fbpx
维基百科

細胞色素c

細胞色素複合體(英語:cytochrome complex)簡稱 細胞色素c(cyt c),是一種血红素蛋白(hemoprotein),屬於“细胞色素c家族英语Cytochrome c family[1]。細胞色素c會與粒線體內膜輕微連接,結構鬆散而微小的它和其他細胞色素不同,是一種高度可溶性蛋白,在水中的可溶性達每公升100克。細胞色素c是電子傳遞鏈不可或缺的元件,負責攜帶一粒電子,在複合物III複合物IV之間傳遞。此外,它能夠接受氧化還原反應,但不與結合。在人體中,細胞色素c已經由CYCS基因完成編碼[2][3]

細胞色素c,體細胞
血紅素及細胞色素c
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 CYCS; HCS; CYC
扩展标识 遗传学:123970 鼠基因:88578 同源基因:68675 GeneCards: CYCS Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 54205 13063
Ensembl ENSG00000172115 n/a
UniProt P99999 n/a
mRNA序列 NM_018947 XM_975140
蛋白序列 NP_061820 XP_980234
基因位置 Chr 7:
25.12 – 25.13 Mb
n/a
PubMed查询 [1] [2]

細胞色素c和細胞程序性死亡有關[4]

交互作用

細胞色素c被證實會和COX4I2進行交互作用[5][6][7][8]

參考資料

  1. ^ 王海波. 植物细胞色素C家族蛋白的同源聚类分析[J]. 生物信息学,2010,8(4):334-335,340. DOI:10.3969/j.issn.1672-5565.2010.04.012.
  2. ^ Entrez Gene: cytochrome c. NCBI. 2011-06-18. (原始内容于2020-05-28) (英语). 
  3. ^ Marco Tafani, Natalie O. Karpinich, Kathryn A. Hurster, John G. Pastorino, Timothy Schneider, Matteo A. Russo, John L. Farber. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. The Journal of Biological Chemistry. 2002-03-22, 277 (12): 10073–10082 [2019-05-25]. ISSN 0021-9258. PMID 11790791. doi:10.1074/jbc.M111350200. (原始内容于2019-10-13). 
  4. ^ . 國立陽明大學生命科學院. [2011-07-02]. (原始内容存档于2012-01-10). 
  5. ^ Michel, B; Bosshard H R. Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase. J. Biol. Chem. (UNITED STATES). Aug 1984, 259 (16): 10085–91. ISSN 0021-9258. PMID 6088481 (英语). 
  6. ^ Wiedemann, F R; Vielhaber S, Schröder R, Elger C E, Kunz W S. Evaluation of methods for the determination of mitochondrial respiratory chain enzyme activities in human skeletal muscle samples. Anal. Biochem. (UNITED STATES). Mar 2000, 279 (1): 55–60. ISSN 0003-2697. PMID 10683230. doi:10.1006/abio.1999.4434 (英语). 
  7. ^ Sampson, V; Alleyne T. Cytochrome c/cytochrome c oxidase interaction. Direct structural evidence for conformational changes during enzyme turnover. Eur. J. Biochem. (Germany). Dec 2001, 268 (24): 6534–44. ISSN 0014-2956. PMID 11737208. doi:10.1046/j.0014-2956.2001.02608.x (英语). 
  8. ^ Lynch, S R; Sherman D, Copeland R A. Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase. J. Biol. Chem. (UNITED STATES). Jan 1992, 267 (1): 298–302. ISSN 0021-9258. PMID 1309738 (英语). 

