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维基百科

肿瘤坏死因子

十月 19, 2023

肿瘤坏死因子（TNF）旧称肿瘤坏死因子-α（TNF-α）[1]以区别肿瘤坏死因子-β，属肿瘤坏死因子超家族一员，是一种涉及到系统性炎症的细胞因子，同时也是属于引起急相反应（英语：Acute-phase protein）的众多细胞因子中的一员。主要由巨噬细胞分泌，不过有一些其它类型的细胞也能生产。

肿瘤坏死因子
PDB rendering based on 1TNF.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 TNF; DIF; TNF-alpha; TNFA; TNFSF2
扩展标识 遗传学：191160 鼠基因：104798 同源基因：496 ChEMBL: 1825 GeneCards: TNF Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 7124 21926
Ensembl ENSG00000204490 ENSMUSG00000024401
UniProt P01375 P06804
mRNA序列 NM_000594.3 NM_013693.2
蛋白序列 NP_000585.2 NP_038721.1
基因位置 Chr 6:
31.54 – 31.55 Mb		 Chr 17:
35.2 – 35.2 Mb
PubMed查询 [1] [2]

功能 编辑

總括而言，腫瘤壞死因子能抑制不同種流感病毒的複製，擁有強大的抗病毒效果[2]。肿瘤坏死因子的主要作用是调节免疫细胞的功能。作为一种内源性致热原，它能够促使发热，引起细胞凋亡，（通过诱使产生IL1和IL6（英语：Interleukin 6））引发败血症，引起恶病体质，引发炎症，阻止肿瘤发生和病毒复制（英语：Viral replication）。

肿瘤坏死因子生产的失调被认为与许多人类疾病有关，包括阿茲海默症[3]、癌症[4]、重性抑郁障碍[5]和肠炎。[6]虽然仍有争议，不过当前的研究认为肿瘤坏死因子α的水平与抑郁和肠炎有关。[7]基因工程生产的肿瘤坏死因子被用作免疫兴奋剂（英语：Immunostimulant）（国际非专利药品名称为他索纳明）。肿瘤的恶变过程中，肿瘤坏死因子α常异位表达，而其过量表达同副甲狀腺素一道与引发继发性高钙血症和癌症有关。

炎症過程中釋放的TNF與H2O2誘導的BCa轉化有關，伴血吸蟲感染的BCa患者血清中TNF水平顯著升高。另外，T3及T4期患者TNF水平高於T1及T2早期患者，提示TNF水平可能有助於BCa的進展[8]。由於TNF有助於BCa的形成和發展，故而可以作為評估BCa侵襲性和惡性程度的指標[9]。

参考文献 编辑

  1. ^ Liu CY, Tam SS, Huang Y, Dubé PE, Alhosh R, Girish N, Punit S, Nataneli S, Li F, Bender JM, Washington MK, Polk DB. TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Rep. 2020 Oct 20;33(3):108275. doi: 10.1016/j.celrep.2020.108275. PMID 33086075; PMCID: PMC7682618.
  2. ^ Seo, S. H.; Webster, R. G. Tumor Necrosis Factor Alpha Exerts Powerful Anti-Influenza Virus Effects in Lung Epithelial Cells. Journal of Virology. 2002-02-01, 76 (3): 1071–1076. ISSN 0022-538X. doi:10.1128/jvi.76.3.1071-1076.2002. 
  3. ^ Swardfager W, Lanctôt K, Rothenburg L, Wong A, Cappell J, Herrmann N. A meta-analysis of cytokines in Alzheimer's disease. Biol Psychiatry. 2010, 68 (10): 930–941. PMID 20692646. doi:10.1016/j.biopsych.2010.06.012. 
  4. ^ Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001, 104 (4): 487–501. PMID 11239407. doi:10.1016/S0092-8674(01)00237-9. 
  5. ^ Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctôt KL. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010, 67 (5): 446–457. PMID 20015486. doi:10.1016/j.biopsych.2009.09.033. 
  6. ^ Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, Bingham A, Saermark T. Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut. 2002, 51 (1): 37–43. PMC 1773288  . PMID 12077089. doi:10.1136/gut.51.1.37. 
  7. ^ Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ. Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients: a literature review. Inflammatory Bowel Diseases. 2007, 13 (2): 225–234. PMID 17206706. doi:10.1002/ibd.20062. 
  8. ^ 葉衛豐,賀敏,吳志斌.膀胱癌患者外周血中IL-2、IFN-γ、TNF的表達及臨床意義.臨床和實驗醫學雜誌,2016,15(11):1064
  9. ^ 孫祖剛、劉碩等.炎症細胞和促炎性細胞因子在膀胱腫瘤炎症微環境中的作用概述.湖北科技學院學報(醫學版).2018年，第5期：P451-454

