^Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC. Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry. October 2002, 41 (42): 12569–74. PMID 12379098. doi:10.1021/bi026561f.
^Walther DJ, Bader M. A unique central tryptophan hydroxylase isoform. Biochem. Pharmacol. November 2003, 66 (9): 1673–80. PMID 14563478. doi:10.1016/S0006-2952(03)00556-2.
扩展阅读编辑
Friedman PA, Kappelman AH, Kaufman S. Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. J. Biol. Chem. 1972, 247 (13): 4165–73. PMID 4402511.
Hamon M, Bourgoin S, Artaud F, Glowinski J. The role of intraneuronal 5-HT and of tryptophan hydroxylase activation in the control of 5-HT synthesis in rat brain slices incubated in K+-enriched medium. J. Neurochem. 1979, 33 (5): 1031–42. PMID 315449. doi:10.1111/j.1471-4159.1979.tb05239.x.
Ichiyama A, Nakamura S, Nishizuka Y, Hayaishi O. Enzymic studies on the biosynthesis of serotonin in mammalian brain. J. Biol. Chem. 1970, 245 (7): 1699–709. PMID 5309585.
Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A. Further studies on tryptophan hydroxylase in rat brainstem and beef pineal. Biochem. Pharmacol. 1969, 18 (5): 1071–81. PMID 5789774. doi:10.1016/0006-2952(69)90111-7.
Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC. Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry. 2002, 41 (42): 12569–74. PMID 12379098. doi:10.1021/bi026561f.
Windahl MS, Petersen CR, Christensen, HEM, Harris P. Crystal Structure of Tryptophan Hydroxylase with Bound Amino Acid Substrate. Biochemistry. 2008, 47 (46): 12087–94. PMID 18937498. doi:10.1021/bi8015263.
九月 15, 2023
色氨酸羟化酶, 英語, tryptophan, hydroxylase, 页面存档备份, 存于互联网档案馆, 也称为色氨酸5, 单加氧酶, 简称tph, 是合成神经递质5, 羟色胺的过程中重要的酶, 可催化如下酶促反应, 色氨酸5, 单加氧酶命名系统命名, tryptophan, tetrahydrobiopterin, oxygen, oxidoreductase, hydroxylating, 缩写, tph别名, tryptophan, hydroxylase, indoleacetic, acid, hyd. 色氨酸羟化酶 英語 Tryptophan hydroxylase EC 1 14 16 4 页面存档备份 存于互联网档案馆 也称为色氨酸5 单加氧酶 简称TPH 是合成神经递质5 羟色胺的过程中重要的酶 色氨酸羟化酶可催化如下酶促反应 色氨酸5 单加氧酶命名系统命名 L tryptophan tetrahydrobiopterin oxygen oxidoreductase 5 hydroxylating 缩写 TPH别名 L tryptophan hydroxylase indoleacetic acid 5 hydroxylase tryptophan 5 hydroxylase tryptophan hydroxylase识别码EC編號 1 14 16 4CAS号 9037 21 2数据库IntEnz IntEnz浏览BRENDA 英语 BRENDA BRENDA入口ExPASy 英语 ExPASy NiceZyme浏览KEGG KEGG入口MetaCyc 英语 MetaCyc 代谢路径PRIAM 英语 PRIAM enzyme specific profiles 概述PDB RCSB PDB PDBj PDBe PDBsum基因本体 AmiGO EGO搜索PMC 相关文献PubMed 相关文献色氨酸羟化酶1 色氨酸5 单加氧酶 識別符號 TPH1替換符號 TPRH TPHEntrez 7166HUGO 12008OMIM 191060PDB 1MLWRefSeq NM 004179UniProt P17752其他資料EC編號 1 14 16 4基因座 11 p15 3 p14色氨酸羟化酶2識別符號 TPH2Entrez 121278HUGO 20692OMIM 607478RefSeq NM 173353UniProt Q8IWU9其他資料基因座 12 q15 L 色氨酸 四氢生物蝶呤 