fbpx
维基百科

丙咪嗪

丙咪嗪是一种口服三环类抗抑郁药,主要用于治疗抑鬱。它还可以治疗焦慮恐慌症[5][6][7]

丙咪嗪
臨床資料
商品名英语Drug nomenclatureTofranil, Tofranil-PM, others
其他名稱Melipramine; G-22355
AHFS/Drugs.comMonograph
MedlinePlusa682389
核准狀況
  •  DailyMed: Imipramine
懷孕分級
给药途径By mouth, intramuscular injection
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度94–96%[2]
血漿蛋白結合率86%[3]
药物代谢Liver (CYP1A2, CYP2C19, CYP2D6)[3]
代謝產物Desipramine[3]
生物半衰期20 hours[3]
排泄途徑Kidney (80%), fecal (20%)[3]
识别信息
  • 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
CAS号50-49-7  Y
PubChem CID
  • 3696
IUPHAR/BPS
  • 357
DrugBank
  • DB00458 Y
ChemSpider
  • 3568 Y
UNII
  • OGG85SX4E4
KEGG
  • D08070 Y
  • as HCl: D00815 Y
ChEBI
  • CHEBI:47499 Y
ChEMBL
  • ChEMBL11 Y
PDB配體ID
  • IXX (PDBe, RCSB PDB)
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
  • DTXSID1043881
ECHA InfoCard100.000.039
化学信息
化学式C19H24N2
摩尔质量280.42 g·mol−1
3D模型(JSmol英语JSmol
  • 交互式图像
  • CN(C)CCCN1c2ccccc2CCc2ccccc21
  • InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 Y
  • Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N Y

丙咪嗪的常见副作用口乾昏睡頭暈低血壓心跳过速尿瀦留。丙咪嗪过量可能會导致死亡。

丙咪嗪于1951年被发现,并于1957年投入臨床使用。

参考文献 编辑

  1. ^ Imipramine Use During Pregnancy. Drugs.com. 28 August 2019 [7 February 2020]. 
  2. ^ Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015. 
  3. ^ 3.0 3.1 3.2 3.3 3.4 . TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. (原始内容存档于10 December 2019). 
  4. ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. (原始内容于2023-08-03) (巴西葡萄牙语). 
  5. ^ Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018. 
  6. ^ Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. Early treatment of acute stress disorder in children with major burn injury. Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da. 
  7. ^ Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009. 

丙咪嗪, 是一种口服三环类抗抑郁药, 主要用于治疗抑鬱, 它还可以治疗焦慮和恐慌症, 臨床資料商品名, 英语, drug, nomenclature, tofranil, tofranil, others其他名稱melipramine, 22355ahfs, drugs, commonographmedlineplusa682389核准狀況美, dailymed, imipramine懷孕分級澳, 给药途径by, mouth, intramuscular, injectionatc碼n06aa02, 法律規範狀態法. 丙咪嗪是一种口服三环类抗抑郁药 主要用于治疗抑鬱 它还可以治疗焦慮和恐慌症 5 6 7 丙咪嗪臨床資料商品名 英语 Drug nomenclature Tofranil Tofranil PM others其他名稱Melipramine G 22355AHFS Drugs comMonographMedlinePlusa682389核准狀況美 DailyMed Imipramine懷孕分級澳 C 1 给药途径By mouth intramuscular injectionATC碼N06AA02 WHO 法律規範狀態法律規範澳 限医生处方 S4 加 处方药 only 英 处方药 only POM 美 处方药 only 藥物動力學數據生物利用度94 96 2 血漿蛋白結合率86 3 药物代谢Liver CYP1A2 CYP2C19 CYP2D6 3 代謝產物Desipramine 3 生物半衰期20 hours 3 排泄途徑Kidney 80 fecal 20 3 识别信息IUPAC命名法 3 10 11 dihydro 5H dibenzo b f azepin 5 yl N N dimethylpropan 1 amineCAS号50 49 7 YPubChem CID3696IUPHAR BPS357DrugBankDB00458 YChemSpider3568 YUNIIOGG85SX4E4KEGGD08070 Yas HCl D00815 YChEBICHEBI 47499 YChEMBLChEMBL11 YPDB配體IDIXX PDBe RCSB PDB CompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID1043881ECHA InfoCard100 000 039化学信息化学式C 19H 24N 2摩尔质量280 42 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES CN C CCCN1c2ccccc2CCc2ccccc21InChI InChI 1S C19H24N2 c1 20 2 14 7 15 21 18 10 5 3 8 16 18 12 13 17 9 4 6 11 19 17 21 h3 6 8 11H 7 12 15H2 1 2H3 YKey BCGWQEUPMDMJNV UHFFFAOYSA N Y本條目存在以下問題 請協助改善本條目或在討論頁針對議題發表看法 此條目可参照英語維基百科相應條目来扩充 2023年11月18日 若您熟悉来源语言和主题 请协助参考外语维基百科扩充条目 请勿直接提交机械翻译 也不要翻译不可靠 低品质内容 依版权协议 译文需在编辑摘要注明来源 或于讨论页顶部标记 a href Template Translated page html title Template Translated page Translated page a 标签 此條目的引用需要进行清理 使其符合格式 2023年11月18日 参考文献应符合正确的引用 脚注及外部链接格式 丙咪嗪的常见副作用有口乾 昏睡 頭暈 低血壓 心跳过速 尿瀦留 丙咪嗪过量可能會导致死亡 丙咪嗪于1951年被发现 并于1957年投入臨床使用 参考文献 编辑 Imipramine Use During Pregnancy Drugs com 28 August 2019 7 February 2020 Heck HA Buttrill SE Flynn NW Dyer RL Anbar M Cairns T et al Bioavailability of imipramine tablets relative to a stable isotope labeled internal standard increasing the power of bioavailability tests Journal of Pharmacokinetics and Biopharmaceutics June 1979 7 3 233 248 PMID 480146 S2CID 23232584 doi 10 1007 BF01060015 3 0 3 1 3 2 3 3 3 4 Product Information Tolerade imipramine hydrochloride TGA eBusiness Services PMIP Pty Ltd 4 June 2013 16 October 2013 原始内容存档于10 December 2019 Anvisa RDC Nº 784 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 784 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control Diario Oficial da Uniao 2023 03 31 2023 04 04 2023 08 16 原始内容存档于2023 08 03 巴西葡萄牙语 请检查 publication date 中的日期值 帮助 Robert R Blakeney PE Villarreal C Rosenberg L Meyer WJ Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder a pilot study Journal of the American Academy of Child and Adolescent Psychiatry July 1999 38 7 873 882 PMID 10405506 doi 10 1097 00004583 199907000 00018 Tcheung WJ Robert R Rosenberg L Rosenberg M Villarreal C Thomas C et al Early treatment of acute stress disorder in children with major burn injury Pediatric Critical Care Medicine November 2005 6 6 676 681 PMID 16276335 S2CID 43261789 doi 10 1097 01 pcc 0000165562 04157 da Robert R Tcheung WJ Rosenberg L Rosenberg M Mitchell C Villarreal C et al Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine a randomized double blind study Burns November 2008 34 7 919 928 PMID 18675519 doi 10 1016 j burns 2008 04 009 取自 https zh wikipedia org w index php title 丙咪嗪 amp oldid 79825756, 维基百科,wiki,书籍,书籍,图书馆,

文章

,阅读,下载,免费,免费下载,mp3,视频,mp4,3gp, jpg,jpeg,gif,png,图片,音乐,歌曲,电影,书籍,游戏,游戏。