· response to amphetamine · protein dephosphorylation · protein import into nucleus · calcium ion transport · response to stress · positive regulation of transcription from RNA polymerase II promoter · negative regulation of insulin secretion · skeletal muscle fiber development · regulation of synaptic transmission · regulation of excitatory postsynaptic membrane potential
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钙调磷酸酶, 英語, calcineurin, 是钙和钙调蛋白依赖性的丝氨酸, 苏氨酸蛋白磷酸酶, 亦称为蛋白磷酸酶3, ppp3, 旧称蛋白磷酸酶2b, pp2b, 其在体内的作用为启动t细胞并可以通过药物来阻断这一过程, 蛋白磷酸酶3, 催化亚基, α同工酶pdb, rendering, based, 1aui, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1aui, 1m63, 1mf8, 2jog, 2jzi, 2p6b, 2r28, 2w73标识代号ppp3ca, caln, . 钙调磷酸酶 1 英語 Calcineurin CaN 是钙和钙调蛋白依赖性的丝氨酸 苏氨酸蛋白磷酸酶 亦称为蛋白磷酸酶3 PPP3 旧称蛋白磷酸酶2B PP2B 其在体内的作用为启动T细胞并可以通过药物来阻断这一过程 蛋白磷酸酶3 催化亚基 a同工酶PDB rendering based on 1aui 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73标识代号PPP3CA CALN CALNA CALNA1 CCN1 CNA1 PPP2B扩展标识遗传学 114105 鼠基因 107164 同源基因 55497 GeneCards PPP3CA GeneEC編號3 1 3 16基因本体论描述分子功能 protein serine threonine phosphatase activity calcium dependent protein serine threonine phosphatase activity calcium ion binding protein binding calmodulin binding hydrolase activity protein heterodimerization activity细胞成分 soluble fraction insoluble fraction nucleus nucleolus cytoplasm mitochondrion microsome cytosol cytosol calcineurin complex membrane Z disc生物过程 G1 S transition of mitotic cell cycle response to amphetamine protein dephosphorylation protein import into nucleus calcium ion transport response to stress positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion skeletal muscle fiber development regulation of synaptic transmission regulation of excitatory postsynaptic membrane potential cellular response to glucose stimulusSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez553019055EnsemblENSG00000138814ENSMUSG00000028161UniProtQ08209P63328mRNA序列NM 000944 4NM 008913 4蛋白序列NP 000935 1NP 032939 1基因位置Chr 4 101 94 102 27 MbChr 3 136 33 136 6 MbPubMed查询 1 2 查论编钙调磷酸酶为很多种免疫抑制药的作用对象如 环孢霉素 吡美莫司和他克莫司 参考文献 编辑 存档副本 2021 12 09 原始内容存档于2021 12 09 深入阅读 编辑Crabtree GR Generic signals and specific outcomes signaling through Ca2 calcineurin and NF AT Cell 1999 96 5 611 4 PMID 10089876 doi 10 1016 S0092 8674 00 80571 1 Giri PR Higuchi S Kincaid RL Chromosomal mapping of the human genes for the calmodulin dependent protein phosphatase calcineurin catalytic subunit Biochem Biophys Res Commun 1992 181 1 252 8 PMID 1659808 doi 10 1016 S0006 291X 05 81410 X Kincaid RL Giri PR Higuchi S et al Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods J Biol Chem 1990 265 19 11312 9 PMID 2162844 引文格式1维护 显式使用等标签 link Guerini D Klee CB Cloning of human calcineurin A evidence for two isozymes and identification of a polyproline structural domain Proc Natl Acad Sci U S A 1990 86 23 9183 7 PMC 298458 PMID 2556704 doi 10 1073 pnas 86 23 9183 Kincaid RL Nightingale MS Martin BM Characterization of a cDNA clone encoding the calmodulin binding domain of mouse brain calcineurin Proc Natl Acad Sci U S A 1988 85 23 8983 7 PMC 282646 PMID 2848250 doi 10 1073 pnas 85 23 8983 Coghlan VM Perrino BA