^Schmuck K, Ullmer C, Engels P, Lübbert H. Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Letters. Mar 1994, 342 (1): 85–90 [2017-01-24]. PMID 8143856. doi:10.1016/0014-5793(94)80590-3. （原始内容于2019-02-15）.
深入閱讀编辑
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacology & Therapeutics. 2002, 92 (2-3): 179–212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3.
Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. British Journal of Pharmacology. Jun 1995, 115 (4): 622–8. PMC 1908489. PMID 7582481. doi:10.1111/j.1476-5381.1995.tb14977.x.
Choi DS, Birraux G, Launay JM, Maroteaux L. The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Letters. Oct 1994, 352 (3): 393–9. PMID 7926008. doi:10.1016/0014-5793(94)00968-6.
Kursar JD, Nelson DL, Wainscott DB, Baez M. Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor. Molecular Pharmacology. Aug 1994, 46 (2): 227–34. PMID 8078486.
Schmuck K, Ullmer C, Engels P, Lübbert H. Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Letters. Mar 1994, 342 (1): 85–90. PMID 8143856. doi:10.1016/0014-5793(94)80590-3.
Launay JM, Birraux G, Bondoux D, Callebert J, Choi DS, Loric S, Maroteaux L. Ras involvement in signal transduction by the serotonin 5-HT2B receptor. The Journal of Biological Chemistry. Feb 1996, 271 (6): 3141–7. PMID 8621713. doi:10.1074/jbc.271.6.3141.
Le Coniat M, Choi DS, Maroteaux L, Launay JM, Berger R. The 5-HT2B receptor gene maps to 2q36.3-2q37.1. Genomics. Feb 1996, 32 (1): 172–3. PMID 8786115. doi:10.1006/geno.1996.0101.
Kim SJ, Veenstra-VanderWeele J, Hanna GL, Gonen D, Leventhal BL, Cook EH. Mutation screening of human 5-HT(2B)receptor gene in early-onset obsessive-compulsive disorder. Molecular and Cellular Probes. Feb 2000, 14 (1): 47–52. PMID 10722792. doi:10.1006/mcpr.1999.0281.
Manivet P, Mouillet-Richard S, Callebert J, Nebigil CG, Maroteaux L, Hosoda S, Kellermann O, Launay JM. PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor. The Journal of Biological Chemistry. Mar 2000, 275 (13): 9324–31. PMID 10734074. doi:10.1074/jbc.275.13.9324.
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. The Journal of Biological Chemistry. Apr 2001, 276 (16): 12974–82. PMID 11150294. doi:10.1074/jbc.M008089200.
Manivet P, Schneider B, Smith JC, Choi DS, Maroteaux L, Kellermann O, Launay JM. The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. The Journal of Biological Chemistry. May 2002, 277 (19): 17170–8. PMID 11859080. doi:10.1074/jbc.M200195200.
Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. British Journal of Pharmacology. Mar 2002, 135 (5): 1144–51. PMC 1573235. PMID 11877320. doi:10.1038/sj.bjp.0704571.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. May 2003, 22 (21): 3307–18. PMID 12761501. doi:10.1038/sj.onc.1206406.
Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J. Functional activity of serotoninergic and melatoninergic systems expressed in the skin. Journal of Cellular Physiology. Jul 2003, 196 (1): 144–53. PMID 12767050. doi:10.1002/jcp.10287.
Lin Z, Walther D, Yu XY, Drgon T, Uhl GR. The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. Pharmacogenetics. Dec 2004, 14 (12): 805–11. PMID 15608559. doi:10.1097/00008571-200412000-00003.
外部链接编辑
5-HT2B. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容于2017-02-02）.
