• mitochondrial outer membrane • 膜 • 線粒體 • integral component of membrane • 細胞質 • 高尔基体 • 细胞膜 • cell surface • 内质网 • 脂筏模型 • anchored component of membrane • 外排體 • 细胞核 • extrinsic component of membrane • 细胞质基质 • 突触后致密物质 • 包涵体 • 树突 • anchored component of external side of plasma membrane • 核膜 • 細胞內膜結合細胞器 • postsynapse
生物學過程
• negative regulation of protein phosphorylation • negative regulation of interferon-gamma production • response to cadmium ion • negative regulation of calcineurin-NFAT signaling cascade • response to copper ion • negative regulation of apoptotic process • response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of T cell receptor signaling pathway • regulation of protein localization • negative regulation of activated T cell proliferation • learning or memory • cellular copper ion homeostasis • cellular response to copper ion • 細胞週期 • 代謝 • negative regulation of interleukin-17 production • protein homooligomerization • negative regulation of interleukin-2 production • regulation of potassium ion transmembrane transport • 长期记忆 • positive regulation of cell death • negative regulation of protein processing • protein destabilization • activation of protein kinase activity • calcium-mediated signaling using intracellular calcium source • negative regulation of catalytic activity • positive regulation of neuron apoptotic process • regulation of peptidyl-tyrosine phosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • positive regulation of protein targeting to membrane • dendritic spine maintenance • negative regulation of long-term synaptic potentiation • regulation of glutamate receptor signaling pathway • positive regulation of neuron death • negative regulation of amyloid-beta formation • regulation of intracellular calcium activated chloride channel activity • negative regulation of dendritic spine maintenance • negative regulation of amyloid precursor protein catabolic process • positive regulation of protein localization to plasma membrane • response to amyloid-beta • cellular response to amyloid-beta • regulation of calcium ion import across plasma membrane • neuron projection maintenance
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000171867 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000079037 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kretzschmar, Hans A.; Stowring, Linda E.; Westaway, David; Stubblebine, William H.; Prusiner, Stanley B.; Dearmond, Stephen J. Molecular Cloning of a Human Prion Protein cDNA. DNA. 1986-08, 5 (4) [2022-11-11]. ISSN 0198-0238. PMID 3755672. doi:10.1089/dna.1986.5.315. （原始内容于2020-02-23） （英语）.
^Sparkes, R S; Simon, M; Cohn, V H; Fournier, R E; Lem, J; Klisak, I; Heinzmann, C; Blatt, C; Lucero, M; Mohandas, T. Assignment of the human and mouse prion protein genes to homologous chromosomes.. Proceedings of the National Academy of Sciences. 1986-10, 83 (19). Bibcode:1986PNAS...83.7358S. ISSN 0027-8424. PMC 386716. PMID 3094007. doi:10.1073/pnas.83.19.7358（英语）. 引文格式1维护：PMC格式 (link)
^Liao, Yu-Cheng; Lebo, Roger V.; Clawson, Gary A.; Smuckler, Edward A. Human Prion Protein cDNA: Molecular Cloning, Chromosomal Mapping, and Biological Implications. Science. 1986-07-18, 233 (4761) [2022-11-11]. Bibcode:1986Sci...233..364L. ISSN 0036-8075. PMID 3014653. doi:10.1126/science.3014653. （原始内容于2022-11-12） （英语）.
^Robakis, N. K.; Devine-Gage, E. A.; Jenkins, E. C.; Kascsak, R. J.; Brown, W. T.; Krawczun, M. S.; Silverman, W. P. Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochemical and Biophysical Research Communications. 1986-10-30, 140 (2) [2022-11-11]. ISSN 0006-291X. PMID 2877664. doi:10.1016/0006-291x(86)90796-5. （原始内容于2022-11-11）.
^Prusiner, Stanley B. Neurodegenerative Diseases and Prions. New England Journal of Medicine. 2001-05-17, 344 (20). ISSN 0028-4793. PMID 11357156. doi:10.1056/NEJM200105173442006（英语）.
