· phosphoglycerate dehydrogenase activity · electron carrier activity
· NAD binding
细胞成分
· cytosol
生物过程
· glutamine metabolic process
· glycine metabolic process · L-serine biosynthetic process · L-serine biosynthetic process · threonine metabolic process · brain development · cellular amino acid biosynthetic process · gamma-aminobutyric acid metabolic process · regulation of gene expression · taurine metabolic process · spinal cord development · glial cell development · neural tube development · cell cycle process · neuron projection development · cellular nitrogen compound metabolic process
^Pizer, L.I. The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J. Biol. Chem. 1986, 243: 2081–2089. PMID 4384871.
^Zhao, G. and Winkler, M.E. A novel α-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. J. Bacteriol. 1996, 178: 232–239. PMID 8550422.
Sugimoto, E. and Pizer, L.I. The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase. J. Biol. Chem. 1968, 243: 2081–1089. PMID 4384871.
Schuller, D.J., Grant, G.A. and Banaszak, L.J. The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase. Nat. Struct. Biol. 1995, 2: 69–76. PMID 7719856.
扩展阅读编辑
Tsang HT, Connell JW, Brown SE; et al. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.. Genomics. 2006, 88 (3): 333–346. PMID 16730941. doi:10.1016/j.ygeno.2006.04.003. 引文格式1维护：显式使用等标签 (link)
Gregory SG, Barlow KF, McLay KE; et al. The DNA sequence and biological annotation of human chromosome 1.. Nature. 2006, 441 (7091): 315–321. PMID 16710414. doi:10.1038/nature04727. 引文格式1维护：显式使用等标签 (link)
Guo D, Han J, Adam BL; et al. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.. Biochem. Biophys. Res. Commun. 2005, 337 (4): 1308–18. PMID 16236267. doi:10.1016/j.bbrc.2005.09.191. 引文格式1维护：显式使用等标签 (link)
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–2127. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504. 引文格式1维护：显式使用等标签 (link)
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–45. PMID 14702039. doi:10.1038/ng1285. 引文格式1维护：显式使用等标签 (link)
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 引文格式1维护：显式使用等标签 (link)
Pind S, Slominski E, Mauthe J; et al. V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.. J. Biol. Chem. 2002, 277 (9): 7136–7143. PMID 11751922. doi:10.1074/jbc.M111419200. 引文格式1维护：显式使用等标签 (link)
Klomp LW, de Koning TJ, Malingré HE; et al. Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.. Am. J. Hum. Genet. 2001, 67 (6): 1389–1399. PMC 1287916. PMID 11055895. doi:10.1086/316886. 引文格式1维护：显式使用等标签 (link)
Pineda M, Vilaseca MA, Artuch R; et al. 3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome.. Developmental medicine and child neurology. 2000, 42 (9): 629–633. PMID 11034457. doi:10.1017/S0012162200001171. 引文格式1维护：显式使用等标签 (link)
Baek JY, Jun DY, Taub D, Kim YH. Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization.. Cytogenet. Cell Genet. 2000, 89 (1-2): 6–7. PMID 10894924. doi:10.1159/000015577.