延伸閱讀

  • R. Kumarswamy, Sudhir Chandna. Putative partners in Bax mediated cytochrome-c release: ANT, CypD, VDAC or none of them?. Mitochondrion. 2009-2, 9 (1): 1–8 [2019-05-25]. ISSN 1567-7249. PMID 18992370. doi:10.1016/j.mito.2008.10.003. (原始内容于2019-08-31). 
  • V. P. Skulachev. Cytochrome c in the apoptotic and antioxidant cascades. FEBS letters. 1998-02-27, 423 (3): 275–280 [2019-05-25]. ISSN 0014-5793. PMID 9515723. (原始内容于2019-08-31). 
  • C. A. Mannella. Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications. Journal of Structural Biology. 1998, 121 (2): 207–218 [2019-05-25]. ISSN 1047-8477. PMID 9615439. doi:10.1006/jsbi.1997.3954. (原始内容于2019-08-31). 
  • K. F. Ferri, E. Jacotot, J. Blanco, J. A. Esté, G. Kroemer. Mitochondrial control of cell death induced by HIV-1-encoded proteins. Annals of the New York Academy of Sciences. 2000, 926: 149–164 [2019-05-25]. ISSN 0077-8923. PMID 11193032. (原始内容于2019-08-25). 
  • Robert S. Britton, Katherine L. Leicester, Bruce R. Bacon. Iron toxicity and chelation therapy. International Journal of Hematology. 2002-10, 76 (3): 219–228 [2019-05-25]. ISSN 0925-5710. PMID 12416732. (原始内容于2019-08-31). 
  • Nezam Haider, Navneet Narula, Jagat Narula. Apoptosis in heart failure represents programmed cell survival, not death, of cardiomyocytes and likelihood of reverse remodeling. Journal of Cardiac Failure. 2002-12, 8 (6 Suppl): S512–517 [2019-05-25]. ISSN 1071-9164. PMID 12555167. doi:10.1054/jcaf.2002.130034. (原始内容于2019-08-31). 
  • Maria Castedo, Jean-Luc Perfettini, Karine Andreau, Thomas Roumier, Mauro Piacentini, Guido Kroemer. Mitochondrial apoptosis induced by the HIV-1 envelope. Annals of the New York Academy of Sciences. 2003-12, 1010: 19–28 [2019-05-25]. ISSN 0077-8923. PMID 15033690. (原始内容于2019-08-28). 
  • S. Ng, M. B. Smith, H. T. Smith, F. Millett. Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b5. Biochemistry. 1977-11-15, 16 (23): 4975–4978 [2019-05-25]. ISSN 0006-2960. PMID 199233. (原始内容于2019-08-31). 
  • S. R. Lynch, D. Sherman, R. A. Copeland. Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase. The Journal of Biological Chemistry. 1992-01-05, 267 (1): 298–302 [2019-05-25]. ISSN 0021-9258. PMID 1309738. (原始内容于2019-08-28). 
  • E. A. Garber, E. Margoliash. Interaction of cytochrome c with cytochrome c oxidase: an understanding of the high- to low-affinity transition. Biochimica Et Biophysica Acta. 1990-02-02, 1015 (2): 279–287 [2019-05-25]. ISSN 0006-3002. PMID 2153405. (原始内容于2019-09-01). 
  • C. D. Bedetti. Immunocytochemical demonstration of cytochrome c oxidase with an immunoperoxidase method: a specific stain for mitochondria in formalin-fixed and paraffin-embedded human tissues. The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society. 1985-5, 33 (5): 446–452 [2019-05-25]. ISSN 0022-1554. PMID 2580882. doi:10.1177/33.5.2580882. (原始内容于2016-03-24). 
  • Y. Tanaka, T. Ashikari, Y. Shibano, T. Amachi, H. Yoshizumi, H. Matsubara. Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae. Journal of Biochemistry. 1988-6, 103 (6): 954–961 [2019-05-25]. ISSN 0021-924X. PMID 2844747. doi:10.1093/oxfordjournals.jbchem.a122393. (原始内容于2019-08-25). 
  • M. J. Evans, R. C. Scarpulla. The human somatic cytochrome c gene: two classes of processed pseudogenes demarcate a period of rapid molecular evolution. Proceedings of the National Academy of Sciences of the United States of America. 1988-12, 85 (24): 9625–9629 [2019-05-25]. ISSN 0027-8424. PMC 282819 . PMID 2849112. doi:10.1073/pnas.85.24.9625. (原始内容于2019-09-03). 
  • P. G. Passon, D. E. Hultquist. Soluble cytochrome b 5 reductase from human erythrocytes. Biochimica Et Biophysica Acta. 1972-07-12, 275 (1): 62–73 [2019-05-25]. ISSN 0006-3002. PMID 4403130. (原始内容于2019-08-23). 
  • R. J. Dowe, L. B. Vitello, J. E. Erman. Sedimentation equilibrium studies on the interaction between cytochrome c and cytochrome c peroxidase. Archives of Biochemistry and Biophysics. 1984-08-01, 232 (2): 566–573 [2019-05-25]. ISSN 0003-9861. PMID 6087732. (原始内容于2019-09-02). 
  • B. Michel, H. R. Bosshard. Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase. The Journal of Biological Chemistry. 1984-08-25, 259 (16): 10085–10091 [2019-05-25]. ISSN 0021-9258. PMID 6088481. (原始内容于2019-09-01). 
  • C. Broger, M. J. Nałecz, A. Azzi. Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain. Biochimica Et Biophysica Acta. 1980-10-03, 592 (3): 519–527 [2019-05-25]. ISSN 0006-3002. PMID 6251869. (原始内容于2019-08-30). 
  • H. T. Smith, A. J. Ahmed, F. Millett. Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase. The Journal of Biological Chemistry. 1981-05-25, 256 (10): 4984–4990 [2019-05-25]. ISSN 0021-9258. PMID 6262312. (原始内容于2019-09-03). 
  • L. M. Geren, F. Millett. Fluorescence energy transfer studies of the interaction between adrenodoxin and cytochrome c. The Journal of Biological Chemistry. 1981-10-25, 256 (20): 10485–10489 [2019-05-25]. ISSN 0021-9258. PMID 6270113. (原始内容于2019-08-31). 
  • B. Favre, S. Zolnierowicz, P. Turowski, B. A. Hemmings. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. The Journal of Biological Chemistry. 1994-06-10, 269 (23): 16311–16317 [2019-05-25]. ISSN 0021-9258. PMID 8206937. (原始内容于2019-08-31). 
  • B. Gao, E. Eisenberg, L. Greene. Effect of constitutive 70-kDa heat shock protein polymerization on its interaction with protein substrate. The Journal of Biological Chemistry. 1996-07-12, 271 (28): 16792–16797 [2019-05-25]. ISSN 0021-9258. PMID 8663341. doi:10.1074/jbc.271.28.16792. (原始内容于2019-09-01). 

