogene 1992 7 2 355 61 PMID 1532244 Seto M Yamamoto K Iida S et al Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t 11 14 q13 q32 translocation Oncogene 1992 7 7 1401 6 PMID 1535701 引文格式1维护 显式使用等标签 link Rosenberg CL Wong E Petty EM et al PRAD1 a candidate BCL1 oncogene mapping and expression in centrocytic lymphoma Proc Natl Acad Sci U S A 1991 88 21 9638 42 PMC 52773 PMID 1682919 doi 10 1073 pnas 88 21 9638 引文格式1维护 显式使用等标签 link Xiong Y Connolly T Futcher B Beach D Human D type cyclin Cell 1991 65 4 691 9 PMID 1827756 doi 10 1016 0092 8674 91 90100 D Withers DA Harvey RC Faust JB et al Characterization of a candidate bcl 1 gene Mol Cell Biol 1991 11 10 4846 53 PMC 361453 PMID 1833629 引文格式1维护 显式使用等标签 link Tsujimoto Y Yunis J Onorato Showe L et al Molecular cloning of the chromosomal breakpoint of B cell lymphomas and leukemias with the t 11 14 chromosome translocation Science 1984 224 4656 1403 6 PMID 6610211 doi 10 1126 science 6610211 引文格式1维护 显式使用等标签 link Hall M Bates S Peters G Evidence for different modes of action of cyclin dependent kinase inhibitors p15 and p16 bind to kinases p21 and p27 bind to cyclins Oncogene 1995 11 8 1581 8 PMID 7478582 Tassan JP Jaquenoud M Leopold P et al Identification of human cyclin dependent kinase 8 a putative protein kinase partner for cyclin C Proc Natl Acad Sci U S A 1995 92 19 8871 5 PMC 41069 PMID 7568034 doi 10 1073 pnas 92 19 8871 引文格式1维护 显式使用等标签 link Fornaro M Dell Arciprete R Stella M et al Cloning of the gene encoding Trop 2 a cell surface glycoprotein expressed by human carcinomas Int J Cancer 1995 62 5 610 8 PMID 7665234 doi 10 1002 ijc 2910620520 引文格式1维护 显式使用等标签 link Motokura T Arnold A PRAD1 cyclin D1 proto oncogene genomic organization 5 DNA sequence and sequence of a tumor specific rearrangement breakpoint Genes Chromosomes Cancer 1993 7 2 89 95 PMID 7687458 doi 10 1002 gcc 2870070205 取自 https zh wikipedia org w index php title 周期蛋白D1 amp oldid 71142699, 维基百科，wiki，书籍，书籍，图书馆，

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