Human HTR2B genome location and HTR2B gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
受體, 羥色胺受體2b或血清素受體2b, 英語, hydroxytryptamine, receptor, ht2b, 或serotonin, receptor, 是在人類中由htr2b基因編碼的蛋白質, ht2b是5, ht2受體家族中的成員, ht2b受體已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4nc3, 4ib4識別號别名htr2b, ht2b, hydroxytryptamine, receptor, 2b外部idomim, 601122, 109323, homologene, . 5 羥色胺受體2B或血清素受體2B 英語 5 Hydroxytryptamine receptor 2B 5 HT2B 或serotonin receptor 2B 是在人類中由HTR2B基因編碼的蛋白質 6 7 5 HT2B是5 HT2受體家族中的成員 5 HT2B受體已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4NC3 4IB4識別號别名HTR2B 5 HT 2B 5 HT2B 5 HT 2B 5 hydroxytryptamine receptor 2B外部IDOMIM 601122 MGI 109323 HomoloGene 55492 GeneCards HTR2B為以下藥物的標靶LSD 5 carboxamidotryptamine 血清素 8 OH DPAT AL 37350A a methyl 5 HT 布苯丙胺 BW 723C86 過乳降 CGS 12066A 2 5 二甲氧基 4 碘代苯丙胺 洛卡色林 MK 212 norfenfluramine Org 12962 ORG 37684 培高利特 吲哚洛尔 quinpirole quipazine ru 24969 N 3 三氟甲基苯基 哌嗪 色胺 VER 3323 brl 15572 邁克寧 又譯麥角胺 gr 127935 m chlorophenylpiperazine 甲基麦角新碱 美西麦角 sb 216641 1 naphthylpiperazine 阿戈美拉汀 阿樸嗎啡 溴隱亭 氯氮平 氟西汀 glemanserin 氟哌啶醇 酮色林 L 741 626 麥角乙脲 褪黑素 mesulergine metergoline metitepine 米塞林 seproxetine piboserod 吡貝地爾 蘿芙木 ritanserin roxindole RS 102221 RS 127445 sarpogrelate SB 204741 sb 206553 SB 242084 SB 243213 SB 277 011 A SDZ SER 082 spiperone spiramide spiroxatrine terguride 曲唑酮 volinanserin 呫诺美林 育亨宾 齐美定 1 基因位置 人类 染色体2號染色體 2 基因座2q37 1起始231 108 230 bp 2 终止231 125 042 bp 2 基因位置 小鼠 染色体小鼠1号染色体 3 基因座1 1 C5起始86 026 748 bp 3 终止86 039 692 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 G protein coupled receptor activity GTPase activator activity signal transducer activity G protein coupled serotonin receptor activity G protein alpha subunit binding serotonin binding neurotransmitter receptor activity細胞組分 細胞質 integral component of membrane 膜 细胞膜 突触 细胞连接 neuron projection integral component of plasma membrane 核质 树突生物學過程 intestine smooth muscle contraction smooth muscle contraction G protein coupled receptor internalization release of sequestered calcium ion into cytosol regulation of behavior positive regulation of endothelial cell proliferation positive regulation of MAP kinase activity 磷酸化 positive regulation of cytokine production 血管收縮 ERK1 and ERK2 cascade positive regulation of phosphatidylinositol biosynthetic process cardiac muscle hypertrophy heart morphogenesis cellular calcium ion homeostasis neural crest cell differentiation negative regulation of apoptotic process negative regulation of cell death activation of phospholipase C activity protein kinase C signaling cGMP biosynthetic process cellular response to temperature stimulus positive regulation of GTPase activity 心脏发育 positive regulation of nitric oxide synthase activity protein kinase C activating G protein coupled receptor signaling pathway embryonic morphogenesis serotonin receptor signaling pathway neural crest cell migration positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of I kappaB kinase NF kappaB signaling phosphatidylinositol 3 kinase signaling negative regulation of autophagy positive regulation of cell division calcium mediated signaling 訊息傳遞 phospholipase C activating G protein coupled receptor signaling pathway G protein coupled serotonin receptor signaling pathway G protein coupled receptor signaling pathway 动物行为 cGMP mediated signaling G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger 化学性突触传递Sources Amigo QuickGO直系同源物種人類小鼠Entrez335715559EnsemblENSG00000135914ENSMUSG00000026228UniProtP41595Q02152mRNA 序列NM 000867 NM 001320758NM 008311蛋白序列NP 000858 NP 001307687NP 032337基因位置 UCSC Chr 2 231 11 231 13 MbChr 1 86 03 86 04 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 参见 2 参考资料 3 深入閱讀 4 外部链接参见 编辑5 羟色胺受体参考资料 编辑 對5 HT2B受體起作用的藥物 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000135914 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000026228 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene HTR2B 5 hydroxytryptamine serotonin receptor 2B 原始内容存档于2019 09 18 Schmuck K Ullmer C Engels P Lubbert H Cloning and functional characterization of the human 5 HT2B serotonin receptor FEBS Letters Mar 1994 342 1 85 90 2017 01 24 PMID 8143856 doi 10 1016 0014 5793 94 80590 3 原始内容存档于2019 02 15 