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维基百科

Γ-谷氨酰水解酶

二月 13, 2024

γ-谷氨酰水解酶（英文：Gamma-glutamyl hydrolase）是一种催化以下化学反应的酶[5][6][7][8]：

γ-谷氨酰水解酶
识别码
EC編號 3.4.19.9
CAS号 9074-87-7
数据库
IntEnz IntEnz浏览
BRENDA（英语：BRENDA） BRENDA入口
ExPASy（英语：ExPASy） NiceZyme浏览
KEGG KEGG入口
MetaCyc（英语：MetaCyc） 代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles） 概述
PDB RCSB PDB PDBj PDBe PDBsum
Γ-谷氨酰水解酶
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名GGH；, GH, gamma-glutamyl hydrolase, GATD10
外部IDOMIM：601509 MGI：1329035 HomoloGene：2881 GeneCards：GGH
基因位置（人类）
染色体8號染色體[1]
基因座8q12.3起始63,014,881 bp[1]
终止63,039,407 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物種人類小鼠
Entrez

8836

14590

Ensembl

ENSG00000137563

ENSMUSG00000073987

UniProt

Q92820

Q9Z0L8

mRNA​序列

​NM_003878

NM_010281

蛋白序列

NP_003869

NP_034411

基因位置​（UCSC）Chr 8: 63.01 – 63.04 MbChr 4: 20.04 – 20.07 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠
γ-谷氨酰键的水解

这种溶酶体或分泌的硫醇依赖性肽酶，在酸性pH值下最活跃。

在人类中，γ-谷氨酰水解酶由GGH基因编码。[7][9][10]该基因通过去除γ联聚谷氨酸和谷氨酸来催化叶酰聚-γ-谷氨酸和抗叶酰聚-γ-谷氨酸的水解。[10]


互动通路图 编辑

 

参考文献 编辑

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000137563 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000073987 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Biochim. Biophys. Acta. August 1993, 1164 (3): 227–35. PMID 8343522. doi:10.1016/0167-4838(93)90253-n. 
  6. ^ Yao R, Rhee MS, Galivan J. Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. Mol. Pharmacol. September 1995, 48 (3): 505–11. PMID 7565632. 
  7. ^ 7.0 7.1 Yao R, Schneider E, Ryan TJ, Galivan J. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. Proc. Natl. Acad. Sci. U.S.A. September 1996, 93 (19): 10134–8. PMC 38349  . PMID 8816764. doi:10.1073/pnas.93.19.10134  . 
  8. ^ Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. April 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525  . 
  9. ^ Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R. Structural organization of the human gamma-glutamyl hydrolase gene. Gene. Dec 1999, 238 (2): 463–70. PMID 10570974. doi:10.1016/S0378-1119(99)00362-5. 
  10. ^ 10.0 10.1 Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase). [2022-12-12]. （原始内容于2022-12-12）. 

拓展阅读 编辑

  • Galivan J, Ryan T, Rhee M, et al. Glutamyl hydrolase: properties and pharmacologic impact. Semin. Oncol. 1999, 26 (2 Suppl 6): 33–7. PMID 10598552. 
  • O'Connor BM, Rotundo RF, Nimec Z, et al. Secretion of gamma-glutamyl hydrolase in vitro. Cancer Res. 1991, 51 (15): 3874–81. PMID 1713122. 
  • Chandler CJ, Wang TT, Halsted CH. Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J. Biol. Chem. 1986, 261 (2): 928–33. PMID 2867095. doi:10.1016/S0021-9258(17)36185-9  . 
  • Wang TT, Chandler CJ, Halsted CH. Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization. J. Biol. Chem. 1986, 261 (29): 13551–5. PMID 3759978. doi:10.1016/S0021-9258(18)67054-1  . 
  • Yao R, Nimec Z, Ryan TJ, Galivan J. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. J. Biol. Chem. 1996, 271 (15): 8525–8. PMID 8621474. doi:10.1074/jbc.271.15.8525  . 
  • Rhee MS, Lindau-Shepard B, Chave KJ, et al. Characterization of human cellular gamma-glutamyl hydrolase. Mol. Pharmacol. 1998, 53 (6): 1040–6. PMID 9614206. 
  • Li H, Ryan TJ, Chave KJ, Van Roey P. Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate. J. Biol. Chem. 2002, 277 (27): 24522–9. PMID 11953431. doi:10.1074/jbc.M202020200  . 
  • Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241  . PMID 12477932. doi:10.1073/pnas.242603899  . 
  • Basrur V, Yang F, Kushimoto T, et al. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J. Proteome Res. 2003, 2 (1): 69–79. PMID 12643545. doi:10.1021/pr025562r. 
  • Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928  . PMID 15489334. doi:10.1101/gr.2596504. 
  • He P, Varticovski L, Bowman ED, et al. Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum. Pathol. 2004, 35 (10): 1196–209 [2022-12-12]. PMID 15492986. doi:10.1016/j.humpath.2004.06.014. （原始内容于2022-10-15）. 
  • Rual JF, Venkatesan K, Hao T, et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005, 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. S2CID 4427026. doi:10.1038/nature04209. 
  • Eisele LE, Chave KJ, Lehning AC, Ryan TJ. Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer. Biochim. Biophys. Acta. 2006, 1764 (9): 1479–86. PMID 16945597. doi:10.1016/j.bbapap.2006.06.008. 
  • Chi A, Valencia JC, Hu ZZ, et al. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J. Proteome Res. 2007, 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j. 
  • Hayashi H, Fujimaki C, Inoue K, et al. Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. Biol. Pharm. Bull. 2007, 30 (4): 839–41. PMID 17409534. doi:10.1248/bpb.30.839  . 

