内皮PAS结构域包含蛋白-1（英語：Endothelial PAS domain-containing protein 1，缩写EPAS1，也被称为缺氧诱导因子-2α亚基，英語：Hypoxia-inducible factor-2alpha，缩写HIF-2α）是一种由人类基因EPAS1 所编码的蛋白质[6][7][8][9]。
• surfactant homeostasis • 细胞分化 • response to hypoxia • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • lung development • norepinephrine metabolic process • iron ion homeostasis • mitochondrion organization • embryonic placenta development • cell maturation • response to oxidative stress • transcription, DNA-templated • regulation of heart rate • multicellular organism development • blood vessel remodeling • myoblast fate commitment • 血管新生 • regulation of transcription from RNA polymerase II promoter in response to hypoxia • erythrocyte differentiation • 訊息傳遞 • 視覺 • positive regulation of transcription by RNA polymerase II • cellular response to hypoxia • transcription by RNA polymerase II • 翻译后修饰 • 造血作用 • regulation of transcription by RNA polymerase II • positive regulation of cold-induced thermogenesis • protein ubiquitination
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000116016 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000024140 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. Feb 1997, 11 (1): 72–82. PMID 9000051. doi:10.1101/gad.11.1.72.
^ 7.07.1Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem. May 1997, 272 (13): 8581–93. PMID 9079689. doi:10.1074/jbc.272.13.8581.
^Percy MJ, Beer PA, Campbell G, Dekker AW, Green AR, Oscier D, Rainey MG, van Wijk R, Wood M, Lappin TR, McMullin MF, Lee FS. Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. Blood. May 2008, 111 (11): 5400–2. PMC 2396730. PMID 18378852. doi:10.1182/blood-2008-02-137703.
^ 9.09.1Entrez Gene: EPAS1 endothelial PAS domain protein 1. （原始内容于2019-10-16）.
^Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. November 1998, 12 (21): 3320–4. PMC 317225. PMID 9808618. doi:10.1101/gad.12.21.3320.
^Hogenesch JB, Gu YZ, Jain S, Bradfield CA. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U.S.A. May 1998, 95 (10): 5474–9. PMC 20401. PMID 9576906. doi:10.1073/pnas.95.10.5474.
Brahimi-Horn MC, Pouysségur J. The hypoxia-inducible factor and tumor progression along the angiogenic pathway.. Int. Rev. Cytol. 2005, 242: 157–213. PMID 15598469. doi:10.1016/S0074-7696(04)42004-X.
Haase VH. Hypoxia-inducible factors in the kidney.. Am. J. Physiol. Renal Physiol. 2006, 291 (2): F271–81. PMID 16554418. doi:10.1152/ajprenal.00071.2006.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA. A "double adaptor" method for improved shotgun library construction.. Anal. Biochem. 1996, 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.. Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (9): 4273–8. PMC 20712. PMID 9113979. doi:10.1073/pnas.94.9.4273.
Hogenesch JB, Gu YZ, Jain S, Bradfield CA. The basic helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors.. Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (10): 5474–9. PMC 20401. PMID 9576906. doi:10.1073/pnas.95.10.5474.
Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y. Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.. Biochem. Biophys. Res. Commun. 1998, 248 (3): 789–94. PMID 9704006. doi:10.1006/bbrc.1998.9012.
Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.. EMBO J. 1999, 18 (7): 1905–14. PMC 1171276. PMID 10202154. doi:10.1093/emboj/18.7.1905.
Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.. J. Biol. Chem. 2000, 275 (33): 25733–41. PMID 10823831. doi:10.1074/jbc.M002740200.
Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression.. J. Biol. Chem. 2001, 275 (47): 36847–51. PMID 11018023. doi:10.1074/jbc.C000629200.
Luo JC, Shibuya M. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha).. Oncogene. 2001, 20 (12): 1435–44. PMID 11313887. doi:10.1038/sj.onc.1204228.
