^ 1.01.11.2GRCh38: Ensembl release 89: ENSG00000137462 - Ensembl, May 2017
^ 2.02.12.2GRCm38: Ensembl release 89: ENSMUSG00000027995 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proceedings of the National Academy of Sciences of the United States of America. January 1998, 95 (2): 588–93. Bibcode:1998PNAS...95..588R. PMC 18464. PMID 9435236. doi:10.1073/pnas.95.2.588.
延伸阅读
Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. August 2000, 406 (6797): 782–7. PMID 10963608. S2CID 4410405. doi:10.1038/35021228.
Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E. Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J. Immunol. June 2013, 190 (11): 5676–88. PMC 3659955. PMID 23636052. doi:10.4049/jimmunol.1201592.
Muzio M, Polentarutti N, Bosisio D, Manoj Kumar PP, Mantovani A. Toll-like receptor family and signalling pathway. Biochemical Society Transactions. October 2000, 28 (5): 563–6. PMID 11044375. doi:10.1042/bst0280563.
Hallman M, Rämet M, Ezekowitz RA. Toll-like receptors as sensors of pathogens. Pediatric Research. September 2001, 50 (3): 315–21. PMID 11518816. S2CID 24420705. doi:10.1203/00006450-200109000-00004.
Dziarski R, Gupta D. Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. Journal of Endotoxin Research. 2001, 6 (5): 401–5. PMID 11521063. doi:10.1177/09680519000060050101.
Lien E, Ingalls RR. Toll-like receptors. Critical Care Medicine. January 2002, 30 (1 Suppl): S1–11. PMID 11782555. doi:10.1097/00003246-200201001-00001.
Xu D, Komai-Koma M, Liew FY. Expression and function of Toll-like receptor on T cells. Cellular Immunology. February 2005, 233 (2): 85–9. PMID 15950961. doi:10.1016/j.cellimm.2005.04.019.
Lorenz E. TLR2 and TLR4 expression during bacterial infections. Current Pharmaceutical Design. 2007, 12 (32): 4185–93. PMID 17100621. doi:10.2174/138161206778743547.
tlr2, toll样受体2, 英語, toll, like, receptor, 是由人类基因, 编码的蛋白质, 是一种膜蛋白质和受体, 也被称为cd282, 分化簇282, cluster, differentiation, 是toll样受体, 家族的成员, 在免疫系统中起到重要作用, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1fyw, 1fyx, 1o77, 2z7x, 2z80識別號别名, cd282, til4, toll, like, receptor, 2外部idomim, . Toll样受体2 英語 Toll like receptor 2 是由人类基因 TLR2 编码的蛋白质 5 是一种膜蛋白质和受体 也被称为CD282 分化簇282 cluster of differentiation 282 是Toll样受体 TLR 家族的成员 在免疫系统中起到重要作用 TLR2已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1FYW 1FYX 1O77 2Z7X 2Z80識別號别名TLR2 CD282 TIL4 toll like receptor 2外部IDOMIM 603028 MGI 1346060 HomoloGene 20695 GeneCards TLR2基因位置 人类 染色体4號染色體 1 基因座4q31 3起始153 684 070 bp 1 终止153 706 260 bp 1 基因位置 小鼠 染色体小鼠3号染色体 2 基因座3 3 E3起始83 743 579 bp 2 终止83 749 074 bp 2 RNA表达模式查阅更多表达数据基因本體分子功能 pattern recognition receptor activity lipopolysaccharide binding Toll like receptor binding triacyl lipopeptide binding 血浆蛋白结合 peptidoglycan binding protein heterodimerization activity lipopolysaccharide immune receptor activity transmembrane signaling receptor activity lipopeptide binding細胞組分 細胞質 integral component of membrane phagocytic vesicle membrane 高尔基体 膜 intrinsic component of plasma membrane 细胞膜 Toll like receptor 1 Toll like receptor 2 protein complex integral component of plasma membrane 脂筏模型 cytoplasmic vesicle cell projection cell surface cell body生物學過程 interleukin 10 production positive regulation of interferon beta production defense response to Gram positive bacterium positive regulation of interleukin 18 production positive regulation of toll like receptor signaling pathway toll like receptor TLR1 TLR2 signaling pathway positive regulation of inflammatory response cellular response to bacterial lipopeptide positive regulation of interleukin 12 production immune system process detection of diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide I kappaB phosphorylation positive regulation of nitric oxide synthase biosynthetic process MyD88 dependent toll like receptor signaling pathway