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一月 07, 2023
黑素皮质素受体4, mc4受體, 即mc4r, 是在人體中由mc4r基因編碼的黑素皮质素受體, 英语, melanocortin, receptor, 它編碼mc4蛋白, 在小鼠中, 已發現mc4受體參與進食行為, 代謝, 性行為和男性勃起功能的調節, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表2iqp, 2iqr, 2iqs, 2iqu, 2iqv, 2iqw識別號别名mc4r, melanocortin, receptor, bmiq20外部idomim, 155541, 99457, . MC4受體 即MC4R 是在人體中由MC4R基因編碼的黑素皮质素受體 英语 Melanocortin receptor 6 7 8 它編碼MC4蛋白 在小鼠中 已發現MC4受體參與進食行為 代謝 性行為和男性勃起功能的調節 9 10 11 黑素皮质素受体4已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表2IQP 2IQR 2IQS 2IQU 2IQV 2IQW識別號别名MC4R Melanocortin 4 receptor BMIQ20外部IDOMIM 155541 MGI 99457 HomoloGene 4320 GeneCards MC4R為以下藥物的標靶美拉諾坦 I 美拉諾坦 II THIQ 1 基因位置 人类 染色体18號染色體 2 基因座18q21 32起始60 371 062 bp 2 终止60 372 775 bp 2 基因位置 小鼠 染色体小鼠18号染色体 3 基因座18 18 E1起始66 990 775 bp 3 终止66 993 577 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 G protein coupled receptor activity signal transducer activity peptide hormone binding melanocyte stimulating hormone receptor activity 血浆蛋白结合 melanocortin receptor activity 泛素蛋白连接酶结合 neuropeptide binding hormone binding細胞組分 integral component of membrane 膜 细胞膜 细胞核生物學過程 regulation of grooming behavior adenylate cyclase modulating G protein coupled receptor signaling pathway insulin secretion regulation of feeding behavior positive regulation of bone resorption diet induced thermogenesis response to insulin feeding behavior negative regulation of feeding behavior energy reserve metabolic process regulation of metabolic process 訊息傳遞 G protein coupled receptor signaling pathway adenylate cyclase activating G protein coupled receptor signaling pathwaySources Amigo QuickGO直系同源物種人類小鼠Entrez416017202EnsemblENSG00000166603ENSMUSG00000047259UniProtP32245P56450mRNA 序列NM 005912NM 016977蛋白序列NP 005903NP 058673基因位置 UCSC Chr 18 60 37 60 37 MbChr 18 66 99 66 99 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠據2008年的報導 MC4R突變與人類遺傳性肥胖有關 12 在體重指數大於30的人群中 該病的患病率為1 0 2 5 是最容易導致肥胖的最常見遺傳缺陷 來源請求 參考文獻 编辑 對黑皮质素受体4起作用的藥物 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000166603 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000047259 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Magenis RE Smith L Nadeau JH Johnson KR Mountjoy KG Cone RD Mapping of the ACTH MSH and neural MC3 and MC4 melanocortin receptors in the mouse and human Mammalian Genome August 1994 5 8 503 8 PMC 请检查 pmc 值 帮助 PMID 7949735 doi 10 1007 BF00369320 Sundaramurthy D Campbell DA Leek JP Markham AF Pieri LF Assignment of the melanocortin 4 receptor MC4R gene to human chromosome band 18q22 by in situ hybridisation and radiation hybrid mapping Cytogenetics and Cell Genetics November 1998 82 1 2 97 8 PMC 请检查 pmc 值 帮助 PMID 9763669 doi 10 1159 000015074 Entrez Gene MC4R melanocortin 4 receptor 原始内容存档于2010 03 07 Fan W Boston BA Kesterson RA Hruby VJ Cone RD Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature January 1997 385 6612 165 8 Bibcode 1997Natur 385 165F PMID 8990120 doi 10 1038 385165a0 Huszar D Lynch CA Fairchild Huntress V Dunmore JH Fang Q Berkemeier LR Gu W Kesterson RA Boston BA Cone RD Smith FJ Campfield LA Burn P Lee F Targeted disruption of the melanocortin 4 receptor results in obesity in mice Cell January 1997 88 1 131 41 PMID 9019399 doi 10 1016 S0092 8674 00 81865 6 Van der Ploeg LH Martin WJ Howard AD Nargund RP Austin CP Guan X et al A role for the melanocortin 4 receptor in sexual function Proceedings of the National Academy of Sciences of the United States of America August 2002 99 17 11381 6 Bibcode 2002PNAS 9911381V PMC 123265 PMID 12172010 doi 10 1073 pnas 172378699 Loos Ruth J F Lindgren Cecilia M Li Shengxu Wheeler Eleanor Zhao Jing Hua Prokopenko Inga Inouye Michael Freathy Rachel M Attwood Antony P Beckmann Jacques S Berndt Sonja I Common variants near MC4R are associated with fat mass weight and risk of obesity Nature Genetics June 2008 40 6 768 775 ISSN 1546 1718 PMC 2669167 PMID 18454148 doi 10 1038 ng 140 取自 https zh wikipedia org w index php title 黑素皮质素受体4 amp oldid 70186481, 维基百科，wiki，书籍，书籍，图书馆，