Woods SL, Whitelaw ML. Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.. J. Biol. Chem. 2002, 277 (12): 10236–43. PMID 11782478. doi:10.1074/jbc.M110752200.
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.. Science. 2002, 295 (5556): 858–61. PMID 11823643. doi:10.1126/science.1068592.
Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.. Adv. Enzyme Regul. 2002, 42: 333–47. PMID 12123724. doi:10.1016/S0065-2571(01)00037-1.
Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.. Cancer. 2002, 95 (5): 1055–63. PMID 12209691. doi:10.1002/cncr.10774.
Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).. J. Biol. Chem. 2003, 278 (9): 7520–30. PMID 12464608. doi:10.1074/jbc.M211298200.
Sang N, Stiehl DP, Bohensky J, Leshchinsky I, Srinivas V, Caro J. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300.. J. Biol. Chem. 2003, 278 (16): 14013–9. PMID 12588875. doi:10.1074/jbc.M209702200.
epas1, 内皮pas结构域包含蛋白, 英語, endothelial, domain, containing, protein, 缩写, 也被称为缺氧诱导因子, 2α亚基, 英語, hypoxia, inducible, factor, 2alpha, 缩写hif, 是一种由人类基因, 所编码的蛋白质, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1p97, 2a24, 3f1n, 3f1o, 3f1p, 3h7w, 3h82, 4ghi, 4gs9, 4pky, 4xt2識別號别名, e. 内皮PAS结构域包含蛋白 1 英語 Endothelial PAS domain containing protein 1 缩写EPAS1 也被称为缺氧诱导因子 2a亚基 英語 Hypoxia inducible factor 2alpha 缩写HIF 2a 是一种由人类基因 EPAS1 所编码的蛋白质 6 7 8 9 EPAS1已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9 4PKY 4XT2識別號别名EPAS1 ECYT4 HIF2A HLF MOP2 PASD2 bHLHe73 endothelial PAS domain protein 1 Hypoxia inducible factor 2alpha外部IDOMIM 603349 MGI 109169 HomoloGene 1095 GeneCards EPAS1相關疾病腎細胞腫瘤 1 基因位置 人类 染色体2號染色體 2 基因座2p21起始46 293 667 bp 2 终止46 386 697 bp 2 基因位置 小鼠 染色体小鼠17号染色体 3 基因座17 17 E4起始87 061 128 bp 3 终止87 140 838 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 DNA结合 sequence specific DNA binding protein dimerization activity DNA结合转录因子活性 DNA binding transcription activator activity RNA polymerase II specific 转录因子结合 血浆蛋白结合 histone acetyltransferase binding protein heterodimerization activity DNA binding transcription factor activity RNA polymerase II specific細胞組分 細胞質 细胞质基质 nuclear speck 轉錄調節複合物 核质 细胞核生物學過程 surfactant homeostasis 细胞分化 response to hypoxia regulation of transcription DNA templated regulation of transcription from RNA polymerase II promoter in response to oxidative stress lung development norepinephrine metabolic process iron ion homeostasis mitochondrion organization embryonic placenta development cell maturation response to oxidative stress transcription DNA templated regulation of heart rate multicellular organism development blood vessel remodeling myoblast fate commitment 血管新生 regulation of transcription from RNA polymerase II promoter in response to hypoxia erythrocyte differentiation 訊息傳遞 視覺 positive regulation of transcription by RNA polymerase II cellular response to hypoxia transcription by RNA polymerase II 翻译后修饰 造血作用 regulation of transcription by RNA polymerase II positive regulation of cold induced thermogenesis protein ubiquitinationSources Amigo QuickGO直系同源物種人類小鼠Entrez203413819EnsemblENSG00000116016ENSMUSG00000024140UniProtQ99814P97481mRNA 序列 NM 001430NM 010137蛋白序列NP 