fbpx
维基百科

E2F1

四月 07, 2024

转录因子E2F1是由人类E2F1基因编码出的蛋白质[1]。

E2F transcription factor 1
PDB rendering based on 2aze.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 E2F1; E2F-1; RBAP1; RBBP3; RBP3
扩展标识 遗传学：189971 鼠基因：101941 同源基因：3828 ChEMBL: 4382 GeneCards: E2F1 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 1869 13555
Ensembl ENSG00000101412 ENSMUSG00000027490
UniProt Q01094 Q61501
mRNA序列 NM_005225 NM_007891
蛋白序列 NP_005216 NP_031917
基因位置 Chr 20:
32.26 – 32.27 Mb		 Chr 2:
154.56 – 154.57 Mb
PubMed查询 [1] [2]

该基因编码出的蛋白质是E2F转录因子家族中的成员。E2F家族在控制细胞周期及抑癌基因功能上起到重要作用，也是小DNA致癌病毒转化蛋白的靶点。E2F家族中的多个成员蛋白包含许多进化保守的结构域。这些结构域包括：DNA结合域、与受分化调控的转录因子蛋白（DP）之间相互作用的二聚化结构域、富含酸性氨基酸的转活化结构域以及位于转活化结构域中的抑癌蛋白关联结构域。该蛋白与其他两个成员E2F2及E2F3具有额外的周期蛋白结合结构域。该蛋白以细胞周期依赖性的模式优先与视网膜母细胞瘤蛋白pRB结合。它可以同时介导细胞增殖及p53-依赖/非依赖的细胞凋亡[2]。

转录 编辑

E2F1的启动子区有PAX8转录因子的结合序列，可促进E2F1的转录[3]。

相互作用 编辑

E2F1与下列蛋白具有相互作用：NCOA6[4]、视网膜母细胞瘤样蛋白1[5]、视网膜母细胞瘤蛋白[5][6][7][8][9][10][11]、GTF2H1[12]、SKP2[13] PURA,[14]、NPDC1[15]、Sp2转录因子[16]、Sp1转录因子[16][17][18]、CUL1[13] ARID3A,[19]、TOPBP1[20][21]、周期蛋白A1[22]、TP53BP1[8]、周期蛋白A2[23]、Sp4转录因子[16]、Sp3转录因子[16]、抗增殖蛋白[24][25][26][27]、NDN[11][28]、MDM4[29] TFDP1[10][19][30][31]及泛素C[32]。

