• sequence-specific DNA binding • NF-kappaB binding • transcription corepressor activity • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • 血浆蛋白结合 • histone deacetylase binding • DNA结合转录因子活性 • NFAT protein binding • histone acetyltransferase binding • 金屬離子結合 • DNA结合 • protein homodimerization activity • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II cis-regulatory region sequence-specific DNA binding
細胞組分
• 细胞核 • 胞內 • 細胞質 • 核质 • 大分子复合体
生物學過程
• negative regulation of cell population proliferation • negative regulation of NF-kappaB transcription factor activity • B cell homeostasis • regulation of isotype switching to IgG isotypes • myeloid cell homeostasis • negative regulation of inflammatory response • positive regulation of interleukin-4 production • regulation of immunoglobulin production • regulation of transcription by RNA polymerase II • regulation of T cell anergy • negative regulation of interleukin-6 production • tolerance induction to self antigen • regulation of transcription, DNA-templated • negative regulation of DNA-binding transcription factor activity • positive regulation of T cell tolerance induction • negative regulation of immune response • negative regulation of interferon-gamma production • tolerance induction • regulatory T cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of interleukin-2 production • positive regulation of histone acetylation • negative regulation of interleukin-5 production • negative regulation of chronic inflammatory response • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • positive regulation of transcription by RNA polymerase II • negative regulation of activated T cell proliferation • positive regulation of gene expression • negative regulation of interleukin-4 production • negative regulation of interleukin-10 production • 腫瘤壞死因子產生的負調控 • T cell homeostasis • negative regulation of CREB transcription factor activity • negative regulation of T-helper 17 cell differentiation • T细胞活化 • positive regulation of immature T cell proliferation in thymus • positive regulation of regulatory T cell differentiation • negative regulation of transcription by RNA polymerase II • positive regulation of peripheral T cell tolerance induction • positive regulation of transforming growth factor beta1 production • negative regulation of transcription, DNA-templated • negative regulation of lymphocyte proliferation • negative regulation of histone acetylation • negative regulation of interleukin-17 production • response to virus • negative regulation of histone deacetylation • CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • negative regulation of T cell proliferation • 染色体重建 • cytokine production • negative regulation of T cell cytokine production • negative regulation of isotype switching to IgE isotypes • T cell receptor signaling pathway • positive regulation of T cell anergy • transcription, DNA-templated • T cell mediated immunity • negative regulation of gene expression • anatomical structure morphogenesis • regulation of Wnt signaling pathway • regulation of regulatory T cell differentiation
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000049768 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000039521 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genetics. January 2001, 27 (1): 68–73. PMID 11138001. S2CID 13389419. doi:10.1038/83784.
外部链接编辑
GeneReviews/NIH/NCBI/UW entry on IPEX Syndrome （页面存档备份，存于互联网档案馆）
foxp3, forkhead, protein, 基因, 即叉头框p3基因, 也称为scurfin蛋白, 位于x染色体, 属于fox蛋白家族, 是一种与免疫系统响应有关的转录因子, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表3qrf, 4wk8識別號别名, aiid, dieter, ipex, pidx, xpid, forkhead, p3外部idomim, 300292, 1891436, homologene, 8516, genecards, 相關疾病ipex症候群, 基因位置,. FOXP3 Forkhead box protein P3 基因 即叉头框P3基因 也称为scurfin蛋白 位于X染色体 属于FOX蛋白家族 是一种与免疫系统响应有关的转录因子 6 FOXP3已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表3QRF 4WK8識別號别名FOXP3 AIID DIETER IPEX JM2 PIDX XPID forkhead box P3外部IDOMIM 300292 MGI 1891436 HomoloGene 8516 GeneCards FOXP3相關疾病IPEX症候群 1 基因位置 人类 染色体X染色體 2 基因座Xp11 23起始49 250 438 bp 2 终止49 270 477 bp 2 基因位置 小鼠 染色体小鼠X染色体 3 基因座X A1 1 X 3 41 cM起始7 439 883 bp 3 终止7 461 484 