001421NP 034267基因位置 UCSC Chr 2 46 29 46 39 MbChr 17 87 06 87 14 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠 目录 1 功能 2 交互作用 3 參考 4 註釋 5 参考文献 6 延伸阅读 7 外部链接功能 编辑EPAS1所表达的蛋白是一个转录因子的组成部分 该转录因子介导一些受氧气调控基因的表达 特别是低氧 缺氧 环境下 该蛋白包含一个碱性螺旋 环 螺旋蛋白二聚化结构域 此结构域也常见于其它氧应激相关信号通路蛋白 EPAS1涉及胚胎心脏 英语 embryonic heart 的发育 并在脐带的血管壁内皮细胞中表达 EPAS1维持儿茶酚胺类物质在胚胎早期发育中的稳定 以防止心臟衰竭 9 儿茶酚胺类物质包括肾上腺素和去甲肾上腺素 其稳定对胎儿与成人的心脏的健康有着重要作用 10 交互作用 编辑EPAS1能与芳香烃受体核转位子 英语 Aryl hydrocarbon receptor nuclear translocator 7 和ARNTL 11 发生交互作用 參考 编辑人類的高海拔適應 英语 High altitude adaptation in humans 丹尼索瓦人註釋 编辑 與EPAS1相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000116016 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000024140 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Tian H McKnight SL Russell DW Endothelial PAS domain protein 1 EPAS1 a transcription factor selectively expressed in endothelial cells Genes Dev Feb 1997 11 1 72 82 PMID 9000051 doi 10 1101 gad 11 1 72 7 0 7 1 Hogenesch JB Chan WK Jackiw VH Brown RC Gu YZ Pray Grant M Perdew GH Bradfield CA Characterization of a subset of the basic helix loop helix PAS superfamily that interacts with components of the dioxin signaling pathway J Biol Chem May 1997 272 13 8581 93 PMID 9079689 doi 10 1074 jbc 272 13 8581 Percy MJ Beer PA Campbell G Dekker AW Green AR Oscier D Rainey MG van Wijk R Wood M Lappin TR McMullin MF Lee FS Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis Blood May 2008 111 11 5400 2 PMC 2396730 PMID 18378852 doi 10 1182 blood 2008 02 137703 9 0 9 1 Entrez Gene EPAS1 endothelial PAS domain protein 1 原始内容存档于2019 10 16 Tian H Hammer RE Matsumoto AM Russell DW McKnight SL The hypoxia responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development Genes Dev November 1998 12 21 3320 4 PMC 317225 PMID 9808618 doi 10 1101 gad 12 21 3320 Hogenesch JB Gu YZ Jain S Bradfield CA The basic helix loop helix PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors Proc Natl Acad Sci U S A May 1998 95 10 5474 9 PMC 20401 PMID 9576906 doi 10 1073 pnas 95 10 5474 参考文献 编辑EPAS1引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 延伸阅读 编辑Brahimi Horn MC Pouyssegur J The hypoxia inducible factor and tumor progression along the angiogenic pathway Int Rev Cytol 2005 242 157 213 PMID 15598469 doi 10 1016 S0074 7696 04 42004 X Haase VH Hypoxia inducible factors in the kidney Am J Physiol Renal Physiol 2006 291 2 F271 81 PMID 16554418 doi 10 1152 ajprenal 00071 2006 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA A double adaptor method for improved shotgun library construction Anal Biochem 1996 236 1 107 13 PMID 8619474 doi 10 1006 abio 1996 0138 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA Large scale concatenation cDNA sequencing Genome Res 1997 7 4 353 8 PMC 139146 PMID 9110174 doi 10 1101 gr 7 4 353 Ema M Taya S Yokotani N Sogawa K Matsuda Y Fujii Kuriyama Y A novel bHLH PAS factor with close sequence similarity to hypoxia inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development Proc Natl Acad Sci U S A 1997 94 9 4273 8 PMC 20712 PMID 9113979 doi 10 1073 pnas 94 9 4273 Hogenesch JB Gu YZ Jain S Bradfield CA The basic