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过氧化物酶体增殖物活化受体γ

十二月 30, 2022

过氧化物酶体增殖物活化受体γ（Peroxisome proliferator-activated receptor gamma ，缩写为PPAR-γ或PPARG），也称胰島素增敏劑受体（glitazone receptor），或 NR1C3（意为核受体第一亚科C集团第3号，nuclear receptor subfamily 1, group C, member 3）是一种位于人类染色体上的二型核受体，由PPARG基因编码。[2][3][4]对脂肪细胞和胰岛素有重要的作用，是治疗糖尿病的研究对象之一。[5]

过氧化物酶体增殖物活化受体γ
PPAR-G dimer bound to DNA. PDB rendering based on 3e00[1].
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 PPARG; CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma
扩展标识 遗传学：601487 鼠基因：97747 同源基因：7899 IUPHAR:   ChEMBL: 235 GeneCards: PPARG Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 5468 19016
Ensembl ENSG00000132170 ENSMUSG00000000440
UniProt P37231 P37238
mRNA序列 NM_005037 NM_001127330
蛋白序列 NP_005028 NP_001120802
基因位置 Chr 3:
12.33 – 12.48 Mb		 Chr 6:
115.36 – 115.49 Mb
PubMed查询 [1] [2]

来源

  1. ^ Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P. Burris, Fraydoon Rastinejad. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008-11-20, 456 (7220): 350–356 [2019-05-26]. ISSN 1476-4687. PMC PMCPMC2743566   请检查|pmc=值 (帮助). PMID 19043829. doi:10.1038/nature07413. 
  2. ^ Greene ME, Blumberg B, McBride OW, Yi HF, Kronquist K, Kwan K, Hsieh L, Greene G, Nimer SD. Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 1995, 4 (4-5): 281–99. PMID 7787419. 
  3. ^ Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz M, Moller DE, Berger J. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2. Biochem. Biophys. Res. Commun. July 1996, 224 (2): 431–7. PMID 8702406. doi:10.1006/bbrc.1996.1044. 
  4. ^ Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev. December 2006, 58 (4): 726–41. PMID 17132851. doi:10.1124/pr.58.4.5. 
  5. ^ 刘英姿 ,刘昭前 , 周宏灏. 过氧化物酶体增殖物激活受体γ激动剂和拮抗剂研究进展 (PDF). 中国临床药理学杂志. 2007, 23 (4): 308–310. 1001-6821(2007)04-0308-03 （中文）. [永久失效連結]