O2 displaystyle rightleftharpoons 5 羟色氨酸 二氢生物蝶呤 H2O以上反应还需要亚铁离子作为辅酶 目录 1 功能 2 异构体 3 参考文献 4 扩展阅读功能 编辑色氨酸 forward enzyme 5 羟色氨酸 nbsp nbsp minor forward substrate s minor forward product s nbsp 色氨酸羟化酶可以使色氨酸的C5羟基化 使色氨酸转化为5 羟色氨酸 5 HTP 这一催化氧化反应是神经递质5 羟色胺生物合成过程中的启示步及限速步 色氨酸羟化酶也是褪黑素生物合成过程中需要用到的第一种酶 色氨酸羟化酶 TPH 与酪氨酸羟化酶 TH 苯丙氨酸羟化酶 PAH 等皆为芳香族氨基酸羟化酶超家族 superfamily 的成员 负责催化重要代谢途径中的关键步骤 1 与酪氨酸羟化酶 苯丙氨酸羟化酶类似 色氨酸羟化酶也以 6R L 赤型 5 6 7 8 四氢生物蝶呤 BH4 及双氧 O2 作为氧化还原的底物 2 人类的色氨酸羟化酶若受到某些物质 如对氯苯丙氨酸 的抑制 可能会引发抑郁症 3 色氨酸羟化酶的酶活性 即色氨酸羟化酶将L 色氨酸转化为5 羟色胺前体L 5 羟色氨酸的反应速率 可以在被蛋白激酶A等激酶催化磷酸化后增加 异构体 编辑哺乳动物都拥有两种不同的TPH基因 人类的两个TPH基因分别位于11号染色体和12号染色体上 它们编码着不同却同源的酶 TPH1及TPH2 这两种基因的序列一致性达71 4 TPH1主要表达在分泌5 羟色胺的组织中 如皮肤 肠道 松果体以及中枢神经系统中 TPH2则仅在神经细胞中表达 且其于中枢神经系统中的表达量较TPH1大 参考文献 编辑 McKinney J Teigen K Froystein NA Salaun C Knappskog PM Haavik J Martinez A Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase Important role of Phe313 in substrate specificity PDF Biochemistry December 2001 40 51 15591 601 PMID 11747434 doi 10 1021 bi015722x 原始内容 PDF 存档于2008 12 17 tetrahydrobiopterin BH4 Databases BH4 org 2005 原始内容存档于2006 12 06 Wang L Erlandsen H Haavik J Knappskog PM Stevens RC Three dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry October 2002 41 42 12569 74 PMID 12379098 doi 10 1021 bi026561f Walther DJ Bader M A unique central tryptophan hydroxylase isoform Biochem Pharmacol November 2003 66 9 1673 80 PMID 14563478 doi 10 1016 S0006 2952 03 00556 2 扩展阅读 编辑Friedman PA Kappelman AH Kaufman S Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain J Biol Chem 1972 247 13 4165 73 PMID 4402511 Hamon M Bourgoin S Artaud F Glowinski J The role of intraneuronal 5 HT and of tryptophan hydroxylase activation in the control of 5 HT synthesis in rat brain slices incubated in K enriched medium J Neurochem 1979 33 5 1031 42 PMID 315449 doi 10 1111 j 1471 4159 1979 tb05239 x Ichiyama A Nakamura S Nishizuka Y Hayaishi O Enzymic studies on the biosynthesis of serotonin in mammalian brain J Biol Chem 1970 245 7 1699 709 PMID 5309585 Jequier E Robinson DS Lovenberg W Sjoerdsma A Further studies on tryptophan hydroxylase in rat brainstem and beef pineal Biochem Pharmacol 1969 18 5 1071 81 PMID 5789774 doi 10 1016 0006 2952 69 90111 7 Wang L Erlandsen H Haavik J Knappskog PM Stevens RC Three dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry 2002 41 42 12569 74 PMID 12379098 doi 10 1021 bi026561f Windahl MS Petersen CR Christensen HEM Harris P Crystal Structure of Tryptophan Hydroxylase with Bound Amino Acid Substrate Biochemistry 2008 47 46 12087 94 PMID 18937498 doi 10 1021 bi8015263 取自 https zh wikipedia org w index php title 色氨酸羟化酶 amp oldid 72709914, 维基百科,wiki,书籍,书籍,图书馆,