Howard M et al Association of protein kinase A and protein phosphatase 2B with a common anchoring protein Science 1995 267 5194 108 11 PMID 7528941 doi 10 1126 science 7528941 引文格式1维护 显式使用等标签 link Griffith JP Kim JL Kim EE et al X ray structure of calcineurin inhibited by the immunophilin immunosuppressant FKBP12 FK506 complex Cell 1995 82 3 507 22 PMID 7543369 doi 10 1016 0092 8674 95 90439 5 引文格式1维护 显式使用等标签 link Shibasaki F McKeon F Calcineurin functions in Ca 2 activated cell death in mammalian cells J Cell Biol 1995 131 3 735 43 PMC 2120616 PMID 7593193 doi 10 1083 jcb 131 3 735 Muramatsu T Kincaid RL Molecular cloning of a full length cDNA encoding the catalytic subunit of human calmodulin dependent protein phosphatase calcineurin A alpha Biochim Biophys Acta 1993 1178 1 117 20 PMID 8392375 doi 10 1016 0167 4889 93 90117 8 Cameron AM Steiner JP Roskams AJ et al Calcineurin associated with the inositol 1 4 5 trisphosphate receptor FKBP12 complex modulates Ca2 flux Cell 1996 83 3 463 72 PMID 8521476 doi 10 1016 0092 8674 95 90124 8 引文格式1维护 显式使用等标签 link Kissinger CR Parge HE Knighton DR et al Crystal structures of human calcineurin and the human FKBP12 FK506 calcineurin complex Nature 1996 378 6557 641 4 PMID 8524402 doi 10 1038 378641a0 引文格式1维护 显式使用等标签 link Wang MG Yi H Guerini D et al Calcineurin A alpha PPP3CA calcineurin A beta PPP3CB and calcineurin B PPP3R1 are located on human chromosomes 4 10q21 q22 and 2p16 p15 respectively Cytogenet Cell Genet 1997 72 2 3 236 41 PMID 8978785 doi 10 1159 000134198 引文格式1维护 显式使用等标签 link Shibasaki F Kondo E Akagi T McKeon F Suppression of signalling through transcription factor NF AT by interactions between calcineurin and Bcl 2 Nature 1997 386 6626 728 31 PMID 9109491 doi 10 1038 386728a0 Kashishian A Howard M Loh C et al AKAP79 inhibits calcineurin through a site distinct from the immunophilin binding region J Biol Chem 1998 273 42 27412 9 PMID 9765270 doi 10 1074 jbc 273 42 27412 引文格式1维护 显式使用等标签 link Wang HG Pathan N Ethell IM et al Ca2 induced apoptosis through calcineurin dephosphorylation of BAD Science 1999 284 5412 339 43 PMID 10195903 doi 10 1126 science 284 5412 339 引文格式1维护 显式使用等标签 link Fuentes JJ Genesca L Kingsbury TJ et al DSCR1 overexpressed in Down syndrome is an inhibitor of calcineurin mediated signaling pathways Hum Mol Genet 2000 9 11 1681 90 PMID 10861295 doi 10 1093 hmg 9 11 1681 引文格式1维护 显式使用等标签 link Hartley JL Temple GF Brasch MA DNA cloning using in vitro site specific recombination Genome Res 2001 10 11 1788 95 PMC 310948 PMID 11076863 doi 10 1101 gr 143000 Frey N Richardson JA Olson EN Calsarcins a novel family of sarcomeric calcineurin binding proteins Proc Natl Acad Sci U S A 2001 97 26 14632 7 PMC 18970 PMID 11114196 doi 10 1073 pnas 260501097 Siddiq A Miyazaki T Takagishi Y et al Expression of ZAKI 4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism Endocrinology 2001 142 5 1752 9 PMID 11316738 doi 10 1210 en 142 5 1752 引文格式1维护 显式使用等标签 link 外部链接 编辑醫學主題詞表 MeSH Calcineurin eMedicine Dictionary上的Calcineurin 取自 https zh wikipedia org w index php title 钙调磷酸酶 amp oldid 72920899, 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