Cho HM, Jun DY, Bae MA; et al. Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.. Gene. 2000, 245 (1): 193–201. PMID 10713460. doi:10.1016/S0378-1119(00)00009-3. 引文格式1维护：显式使用等标签 (link)
Jaeken J, Detheux M, Van Maldergem L; et al. 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.. Arch. Dis. Child. 1996, 74 (6): 542–545. PMC 1511571. PMID 8758134. doi:10.1136/adc.74.6.542. 引文格式1维护：显式使用等标签 (link)
一月 01, 1970
磷酸甘油酸脱氢酶, 英語, phosphoglycerate, dehydrogenase, 页面存档备份, 存于互联网档案馆, 是一种以nad, 或nadp, 为受体, 作用于供体ch, oh基团上的氧化还原酶, 这种酶能催化以下两种酶促反应, 命名, 系统命名, phospho, glycerate, oxidoreductase, 缩写, phgdh, 别名, phosphoglycerate, oxidoreductase, phosphoglycerate, dehydrogenase, phosphog. 磷酸甘油酸脱氢酶 英語 phosphoglycerate dehydrogenase EC 1 1 1 95 页面存档备份 存于互联网档案馆 是一种以NAD 或NADP 为受体 作用于供体CH OH基团上的氧化还原酶 这种酶能催化以下两种酶促反应 磷酸甘油酸脱氢酶 命名 系统命名 3 phospho D glycerate NAD 2 oxidoreductase 缩写 PHGDH 别名 D 3 phosphoglycerate NAD oxidoreductase a phosphoglycerate dehydrogenase 3 phosphoglycerate dehydrogenase 3 phosphoglyceric acid dehydrogenase D 3 phosphoglycerate dehydrogenase glycerate 3 phosphate dehydrogenase glycerate 1 3 phosphate dehydrogenase phosphoglycerate oxidoreductase phosphoglyceric acid dehydrogenase SerA 3 phosphoglycerate NAD 2 oxidoreductase SerA 3PG dehydrogenase 3PHP reductase aKG reductase D and L HGA 识别码 EC編號 1 1 1 95 CAS号 9075 29 0 数据库 IntEnz IntEnz浏览 BRENDA 英语 BRENDA BRENDA入口 ExPASy 英语 ExPASy NiceZyme浏览 KEGG KEGG入口 MetaCyc 英语 MetaCyc 代谢路径 PRIAM 英语 PRIAM enzyme specific profiles 概述 PDB RCSB PDB PDBj PDBe PDBsum 基因本体 AmiGO EGO 搜索 PMC 相关文献 PubMed 相关文献 磷酸甘油酸脱氢酶磷酸甘油酸的晶体结构 PDB 2g76 有效结构 PDB 直系同源检索 PDBe RCSB PDB查询代码列表 2G76标识代号PHGDH 3 PGDH 3PGDH PDG PGAD PGD PGDH SERA扩展标识遗传学 606879 鼠基因 1355330 同源基因 39318 GeneCards PHGDH GeneEC編號1 1 1 95基因本体论描述 分子功能 phosphoglycerate dehydrogenase activity phosphoglycerate dehydrogenase activity electron carrier activity NAD binding 细胞成分 cytosol 生物过程 glutamine metabolic process glycine metabolic process L serine biosynthetic process L serine biosynthetic process threonine metabolic process brain development cellular amino acid biosynthetic process gamma aminobutyric acid metabolic process regulation of gene expression taurine metabolic process spinal cord development glial cell development neural tube development cell cycle process neuron projection development cellular nitrogen compound metabolic process small molecule metabolic process Sources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez26227236539EnsemblENSG00000092621ENSMUSG00000053398UniProtO43175Q61753mRNA序列NM 006623 3NM 016966 3蛋白序列NP 006614 2NP 058662 2基因位置Chr 1 120 2 120 29 MbChr 3 98 12 98 14 MbPubMed查询 1 2 查论编 3 磷酸化 D 甘油酸 NAD displaystyle rightleftharpoons 3 磷酸羟基丙酮酸 NADH H 2 羟基戊二酸 NAD displaystyle rightleftharpoons a 酮戊二酸 NADH H 在大肠杆菌 Escherichia coli 中 磷酸甘油酸脱氢酶参与催化丝氨酸生物合成的磷酸丝氨酸途径中的第一步 1 上述可逆反应主要逆向进行 磷酸甘油酸脱氢酶可被丝氨酸或甘氨酸抑制 这种酶很不寻常 因为它还能像D 2 羟基戊二酸脱氢酶和L 2 羟基戊二酸脱氢酶一样还原a 酮戊二酸 其中 D型底物更适合磷酸甘油酸脱氢酶 2 参考文献 编辑 Pizer L I The mechanism of end product inhibition of serine biosynthesis I Purification and kinetics of phosphoglycerate dehydrogenase J Biol Chem 1986 243 2081 2089 PMID 4384871 Zhao G and Winkler M E A novel a ketoglutarate reductase activity of the serA encoded 3 phosphoglycerate