外部链接 编辑

二月 13, 2024
谷氨酰水解酶, 谷氨酰水解酶, 英文, gamma, glutamyl, hydrolase, 是一种催化以下化学反应的酶, 谷氨酰水解酶命名系统命名缩写识别码ec編號, 9cas号, 9074, 7数据库intenz, intenz浏览brenda, 英语, brenda, brenda入口expasy, 英语, expasy, nicezyme浏览kegg, kegg入口metacyc, 英语, metacyc, 代谢路径priam, 英语, priam, enzyme, specific, profiles,. g 谷氨酰水解酶 英文 Gamma glutamyl hydrolase 是一种催化以下化学反应的酶 5 6 7 8 g 谷氨酰水解酶命名系统命名缩写识别码EC編號 3 4 19 9CAS号 9074 87 7数据库IntEnz IntEnz浏览BRENDA 英语 BRENDA BRENDA入口ExPASy 英语 ExPASy NiceZyme浏览KEGG KEGG入口MetaCyc 英语 MetaCyc 代谢路径PRIAM 英语 PRIAM enzyme specific profiles 概述PDB RCSB PDB PDBj PDBe PDBsum搜索PMC 相关文献PubMed 相关文献G 谷氨酰水解酶已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1L9X識別號别名GGH GH gamma glutamyl hydrolase GATD10外部IDOMIM 601509 MGI 1329035 HomoloGene 2881 GeneCards GGH基因位置 人类 染色体8號染色體 1 基因座8q12 3起始63 014 881 bp 1 终止63 039 407 bp 1 基因位置 小鼠 染色体小鼠4号染色体 2 基因座4 4 A3起始20 042 052 bp 2 终止20 066 750 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 exopeptidase activity omega peptidase activity 水解酶活性 gamma glutamyl peptidase activity細胞組分 黑色素体 细胞质基质 溶酶体 外排體 细胞核 細胞外區域 細胞外空間 azurophil granule lumen specific granule lumen tertiary granule lumen 液胞生物學過程 response to insulin response to zinc ion response to ethanol 蛋白酶解 neutrophil degranulation tetrahydrofolylpolyglutamate metabolic processSources Amigo QuickGO直系同源物種人類小鼠Entrez883614590EnsemblENSG00000137563ENSMUSG00000073987UniProtQ92820Q9Z0L8mRNA 序列 NM 003878NM 010281蛋白序列NP 003869NP 034411基因位置 UCSC Chr 8 63 01 63 04 MbChr 4 20 04 20 07 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 g 谷氨酰键的水解这种溶酶体或分泌的硫醇依赖性肽酶 在酸性pH值下最活跃 在人类中 g 谷氨酰水解酶由GGH基因编码 7 9 10 该基因通过去除g联聚谷氨酸和谷氨酸来催化叶酰聚 g 谷氨酸和抗叶酰聚 g 谷氨酸的水解 10 目录 1 互动通路图 2 参考文献 3 拓展阅读 4 外部链接互动通路图 编辑 nbsp 参考文献 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000137563 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000073987 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Wang Y Nimec Z Ryan TJ Dias JA Galivan J The properties of the secreted gamma glutamyl hydrolases from H35 hepatoma cells Biochim Biophys Acta August 1993 1164 3 227 35 PMID 8343522 doi 10 1016 0167 4838 93 90253 n Yao R Rhee MS Galivan J Effects of gamma glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells Mol Pharmacol September 1995 48 3 505 11 PMID 7565632 7 0 7 1 Yao R Schneider E Ryan TJ Galivan J Human gamma glutamyl hydrolase cloning and characterization of the enzyme expressed in vitro Proc Natl Acad Sci U S A September 1996 93 19 10134 8 PMC 38349 nbsp PMID 8816764 doi 10 1073 pnas 93 19 10134 nbsp Yao R Nimec Z Ryan TJ Galivan J Identification cloning and sequencing of a cDNA coding for rat gamma glutamyl hydrolase J Biol Chem April 1996 271 15 8525 8 PMID 8621474 doi 10 1074 jbc 271 15 8525 nbsp Yin D Chave KJ Macaluso CR Galivan J Yao R Structural organization of the human gamma glutamyl hydrolase gene Gene Dec 1999 238 2 463 70 PMID 10570974 doi 10 1016 S0378 1119 99 00362 5 10 0 10 1 Entrez Gene GGH gamma glutamyl hydrolase conjugase folylpolygammaglutamyl hydrolase 2022 12 12 原始内容存档于2022 12 12 拓展阅读 编辑Galivan J