^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000026508 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000005087 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Spring FA, Dalchau R, Daniels GL, Mallinson G, Judson PA, Parsons SF, Fabre JW, Anstee DJ. The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene. Immunology. May 1988, 64 (1): 37–43. PMC 1385183. PMID 2454887.
^ 7.07.1Morath, I.; Hartmann, T.N.; Orian-Rousseau, V. CD44: More than a mere stem cell marker. The International Journal of Biochemistry & Cell Biology. 2016, 81: 166–173. ISSN 1357-2725. doi:10.1016/j.biocel.2016.09.009.
^Senbanjo, Linda T.; Chellaiah, Meenakshi A. CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Frontiers in Cell and Developmental Biology. 2017, 5. ISSN 2296-634X. doi:10.3389/fcell.2017.00018.
^Naor, David; Sionov, Ronit Vogt; Ish-Shalom, Dvorah. CD44: Structure, Function and Association with the Malignant Process 71: 241–319. 1997. ISSN 0065-230X. doi:10.1016/S0065-230X(08)60101-3.
^Telen MJ, Udani M, Washington MK, Levesque MC, Lloyd E, Rao N. A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J. Biol. Chem. March 1996, 271 (12): 7147–53. PMID 8636151. doi:10.1074/jbc.271.12.7147.
十月 20, 2023
cd44, 在人體內是一種由11號染色體上的基因編碼的細胞表面黏附分子, 化學本質是糖蛋白, 屬於一類分化簇, 是一種常用的幹細胞表面標記物, 同時在人體內也參與淋巴細胞活化, 循環, 以及歸巢, 惡性腫瘤的發生及轉移等過程, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1poz, 1uuh, 2i83, 4pz3, 4pz4識別號别名, cdw44, cspg8, ecmr, hcell, hutch, mc56, mdu2, mdu3, mic4, pgp1, molecule, indi. CD44 在人體內是一種由11號染色體上的CD44基因編碼的細胞表面黏附分子 化學本質是糖蛋白 屬於一類分化簇 CD 5 6 CD44是一種常用的幹細胞表面標記物 同時在人體內也參與淋巴細胞活化 循環 以及歸巢 惡性腫瘤的發生及轉移等過程 7 6 CD44已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1POZ 1UUH 2I83 4PZ3 4PZ4識別號别名CD44 CDW44 CSPG8 ECMR III HCELL HUTCH I IN LHR MC56 MDU2 MDU3 MIC4 Pgp1 CD44 molecule Indian blood group 外部IDOMIM 107269 MGI 88338 HomoloGene 508 GeneCards CD44基因位置 人类 染色体11號染色體 1 基因座11p13起始35 138 882 bp 1 终止35 232 402 bp 1 基因位置 小鼠 染色体小鼠2号染色体 2 基因座2 E2 2 54 13 cM起始102 641 486 bp 2 终止102 732 010 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 collagen binding 血浆蛋白结合 hyaluronic acid binding cytokine receptor activity transmembrane signaling receptor activity細胞組分 integral component of membrane 高尔基体 macrophage migration inhibitory factor receptor complex 膜 粘着斑 细胞膜 integral component of plasma membrane cell surface 外排體 细胞质基质 secretory granule membrane apical plasma membrane lamellipodium membrane cell projection 微绒毛 basolateral plasma membrane生物學過程 negative regulation of cysteine type endopeptidase activity involved in apoptotic process monocyte aggregation positive regulation of heterotypic cell cell adhesion hyaluronan catabolic process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator interferon gamma mediated signaling pathway extracellular matrix disassembly extracellular matrix organization negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of peptidyl serine phosphorylation 軟骨生成 細胞粘附 negative regulation of DNA damage response signal transduction by p53 class mediator positive regulation of ERK1 and ERK2 cascade positive regulation of peptidyl tyrosine phosphorylation