另见 编辑

参考文献 编辑

  1. ^ Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG Jr. Structure and partial genomic sequence of the human E2F1 gene. Gene. December 1996, 173 (2): 163–9. PMID 8964493. doi:10.1016/0378-1119(96)00184-9. 
  2. ^ Entrez Gene: E2F1 E2F transcription factor 1. （原始内容于2019-10-16）. 
  3. ^ Li, C G; Nyman, J E; Braithwaite, A W; Eccles, M R. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011, 30 (48): 4824–4834. ISSN 0950-9232. doi:10.1038/onc.2011.190. 
  4. ^ Kong, Hee Jeong; Yu Hyun Jung, Hong SunHwa, Park Min Jung, Choi Young Hyun, An Won Gun, Lee Jae Woon, Cheong JaeHun. Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation. Mol. Cancer Res. (United States). November 2003, 1 (13): 948–58. ISSN 1541-7786. PMID 14638867. 
  5. ^ 5.0 5.1 Dyson, N; Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. (UNITED STATES). December 1993, 67 (12): 7641–7. ISSN 0022-538X. PMC 238233  . PMID 8230483. 
  6. ^ Nicolas, E; Ait-Si-Ali S, Trouche D. The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res. (England). August 2001, 29 (15): 3131–6. PMC 55834  . PMID 11470869. doi:10.1093/nar/29.15.3131. 
  7. ^ Pardo, Patricia S; Leung James K, Lucchesi John C, Pereira-Smith Olivia M. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J. Biol. Chem. (United States). December 2002, 277 (52): 50860–6. ISSN 0021-9258. PMID 12397079. doi:10.1074/jbc.M203839200. 
  8. ^ 8.0 8.1 Choubey, D; Li S J, Datta B, Gutterman J U, Lengyel P. Inhibition of E2F-mediated transcription by p202. EMBO J. (ENGLAND). October 1996, 15 (20): 5668–78. ISSN 0261-4189. PMC 452311  . PMID 8896460. 
  9. ^ Fajas, L; Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais M L, Sardet C. pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). July 2000, 97 (14): 7738–43. ISSN 0027-8424. PMC 16614  . PMID 10869426. doi:10.1073/pnas.130198397. 
  10. ^ 10.0 10.1 Wu, C L; Zukerberg L R, Ngwu C, Harlow E, Lees J A. In vivo association of E2F and DP family proteins. Mol. Cell. Biol. (UNITED STATES). May 1995, 15 (5): 2536–46. ISSN 0270-7306. PMC 230484  . PMID 7739537. 
  11. ^ 11.0 11.1 Taniura, H; Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1. J. Biol. Chem. (UNITED STATES). January 1998, 273 (2): 720–8. ISSN 0021-9258. PMID 9422723. doi:10.1074/jbc.273.2.720. 
  12. ^ Vandel, L; Kouzarides T. Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase. EMBO J. (ENGLAND). August 1999, 18 (15): 4280–91. ISSN 0261-4189. PMC 1171504  . PMID 10428966. doi:10.1093/emboj/18.15.4280. 
  13. ^ 13.0 13.1 Marti, A; Wirbelauer C, Scheffner M, Krek W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat. Cell Biol. (ENGLAND). May 1999, 1 (1): 14–9. ISSN 1465-7392. PMID 10559858. doi:10.1038/8984. 
  14. ^ Darbinian, N; Gallia G L, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K. Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene (ENGLAND). November 1999, 18 (46): 6398–402. ISSN 0950-9232. PMID 10597240. doi:10.1038/sj.onc.1203011. 
  15. ^ Sansal, I; Dupont E, Toru D, Evrard C, Rouget P. NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity. Oncogene (ENGLAND). October 2000, 19 (43): 5000–9. ISSN 0950-9232. PMID 11042687. doi:10.1038/sj.onc.1203843. 
  16. ^ 16.0 16.1 16.2 16.3 Rotheneder, H; Geymayer S, Haidweger E. Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. J. Mol. Biol. (ENGLAND). November 1999, 293 (5): 1005–15. ISSN 0022-2836. PMID 10547281. doi:10.1006/jmbi.1999.3213. 