helix loop helix PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors Proc Natl Acad Sci U S A 1998 95 10 5474 9 PMC 20401 PMID 9576906 doi 10 1073 pnas 95 10 5474 Takahata S Sogawa K Kobayashi A Ema M Mimura J Ozaki N Fujii Kuriyama Y Transcriptionally active heterodimer formation of an Arnt like PAS protein Arnt3 with HIF 1a HLF and clock Biochem Biophys Res Commun 1998 248 3 789 94 PMID 9704006 doi 10 1006 bbrc 1998 9012 Ema M Hirota K Mimura J Abe H Yodoi J Sogawa K Poellinger L Fujii Kuriyama Y Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia their stabilization and redox signal induced interaction with CBP p300 EMBO J 1999 18 7 1905 14 PMC 1171276 PMID 10202154 doi 10 1093 emboj 18 7 1905 Cockman ME Masson N Mole DR Jaakkola P Chang GW Clifford SC Maher ER Pugh CW Ratcliffe PJ Maxwell PH Hypoxia inducible factor alpha binding and ubiquitylation by the von Hippel Lindau tumor suppressor protein J Biol Chem 2000 275 33 25733 41 PMID 10823831 doi 10 1074 jbc M002740200 Maemura K de la Monte SM Chin MT Layne MD Hsieh CM Yet SF Perrella MA Lee ME CLIF a novel cycle like factor regulates the circadian oscillation of plasminogen activator inhibitor 1 gene expression J Biol Chem 2001 275 47 36847 51 PMID 11018023 doi 10 1074 jbc C000629200 Luo JC Shibuya M A variant of nuclear localization signal of bipartite type is required for the nuclear translocation of hypoxia inducible factors 1alpha 2alpha and 3alpha Oncogene 2001 20 12 1435 44 PMID 11313887 doi 10 1038 sj onc 1204228 Woods SL Whitelaw ML Differential activities of murine single minded 1 SIM1 and SIM2 on a hypoxic response element Cross talk between basic helix loop helix per Arnt Sim homology transcription factors J Biol Chem 2002 277 12 10236 43 PMID 11782478 doi 10 1074 jbc M110752200 Lando D Peet DJ Whelan DA Gorman JJ Whitelaw ML Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch Science 2002 295 5556 858 61 PMID 11823643 doi 10 1126 science 1068592 Mole DR Pugh CW Ratcliffe PJ Maxwell PH Regulation of the HIF pathway enzymatic hydroxylation of a conserved prolyl residue in hypoxia inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex Adv Enzyme Regul 2002 42 333 47 PMID 12123724 doi 10 1016 S0065 2571 01 00037 1 Sivridis E Giatromanolaki A Gatter KC Harris AL Koukourakis MI Association of hypoxia inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma Cancer 2002 95 5 1055 63 PMID 12209691 doi 10 1002 cncr 10774 Elvert G Kappel A Heidenreich R Englmeier U Lanz S Acker T Rauter M Plate K Sieweke M Breier G Flamme I Cooperative interaction of hypoxia inducible factor 2alpha HIF 2alpha and Ets 1 in the transcriptional activation of vascular endothelial growth factor receptor 2 Flk 1 J Biol Chem 2003 278 9 7520 30 PMID 12464608 doi 10 1074 jbc M211298200 Sang N Stiehl DP Bohensky J Leshchinsky I Srinivas V Caro J MAPK signaling up regulates the activity of hypoxia inducible factors by its effects on p300 J Biol Chem 2003 278 16 14013 9 PMID 12588875 doi 10 1074 jbc M209702200 外部链接 编辑醫學主題詞表 MeSH EPAS1 protein human 取自 https zh wikipedia org w index php title EPAS1 amp oldid 75364941, 维基百科，wiki，书籍，书籍，图书馆，