十二月 30, 2022
过氧化物酶体增殖物活化受体γ, peroxisome, proliferator, activated, receptor, gamma, 缩写为ppar, γ或pparg, 也称胰島素增敏劑受体, glitazone, receptor, nr1c3, 意为核受体第一亚科c集团第3号, nuclear, receptor, subfamily, group, member, 是一种位于人类染色体上的二型核受体, 由pparg基因编码, 对脂肪细胞和胰岛素有重要的作用, 是治疗糖尿病的研究对象之一, ppar, d. 过氧化物酶体增殖物活化受体g Peroxisome proliferator activated receptor gamma 缩写为PPAR g或PPARG 也称胰島素增敏劑受体 glitazone receptor 或 NR1C3 意为核受体第一亚科C集团第3号 nuclear receptor subfamily 1 group C member 3 是一种位于人类染色体上的二型核受体 由PPARG基因编码 2 3 4 对脂肪细胞和胰岛素有重要的作用 是治疗糖尿病的研究对象之一 5 过氧化物酶体增殖物活化受体gPPAR G dimer bound to DNA PDB rendering based on 3e00 1 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 4A4V 4A4W 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4PRG标识代号PPARG CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma扩展标识遗传学 601487 鼠基因 97747 同源基因 7899 IUPHAR ChEMBL 235 GeneCards PPARG Gene基因本体论描述分子功能 RNA polymerase II regulatory region DNA binding DNA binding chromatin binding sequence specific DNA binding transcription factor activity steroid hormone receptor activity ligand activated sequence specific DNA binding RNA polymerase II transcription factor activity prostaglandin receptor activity protein binding drug binding zinc ion binding enzyme binding ligand dependent nuclear receptor transcription coactivator activity activating transcription factor binding sequence specific DNA binding transcription regulatory region DNA binding retinoid X receptor binding arachidonic acid binding细胞成分 nucleus nucleoplasm cytosol生物过程 negative regulation of transcription from RNA polymerase II promoter placenta development negative regulation of acute inflammatory response transcription initiation from RNA polymerase II promoter lipid metabolic process induction of apoptosis activation of cysteine type endopeptidase activity involved in apoptotic process signal transduction heart development response to nutrient regulation of blood pressure response to cold gene expression negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride long chain fatty acid transport fatty acid oxidation monocyte differentiation negative regulation of cell growth epithelial cell differentiation response to caffeine organ regeneration response to retinoic acid cellular response to insulin stimulus response to vitamin A response to lipid peroxisome proliferator activated receptor signaling pathway response to drug glucose homeostasis lipoprotein transport response to estrogen stimulus innate immune response cell fate commitment positive regulation of fat cell differentiation low density lipoprotein particle receptor biosynthetic process negative regulation of transcription DNA dependent positive regulation of transcription DNA dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation cell maturation negative regulation of smooth muscle cell proliferation positive regulation of oligodendrocyte differentiation white fat cell differentiation brown fat cell differentiation positive regulation of sequence specific DNA binding transcription factor activity negative regulation of telomerase activity lipid homeostasis response to low density lipoprotein particle stimulus negative regulation of interferon gamma mediated signaling pathway regulation of cholesterol transporter activity cellular response to lithium ionSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez546819016EnsemblENSG00000132170ENSMUSG00000000440UniProtP37231P37238mRNA序列NM 005037NM 001127330蛋白序列NP 005028NP 001120802基因位置Chr 3 12 33 12 48 MbChr 6 115 36 115 49 MbPubMed查询 1 2 查论编来源 编辑 Vikas Chandra Pengxiang Huang Yoshitomo Hamuro Srilatha Raghuram Yongjun Wang Thomas P Burris Fraydoon Rastinejad Structure of the intact PPAR gamma RXR nuclear receptor complex on DNA Nature 2008 11 20 456 7220 350 356 2019 05 26 ISSN 1476 4687 PMC PMCPMC2743566 请检查 pmc 值 帮助 PMID 19043829 doi 10 1038 nature07413 Greene ME Blumberg B McBride OW Yi HF Kronquist K Kwan K Hsieh L Greene G Nimer SD Isolation of the human peroxisome proliferator activated receptor gamma cDNA expression in hematopoietic cells and chromosomal mapping Gene Expr 1995 4 4 5 281 99 PMID 7787419 Elbrecht A Chen Y Cullinan CA Hayes N Leibowitz M Moller DE Berger J Molecular cloning expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2 Biochem Biophys Res Commun July 1996 224 2 431 7 PMID 8702406 doi 10 1006 bbrc 1996 1044 Michalik L Auwerx J Berger JP Chatterjee VK Glass CK Gonzalez FJ Grimaldi PA Kadowaki T Lazar MA O Rahilly S Palmer CN Plutzky J Reddy JK Spiegelman BM Staels B Wahli W International Union of Pharmacology LXI Peroxisome proliferator activated receptors Pharmacol Rev December 2006 58 4 726 41 PMID 17132851 doi 10 1124 pr 58 4 5 刘英姿 刘昭前 周宏灏 过氧化物酶体增殖物激活受体g激动剂和拮抗剂研究进展 PDF 中国临床药理学杂志 2007 23 4 308 310 1001 6821 2007 04 0308 03 中文 永久失效連結 取自 https zh wikipedia org w index php title 过氧化物酶体增殖物活化受体g amp oldid 71382867, 维基百科，wiki，书籍，书籍，图书馆，

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