^Weissmann, Charles. The state of the prion. Nature Reviews Microbiology. 2004-11, 2 (11) [2022-11-11]. ISSN 1740-1526. PMID 15494743. doi:10.1038/nrmicro1025. （原始内容于2022-11-11） （英语）.
^Zomosa-Signoret, Viviana; Arnaud, Jacques-Damien; Fontes, Pascaline; Alvarez-Martinez, Maria-Terresa; Liautard, Jean-Pierre. Physiological role of the cellular prion protein. Veterinary Research. 2008-07, 39 (4). ISSN 0928-4249. PMID 18073096. doi:10.1051/vetres:2007048.
行進 01, 2023
prnp, 普里昂蛋白, 為人類主要普里昂蛋白prp的基因編碼, 也稱之為cd230, 分化簇230, 該蛋白的主要表达于神經系統, 但也會表达在人體其他組織, 朊毒體蛋白已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1e1g, 1e1j, 1e1p, 1e1s, 1e1u, 1e1w, 1fkc, 1fo7, 1h0l, 1hjm, 1hjn, 1i4m, 1oeh, 1oei, 1qlx, 1qlz, 1qm0, 1qm1, 1qm2, 1qm3, 2iv4, 2iv5, 2iv6, 2k1. PRNP 普里昂蛋白 為人類主要普里昂蛋白PrP的基因編碼 也稱之為CD230 分化簇230 6 7 8 9 該蛋白的主要表达于神經系統 但也會表达在人體其他組織 10 11 12 朊毒體蛋白已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I s1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NVF 4DGI 4E1H 4E1I 4KML 4N9O識別號别名PRNP ASCR AltPrP CD230 CJD GSS KURU PRIP PrP PrP27 30 PrP33 35C PrPc p27 30 prion protein外部IDOMIM 176640 MGI 97769 HomoloGene 7904 GeneCards PRNP相關疾病傳染性海綿狀腦病 克雅二氏病 致死性家族失眠症 Gerstmann Straussler Scheinker症候群 Huntington disease like 1 spongiform encephalopathy with neuropsychiatric features 1 基因位置 人类 染色体20號染色體 2 基因座20p13起始4 686 350 bp 2 终止4 701 590 bp 2 基因位置 小鼠 染色体小鼠2号染色体 3 基因座2 F2 2 64 07 cM起始131 751 848 bp 3 终止131 780 349 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 chaperone binding transmembrane transporter binding microtubule binding ATP dependent protein binding 金屬離子結合 tubulin binding 血浆蛋白结合 相同蛋白质结合 copper ion binding lamin binding amyloid beta binding 蛋白酶結合 glycosaminoglycan binding type 5 metabotropic glutamate receptor binding type 8 metabotropic glutamate receptor binding signaling receptor activity 大分子复合物结合 cupric ion binding cuprous ion binding細胞組分 mitochondrial outer membrane 膜 線粒體 integral component of membrane 細胞質 高尔基体 细胞膜 cell surface 内质网 脂筏模型 anchored component of membrane 外排體 细胞核 extrinsic component of membrane 细胞质基质 突触后致密物质 包涵体 树突 anchored component of external side of plasma membrane 核膜 細胞內膜結合細胞器 postsynapse生物學過程 negative regulation of protein phosphorylation negative regulation of interferon gamma production response to cadmium ion negative regulation of calcineurin NFAT signaling cascade response to copper ion negative regulation of apoptotic process response to oxidative stress negative regulation of DNA binding transcription factor activity negative regulation of T cell receptor signaling pathway regulation of protein localization negative regulation of activated T cell proliferation learning or memory cellular copper ion homeostasis cellular response to copper ion 細胞週期 代謝 negative regulation of interleukin 17 production protein homooligomerization negative regulation of interleukin 2 production regulation of potassium ion transmembrane transport 长期记忆 positive regulation of cell death negative regulation of protein processing protein destabilization activation of protein kinase activity calcium mediated signaling using intracellular calcium source negative regulation of catalytic activity positive regulation of neuron apoptotic process regulation of peptidyl tyrosine phosphorylation positive regulation of peptidyl tyrosine phosphorylation positive