其他圖像

外部連結

Template:Fas apoptosis signaling pathway

細胞色素c, 此條目需要擴充, 2013年2月14日, 请協助改善这篇條目, 更進一步的信息可能會在討論頁或扩充请求中找到, 请在擴充條目後將此模板移除, 細胞色素複合體, 英語, cytochrome, complex, 簡稱, 是一種血红素蛋白, hemoprotein, 屬於, 细胞色素c家族, 英语, cytochrome, family, 會與粒線體內膜輕微連接, 結構鬆散而微小的它和其他細胞色素不同, 是一種高度可溶性蛋白, 在水中的可溶性達每公升100克, 是電子傳遞鏈不可或缺的元件, 負責攜帶一粒電. 此條目需要擴充 2013年2月14日 请協助改善这篇條目 更進一步的信息可能會在討論頁或扩充请求中找到 请在擴充條目後將此模板移除 細胞色素複合體 英語 cytochrome complex 簡稱 細胞色素c cyt c 是一種血红素蛋白 hemoprotein 屬於 细胞色素c家族 英语 Cytochrome c family 1 細胞色素c會與粒線體內膜輕微連接 結構鬆散而微小的它和其他細胞色素不同 是一種高度可溶性蛋白 在水中的可溶性達每公升100克 細胞色素c是電子傳遞鏈不可或缺的元件 負責攜帶一粒電子 在複合物III和複合物IV之間傳遞 此外 它能夠接受氧化和還原反應 但不與氧結合 在人體中 細胞色素c已經由CYCS基因完成編碼 2 3 細胞色素c 體細胞血紅素及細胞色素c有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1j3s 2b4z标识代号CYCS HCS CYC扩展标识遗传学 123970 鼠基因 88578 同源基因 68675 GeneCards CYCS Gene基因本体论描述分子功能 protein phosphatase type 2A activity iron ion binding protein binding heme binding electron transporter transferring electrons from CoQH2 cytochrome c reductase complex and cytochrome c oxidase complex activity metal ion binding细胞成分 protein phosphatase type 2A complex nucleus mitochondrion mitochondrial respiratory chain mitochondrial intermembrane space cytosol生物过程 electron transport DNA fragmentation during apoptosis transport apoptosis caspase activation via cytochrome c cellular respirationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez5420513063EnsemblENSG00000172115n aUniProtP99999n amRNA序列NM 018947XM 975140蛋白序列NP 061820XP 980234基因位置Chr 7 25 12 25 13 Mbn aPubMed查询 1 2 查论编細胞色素c和細胞程序性死亡有關 4 目录 1 交互作用 2 參考資料 3 延伸閱讀 4 其他圖像 5 外部連結交互作用 编辑細胞色素c被證實會和COX4I2進行交互作用 5 6 7 8 參考資料 编辑 王海波 植物细胞色素C家族蛋白的同源聚类分析 J 生物信息学 2010 8 4 334 335 340 DOI 10 3969 j issn 1672 5565 2010 04 012 Entrez Gene cytochrome c NCBI 2011 06 18 原始内容存档于2020 05 28 英语 Marco Tafani Natalie O Karpinich Kathryn A Hurster John G Pastorino Timothy Schneider Matteo A Russo John L Farber Cytochrome c release upon Fas receptor activation depends on translocation of full length bid and the induction of the mitochondrial permeability transition The Journal of Biological Chemistry 2002 03 22 277 12 10073 10082 2019 05 25 ISSN 0021 9258 PMID 11790791 doi 10 1074 jbc M111350200 原始内容存档于2019 10 13 新世紀生命科學課程改進計畫 神經生物學 第一章 國立陽明大學生命科學院 2011 07 02 原始内容存档于2012 01 10 Michel B Bosshard H R Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase J Biol Chem UNITED STATES Aug 1984 259 16 10085 91 ISSN 0021 9258 PMID 6088481 英语 引文使用过时参数coauthors 帮助 Wiedemann F R Vielhaber S Schroder R Elger C E Kunz W S Evaluation of methods for the determination of mitochondrial respiratory chain enzyme activities in human skeletal muscle samples Anal Biochem UNITED STATES Mar 2000 279 1 55 60 ISSN 0003 2697 PMID 10683230 doi 10 1006 abio 1999 4434 英语 引文使用过时参数coauthors 帮助 Sampson V Alleyne T Cytochrome c cytochrome c oxidase interaction Direct structural evidence for conformational changes during enzyme turnover Eur J Biochem Germany Dec 2001 268 24 6534 44 ISSN 0014 