參見 编辑

  • 單株益生菌(Bifidobacterium animalis)

外部連結 编辑



十月 19, 2023
肿瘤坏死因子, 旧称, 以区别, 属超家族一员, 是一种涉及到系统性炎症的细胞因子, 同时也是属于引起急相反应, 英语, acute, phase, protein, 的众多细胞因子中的一员, 主要由巨噬细胞分泌, 不过有一些其它类型的细胞也能生产, rendering, based, 1tnf, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1a8m, 1tnf, 2az5, 2e7a, 2tun, 2zjc, 2zpx, 3alq, 3it8, 3l9j, 4tsv, 5tsw标识代号. 肿瘤坏死因子 TNF 旧称肿瘤坏死因子 a TNF a 1 以区别肿瘤坏死因子 b 属肿瘤坏死因子超家族一员 是一种涉及到系统性炎症的细胞因子 同时也是属于引起急相反应 英语 Acute phase protein 的众多细胞因子中的一员 主要由巨噬细胞分泌 不过有一些其它类型的细胞也能生产 肿瘤坏死因子PDB rendering based on 1TNF 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 4TSV 5TSW标识代号TNF DIF TNF alpha TNFA TNFSF2扩展标识遗传学 191160 鼠基因 104798 同源基因 496 ChEMBL 1825 GeneCards TNF Gene基因本体论描述分子功能 protease binding cytokine activity tumor necrosis factor receptor binding protein binding identical protein binding transcription regulatory region DNA binding细胞成分 phagocytic cup extracellular space plasma membrane integral to plasma membrane external side of plasma membrane cell surface membrane raft recycling endosome生物过程 protein import into nucleus translocation negative regulation of transcription from RNA polymerase II promoter MAPK cascade activation of MAPKKK activity activation of MAPK activity response to hypoxia cell activation positive regulation of cytokine production positive regulation of protein phosphorylation negative regulation of L glutamate transport chronic inflammatory response to antigenic stimulus negative regulation of cytokine secretion involved in immune response positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin skeletal muscle contraction glucose metabolic process apoptotic process anti apoptosis induction of apoptosis activation of cysteine type endopeptidase activity involved in apoptotic process transformed cell apoptotic process inflammatory response humoral immune response JNK cascade negative regulation of cell proliferation induction of apoptosis by extracellular signals induction of apoptosis by extracellular signals induction of apoptosis via death domain receptors response to mechanical stimulus response to virus response to salt stress organ morphogenesis negative regulation of gene expression negative regulation of alkaline phosphatase activity negative regulation of lipid storage positive regulation of necrotic cell death response to activity calcium mediated signaling extracellular matrix organization sequestering of triglyceride positive regulation of protein complex assembly positive regulation of fever generation lipopolysaccharide mediated signaling pathway negative regulation of interleukin 6 production positive regulation of chemokine production positive regulation of interferon gamma production positive regulation of interleukin 6 production receptor biosynthetic process positive regulation of peptidyl serine phosphorylation tumor necrosis factor mediated signaling pathway positive regulation of heterotypic cell cell adhesion positive regulation of NF kappaB import into nucleus response to drug positive regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death regulation of I kappaB kinase NF kappaB cascade positive regulation of I kappaB kinase NF kappaB cascade positive regulation of protein complex disassembly positive regulation of MAP kinase activity protein kinase B signaling cascade positive regulation of neuron apoptotic process negative regulation of growth of symbiont in host negative regulation of viral genome replication positive regulation of chemokine biosynthetic process positive regulation of interleukin 8 biosynthetic process positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of osteoclast differentiation positive regulation of mitosis negative regulation of transcription DNA dependent positive regulation of transcription DNA dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron negative regulation of glucose import positive regulation of JNK cascade embryonic digestive tract development positive regulation of smooth muscle cell proliferation positive regulation of cytokine secretion regulation of insulin secretion positive regulation of synaptic