Ryan T Rhee M et al Glutamyl hydrolase properties and pharmacologic impact Semin Oncol 1999 26 2 Suppl 6 33 7 PMID 10598552 O Connor BM Rotundo RF Nimec Z et al Secretion of gamma glutamyl hydrolase in vitro Cancer Res 1991 51 15 3874 81 PMID 1713122 Chandler CJ Wang TT Halsted CH Pteroylpolyglutamate hydrolase from human jejunal brush borders Purification and characterization J Biol Chem 1986 261 2 928 33 PMID 2867095 doi 10 1016 S0021 9258 17 36185 9 nbsp Wang TT Chandler CJ Halsted CH Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa Isolation and characterization J Biol Chem 1986 261 29 13551 5 PMID 3759978 doi 10 1016 S0021 9258 18 67054 1 nbsp Yao R Nimec Z Ryan TJ Galivan J Identification cloning and sequencing of a cDNA coding for rat gamma glutamyl hydrolase J Biol Chem 1996 271 15 8525 8 PMID 8621474 doi 10 1074 jbc 271 15 8525 nbsp Rhee MS Lindau Shepard B Chave KJ et al Characterization of human cellular gamma glutamyl hydrolase Mol Pharmacol 1998 53 6 1040 6 PMID 9614206 Li H Ryan TJ Chave KJ Van Roey P Three dimensional structure of human gamma glutamyl hydrolase A class I glatamine amidotransferase adapted for a complex substate J Biol Chem 2002 277 27 24522 9 PMID 11953431 doi 10 1074 jbc M202020200 nbsp Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 Bibcode 2002PNAS 9916899M PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 nbsp Basrur V Yang F Kushimoto T et al Proteomic analysis of early melanosomes identification of novel melanosomal proteins J Proteome Res 2003 2 1 69 79 PMID 12643545 doi 10 1021 pr025562r Gerhard DS Wagner L Feingold EA et al The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 He P Varticovski L Bowman ED et al Identification of carboxypeptidase E and gamma glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray Hum Pathol 2004 35 10 1196 209 2022 12 12 PMID 15492986 doi 10 1016 j humpath 2004 06 014 原始内容存档于2022 10 15 Rual JF Venkatesan K Hao T et al Towards a proteome scale map of the human protein protein interaction network Nature 2005 437 7062 1173 8 Bibcode 2005Natur 437 1173R PMID 16189514 S2CID 4427026 doi 10 1038 nature04209 Eisele LE Chave KJ Lehning AC Ryan TJ Characterization of Human gamma glutamyl hydrolase in solution demonstrates that the enzyme is a non dissociating homodimer Biochim Biophys Acta 2006 1764 9 1479 86 PMID 16945597 doi 10 1016 j bbapap 2006 06 008 Chi A Valencia JC Hu ZZ et al Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes J Proteome Res 2007 5 11 3135 44 PMID 17081065 doi 10 1021 pr060363j Hayashi H Fujimaki C Inoue K et al Genetic polymorphism of C452T T127I in human gamma glutamyl hydrolase in a Japanese population Biol Pharm Bull 2007 30 4 839 41 PMID 17409534 doi 10 1248 bpb 30 839 nbsp 外部链接 编辑醫學主題詞表 MeSH Gamma glutamyl hydrolase PDB中UniProt可用的所有結構信息之概述 Q92820 Gamma glutamyl hydrolase 在PDBe KB 英语 PDBe KB nbsp 生物学主题 取自 https zh wikipedia org w index php title G 谷氨酰水解酶 amp oldid 75665477, 维基百科，wiki，书籍，书籍，图书馆，

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