^Scheller, Jürgen; Chalaris, Athena; Schmidt-Arras, Dirk; Rose-John, Stefan. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2011, 1813 (5): 878–888. ISSN 0167-4889. doi:10.1016/j.bbamcr.2011.01.034.
^Keystone, Edward; Omair, Mohammed A. Interleukin-6 inhibition: 485–491. 2015. doi:10.1016/B978-0-323-09138-1.00062-0.
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十二月 10, 2023
白细胞介素, interleukin, 简称白介素, 在人体内由il6基因编码, 最初由日本免疫学家岸本忠三团队发现, 是一种介导炎症的白细胞介素, 但在某些情况下也具有抗炎症作用, 可由t细胞, b细胞, 单核细胞, 成纤维细胞, 角质形成细胞, 内皮细胞, 系膜细胞, 英语, mesangial, cell, 以及一部分肿瘤细胞分泌, 白細胞介素6已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4o9h, 1alu, 1il6, 1p9m, 2il6, 4cni, 4j4l, 4ni7, 4n. 白细胞介素 6 Interleukin 6 简称白介素 6 IL 6 在人体内由IL6基因编码 5 最初由日本免疫学家岸本忠三团队发现 6 是一种介导炎症的白细胞介素 但在某些情况下也具有抗炎症作用 7 5 白细胞介素 6可由T细胞 B细胞 单核细胞 成纤维细胞 角质形成细胞 内皮细胞 系膜细胞 英语 mesangial cell 以及一部分肿瘤细胞分泌 8 白細胞介素6已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4O9H 1ALU 1IL6 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4ZS7識別號别名IL6 BSF2 HGF HSF IFNB2 IL 6 BSF 2 CDF IFN beta 2 interleukin 6外部IDOMIM 147620 MGI 96559 HomoloGene 502 GeneCards IL6基因位置 人类 染色体7號染色體 1 基因座7p15 3起始22 725 884 bp 1 终止22 732 002 bp 1 基因位置 小鼠 染色体小鼠5号染色体 2 基因座5 B1 5 15 7 cM起始30 218 112 bp 2 终止30 224 979 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 細胞因子活性 生長因子活性 interleukin 6 receptor binding 血浆蛋白结合細胞組分 細胞外區域 interleukin 6 receptor complex 細胞外空間 endoplasmic reticulum lumen生物學過程 regulation of angiogenesis positive regulation of translation platelet activation humoral immune response defense response to virus response to peptidoglycan neuron projection development defense response to Gram positive bacterium negative regulation of fat cell differentiation positive regulation of peptidyl serine phosphorylation positive regulation of leukocyte chemotaxis positive regulation of T cell proliferation positive regulation of interleukin 6 production positive regulation of peptidyl tyrosine phosphorylation positive regulation of acute inflammatory response inflammatory response negative regulation of collagen biosynthetic process positive regulation of MAPK cascade hepatic immune response monocyte chemotaxis positive regulation of DNA binding transcription factor activity negative regulation of apoptotic process positive regulation of osteoblast differentiation positive regulation of NF kappaB transcription factor activity 急性期反应 免疫反应 regulation of vascular endothelial growth factor production positive regulation of chemokine production negative regulation of lipid storage neutrophil mediated immunity positive regulation of smooth muscle cell proliferation positive regulation of type B pancreatic cell apoptotic process response to glucocorticoid defense response to Gram negative bacterium positive regulation of cell population proliferation positive regulation of apoptotic process positive regulation of B cell activation 翻译后修饰 regulation of signaling receptor activity positive regulation of tyrosine phosphorylation of STAT protein neutrophil apoptotic process negative regulation of cell population proliferation positive regulation of gene expression endocrine pancreas development negative regulation of bone resorption positive regulation of transcription DNA templated positive regulation of transcription by RNA polymerase II glucagon secretion cellular response to hydrogen peroxide cellular response to lipopolysaccharide T helper 17 cell lineage commitment positive regulation of T helper 2 cell cytokine production negative regulation of interleukin 1 mediated signaling pathway cytokine mediated signaling pathway interleukin 6 mediated signaling pathway positive regulation of receptor signaling pathway via JAK STAT 訊息傳遞Sources Amigo QuickGO直系同源物種人類小鼠Entrez356916193EnsemblENSG00000136244ENSMUSG00000025746UniProtP05231P08505mRNA 序列NM 000600 NM 001318095 NM 001371096NM 031168 NM 001314054蛋白序列NP 000591 NP 001305024 NP 001358025NP 001300983 NP 112445基因位置 UCSC Chr 7 22 73 22 73 MbChr 5 30 22 30 22 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠白细胞介素 6最初被认为是一种能促进B细胞分化为浆细胞的因子 后来陆续发现有其他功能 9 例如 白细胞介素 6能够穿过血脑屏障 10 与中枢神经系统的正常生理过程与损伤修复过程都有关联 9 参考资料 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000136244 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000025746 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine 5 0 5 1 Ferguson Smith AC Chen YF Newman MS May LT Sehgal PB Ruddle FH Regional localization of the interferon beta 2 B cell stimulatory factor 2 hepatocyte stimulating factor gene to human chromosome 7p15 p21 Genomics April 1988 2 3 203 8 PMID 3294161 doi 10 1016 0888 7543 88 90003 1 Immune Regulation Osaka University 2021 04 18 原始内容存档于2021 04 18 Scheller Jurgen Chalaris Athena Schmidt Arras Dirk Rose John Stefan The pro and anti inflammatory properties of the cytokine interleukin 6 Biochimica et Biophysica Acta BBA Molecular Cell Research 2011 1813 5 878 888 ISSN 0167 4889 doi 10 1016 j bbamcr 2011 01 034 Keystone Edward Omair Mohammed A Interleukin 6 inhibition 485 491 2015 doi 10 1016 B978 0 323 09138 1 00062 0 9 0 9 1 Erta Maria Quintana Albert Hidalgo Juan Interleukin 6 a Major Cytokine in the Central Nervous System International Journal of Biological Sciences 2012 8 9 1254 1266 ISSN 1449 2288 doi 10 7150 ijbs 4679 Banks WA Kastin AJ Gutierrez EG Penetration of interleukin 6 across the murine blood brain barrier Neuroscience Letters September 1994 179 1 2 53 6 PMID 7845624 doi 10 1016 0304 3940 94 90933 4 取自 https zh wikipedia org w index php title 白细胞介素 6 amp oldid 69730377, 维基百科，wiki，书籍，书籍，图书馆，
