• regulation of transcription by RNA polymerase II • positive regulation of transcription, DNA-templated • regulation of steroid biosynthetic process • hormone metabolic process • luteinization • reproductive process • primary sex determination • 组织发生 • multicellular organism aging • 细胞分化 • maintenance of protein location in nucleus • regulation of transcription, DNA-templated • adrenal gland development • transcription, DNA-templated • steroid hormone mediated signaling pathway • cell-cell signaling • transcription by RNA polymerase II • negative regulation of female gonad development • transcription initiation from RNA polymerase II promoter • positive regulation of male gonad development • intracellular receptor signaling pathway • positive regulation of transcription by RNA polymerase II • 性别决定系统 • male gonad development • female gonad development • positive regulation of gene expression • hormone-mediated signaling pathway • calcineurin-mediated signaling • response to gonadotropin-releasing hormone • male sex determination
^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000136931 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000026751 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Reference, Genetics Home. NR5A1 gene. Genetics Home Reference. [2017-11-30]. （原始内容于2020-08-07） （英语）.
^ 6.06.1Parker KL, Schimmer BP. Steroidogenic factor 1: a key determinant of endocrine development and function. Endocrine Reviews. June 1997, 18 (3): 361–77. PMID 9183568. doi:10.1210/edrv.18.3.0301.
^J W Clemens, D S Lala, K L Parker, J S Richards. Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells.. Endocrinology. 1994-03, 134 (3): 1499–1508 [2020-02-02]. ISSN 0013-7227. doi:10.1210/endo.134.3.8119192（英语）.
^R.J. Ferrier. Synthetic Carbohydrate Chemistry of the 1980s. Carbohydrate Research. 1990-07, 202: ix–xi [2020-02-02]. doi:10.1016/0008-6215(90)84066-4. （原始内容于2018-06-23） （英语）.
^U. Wehrenberg, R. Ivell, M. Jansen, S. von Goedecke, N. Walther. Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary.. Proceedings of the National Academy of Sciences. 1994-02-15, 91 (4): 1440–1444 [2020-02-02]. ISSN 0027-8424. PMC 43175. PMID 8108428. doi:10.1073/pnas.91.4.1440（英语）. 引文格式1维护：PMC格式 (link)
^K. M. Caron. Characterization of the Promoter Region of the Mouse Gene Encoding the Steroidogenic Acute Regulatory Protein. Molecular Endocrinology. 1997-02-01, 11 (2): 138–147 [2020-02-02]. ISSN 0888-8809. doi:10.1210/me.11.2.138（英语）.[永久失效連結]
外部链接
GeneReviews/NCBI/NIH/UW entry on 46,XY Disorder of Sex Development and 46,XY Complete Gonadal Dysgenesis （页面存档备份，存于互联网档案馆）
OMIM entries on 46,XY Disorder of Sex Development and 46,XY Complete Gonadal Dysgenesis
类固醇生成因子1, 英語, steroidogenic, factor, 缩写sf, 是一种参与性別決定的转录因子, 涉及生殖腺与肾上腺, 这一蛋白由nr5a1基因编码, 属于核受体超家族, 位于9号染色体长臂段的位置33, 1最初发现于其能调节cyp450类固醇羟化酶的表达, 因而得名, 之后又发现了参与调控许多相关基因, 類固醇生成因子已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1yow, 1zdt, 4qjr, 4qk4識別號别名nr5a1, ad4bp, ftz1, ftzf1, po. 类固醇生成因子1 英語 steroidogenic factor 1 缩写SF 1 是一种参与性別決定的转录因子 涉及生殖腺与肾上腺 5 这一蛋白由NR5A1基因编码 属于核受体超家族 位于9号染色体长臂段的位置33 3 SF 1最初发现于其能调节CYP450类固醇羟化酶的表达 因而得名 之后又发现了参与调控许多相关基因 6 類固醇生成因子已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1YOW 1ZDT 4QJR 4QK4識別號别名NR5A1 AD4BP ELP FTZ1 FTZF1 POF7 SF 1 SF1 SPGF8 SRXY3 hSF 1 nuclear receptor subfamily 5 group A member 1 SRXX4外部IDOMIM 184757 MGI 1346833 HomoloGene 3638 GeneCards NR5A1基因位置 人类 染色体9號染色體 1 基因座9q33 3起始124 481 236 bp 1 终止124 507 420 bp 1 基因位置 小鼠 染色体小鼠2号染色体 2 基因座2 B 2 24 42 cM起始38 582 668 bp 2 终止38 604 554 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 血浆蛋白结合 鋅離子結合 lipid binding double stranded DNA binding 酶结合 transcription factor activity RNA polymerase II distal enhancer sequence specific binding steroid hormone receptor activity 