cellular response to triacyl bacterial lipopeptide detection of triacyl bacterial lipopeptide positive regulation of Wnt signaling pathway positive regulation of gene expression cellular response to lipoteichoic acid positive regulation of NF kappaB transcription factor activity 免疫反应 positive regulation of interleukin 8 production positive regulation of interleukin 6 production positive regulation of tumor necrosis factor production positive regulation of chemokine production 先天免疫系統 inflammatory response toll like receptor TLR6 TLR2 signaling pathway response to molecule of bacterial origin 訊息傳遞 positive regulation of transcription by RNA polymerase II 细胞凋亡 response to lipopolysaccharide response to progesterone toll like receptor signaling pathway response to insulin central nervous system myelin formation nitric oxide metabolic process response to fatty acid leukotriene metabolic process toll like receptor 2 signaling pathway positive regulation of oligodendrocyte differentiation response to bacterial lipoprotein negative regulation of cell population proliferation response to toxic substance response to hypoxia positive regulation of interleukin 10 production lipopolysaccharide mediated signaling pathway microglial cell activationSources Amigo QuickGO直系同源物種人類小鼠Entrez709724088EnsemblENSG00000137462ENSMUSG00000027995UniProtO60603Q9QUN7mRNA 序列 NM 003264 NM 001318787 NM 001318789 NM 001318790 NM 001318791 NM 001318793 NM 001318795 NM 001318796NM 011905蛋白序列NP 001305716 NP 001305718 NP 001305719 NP 001305720 NP 001305722 NP 001305724 NP 001305725 NP 003255NP 036035基因位置 UCSC Chr 4 153 68 153 71 MbChr 3 83 74 83 75 MbPubMed 查找 3 4 維基數據檢視 編輯人類檢視 編輯小鼠参考文献 编辑 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000137462 Ensembl May 2017 2 0 2 1 2 2 GRCm38 Ensembl release 89 ENSMUSG00000027995 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Rock FL Hardiman G Timans JC Kastelein RA Bazan JF A family of human receptors structurally related to Drosophila Toll Proceedings of the National Academy of Sciences of the United States of America January 1998 95 2 588 93 Bibcode 1998PNAS 95 588R PMC 18464 PMID 9435236 doi 10 1073 pnas 95 2 588 延伸阅读 编辑Aderem A Ulevitch RJ Toll like receptors in the induction of the innate immune response Nature August 2000 406 6797 782 7 PMID 10963608 S2CID 4410405 doi 10 1038 35021228 Ey B Eyking A Klepak M Salzman NH Gothert JR Runzi M Schmid KW Gerken G Podolsky DK Cario E Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis J Immunol June 2013 190 11 5676 88 PMC 3659955 PMID 23636052 doi 10 4049 jimmunol 1201592 Muzio M Polentarutti N Bosisio D Manoj Kumar PP Mantovani A Toll like receptor family and signalling pathway Biochemical Society Transactions October 2000 28 5 563 6 PMID 11044375 doi 10 1042 bst0280563 Hallman M Ramet M Ezekowitz RA Toll like receptors as sensors of pathogens Pediatric Research September 2001 50 3 315 21 PMID 11518816 S2CID 24420705 doi 10 1203 00006450 200109000 00004 Dziarski R Gupta D Role of MD 2 in TLR2 and TLR4 mediated recognition of Gram negative and Gram positive bacteria and activation of chemokine genes Journal of Endotoxin Research 2001 6 5 401 5 PMID 11521063 doi 10 1177 09680519000060050101 Lien E Ingalls RR Toll like receptors Critical Care Medicine January 2002 30 1 Suppl S1 11 PMID 11782555 doi 10 1097 00003246 200201001 00001 Xu D Komai Koma M Liew FY Expression and function of Toll like receptor on T cells Cellular Immunology February 2005 233 2 85 9 PMID 15950961 doi 10 1016 j cellimm 2005 04 019 Lorenz E TLR2 and TLR4 expression during bacterial infections Current Pharmaceutical Design 2007 12 32 4185 93 PMID 17100621 doi 10 2174 138161206778743547 外部链接 编辑醫學主題詞表 MeSH TLR2 protein human 取自 https zh wikipedia org w index php title TLR2 amp oldid 65745444, 维基百科，wiki，书籍，书籍，图书馆，