  17. ^ Lin, S Y; Black A R, Kostic D, Pajovic S, Hoover C N, Azizkhan J C. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1668–75. ISSN 0270-7306. PMC 231153  . PMID 8657142. 
  18. ^ Karlseder, J; Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol. Cell. Biol. (UNITED STATES). April 1996, 16 (4): 1659–67. ISSN 0270-7306. PMC 231152  . PMID 8657141. 
  19. ^ 19.0 19.1 Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K. A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. Oncogene (ENGLAND). August 1998, 17 (7): 853–65. ISSN 0950-9232. PMID 9780002. doi:10.1038/sj.onc.1202163. 
  20. ^ Liu, Kang; Lin Fang-Tsyr, Ruppert J Michael, Lin Weei-Chin. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol. Cell. Biol. (United States). May 2003, 23 (9): 3287–304. ISSN 0270-7306. PMC 153207  . PMID 12697828. doi:10.1128/MCB.23.9.3287-3304.2003. 
  21. ^ Yu, Xiaochun; Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie. The BRCT domain is a phospho-protein binding domain. Science (United States). October 2003, 302 (5645): 639–42. PMID 14576433. doi:10.1126/science.1088753. 
  22. ^ Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032  . PMID 10022926. 
  23. ^ Xu, M; Sheppard K A, Peng C Y, Yee A S, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. (UNITED STATES). December 1994, 14 (12): 8420–31. ISSN 0270-7306. PMC 359381  . PMID 7969176. 
  24. ^ Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P. A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochem. Biophys. Res. Commun. (United States). December 2003, 312 (2): 459–66. ISSN 0006-291X. PMID 14637159. doi:10.1016/j.bbrc.2003.10.148. 
  25. ^ Fusaro, Gina; Dasgupta Piyali, Rastogi Shipra, Joshi Bharat, Chellappan Srikumar. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J. Biol. Chem. (United States). November 2003, 278 (48): 47853–61. ISSN 0021-9258. PMID 14500729. doi:10.1074/jbc.M305171200. 
  26. ^ Wang, Sheng; Zhang Baohua, Faller Douglas V. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. (England). June 2002, 21 (12): 3019–28. ISSN 0261-4189. PMC 126057  . PMID 12065415. doi:10.1093/emboj/cdf302. 
  27. ^ Wang, S; Nath N, Fusaro G, Chellappan S. Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Mol. Cell. Biol. (UNITED STATES). November 1999, 19 (11): 7447–60. ISSN 0270-7306. PMC 84738  . PMID 10523633. 
  28. ^ Kuwako, Ken-ichiro; Taniura Hideo, Yoshikawa Kazuaki. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J. Biol. Chem. (United States). January 2004, 279 (3): 1703–12. ISSN 0021-9258. PMID 14593116. doi:10.1074/jbc.M308454200. 
  29. ^ Strachan, Gordon D; Jordan-Sciutto Kelly L, Rallapalli Ravikumar, Tuan Rocky S, Hall David J. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J. Cell. Biochem. (United States). February 2003, 88 (3): 557–68. ISSN 0730-2312. PMID 12532331. doi:10.1002/jcb.10318. 
  30. ^ Sardet, C; Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg R A. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). March 1995, 92 (6): 2403–7. ISSN 0027-8424. PMC 42492  . PMID 7892279. doi:10.1073/pnas.92.6.2403. 
  31. ^ Helin, K; Wu C L, Fattaey A R, Lees J A, Dynlacht B D, Ngwu C, Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. (UNITED STATES). October 1993, 7 (10): 1850–61. ISSN 0890-9369. PMID 8405995. doi:10.1101/gad.7.10.1850. 
  32. ^ Zhou, Fangfang; Zhang Long, Wang Aijun, Song Bo, Gong Kai, Zhang Lihai, Hu Min, Zhang Xiufang, Zhao Nanming, Gong Yandao. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J. Biol. Chem. (United States). May 2008, 283 (21): 14506–15. ISSN 0021-9258. PMID 18367454. doi:10.1074/jbc.M706136200. 