转录共激活因子活性 phospholipid binding 金屬離子結合 DNA结合转录因子活性 RNA polymerase II cis regulatory region sequence specific DNA binding DNA结合 chromatin binding RNA polymerase II transcription regulatory region sequence specific DNA binding nuclear receptor activity sequence specific DNA binding DNA binding transcription factor activity RNA polymerase II specific transcription cis regulatory region binding細胞組分 核质 RNA polymerase II transcription regulator complex 细胞核生物學過程 regulation of transcription by RNA polymerase II positive regulation of transcription DNA templated regulation of steroid biosynthetic process hormone metabolic process luteinization reproductive process primary sex determination 组织发生 multicellular organism aging 细胞分化 maintenance of protein location in nucleus regulation of transcription DNA templated adrenal gland development transcription DNA templated steroid hormone mediated signaling pathway cell cell signaling transcription by RNA polymerase II negative regulation of female gonad development transcription initiation from RNA polymerase II promoter positive regulation of male gonad development intracellular receptor signaling pathway positive regulation of transcription by RNA polymerase II 性别决定系统 male gonad development female gonad development positive regulation of gene expression hormone mediated signaling pathway calcineurin mediated signaling response to gonadotropin releasing hormone male sex determinationSources Amigo QuickGO直系同源物種人類小鼠Entrez251626423EnsemblENSG00000136931ENSMUSG00000026751UniProtQ13285P33242mRNA 序列NM 004959NM 139051 NM 001316687蛋白序列NP 004950NP 004950 2NP 001303616 NP 620639基因位置 UCSC Chr 9 124 48 124 51 MbChr 2 38 58 38 6 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 目标基因 1 1 类固醇生成细胞 2 参考文献 3 外部链接目标基因 编辑类固醇生成细胞 编辑 SF 1最早在肾上腺皮质的类固醇生成细胞中被鉴定出具有调控类固醇生成酶活性 此后又发现在其它类固醇生成细胞中的活性 6 表 1 SF 1 在类固醇生成细胞中的目标基因 物种 基因 细胞 组织 来源大鼠 CYP11A1 颗粒细胞 7 小鼠 CYP11A1 Y1肾上腺皮质细胞 8 牛 催产素 卵巢 9 小鼠 StAR MA 10细胞 10 参考文献 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000136931 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000026751 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Reference Genetics Home NR5A1 gene Genetics Home Reference 2017 11 30 原始内容存档于2020 08 07 英语 6 0 6 1 Parker KL Schimmer BP Steroidogenic factor 1 a key determinant of endocrine development and function Endocrine Reviews June 1997 18 3 361 77 PMID 9183568 doi 10 1210 edrv 18 3 0301 J W Clemens D S Lala K L Parker J S Richards Steroidogenic factor 1 binding and transcriptional activity of the cholesterol side chain cleavage promoter in rat granulosa cells Endocrinology 1994 03 134 3 1499 1508 2020 02 02 ISSN 0013 7227 doi 10 1210 endo 134 3 8119192 英语 R J Ferrier Synthetic Carbohydrate Chemistry of the 1980s Carbohydrate Research 1990 07 202 ix xi 2020 02 02 doi 10 1016 0008 6215 90 84066 4 原始内容存档于2018 06 23 英语 U Wehrenberg R Ivell M Jansen S von Goedecke N Walther Two orphan receptors binding to a common site are involved in the regulation of the oxytocin gene in the bovine ovary Proceedings of the National Academy of Sciences 1994 02 15 91 4 1440 1444 2020 02 02 ISSN 0027 8424 PMC 43175 PMID 8108428 doi 10 1073 pnas 91 4 1440 英语 引文格式1维护 PMC格式 link K M Caron Characterization of the Promoter Region of the Mouse Gene Encoding the Steroidogenic Acute Regulatory Protein Molecular Endocrinology 1997 02 01 11 2 138 147 2020 02 02 ISSN 0888 8809 doi 10 1210 me 11 2 138 英语 永久失效連結 外部链接 编辑GeneReviews NCBI NIH UW entry on 46 XY Disorder of Sex Development and 46 XY Complete Gonadal Dysgenesis 页面存档备份 存于互联网档案馆 OMIM entries on 46 XY Disorder of Sex Development and 46 XY Complete Gonadal Dysgenesis 醫學主題詞表 MeSH steroidogenic factor 1 取自 https zh wikipedia org w index php title 类固醇生成因子1 amp oldid 70052798, 维基百科，wiki，书籍，书籍，图书馆，
