^Stojanovic I, Cuzzocrea S, Mangano K, Mazzon E, Miljkovic D, Wang M, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clinical Immunology. June 2007, 123 (3): 311–23. PMID 17449326. doi:10.1016/j.clim.2007.03.004.
^Cha JJ, Hyun YY, Lee MH, Kim JE, Nam DH, Song HK, et al. Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology. June 2013, 154 (6): 2144–55. PMID 23568555. doi:10.1210/en.2012-2080.
^Saurus P, Kuusela S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, et al. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell Death & Disease. May 2015, 6 (5): e1752. PMC 4669704. PMID 25950482. doi:10.1038/cddis.2015.125.
^Lee JC, Menacherry S, Diehl MC, Giffear MD, White CJ, Juba R, et al. Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects. Clinical Pharmacology in Drug Development. March 2016, 5 (2): 91–101. PMID 27138022. S2CID 22577185. doi:10.1002/cpdd.193.
^Xu M, Li F, Wang M, Zhang H, Xu L, Adcock IM, et al. Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness. European Journal of Pharmacology. January 2019, 842: 373–383. PMID 30419239. S2CID 53292202. doi:10.1016/j.ejphar.2018.11.010. hdl:10044/1/66292.
^Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Alasmari F, Alasmari AF, et al. The potent immunomodulatory compound VGX-1027 regulates inflammatory mediators in CD4+ T cells, which are concomitant with the prevention of neuroimmune dysregulation in BTBR T+ Itpr3tf/J mice. Life Sciences. November 2019, 237: 116930. PMID 31610190. doi:10.1016/j.lfs.2019.116930.
1027, 也称为git, 分子式为c11h11no3, 是一种免疫調節劑, 可阻断tlr2, tlr4, tlr6等toll样受体的下游信号, 因此可减少白介素, α等多种细胞因子造成的影响, 识别信息iupac命名法, phenyl, dihydro, oxazol, acetic, acidcas号6501, pubchem, cid10798271chemspider8973577uniiakt814n13rchemblchembl1320667comptox, dashboard, 英语, comptox. VGX 1027也称为GIT 27 分子式为C11H11NO3 是一种免疫調節劑 可阻断TLR2 TLR4 TLR6等Toll样受体的下游信号 因此可减少白介素 TNF a等多种细胞因子造成的影响 1 2 3 4 5 6 VGX 1027识别信息IUPAC命名法 2 3 phenyl 4 5 dihydro 1 2 oxazol 5 yl acetic acidCAS号6501 72 0 PubChem CID10798271ChemSpider8973577UNIIAKT814N13RChEMBLChEMBL1320667CompTox Dashboard 英语 CompTox Chemicals Dashboard EPA DTXSID50445023化学信息化学式C 11H 11N O 3摩尔质量205 21 g mol 13D模型 JSmol 英语 JSmol 交互式图像SMILES C1C ON C1C2 CC CC C2 CC O OInChI InChI 1S C11H11NO3 c13 11 14 7 9 6 10 12 15 9 8 4 2 1 3 5 8 h1 5 9H 6 7H2 H 13 14 Key MUFJHYRCIHHATF UHFFFAOYSA N参考文献 编辑 Stojanovic I Cuzzocrea S Mangano K Mazzon E Miljkovic D Wang M et al In vitro ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX 1027 modulation of cytokine synthesis and prevention of both organ specific and systemic autoimmune diseases in murine models Clinical Immunology June 2007 123 3 311 23 PMID 17449326 doi 10 1016 j clim 2007 03 004 Cha JJ Hyun YY Lee MH Kim JE Nam DH Song HK et al Renal protective effects of toll like receptor 4 signaling blockade in type 2 diabetic mice Endocrinology June 2013 154 6 2144 55 PMID 23568555 doi 10 1210 en 2012 2080 nbsp Saurus P Kuusela S Lehtonen E Hyvonen ME Ristola M Fogarty CL et al Podocyte apoptosis is prevented by blocking the Toll like receptor pathway Cell Death amp Disease May 2015 6 5 e1752 PMC 4669704 nbsp PMID 25950482 doi 10 1038 cddis 2015 125 Lee JC Menacherry S Diehl MC Giffear MD White CJ Juba R et al Safety bioavailability and pharmacokinetics of VGX 1027 A novel oral anti inflammatory drug in healthy human subjects Clinical Pharmacology in Drug Development March 2016 5 2 91 101 PMID 27138022 S2CID 22577185 doi 10 1002 cpdd 193 Xu M Li F Wang M Zhang H Xu L Adcock IM et al Protective effects of VGX 1027 in PM2 5 induced airway inflammation and bronchial hyperresponsiveness European Journal of Pharmacology January 2019 842 373 383 PMID 30419239 S2CID 53292202 doi 10 1016 j ejphar 2018 11 010 hdl 10044 1 66292 nbsp Ahmad SF Nadeem A Ansari MA Bakheet SA Alasmari F Alasmari AF et al The potent immunomodulatory compound VGX 1027 regulates inflammatory mediators in CD4 T cells which are concomitant with the prevention of neuroimmune dysregulation in BTBR T Itpr3tf J mice Life Sciences November 2019 237 116930 PMID 31610190 doi 10 1016 j lfs 2019 116930 外部链接 编辑 nbsp 这是一篇與药学相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title VGX 1027 amp oldid 75423500, 维基百科，wiki，书籍，书籍，图书馆，