深入閱讀 编辑Raymond JR Mukhin YV Gelasco A Turner J Collinsworth G Gettys TW Grewal JS Garnovskaya MN Multiplicity of mechanisms of serotonin receptor signal transduction Pharmacology amp Therapeutics 2002 92 2 3 179 212 PMID 11916537 doi 10 1016 S0163 7258 01 00169 3 Bonhaus DW Bach C DeSouza A Salazar FH Matsuoka BD Zuppan P Chan HW Eglen RM The pharmacology and distribution of human 5 hydroxytryptamine2B 5 HT2B receptor gene products comparison with 5 HT2A and 5 HT2C receptors British Journal of Pharmacology Jun 1995 115 4 622 8 PMC 1908489 nbsp PMID 7582481 doi 10 1111 j 1476 5381 1995 tb14977 x Choi DS Birraux G Launay JM Maroteaux L The human serotonin 5 HT2B receptor pharmacological link between 5 HT2 and 5 HT1D receptors FEBS Letters Oct 1994 352 3 393 9 PMID 7926008 doi 10 1016 0014 5793 94 00968 6 Kursar JD Nelson DL Wainscott DB Baez M Molecular cloning functional expression and mRNA tissue distribution of the human 5 hydroxytryptamine2B receptor Molecular Pharmacology Aug 1994 46 2 227 34 PMID 8078486 Schmuck K Ullmer C Engels P Lubbert H Cloning and functional characterization of the human 5 HT2B serotonin receptor FEBS Letters Mar 1994 342 1 85 90 PMID 8143856 doi 10 1016 0014 5793 94 80590 3 Launay JM Birraux G Bondoux D Callebert J Choi DS Loric S Maroteaux L Ras involvement in signal transduction by the serotonin 5 HT2B receptor The Journal of Biological Chemistry Feb 1996 271 6 3141 7 PMID 8621713 doi 10 1074 jbc 271 6 3141 Le Coniat M Choi DS Maroteaux L Launay JM Berger R The 5 HT2B receptor gene maps to 2q36 3 2q37 1 Genomics Feb 1996 32 1 172 3 PMID 8786115 doi 10 1006 geno 1996 0101 Kim SJ Veenstra VanderWeele J Hanna GL Gonen D Leventhal BL Cook EH Mutation screening of human 5 HT 2B receptor gene in early onset obsessive compulsive disorder Molecular and Cellular Probes Feb 2000 14 1 47 52 PMID 10722792 doi 10 1006 mcpr 1999 0281 Manivet P Mouillet Richard S Callebert J Nebigil CG Maroteaux L Hosoda S Kellermann O Launay JM PDZ dependent activation of nitric oxide synthases by the serotonin 2B receptor The Journal of Biological Chemistry Mar 2000 275 13 9324 31 PMID 10734074 doi 10 1074 jbc 275 13 9324 Becamel C Figge A Poliak S Dumuis A Peles E Bockaert J Lubbert H Ullmer C Interaction of serotonin 5 hydroxytryptamine type 2C receptors with PDZ10 of the multi PDZ domain protein MUPP1 The Journal of Biological Chemistry Apr 2001 276 16 12974 82 PMID 11150294 doi 10 1074 jbc M008089200 Manivet P Schneider B Smith JC Choi DS Maroteaux L Kellermann O Launay JM The serotonin binding site of human and murine 5 HT2B receptors molecular modeling and site directed mutagenesis The Journal of Biological Chemistry May 2002 277 19 17170 8 PMID 11859080 doi 10 1074 jbc M200195200 Borman RA Tilford NS Harmer DW Day N Ellis ES Sheldrick RL Carey J Coleman RA Baxter GS 5 HT 2B receptors play a key role in mediating the excitatory effects of 5 HT in human colon in vitro British Journal of Pharmacology Mar 2002 135 5 1144 51 PMC 1573235 nbsp PMID 11877320 doi 10 1038 sj bjp 0704571 Matsuda A Suzuki Y Honda G Muramatsu S Matsuzaki O Nagano Y Doi T Shimotohno K Harada T Nishida E Hayashi H Sugano S Large scale identification and characterization of human genes that activate NF kappaB and MAPK signaling pathways Oncogene May 2003 22 21 3307 18 PMID 12761501 doi 10 1038 sj onc 1206406 Slominski A Pisarchik A Zbytek B Tobin DJ Kauser S Wortsman J Functional activity of serotoninergic and melatoninergic systems expressed in the skin Journal of Cellular Physiology Jul 2003 196 1 144 53 PMID 12767050 doi 10 1002 jcp 10287 Lin Z Walther D Yu XY Drgon T Uhl GR The human serotonin receptor 2B coding region polymorphisms and association with vulnerability to illegal drug abuse Pharmacogenetics Dec 2004 14 12 805 11 PMID 15608559 doi 10 1097 00008571 200412000 00003 外部链接 编辑5 HT2B IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology 原始内容存档于2017 02 02 Human HTR2B genome location and HTR2B gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser 5 HT2B受體引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 Template Serotonergics 取自 https zh wikipedia org w index php title 5 HT2B受體 amp oldid 68256414, 维基百科，wiki，书籍，书籍，图书馆，