transmission defense response to Gram positive bacterium leukocyte tethering or rolling negative regulation of lipid catabolic process regulation of immunoglobulin secretion positive regulation of membrane protein ectodomain proteolysis positive regulation of sequence specific DNA binding transcription factor activity positive regulation of NF kappaB transcription factor activity positive regulation of protein transport response to glucocorticoid stimulus positive regulation of NFAT protein import into nucleus positive regulation of hair follicle development positive regulation of protein kinase B signaling cascade induction of necroptosis by extracellular signals positive regulation of vitamin D biosynthetic process positive regulation of calcidiol 1 monooxygenase activity epithelial cell proliferation involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis negative regulation of branching involved in lung morphogenesis necrotic cell death positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to nicotine cellular response to organic cyclic compound positive regulation of mononuclear cell migration positive regulation of podosome assembly extrinsic apoptotic signaling pathway positive regulation of protein localization at cell surface positive regulation of chemokine C X C motif ligand 2 productionSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez712421926EnsemblENSG00000204490ENSMUSG00000024401UniProtP01375P06804mRNA序列NM 000594 3NM 013693 2蛋白序列NP 000585 2NP 038721 1基因位置Chr 6 31 54 31 55 MbChr 17 35 2 35 2 MbPubMed查询 1 2 查论编 目录 1 功能 2 参考文献 3 參見 4 外部連結功能 编辑總括而言 腫瘤壞死因子能抑制不同種流感病毒的複製 擁有強大的抗病毒效果 2 肿瘤坏死因子的主要作用是调节免疫细胞的功能 作为一种内源性致热原 它能够促使发热 引起细胞凋亡 通过诱使产生IL1和IL6 英语 Interleukin 6 引发败血症 引起恶病体质 引发炎症 阻止肿瘤发生和病毒复制 英语 Viral replication 肿瘤坏死因子生产的失调被认为与许多人类疾病有关 包括阿茲海默症 3 癌症 4 重性抑郁障碍 5 和肠炎 6 虽然仍有争议 不过当前的研究认为肿瘤坏死因子a的水平与抑郁和肠炎有关 7 基因工程生产的肿瘤坏死因子被用作免疫兴奋剂 英语 Immunostimulant 国际非专利药品名称为他索纳明 肿瘤的恶变过程中 肿瘤坏死因子a常异位表达 而其过量表达同副甲狀腺素一道与引发继发性高钙血症和癌症有关 炎症過程中釋放的TNF與H2O2誘導的BCa轉化有關 伴血吸蟲感染的BCa患者血清中TNF水平顯著升高 另外 T3及T4期患者TNF水平高於T1及T2早期患者 提示TNF水平可能有助於BCa的進展 8 由於TNF有助於BCa的形成和發展 故而可以作為評估BCa侵襲性和惡性程度的指標 9 参考文献 编辑 Liu CY Tam SS Huang Y Dube PE Alhosh R Girish N Punit S Nataneli S Li F Bender JM Washington MK Polk DB TNF Receptor 1 Promotes Early Life Immunity and Protects against Colitis in Mice Cell Rep 2020 Oct 20 33 3 108275 doi 10 1016 j celrep 2020 108275 PMID 33086075 PMCID PMC7682618 Seo S H Webster R G Tumor Necrosis Factor Alpha Exerts Powerful Anti Influenza Virus Effects in Lung Epithelial Cells Journal of Virology 2002 02 01 76 3 1071 1076 ISSN 0022 538X doi 10 1128 jvi 76 3 1071 1076 2002 Swardfager W Lanctot K Rothenburg L Wong A Cappell J Herrmann N A meta analysis of cytokines in Alzheimer s disease Biol Psychiatry 2010 68 10 930 941 PMID 20692646 doi 10 1016 j biopsych 2010 06 012 Locksley RM Killeen N Lenardo MJ The TNF and TNF receptor superfamilies integrating mammalian biology Cell 2001 104 4 487 501 PMID 11239407 doi 10 1016 S0092 8674 01 00237 9 Dowlati Y Herrmann N Swardfager W Liu H Sham L Reim EK Lanctot KL A meta analysis of cytokines in major depression Biol Psychiatry 2010 67 5 446 457 PMID 20015486 doi 10 1016 j biopsych 2009 09 033 Brynskov J Foegh P Pedersen G Ellervik C Kirkegaard T Bingham A Saermark T Tumour necrosis factor alpha converting enzyme TACE activity in the colonic mucosa of patients with inflammatory bowel disease Gut 2002 51 1 37 43 PMC 1773288 nbsp PMID 12077089 doi 10 1136 gut 51 1 37 Mikocka Walus AA Turnbull DA Moulding NT Wilson IG Andrews JM Holtmann GJ Controversies surrounding the comorbidity of depression and anxiety in inflammatory bowel disease patients a literature review Inflammatory Bowel Diseases 2007 13 2 225 234 PMID 17206706 doi 10 1002 ibd 20062 葉衛豐 賀敏 吳志斌 膀胱癌患者外周血中IL 2 IFN g TNF的表達及臨床意義 臨床和實驗醫學雜誌 2016 15 11 1064 孫祖剛 劉碩等 炎症細胞和促炎性細胞因子在膀胱腫瘤炎症微環境中的作用概述 湖北科技學院學報 醫學版 2018年 第5期 P451 454參見 编辑單株益生菌 Bifidobacterium animalis 外部連結 编辑醫學主題詞表 MeSH Tumor Necrosis Factor alpha 取自 https zh wikipedia org w index php title 肿瘤坏死因子 amp oldid 74827929, 维基百科，wiki，书籍，书籍，图书馆，

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