dehydrogenase of Escherichia coli K 12 and its possible implications for human 2 hydroxyglutaric aciduria J Bacteriol 1996 178 232 239 PMID 8550422 Sugimoto E and Pizer L I The mechanism of end product inhibition of serine biosynthesis I Purification and kinetics of phosphoglycerate dehydrogenase J Biol Chem 1968 243 2081 1089 PMID 4384871 Schuller D J Grant G A and Banaszak L J The allosteric ligand site in the Vmax type cooperative enzyme phosphoglycerate dehydrogenase Nat Struct Biol 1995 2 69 76 PMID 7719856 扩展阅读 编辑Tsang HT Connell JW Brown SE et al A systematic analysis of human CHMP protein interactions additional MIT domain containing proteins bind to multiple components of the human ESCRT III complex Genomics 2006 88 3 333 346 PMID 16730941 doi 10 1016 j ygeno 2006 04 003 引文格式1维护 显式使用等标签 link Gregory SG Barlow KF McLay KE et al The DNA sequence and biological annotation of human chromosome 1 Nature 2006 441 7091 315 321 PMID 16710414 doi 10 1038 nature04727 引文格式1维护 显式使用等标签 link Guo D Han J Adam BL et al Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation induced stress Biochem Biophys Res Commun 2005 337 4 1308 18 PMID 16236267 doi 10 1016 j bbrc 2005 09 191 引文格式1维护 显式使用等标签 link Gerhard DS Wagner L Feingold EA et al The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 2127 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 引文格式1维护 显式使用等标签 link Ota T Suzuki Y Nishikawa T et al Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 2004 36 1 40 45 PMID 14702039 doi 10 1038 ng1285 引文格式1维护 显式使用等标签 link Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 16903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Pind S Slominski E Mauthe J et al V490M a common mutation in 3 phosphoglycerate dehydrogenase deficiency causes enzyme deficiency by decreasing the yield of mature enzyme J Biol Chem 2002 277 9 7136 7143 PMID 11751922 doi 10 1074 jbc M111419200 引文格式1维护 显式使用等标签 link Klomp LW de Koning TJ Malingre HE et al Molecular characterization of 3 phosphoglycerate dehydrogenase deficiency a neurometabolic disorder associated with reduced L serine biosynthesis Am J Hum Genet 2001 67 6 1389 1399 PMC 1287916 nbsp PMID 11055895 doi 10 1086 316886 引文格式1维护 显式使用等标签 link Pineda M Vilaseca MA Artuch R et al 3 phosphoglycerate dehydrogenase deficiency in a patient with West syndrome Developmental medicine and child neurology 2000 42 9 629 633 PMID 11034457 doi 10 1017 S0012162200001171 引文格式1维护 显式使用等标签 link Baek JY Jun DY Taub D Kim YH Assignment of human 3 phosphoglycerate dehydrogenase PHGDH to human chromosome band 1p12 by fluorescence in situ hybridization Cytogenet Cell Genet 2000 89 1 2 6 7 PMID 10894924 doi 10 1159 000015577 Cho HM Jun DY Bae MA et al Nucleotide sequence and differential expression of the human 3 phosphoglycerate dehydrogenase gene Gene 2000 245 1 193 201 PMID 10713460 doi 10 1016 S0378 1119 00 00009 3 引文格式1维护 显式使用等标签 link Jaeken J Detheux M Van Maldergem L et al 3 Phosphoglycerate dehydrogenase deficiency an inborn error of serine biosynthesis Arch Dis Child 1996 74 6 542 545 PMC 1511571 nbsp PMID 8758134 doi 10 1136 adc 74 6 542 引文格式1维护 显式使用等标签 link 取自 https zh wikipedia org w index php title 磷酸甘油酸脱氢酶 amp oldid 69141382, 维基百科，wiki，书籍，书籍，图书馆，