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells.[永久失效連結]

深入阅读 编辑

  • Dupont E, Sansal I, Toru D; et al. [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]. C. R. Seances Soc. Biol. Fil. 1997, 191 (1): 95–104. PMID 9181131. 
  • Stevens C, La Thangue NB. The emerging role of E2F-1 in the DNA damage response and checkpoint control.. DNA Repair (Amst.). 2005, 3 (8-9): 1071–9. PMID 15279795. doi:10.1016/j.dnarep.2004.03.034. 
  • Zhang Z, Wang H, Li M; et al. Novel MDM2 p53-independent functions identified through RNA silencing technologies.. Ann. N. Y. Acad. Sci. 2006, 1058 (1): 205–14. PMID 16394138. doi:10.1196/annals.1359.030. 
  • Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G. PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells. Mol. Carcinog. July 2009, 48 (12): 1149–58. PMID 19603422. doi:10.1002/mc.20569. 

外部链接 编辑

E2F1引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

四月 07, 2024
e2f1, 转录因子是由人类基因编码出的蛋白质, transcription, factor, 1pdb, rendering, based, 2aze, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1h24, 1o9k, 2aze标识代号, rbap1, rbbp3, rbp3扩展标识遗传学, 189971, 鼠基因, 101941, 同源基因, 3828, chembl, 4382, genecards, gene基因本体论描述分子功能, core, promoter, bindin. 转录因子E2F1是由人类E2F1基因编码出的蛋白质 1 E2F transcription factor 1PDB rendering based on 2aze 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1H24 1O9K 2AZE标识代号E2F1 E2F 1 RBAP1 RBBP3 RBP3扩展标识遗传学 189971 鼠基因 101941 同源基因 3828 ChEMBL 4382 GeneCards E2F1 Gene基因本体论描述分子功能 core promoter binding DNA binding sequence specific DNA binding transcription factor activity transcription corepressor activity protein binding transcription factor binding sequence specific DNA binding细胞成分 nucleus nucleoplasm cytoplasm Rb E2F complex生物过程 DNA damage checkpoint G1 phase of mitotic cell cycle G1 S transition of mitotic cell cycle G2 phase of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter mitotic cell cycle transcription DNA dependent regulation of transcription DNA dependent apoptotic process spermatogenesis cell proliferation positive regulation of gene expression forebrain development negative regulation of transcription DNA dependent positive regulation of transcription DNA dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation mRNA stabilization cellular response to fatty acid cellular response to hypoxia negative regulation of transcription involved in G1 S phase of mitotic cell cycle regulation of G1 S transition of mitotic cell cycleSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez186913555EnsemblENSG00000101412ENSMUSG00000027490UniProtQ01094Q61501mRNA序列NM 005225NM 007891蛋白序列NP 005216NP 031917基因位置Chr 20 32 26 32 27 MbChr 2 154 56 154 57 MbPubMed查询 1 2 查论编该基因编码出的蛋白质是E2F转录因子家族中的成员 E2F家族在控制细胞周期及抑癌基因功能上起到重要作用 也是小DNA致癌病毒转化蛋白的靶点 E2F家族中的多个成员蛋白包含许多进化保守的结构域 这些结构域包括 DNA结合域 与受分化调控的转录因子蛋白 DP 之间相互作用的二聚化结构域 富含酸性氨基酸的转活化结构域以及位于转活化结构域中的抑癌蛋白关联结构域 该蛋白与其他两个成员E2F2及E2F3具有额外的周期蛋白结合结构域 该蛋白以细胞周期依赖性的模式优先与视网膜母细胞瘤蛋白pRB结合 它可以同时介导细胞增殖及p53 依赖 非依赖的细胞凋亡 2 目录 1 转录 2 相互作用 3 另见 4 参考文献 5 深入阅读 6 外部链接转录 编辑E2F1的启动子区有PAX8转录因子的结合序列 可促进E2F1的转录 3 相互作用 编辑E2F1与下列蛋白具有相互作用 NCOA6 4 视网膜母细胞瘤样蛋白1 5 视网膜母细胞瘤蛋白 5 6 7 8 9 10 11 GTF2H1 12 SKP2 13 PURA 14 NPDC1 15 Sp2转录因子 16 Sp1转录因子 16 17 18 CUL1 13 ARID3A 19 TOPBP1 20 21 周期蛋白A1 22 TP53BP1 8 周期蛋白A2 23 Sp4转录因子 16 Sp3转录因子 16 抗增殖蛋白 24 25 26 27 NDN 11 