2956 PMID 11737208 doi 10 1046 j 0014 2956 2001 02608 x 英语 引文使用过时参数coauthors 帮助 Lynch S R Sherman D Copeland R A Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase J Biol Chem UNITED STATES Jan 1992 267 1 298 302 ISSN 0021 9258 PMID 1309738 英语 引文使用过时参数coauthors 帮助 延伸閱讀 编辑R Kumarswamy Sudhir Chandna Putative partners in Bax mediated cytochrome c release ANT CypD VDAC or none of them Mitochondrion 2009 2 9 1 1 8 2019 05 25 ISSN 1567 7249 PMID 18992370 doi 10 1016 j mito 2008 10 003 原始内容存档于2019 08 31 请检查 date 中的日期值 帮助 V P Skulachev Cytochrome c in the apoptotic and antioxidant cascades FEBS letters 1998 02 27 423 3 275 280 2019 05 25 ISSN 0014 5793 PMID 9515723 原始内容存档于2019 08 31 C A Mannella Conformational changes in the mitochondrial channel protein VDAC and their functional implications Journal of Structural Biology 1998 121 2 207 218 2019 05 25 ISSN 1047 8477 PMID 9615439 doi 10 1006 jsbi 1997 3954 原始内容存档于2019 08 31 K F Ferri E Jacotot J Blanco J A Este G Kroemer Mitochondrial control of cell death induced by HIV 1 encoded proteins Annals of the New York Academy of Sciences 2000 926 149 164 2019 05 25 ISSN 0077 8923 PMID 11193032 原始内容存档于2019 08 25 Robert S Britton Katherine L Leicester Bruce R Bacon Iron toxicity and chelation therapy International Journal of Hematology 2002 10 76 3 219 228 2019 05 25 ISSN 0925 5710 PMID 12416732 原始内容存档于2019 08 31 Nezam Haider Navneet Narula Jagat Narula Apoptosis in heart failure represents programmed cell survival not death of cardiomyocytes and likelihood of reverse remodeling Journal of Cardiac Failure 2002 12 8 6 Suppl S512 517 2019 05 25 ISSN 1071 9164 PMID 12555167 doi 10 1054 jcaf 2002 130034 原始内容存档于2019 08 31 Maria Castedo Jean Luc Perfettini Karine Andreau Thomas Roumier Mauro Piacentini Guido Kroemer Mitochondrial apoptosis induced by the HIV 1 envelope Annals of the New York Academy of Sciences 2003 12 1010 19 28 2019 05 25 ISSN 0077 8923 PMID 15033690 原始内容存档于2019 08 28 S Ng M B Smith H T Smith F Millett Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b5 Biochemistry 1977 11 15 16 23 4975 4978 2019 05 25 ISSN 0006 2960 PMID 199233 原始内容存档于2019 08 31 S R Lynch D Sherman R A Copeland Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase The Journal of Biological Chemistry 1992 01 05 267 1 298 302 2019 05 25 ISSN 0021 9258 PMID 1309738 原始内容存档于2019 08 28 E A Garber E Margoliash Interaction of cytochrome c with cytochrome c oxidase an understanding of the high to low affinity transition Biochimica Et Biophysica Acta 1990 02 02 1015 2 279 287 2019 05 25 ISSN 0006 3002 PMID 2153405 原始内容存档于2019 09 01 C D Bedetti Immunocytochemical demonstration of cytochrome c oxidase with an immunoperoxidase method a specific stain for mitochondria in formalin fixed and paraffin embedded human tissues The Journal of Histochemistry and Cytochemistry Official Journal of the Histochemistry Society 1985 5 33 5 446 452 2019 05 25 ISSN 0022 1554 PMID 2580882 