• bone mineralization • response to vitamin D • calcium ion homeostasis • response to interferon-gamma • vitamin D metabolic process • regulation of bone mineralization • positive regulation of keratinocyte differentiation • G1 to G0 transition • response to estrogen • response to lipopolysaccharide • negative regulation of calcidiol 1-monooxygenase activity • 蛻膜化 • vitamin metabolic process • negative regulation of cell growth • calcitriol biosynthetic process from calciol • positive regulation of vitamin D 24-hydroxylase activity • vitamin D catabolic process • positive regulation of vitamin D receptor signaling pathway • calcium ion transport • negative regulation of cell population proliferation
^Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S. 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science. Sep 1997, 277 (5333): 1827–30. PMID 9295274. doi:10.1126/science.277.5333.1827.
^Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T. Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase. Biochemical and Biophysical Research Communications. Oct 1997, 239 (2): 527–33. PMID 9344864. doi:10.1006/bbrc.1997.7508.
^Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. (PDF). Nature Immunology. Mar 2007, 8 (3): 285–93 [2020-04-30]. PMID 17259988. doi:10.1038/ni1433. （原始内容 (PDF)存档于2020-03-19）.
^Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ. Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption. Endocrinology. Oct 2010, 151 (10): 4613–25. PMID 20739402. doi:10.1210/en.2010-0334.
^Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties. The Journal of Biological Chemistry. Dec 1972, 247 (23): 7528–32. PMID 4404596. doi:10.1016/S0021-9258(19)44557-2.
外部链接编辑
GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis（页面存档备份，存于互联网档案馆）
Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
九月 28, 2023
cyp27b1, 细胞色素, p450, 27b1, 英語, cytochrome, p450, 27b1, 缩写, 也被称为25, 羟基维生素, 羟化酶, hydroxyvitamin, alpha, hydroxylase, 是细胞色素p450超家族的一员, 由基因编码, 定位于线粒体内膜, 在许多组织细胞中表达, 如腎的近曲小管, 英语, proximal, tubule, 皮肤角质形成细胞, 免疫细胞, 成骨细胞等, 催化骨化二醇羟基化生成骨化三醇, 维生素d的活性形式, 羥基維生素d3, 羥化酶識別號别名. 细胞色素 P450 27B1 英語 Cytochrome P450 27B1 缩写CYP27B1 也被称为25 羟基维生素 D3 1 a 羟化酶 25 Hydroxyvitamin D3 1 alpha hydroxylase EC 1 14 15 18 是细胞色素P450超家族的一员 由CYP27B1基因编码 定位于线粒体内膜 6 7 8 在许多组织细胞中表达 如腎的近曲小管 英语 Proximal tubule 皮肤角质形成细胞 免疫细胞 9 成骨细胞等 10 催化骨化二醇羟基化生成骨化三醇 维生素D的活性形式 11 25 羥基維生素D3 1 a 羥化酶識別號别名CYP27B1 CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR cytochrome P450 family 27 subfamily B member 1外部IDOMIM 609506 MGI 1098274 HomoloGene 37139 GeneCards CYP27B1EC number1 14 15 18相關疾病1 alpha hydroxylase deficiency 1 基因位置 人类 染色体12號染色體 2 基因座12q14 1起始57 762 334 bp 2 终止57 768 986 bp 2 基因位置 小鼠 染色体小鼠10号染色体 3 基因座10 10 D3起始126 884 119 bp 3 终止126 888 875 bp 3 基因本體分子功能 iron ion binding 金屬離子結合 monooxygenase activity heme binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen oxidoreductase activity calcidiol 1 monooxygenase activity細胞組分 細胞質 膜 mitochondrial membrane mitochondrial outer membrane 線粒體生物學過程 bone mineralization response to vitamin D calcium ion homeostasis response to interferon gamma vitamin D metabolic process regulation of bone mineralization positive regulation of keratinocyte differentiation G1 to G0 transition response to estrogen response to lipopolysaccharide negative regulation of calcidiol 1 monooxygenase activity 蛻膜化 vitamin metabolic process negative regulation of cell growth calcitriol biosynthetic process from calciol positive regulation of vitamin D 24 hydroxylase activity vitamin D catabolic process positive regulation of vitamin D receptor signaling pathway calcium ion transport negative regulation of cell population proliferationSources Amigo QuickGO直系同源物種人類小鼠Entrez159413115EnsemblENSG00000111012ENSMUSG00000006724UniProtO15528O35084mRNA 序列NM 000785NM 010009蛋白序列NP 000776NP 034139基因位置 UCSC Chr 12 57 76 57 77 MbChr 10 126 88 126 89 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠 骨化二醇 2 还原型 Adx 2 H O2 骨化三醇 2 氧化型 Adx H2O骨化二醇 骨化三醇calcidiol 1 monooxygenase命名系统命名缩写识别码EC編號 1 14 15 18CAS号 9081 36 1数据库IntEnz IntEnz浏览BRENDA 英语 BRENDA BRENDA入口ExPASy 英语 ExPASy NiceZyme浏览KEGG KEGG入口MetaCyc 英语 MetaCyc 代谢路径PRIAM 英语 PRIAM enzyme specific profiles 概述PDB RCSB PDB PDBj PDBe PDBsum基因本体 AmiGO EGO搜索PMC 相关文献PubMed 相关文献参考文献 编辑 與25 羥基維生素D3 1 a 羥化酶相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000111012 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000006724 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene cytochrome P450 原始内容存档于2009 05 11 Takeyama K Kitanaka S Sato T Kobori M Yanagisawa J Kato S 25 Hydroxyvitamin D3 1alpha hydroxylase and vitamin D synthesis Science Sep 1997 277 5333 1827 30 PMID 9295274 doi 10 1126 science 277 5333 1827 Monkawa T Yoshida T Wakino S Shinki T Anazawa H Deluca HF Suda T Hayashi M Saruta T Molecular cloning of cDNA and genomic DNA for human 25 hydroxyvitamin D3 1 alpha hydroxylase Biochemical and Biophysical Research Communications Oct 1997 239 2 527 33 PMID 9344864 doi 10 1006 bbrc 1997 7508 Sigmundsdottir H Pan J Debes GF Alt C Habtezion A Soler D Butcher EC DCs metabolize sunlight induced vitamin D3 to program T cell attraction to the epidermal chemokine CCL27 PDF Nature Immunology Mar 2007 8 3 285 93 2020 04 30 PMID 17259988 doi 10 1038 ni1433 原始内容 PDF 存档于2020 03 19 Kogawa M Findlay DM Anderson PH Ormsby R Vincent C Morris HA Atkins GJ Osteoclastic metabolism of 25 OH vitamin D3 a potential mechanism for optimization of bone resorption Endocrinology Oct 2010 151 10 4613 25 PMID 20739402 doi 10 1210 en 2010 0334 nbsp Gray RW Omdahl JL Ghazarian JG DeLuca HF 25 Hydroxycholecalciferol 1 hydroxylase Subcellular location and properties The Journal of Biological Chemistry Dec 1972 247 23 7528 32 PMID 4404596 doi 10 1016 S0021 9258 19 44557 2 外部链接 编辑GeneReviews NCBI NIH UW entry on Cerebrotendinous Xanthomatosis 页面存档备份 存于互联网档案馆 醫學主題詞表 MeSH Cytochrome P 450 CYP27A1 Human CYP27A1 genome location and CYP27A1 gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser 取自 https zh wikipedia org w index php title CYP27B1 amp oldid 75599589, 维基百科，wiki，书籍，书籍，图书馆，