cell matrix adhesion positive regulation of monocyte aggregation leukocyte migration neutrophil degranulation wound healing spreading of cells regulation of lamellipodium morphogenesis cell cell adhesion inflammatory response 细胞迁移 T细胞活化 positive regulation of kinase activitySources Amigo QuickGO直系同源物種人類小鼠Entrez96012505EnsemblENSG00000026508ENSMUSG00000005087UniProtP16070P15379mRNA 序列 NM 000610 NM 001001389 NM 001001390 NM 001001391 NM 001001392 NM 001202555 NM 001202556 NM 001202557NM 001039150 NM 001039151 NM 001177785 NM 001177786 NM 001177787 NM 009851蛋白序列NP 000601 NP 001001389 NP 001001390 NP 001001391 NP 001001392 NP 001189484 NP 001189485 NP 001189486NP 001034239 NP 001034240 NP 001171256 NP 001171257 NP 001171258 NP 033981基因位置 UCSC Chr 11 35 14 35 23 MbChr 2 102 64 102 73 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 遺傳學與分子生物學 2 應用 3 參見 4 參考遺傳學與分子生物學 编辑CD44的基因位於人11號染色體上 具有可變剪接現象 已有研究證明 不同轉錄本轉譯的CD44具有不同的功能 分子量從85到200kD不等 其中最經典的標準CD44分子 sCD44 是從造血細胞中分離出來的 分子量約爲85 90kD 由外顯子1 5和16 20組合而成 CD44分子在人體內廣泛分佈 並參與許多生物學過程 比如淋巴細胞的活化 再循環 recirculation 以及歸巢 homing 造血過程 惡性腫瘤的發生與轉移等 8 6 9 CD44蛋白由一條肽鏈組成 膜外結構域位於肽鏈一端 一個膜側翼區與之相連 另有一個穿膜結構域和一個位於細胞膜靠細胞質一側的尾部 10 應用 编辑在生物學和醫學研究中 CD44可用作幹細胞標記物 用於幹細胞的鑑定 7 許多惡性腫瘤細胞中CD44的表達上調 比如卵巢癌 11 另外 CD44可能和惡性腫瘤的發生和轉移有關 在相關過程中發揮一定的作用 比如已有證據表明CD44與頭頸鱗狀细胞癌的發展有關 6 CD44蛋白决定了人類的印度血型 英语 Indian blood group system In 12 參見 编辑分化群參考 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000026508 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000005087 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Spring FA Dalchau R Daniels GL Mallinson G Judson PA Parsons SF Fabre JW Anstee DJ The Ina and Inb blood group antigens are located on a glycoprotein of 80 000 MW the CDw44 glycoprotein whose expression is influenced by the In Lu gene Immunology May 1988 64 1 37 43 PMC 1385183 nbsp PMID 2454887 6 0 6 1 6 2 6 3 CD44 GeneCards 2018 07 09 原始内容存档于2018 07 09 7 0 7 1 Morath I Hartmann T N Orian Rousseau V CD44 More than a mere stem cell marker The International Journal of Biochemistry amp Cell Biology 2016 81 166 173 ISSN 1357 2725 doi 10 1016 j biocel 2016 09 009 CD44 NCBI 2018 07 09 原始内容存档于2018 08 20 Senbanjo Linda T Chellaiah Meenakshi A CD44 A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells Frontiers in Cell and Developmental Biology 2017 5 ISSN 2296 634X doi 10 3389 fcell 2017 00018 Naor David Sionov Ronit Vogt Ish Shalom Dvorah CD44 Structure Function and Association with the Malignant Process 71 241 319 1997 ISSN 0065 230X doi 10 1016 S0065 230X 08 60101 3 Sillanpaa S Anttila MA Voutilainen K Tammi RH Tammi MI Saarikoski SV Kosma VM CD44 expression indicates favorable prognosis in epithelial ovarian cancer Clinical Cancer Research Nov 2003 9 14 5318 24 2018 07 09 PMID 14614016 原始内容存档于2015 09 27 Telen MJ Udani M Washington MK Levesque MC Lloyd E Rao N A blood group related polymorphism of CD44 abolishes a hyaluronan binding consensus sequence without preventing hyaluronan binding J Biol Chem March 1996 271 12 7147 53 PMID 8636151 doi 10 1074 jbc 271 12 7147 取自 https zh wikipedia org w index php title CD44 amp oldid 68256662, 维基百科，wiki，书籍，书籍，图书馆，