doi 10 1177 33 5 2580882 原始内容存档于2016 03 24 请检查 date 中的日期值 帮助 Y Tanaka T Ashikari Y Shibano T Amachi H Yoshizumi H Matsubara Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae Journal of Biochemistry 1988 6 103 6 954 961 2019 05 25 ISSN 0021 924X PMID 2844747 doi 10 1093 oxfordjournals jbchem a122393 原始内容存档于2019 08 25 请检查 date 中的日期值 帮助 M J Evans R C Scarpulla The human somatic cytochrome c gene two classes of processed pseudogenes demarcate a period of rapid molecular evolution Proceedings of the National Academy of Sciences of the United States of America 1988 12 85 24 9625 9629 2019 05 25 ISSN 0027 8424 PMC 282819 PMID 2849112 doi 10 1073 pnas 85 24 9625 原始内容存档于2019 09 03 引文格式1维护 PMC格式 link P G Passon D E Hultquist Soluble cytochrome b 5 reductase from human erythrocytes Biochimica Et Biophysica Acta 1972 07 12 275 1 62 73 2019 05 25 ISSN 0006 3002 PMID 4403130 原始内容存档于2019 08 23 R J Dowe L B Vitello J E Erman Sedimentation equilibrium studies on the interaction between cytochrome c and cytochrome c peroxidase Archives of Biochemistry and Biophysics 1984 08 01 232 2 566 573 2019 05 25 ISSN 0003 9861 PMID 6087732 原始内容存档于2019 09 02 B Michel H R Bosshard Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase The Journal of Biological Chemistry 1984 08 25 259 16 10085 10091 2019 05 25 ISSN 0021 9258 PMID 6088481 原始内容存档于2019 09 01 C Broger M J Nalecz A Azzi Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain Biochimica Et Biophysica Acta 1980 10 03 592 3 519 527 2019 05 25 ISSN 0006 3002 PMID 6251869 原始内容存档于2019 08 30 H T Smith A J Ahmed F Millett Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase The Journal of Biological Chemistry 1981 05 25 256 10 4984 4990 2019 05 25 ISSN 0021 9258 PMID 6262312 原始内容存档于2019 09 03 L M Geren F Millett Fluorescence energy transfer studies of the interaction between adrenodoxin and cytochrome c The Journal of Biological Chemistry 1981 10 25 256 20 10485 10489 2019 05 25 ISSN 0021 9258 PMID 6270113 原始内容存档于2019 08 31 B Favre S Zolnierowicz P Turowski B A Hemmings The catalytic subunit of protein phosphatase 2A is carboxyl methylated in vivo The Journal of Biological Chemistry 1994 06 10 269 23 16311 16317 2019 05 25 ISSN 0021 9258 PMID 8206937 原始内容存档于2019 08 31 B Gao E Eisenberg L Greene Effect of constitutive 70 kDa heat shock protein polymerization on its interaction with protein substrate The Journal of Biological Chemistry 1996 07 12 271 28 16792 16797 2019 05 25 ISSN 0021 9258 PMID 8663341 doi 10 1074 jbc 271 28 16792 原始内容存档于2019 09 01 其他圖像 编辑 ETC外部連結 编辑細胞色素c蛋白 页面存档备份 存于互联网档案馆 英文 細胞凋亡 amp Caspase 3 蛋白酶 页面存档备份 存于互联网档案馆 PMAP 蛋白酶動畫 英文 Template UMichOPM Calculated orientations of cytochromes c in the lipid bilayer 醫學主題詞表 MeSH Cytochrome c 英文 Template Fas apoptosis signaling pathway 取自 https zh wikipedia org w index php title 細胞色素c amp oldid 71531560, 维基百科,wiki,书籍,书籍,图书馆,

文章

,阅读,下载,免费,免费下载,mp3,视频,mp4,3gp, jpg,jpeg,gif,png,图片,音乐,歌曲,电影,书籍,游戏,游戏。