^Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. October 1980, 287 (5785): 795–801. PMID 6776413. doi:10.1038/287795a0.
二月 02, 2023
音猬因子, 此條目可参照英語維基百科相應條目来扩充, 2023年1月5日, 若您熟悉来源语言和主题, 请协助参考外语维基百科扩充条目, 请勿直接提交机械翻译, 也不要翻译不可靠, 低品质内容, 依版权协议, 译文需在编辑摘要注明来源, 或于讨论页顶部标记, href, template, translated, page, html, title, template, translated, page, translated, page, 标签, 音蝟因子, 英語, sonic, hedgehog, 简称shh, . 此條目可参照英語維基百科相應條目来扩充 2023年1月5日 若您熟悉来源语言和主题 请协助参考外语维基百科扩充条目 请勿直接提交机械翻译 也不要翻译不可靠 低品质内容 依版权协议 译文需在编辑摘要注明来源 或于讨论页顶部标记 a href Template Translated page html title Template Translated page Translated page a 标签 音蝟因子 英語 sonic hedgehog 简称SHH 是5種刺蝟因子 hedgehog 简称HH 其他四种是沙漠刺猬因子 英语 DHH hedgehog DHH 印度刺猬因子 英语 IHH protein IHH Echidna Hedgehog EHH和Tiggywinkle Hedgehog TwHH 中的一種 音猬因子3D structure of the signaling domain of the murine Sonic hedgehog from PDB 1vhh有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表3HO5 3M1N 3MXW标识代号SHH HHG1 HLP3 HPE3 MCOPCB5 SMMCI TPT TPTPS扩展标识遗传学 600725 鼠基因 98297 同源基因 30961 GeneCards SHH Gene基因本体论描述分子功能 glycoprotein binding signal transducer activity patched binding calcium ion binding protein binding glycosaminoglycan binding peptidase activity zinc ion binding laminin 1 binding细胞成分 extracellular region extracellular space extracellular space membrane fraction nucleus endoplasmic reticulum Golgi apparatus plasma membrane cell surface transport vesicle extracellular matrix membrane raft生物过程 patterning of blood vessels vasculogenesis metanephros development branching involved in ureteric bud morphogenesis response to hypoxia cell fate specification neural crest cell migration neural tube formation vasculature development heart looping positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation osteoblast development lymphoid progenitor cell differentiation endocytosis signal transduction smoothened signaling pathway positive regulation of hh target transcription factor activity cell cell signaling determination of left right symmetry pattern specification process ectoderm development neuroblast proliferation axon guidance central nervous system development ventral midline development hindgut morphogenesis digestive tract mesoderm development heart development blood coagulation androgen metabolic process cell death positive regulation of cell proliferation embryo development anterior posterior pattern formation dorsal ventral pattern formation response to organic nitrogen oligodendrocyte development striated muscle tissue development positive regulation of skeletal muscle cell proliferation myotube differentiation intein mediated protein splicing spinal cord dorsal ventral patterning ventral spinal cord interneuron specification dorsal ventral neural tube patterning smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation positive regulation of cerebellar granule cell precursor proliferation telencephalon regionalization establishment of cell polarity regulation of proteolysis positive regulation of Wnt receptor signaling pathway lung development embryonic limb morphogenesis negative regulation of cell migration male genitalia development prostate gland development regulation of epithelial cell differentiation thyroid gland development forebrain development midbrain development hindbrain development pancreas development hair follicle morphogenesis response to estradiol stimulus negative regulation of proteasomal ubiquitin dependent protein catabolic process response to retinoic acid T cell differentiation in thymus positive regulation of T cell differentiation in thymus positive regulation of immature T cell proliferation in thymus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis regulation of cell proliferation negative regulation of T cell proliferation positive regulation of protein import into nucleus odontogenesis of dentine containing tooth embryonic digit morphogenesis camera type eye development negative regulation of apoptosis CD4 positive or CD8 positive alpha beta T cell lineage commitment tongue morphogenesis skin development