28 MDM4 29 TFDP1 10 19 30 31 及泛素C 32 另见 编辑E2F 视网膜母细胞瘤蛋白参考文献 编辑 Neuman E Sellers WR McNeil JA Lawrence JB Kaelin WG Jr Structure and partial genomic sequence of the human E2F1 gene Gene December 1996 173 2 163 9 PMID 8964493 doi 10 1016 0378 1119 96 00184 9 Entrez Gene E2F1 E2F transcription factor 1 原始内容存档于2019 10 16 Li C G Nyman J E Braithwaite A W Eccles M R PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein Oncogene 2011 30 48 4824 4834 ISSN 0950 9232 doi 10 1038 onc 2011 190 Kong Hee Jeong Yu Hyun Jung Hong SunHwa Park Min Jung Choi Young Hyun An Won Gun Lee Jae Woon Cheong JaeHun Interaction and functional cooperation of the cancer amplified transcriptional coactivator activating signal cointegrator 2 and E2F 1 in cell proliferation Mol Cancer Res United States November 2003 1 13 948 58 ISSN 1541 7786 PMID 14638867 引文使用过时参数coauthors 帮助 5 0 5 1 Dyson N Dembski M Fattaey A Ngwu C Ewen M Helin K Analysis of p107 associated proteins p107 associates with a form of E2F that differs from pRB associated E2F 1 J Virol UNITED STATES December 1993 67 12 7641 7 ISSN 0022 538X PMC 238233 nbsp PMID 8230483 引文使用过时参数coauthors 帮助 Nicolas E Ait Si Ali S Trouche D The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein Nucleic Acids Res England August 2001 29 15 3131 6 PMC 55834 nbsp PMID 11470869 doi 10 1093 nar 29 15 3131 引文使用过时参数coauthors 帮助 Pardo Patricia S Leung James K Lucchesi John C Pereira Smith Olivia M MRG15 a novel chromodomain protein is present in two distinct multiprotein complexes involved in transcriptional activation J Biol Chem United States December 2002 277 52 50860 6 ISSN 0021 9258 PMID 12397079 doi 10 1074 jbc M203839200 引文使用过时参数coauthors 帮助 8 0 8 1 Choubey D Li S J Datta B Gutterman J U Lengyel P Inhibition of E2F mediated transcription by p202 EMBO J ENGLAND October 1996 15 20 5668 78 ISSN 0261 4189 PMC 452311 nbsp PMID 8896460 引文使用过时参数coauthors 帮助 Fajas L Paul C Zugasti O Le Cam L Polanowska J Fabbrizio E Medema R Vignais M L Sardet C pRB binds to and modulates the transrepressing activity of the E1A regulated transcription factor p120E4F Proc Natl Acad Sci U S A UNITED STATES July 2000 97 14 7738 43 ISSN 0027 8424 PMC 16614 nbsp PMID 10869426 doi 10 1073 pnas 130198397 引文使用过时参数coauthors 帮助 10 0 10 1 Wu C L Zukerberg L R Ngwu C Harlow E Lees J A In vivo association of E2F and DP family proteins Mol Cell Biol UNITED STATES May 1995 15 5 2536 46 ISSN 0270 7306 PMC 230484 nbsp PMID 7739537 引文使用过时参数coauthors 帮助 11 0 11 1 Taniura H Taniguchi N Hara M Yoshikawa K Necdin a postmitotic neuron specific growth suppressor interacts with viral transforming proteins and cellular transcription factor E2F1 J Biol Chem UNITED STATES January 1998 273 2 720 8 ISSN 0021 9258 PMID 9422723 doi 10 1074 jbc 273 2 720 引文使用过时参数coauthors 帮助 Vandel L Kouzarides T Residues phosphorylated by TFIIH are required for E2F 1 degradation during S phase EMBO J ENGLAND August 1999 18 15 4280 91 ISSN 0261 4189 PMC 1171504 nbsp PMID 10428966 doi 10 1093 emboj 18 15 4280 引文使用过时参数coauthors 帮助 13 0 13 1 Marti A Wirbelauer C Scheffner M Krek W Interaction between ubiquitin protein ligase SCFSKP2 and E2F 1 underlies the regulation of E2F 1 degradation Nat Cell Biol ENGLAND May 1999 1 1 14 9 ISSN 1465 7392 PMID 10559858 doi 10 1038 8984 引文使用过时参数coauthors 