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 sequence specific DNA binding NF kappaB binding transcription corepressor activity nucleic acid binding transcription factor activity RNA polymerase II distal enhancer sequence specific binding 血浆蛋白结合 histone deacetylase binding DNA结合转录因子活性 NFAT protein binding histone acetyltransferase binding 金屬離子結合 DNA结合 protein homodimerization activity DNA binding transcription factor activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA binding細胞組分 细胞核 胞內 細胞質 核质 大分子复合体生物學過程 negative regulation of cell population proliferation negative regulation of NF kappaB transcription factor activity B cell homeostasis regulation of isotype switching to IgG isotypes myeloid cell homeostasis negative regulation of inflammatory response positive regulation of interleukin 4 production regulation of immunoglobulin production regulation of transcription by RNA polymerase II regulation of T cell anergy negative regulation of interleukin 6 production tolerance induction to self antigen regulation of transcription DNA templated negative regulation of DNA binding transcription factor activity positive regulation of T cell tolerance induction negative regulation of immune response negative regulation of interferon gamma production tolerance induction regulatory T cell differentiation positive regulation of transcription DNA templated negative regulation of interleukin 2 production positive regulation of histone acetylation negative regulation of interleukin 5 production negative regulation of chronic inflammatory response CD4 positive CD25 positive alpha beta regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of activated T cell proliferation positive regulation of gene expression negative regulation of interleukin 4 production negative regulation of interleukin 10 production 腫瘤壞死因子產生的負調控 T cell homeostasis negative regulation of CREB transcription factor activity negative regulation of T helper 17 cell differentiation T细胞活化 positive regulation of immature T cell proliferation in thymus positive regulation of regulatory T cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of peripheral T cell tolerance induction positive regulation of transforming growth factor beta1 production negative regulation of transcription DNA templated negative regulation of lymphocyte proliferation negative regulation of histone acetylation negative regulation of interleukin 17 production response to virus negative regulation of histone deacetylation CD4 positive CD25 positive alpha beta regulatory T cell lineage commitment positive regulation of CD4 positive CD25 positive alpha beta regulatory T cell differentiation negative regulation of T cell proliferation 染色体重建 cytokine production negative regulation of T cell cytokine production negative regulation of isotype switching to IgE isotypes T cell receptor signaling pathway positive regulation of T cell anergy transcription DNA templated T cell mediated immunity negative regulation of gene expression anatomical structure morphogenesis regulation of Wnt signaling pathway regulation of regulatory T cell differentiationSources Amigo QuickGO直系同源物種人類小鼠Entrez5094320371EnsemblENSG00000049768ENSMUSG00000039521UniProtQ9BZS1Q99JB6mRNA 序列NM 001114377 NM 014009NM 001199347 NM 001199348 NM 054039蛋白序列NP 001107849 NP 054728NP 001186276 NP 001186277 NP 473380基因位置 UCSC Chr X 49 25 49 27 MbChr X 7 44 7 46 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠参考文献 编辑 與FOXP3相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000049768 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000039521 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Brunkow ME Jeffery EW Hjerrild KA Paeper B Clark LB Yasayko SA Wilkinson JE Galas D Ziegler SF Ramsdell F Disruption of a new forkhead winged helix protein scurfin results in the fatal lymphoproliferative disorder of the scurfy mouse Nature Genetics January 2001 27 1 68 73 PMID 11138001 S2CID 13389419 doi 10 1038 83784 外部链接 编辑GeneReviews NIH NCBI UW entry on IPEX Syndrome 页面存档备份 存于互联网档案馆 醫學主題詞表 MeSH FOXP3 protein human 取自 https zh wikipedia org w index php title FOXP3 amp oldid 77641164, 维基百科，wiki，书籍，书籍，图书馆，