regulation of protein tyrosine kinase activity positive regulation of protein targeting to membrane dendritic spine maintenance negative regulation of long term synaptic potentiation regulation of glutamate receptor signaling pathway positive regulation of neuron death negative regulation of amyloid beta formation regulation of intracellular calcium activated chloride channel activity negative regulation of dendritic spine maintenance negative regulation of amyloid precursor protein catabolic process positive regulation of protein localization to plasma membrane response to amyloid beta cellular response to amyloid beta regulation of calcium ion import across plasma membrane neuron projection maintenanceSources Amigo QuickGO直系同源物種人類小鼠Entrez562119122EnsemblENSG00000171867ENSMUSG00000079037UniProtP04156P04925mRNA 序列NM 183079 NM 000311 NM 001080121 NM 001080122 NM 001080123 NM 001271561NM 001278256 NM 011170蛋白序列NP 000302 NP 001073590 NP 001073591 NP 001073592 NP 001258490 NP 898902NP 000302 1 NP 001073590 1 NP 001073591 1 NP 001073592 1 NP 898902 1NP 001265185 NP 035300基因位置 UCSC Chr 20 4 69 4 7 MbChr 2 131 75 131 78 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠參考文獻 编辑 與朊毒體蛋白相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000171867 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000079037 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kretzschmar Hans A Stowring Linda E Westaway David Stubblebine William H Prusiner Stanley B Dearmond Stephen J Molecular Cloning of a Human Prion Protein cDNA DNA 1986 08 5 4 2022 11 11 ISSN 0198 0238 PMID 3755672 doi 10 1089 dna 1986 5 315 原始内容存档于2020 02 23 英语 Sparkes R S Simon M Cohn V H Fournier R E Lem J Klisak I Heinzmann C Blatt C Lucero M Mohandas T Assignment of the human and mouse prion protein genes to homologous chromosomes Proceedings of the National Academy of Sciences 1986 10 83 19 Bibcode 1986PNAS 83 7358S ISSN 0027 8424 PMC 386716 PMID 3094007 doi 10 1073 pnas 83 19 7358 英语 引文格式1维护 PMC格式 link Liao Yu Cheng Lebo Roger V Clawson Gary A Smuckler Edward A Human Prion Protein cDNA Molecular Cloning Chromosomal Mapping and Biological Implications Science 1986 07 18 233 4761 2022 11 11 Bibcode 1986Sci 233 364L ISSN 0036 8075 PMID 3014653 doi 10 1126 science 3014653 原始内容存档于2022 11 12 英语 Robakis N K Devine Gage E A Jenkins E C Kascsak R J Brown W T Krawczun M S Silverman W P Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP related antigens in normal human brain Biochemical and Biophysical Research Communications 1986 10 30 140 2 2022 11 11 ISSN 0006 291X PMID 2877664 doi 10 1016 0006 291x 86 90796 5 原始内容存档于2022 11 11 Prusiner Stanley B Neurodegenerative Diseases and Prions New England Journal of Medicine 2001 05 17 344 20 ISSN 0028 4793 PMID 11357156 doi 10 1056 NEJM200105173442006 英语 Weissmann Charles The state of the prion Nature Reviews Microbiology 2004 11 2 11 2022 11 11 ISSN 1740 1526 PMID 15494743 doi 10 1038 nrmicro1025 原始内容存档于2022 11 11 英语 Zomosa Signoret Viviana Arnaud Jacques Damien Fontes Pascaline Alvarez Martinez Maria Terresa Liautard Jean Pierre Physiological role of the cellular prion protein Veterinary Research 2008 07 39 4 ISSN 0928 4249 PMID 18073096 doi 10 1051 vetres 2007048 取自 https zh wikipedia org w index php title PRNP amp oldid 75634477, 维基百科，wiki，书籍，书籍，图书馆，