帮助 Darbinian N Gallia G L Kundu M Shcherbik N Tretiakova A Giordano A Khalili K Association of Pur alpha and E2F 1 suppresses transcriptional activity of E2F 1 Oncogene ENGLAND November 1999 18 46 6398 402 ISSN 0950 9232 PMID 10597240 doi 10 1038 sj onc 1203011 引文使用过时参数coauthors 帮助 Sansal I Dupont E Toru D Evrard C Rouget P NPDC 1 a regulator of neural cell proliferation and differentiation interacts with E2F 1 reduces its binding to DNA and modulates its transcriptional activity Oncogene ENGLAND October 2000 19 43 5000 9 ISSN 0950 9232 PMID 11042687 doi 10 1038 sj onc 1203843 引文使用过时参数coauthors 帮助 16 0 16 1 16 2 16 3 Rotheneder H Geymayer S Haidweger E Transcription factors of the Sp1 family interaction with E2F and regulation of the murine thymidine kinase promoter J Mol Biol ENGLAND November 1999 293 5 1005 15 ISSN 0022 2836 PMID 10547281 doi 10 1006 jmbi 1999 3213 引文使用过时参数coauthors 帮助 Lin S Y Black A R Kostic D Pajovic S Hoover C N Azizkhan J C Cell cycle regulated association of E2F1 and Sp1 is related to their functional interaction Mol Cell Biol UNITED STATES April 1996 16 4 1668 75 ISSN 0270 7306 PMC 231153 nbsp PMID 8657142 引文使用过时参数coauthors 帮助 Karlseder J Rotheneder H Wintersberger E Interaction of Sp1 with the growth and cell cycle regulated transcription factor E2F Mol Cell Biol UNITED STATES April 1996 16 4 1659 67 ISSN 0270 7306 PMC 231152 nbsp PMID 8657141 引文使用过时参数coauthors 帮助 19 0 19 1 Suzuki M Okuyama S Okamoto S Shirasuna K Nakajima T Hachiya T Nojima H Sekiya S Oda K A novel E2F binding protein with Myc type HLH motif stimulates E2F dependent transcription by forming a heterodimer Oncogene ENGLAND August 1998 17 7 853 65 ISSN 0950 9232 PMID 9780002 doi 10 1038 sj onc 1202163 引文使用过时参数coauthors 帮助 Liu Kang Lin Fang Tsyr Ruppert J Michael Lin Weei Chin Regulation of E2F1 by BRCT domain containing protein TopBP1 Mol Cell Biol United States May 2003 23 9 3287 304 ISSN 0270 7306 PMC 153207 nbsp PMID 12697828 doi 10 1128 MCB 23 9 3287 3304 2003 引文使用过时参数coauthors 帮助 Yu Xiaochun Chini Claudia Christiano Silva He Miao Mer Georges Chen Junjie The BRCT domain is a phospho protein binding domain Science United States October 2003 302 5645 639 42 PMID 14576433 doi 10 1126 science 1088753 引文使用过时参数coauthors 帮助 Yang R Muller C Huynh V Fung Y K Yee A S Koeffler H P Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F 1 and the Rb family of proteins Mol Cell Biol UNITED STATES March 1999 19 3 2400 7 ISSN 0270 7306 PMC 84032 nbsp PMID 10022926 引文使用过时参数coauthors 帮助 Xu M Sheppard K A Peng C Y Yee A S Piwnica Worms H Cyclin A CDK2 binds directly to E2F 1 and inhibits the DNA binding activity of E2F 1 DP 1 by phosphorylation Mol Cell Biol UNITED STATES December 1994 14 12 8420 31 ISSN 0270 7306 PMC 359381 nbsp PMID 7969176 引文使用过时参数coauthors 帮助 Joshi Bharat Ko Danette Ordonez Ercan Dalia Chellappan Srikumar P A putative coiled coil domain of prohibitin is sufficient to repress E2F1 mediated transcription and induce apoptosis Biochem Biophys Res Commun United States December 2003 312 2 459 66 ISSN 0006 291X PMID 14637159 doi 10 1016 j bbrc 2003 10 148 引文使用过时参数coauthors 帮助 Fusaro Gina Dasgupta Piyali Rastogi Shipra Joshi Bharat Chellappan Srikumar Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling J Biol Chem United States