· iron ion binding · drug binding · arachidonic acid epoxygenase activity · steroid hydroxylase activity · oxidoreductase activity · oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen · oxygen binding · heme binding
· aromatase activity
细胞成分
· cytoplasm
· mitochondrion · endoplasmic reticulum
· endoplasmic reticulum membrane
生物过程
· xenobiotic metabolic process
· steroid metabolic process · coumarin metabolic process · alkaloid metabolic process · alkaloid catabolic process · monoterpenoid metabolic process · drug metabolic process · arachidonic acid metabolic process · isoquinoline alkaloid metabolic process · drug catabolic process · exogenous drug catabolic process · small molecule metabolic process · heterocycle metabolic process · negative regulation of binding · oxidation-reduction process · oxidative demethylation
· negative regulation of cellular organofluorine metabolic process
^ 1.01.1Wang B, Yang LP, Zhang XZ, Huang SQ, Bartlam M, Zhou SF. New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metab. Rev. 2009, 41 (4): 573–643. PMID 19645588. doi:10.1080/03602530903118729.
延伸閱讀
Smith G, Stubbins MJ, Harries LW, Wolf CR. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica. 1998, 28 (12): 1129–65. PMID 9890157. doi:10.1080/004982598238868.
Wolf CR, Smith G. Cytochrome P450 CYP2D6. IARC Sci. Publ. 1999, (148): 209–29. PMID 10493260.
Ding X, Kaminsky LS. Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu. Rev. Pharmacol. Toxicol. 2003, 43 (1): 149–73. PMID 12171978. doi:10.1146/annurev.pharmtox.43.100901.140251.
Lilienfeld S. Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002, 8 (2): 159–76. PMID 12177686. doi:10.1111/j.1527-3458.2002.tb00221.x.
Yu AM, Idle JR, Gonzalez FJ. Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab. Rev. 2004, 36 (2): 243–77. PMID 15237854. doi:10.1081/DMR-120034000.
Abraham JE, Maranian MJ, Driver KE, Platte R, Kalmyrzaev B, Baynes C, Luccarini C, Shah M, Ingle S, Greenberg D, Earl HM, Dunning AM, Pharoah PD, Caldas C. CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res. 2010, 12 (4): R64. PMC 2949659. PMID 20731819. doi:10.1186/bcr2629.
Abraham JE, Maranian MJ, Driver KE, Platte R, Kalmyrzaev B, Baynes C, Luccarini C, Earl HM, Dunning AM, Pharoah PD, Caldas C. CYP2D6 gene variants and their association with breast cancer susceptibility. Cancer Epidemiol. Biomarkers Prev. 2011, 20 (6): 1255–8. PMID 21527579. doi:10.1158/1055-9965.EPI-11-0321.
外部連結
Flockhart Lab Cyp2D6 Substrates Page（页面存档备份，存于互联网档案馆） at IUPUI
七月 29, 2023
cyp2d6, 细胞色素, p450, cytochrome, p450, 是一种由人类基因编码的酶, 主要合成而显现于肝脏, 并且也表现在中枢神经系统中, 包括黑质, cytochrome, p450, family, subfamily, polypeptide, 6pdb基于2f9q的渲染图有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表2f9q, 3qm4, 3tbg, 3tda, 4wnt, 4wnu, 4wnv, 4wnw标识代号, cpd6, cyp2d, cyp2d7ap, . 细胞色素 P450 2D6 cytochrome P450 2D6 CYP2D6 是一种由人类CYP2D6基因编码的酶 CYP2D6主要合成而显现于肝脏 并且也表现在中枢神经系统中 包括黑质 Cytochrome P450 family 2 subfamily D polypeptide 6PDB基于2f9q的渲染图有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW标识代号CYP2D6 CPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450 DB1 P450C2D P450DB1扩展标识遗传学 124030 鼠基因 1929474 同源基因 133550 GeneCards CYP2D6 GeneEC編號1 14 14 1基因本体论描述分子功能 monooxygenase activity iron ion binding drug binding arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen oxygen binding heme binding aromatase activity细胞成分 cytoplasm mitochondrion endoplasmic reticulum endoplasmic reticulum membrane生物过程 xenobiotic metabolic process steroid metabolic process coumarin metabolic process alkaloid metabolic process alkaloid catabolic process monoterpenoid metabolic process drug metabolic process arachidonic acid metabolic process isoquinoline alkaloid metabolic process drug catabolic process exogenous drug catabolic process small molecule metabolic process heterocycle metabolic process negative regulation of binding oxidation reduction process oxidative demethylation negative regulation of cellular organofluorine metabolic processSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez156513101EnsemblENSG00000100197ENSMUSG00000094806UniProtP10635P24456mRNA序列NM 000106NM 010005蛋白序列NP 000097NP 034135基因位置Chr 22 42 13 42 13 MbChr 15 82 4 82 41 MbPubMed查询 1 2 查论编CYP2D6是细胞色素P450混合功能氧化酶系统的成员之一 是人体中最重要的代谢酶之一 CYP2D6参与25 的临床药物的代谢和清除 过程主要是O 去甲基化 1 CYP2D6也参与多种内源性物质的代谢 如5 羟色胺和神经类固醇 1 引用 编辑 1 0 1 1 Wang B Yang LP Zhang XZ Huang SQ Bartlam M Zhou SF New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme Drug Metab Rev 2009 41 4 573 643 PMID 19645588 doi 10 1080 03602530903118729 延伸閱讀 编辑Smith G Stubbins MJ Harries LW Wolf CR Molecular genetics of the human cytochrome P450 monooxygenase superfamily Xenobiotica 1998 28 12 1129 65 PMID 9890157 doi 10 1080 004982598238868 Wolf CR Smith G Cytochrome P450 CYP2D6 IARC Sci Publ 1999 148 209 29 PMID 10493260 Ding X Kaminsky LS Human extrahepatic cytochromes P450 function in xenobiotic metabolism and tissue selective chemical toxicity in the respiratory and gastrointestinal tracts Annu Rev Pharmacol Toxicol 2003 43 1 149 73 PMID 12171978 doi 10 1146 annurev pharmtox 43 100901 140251 Lilienfeld S Galantamine a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer s disease CNS Drug Rev 2002 8 2 159 76 PMID 12177686 doi 10 1111 j 1527 3458 2002 tb00221 x Yu AM Idle JR Gonzalez FJ Polymorphic cytochrome P450 2D6 humanized mouse model and endogenous substrates Drug Metab Rev 2004 36 2 243 77 PMID 15237854 doi 10 1081 DMR 120034000 Abraham JE Maranian MJ Driver KE Platte R Kalmyrzaev B Baynes C Luccarini C Shah M Ingle S Greenberg D Earl HM Dunning AM Pharoah PD Caldas C CYP2D6 gene variants association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen Breast Cancer Res 2010 12 4 R64 PMC 2949659 PMID 20731819 doi 10 1186 bcr2629 Abraham JE Maranian MJ Driver KE Platte R Kalmyrzaev B Baynes C Luccarini C Earl HM Dunning AM Pharoah PD Caldas C CYP2D6 gene variants and their association with breast cancer susceptibility Cancer Epidemiol Biomarkers Prev 2011 20 6 1255 8 PMID 21527579 doi 10 1158 1055 9965 EPI 11 0321 外部連結 编辑Flockhart Lab Cyp2D6 Substrates Page 页面存档备份 存于互联网档案馆 at IUPUI PharmGKB Annotated PGx Gene Information for CYP2D6 取自 https zh wikipedia org w index php title CYP2D6 amp oldid 76139107, 维基百科，wiki，书籍，书籍，图书馆，