positive thymic T cell selection negative thymic T cell selection intermediate filament organization myoblast differentiation response to ethanol negative regulation of cell differentiation positive regulation of transcription DNA dependent positive regulation of transcription from RNA polymerase II promoter positive regulation of photoreceptor cell differentiation positive regulation of alpha beta T cell differentiation negative regulation of alpha beta T cell differentiation cell development thymus development embryonic digestive tract morphogenesis embryonic organ development developmental growth embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development organ formation neuron fate commitment response to axon injury embryonic skeletal system development positive regulation of oligodendrocyte differentiation branching morphogenesis of a tube male genitalia morphogenesis inner ear development formation of anatomical boundary stem cell development positive regulation of striated muscle cell differentiation Bergmann glial cell differentiation palate development limb development limb bud formation positive regulation of penile erection lung epithelium development trachea morphogenesis branching involved in salivary gland morphogenesis bud outgrowth involved in lung branching right lung development left lung development lung lobe morphogenesis lung associated mesenchyme development primary prostatic bud elongation prostate epithelial cord elongation salivary gland cavitation epithelial cell proliferation involved in salivary gland morphogenesis regulation of prostatic bud formation epithelial mesenchymal signaling involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of mesenchymal cell proliferation involved in prostate gland development mesenchymal smoothened signaling pathway involved in prostate gland development artery development mesenchymal cell proliferation involved in lung development sclerotome development positive regulation of oligodendrocyte progenitor proliferation cellular response to lithium ion metanephric mesenchymal cell proliferation involved in metanephros development regulation of mesenchymal cell proliferation involved in ureter development multicellular structure septum development negative regulation of canonical Wnt receptor signaling pathway negative regulation of ureter smooth muscle cell differentiation positive regulation of ureter smooth muscle cell differentiation negative regulation of kidney smooth muscle cell differentiation positive regulation of kidney smooth muscle cell differentiationSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez646920423EnsemblENSG00000164690ENSMUSG00000002633UniProtQ15465Q8C765mRNA序列NM 000193 2NM 009170 3蛋白序列NP 000184 1NP 033196 1基因位置Chr 7 155 59 155 6 MbChr 5 28 78 28 79 MbPubMed查询 1 2 查论编刺蝟因子是重要的信号传导途径 而音蝟因子則是刺蝟信号传导途径中研究最透彻的配体 這種因子作为重要的形态发生素 Morphogen 在调节脊椎动物器官发育中起关键作用 比如它决定四肢以及腦脊髓正中線的形成 音蝟因子在成年个体中也很重要 它控制成年体细胞的分裂 音蝟因子的失控将导致癌症 目录 1 發表 2 命名 3 研究 4 疾病 5 逸聞 6 另見 7 參考文獻發表 编辑這種刺猬基因 刺猬信号通路 hh 是由1995年諾貝爾生理學或醫學獎得主艾瑞克 威斯喬斯以及克里斯汀 紐斯林 沃爾哈德所確認 他們的研究於1980年發表 1 這個發表更為他們帶來了1995年的諾貝爾生理學或醫學獎 命名 编辑當初於黑腹果蠅 Drosophila 身上進行研究時 發現當這類因子發生突變時 果蠅的幼蟲表皮上會長滿了短的倒刺 就好像刺蝟的模樣 因此就命名為 刺蝟 Hedgehog 及後當發現了更多此類型的基因後 為分別就以 刺蝟 為基本去進行命名 當中有兩種先被發現的刺蝟因子 沙漠刺猬因子 英语 DHH hedgehog Desert Hedgehog DHH 以及印度刺猬因子 英语 IHH protein Indian Hedgehog IHH 就是以兩種現實存在的刺蝟去進行命名 而及後發現的 音蝟因子 則是以世嘉一套相當有名的電玩主角刺蝟索尼克 Sonic the Hedgehog 即 音速小子 或 超音鼠 而進行命名 研究 编辑果蝇的刺蝟因子在上世纪的90年代早期被克隆 除果蝇外 也有在其他非脊椎动物中克隆這類基因 如水蛭和海胆 至於脊椎动物 其直系同源基因于1993年被克隆 包括的動物有小鼠 斑马鱼和鸡 之后不久 分别于1994年及1995年 第一个大鼠和人的刺蝟因子也宣告克隆成功 疾病 编辑當音蝟因子發生突變 會因腹側正中線缺失而引起前腦發育畸形症Holoprosencephaly HPE 而音蝟因子在成年个体中的失调亦会导致癌症 逸聞 编辑這種利用電玩去命名的原則也發生在前稱 Pokemon 的Zbtb7因子 與 寵物小精靈 的名字相同 以及對視力相關的皮卡丘素 Pikachurin 以寵物小精靈中的皮卡丘命名 然前者卻因專利與商標問題被迫更名 另見 编辑名稱獨特的化學物質列表參考文獻 编辑 Nusslein Volhard C Wieschaus E Mutations affecting segment number and polarity in Drosophila Nature October 1980 287 5785 795 801 PMID 6776413 doi 10 1038 287795a0 取自 https zh wikipedia org w index php title 音猬因子 amp oldid 75385220, 维基百科，wiki，书籍，书籍，图书馆，