November 2003 278 48 47853 61 ISSN 0021 9258 PMID 14500729 doi 10 1074 jbc M305171200 引文使用过时参数coauthors 帮助 Wang Sheng Zhang Baohua Faller Douglas V Prohibitin requires Brg 1 and Brm for the repression of E2F and cell growth EMBO J England June 2002 21 12 3019 28 ISSN 0261 4189 PMC 126057 nbsp PMID 12065415 doi 10 1093 emboj cdf302 引文使用过时参数coauthors 帮助 Wang S Nath N Fusaro G Chellappan S Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals Mol Cell Biol UNITED STATES November 1999 19 11 7447 60 ISSN 0270 7306 PMC 84738 nbsp PMID 10523633 引文使用过时参数coauthors 帮助 Kuwako Ken ichiro Taniura Hideo Yoshikawa Kazuaki Necdin related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor J Biol Chem United States January 2004 279 3 1703 12 ISSN 0021 9258 PMID 14593116 doi 10 1074 jbc M308454200 引文使用过时参数coauthors 帮助 Strachan Gordon D Jordan Sciutto Kelly L Rallapalli Ravikumar Tuan Rocky S Hall David J The E2F 1 transcription factor is negatively regulated by its interaction with the MDMX protein J Cell Biochem United States February 2003 88 3 557 68 ISSN 0730 2312 PMID 12532331 doi 10 1002 jcb 10318 引文使用过时参数coauthors 帮助 Sardet C Vidal M Cobrinik D Geng Y Onufryk C Chen A Weinberg R A E2F 4 and E2F 5 two members of the E2F family are expressed in the early phases of the cell cycle Proc Natl Acad Sci U S A UNITED STATES March 1995 92 6 2403 7 ISSN 0027 8424 PMC 42492 nbsp PMID 7892279 doi 10 1073 pnas 92 6 2403 引文使用过时参数coauthors 帮助 Helin K Wu C L Fattaey A R Lees J A Dynlacht B D Ngwu C Harlow E Heterodimerization of the transcription factors E2F 1 and DP 1 leads to cooperative trans activation Genes Dev UNITED STATES October 1993 7 10 1850 61 ISSN 0890 9369 PMID 8405995 doi 10 1101 gad 7 10 1850 引文使用过时参数coauthors 帮助 Zhou Fangfang Zhang Long Wang Aijun Song Bo Gong Kai Zhang Lihai Hu Min Zhang Xiufang Zhao Nanming Gong Yandao The association of GSK3 beta with E2F1 facilitates nerve growth factor induced neural cell differentiation J Biol Chem United States May 2008 283 21 14506 15 ISSN 0021 9258 PMID 18367454 doi 10 1074 jbc M706136200 引文使用过时参数coauthors 帮助 PI3K signaling maintains c myc expression to regulate transcription of E2F1 in pancreatic cancer cells 永久失效連結 深入阅读 编辑Dupont E Sansal I Toru D et al Identification of NPDC 1 gene involved in the control of proliferation and differentiation of neural and glial precursors C R Seances Soc Biol Fil 1997 191 1 95 104 PMID 9181131 引文格式1维护 显式使用等标签 link Stevens C La Thangue NB The emerging role of E2F 1 in the DNA damage response and checkpoint control DNA Repair Amst 2005 3 8 9 1071 9 PMID 15279795 doi 10 1016 j dnarep 2004 03 034 Zhang Z Wang H Li M et al Novel MDM2 p53 independent functions identified through RNA silencing technologies Ann N Y Acad Sci 2006 1058 1 205 14 PMID 16394138 doi 10 1196 annals 1359 030 引文格式1维护 显式使用等标签 link Schild C Wirth M Reichert M Schmid RM Saur D Schneider G PI3K signaling maintains c myc expression to regulate transcription of E2F1 in pancreatic cancer cells Mol Carcinog July 2009 48 12 1149 58 PMID 19603422 doi 10 1002 mc 20569 外部链接 编辑醫學主題詞表 MeSH E2F1 protein human FactorBook E2F1E2F1引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title E2F1 amp oldid 69716717, 维基百科，wiki，书籍，书籍，图书馆，

文章

，阅读，下载，免费，免费下载，mp3，视频，mp4，3gp， jpg，jpeg，gif，png，图片，音乐，歌曲，电影，书籍，游戏，游戏。