· regulation of transcription from RNA polymerase I promoter · transcription from RNA polymerase I promoter · transcription initiation from RNA polymerase I promoter · transcription elongation from RNA polymerase I promoter · termination of RNA polymerase I transcription · embryo implantation · gene expression
· positive regulation of transcription from RNA polymerase I promoter
^Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK. Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. Genomics. May 1997, 41 (1): 135–8. PMID 9126496. doi:10.1006/geno.1997.4647.
^Voit, R; Kuhn A, Sander E E, Grummt I. Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. Nucleic Acids Res. (ENGLAND). July 1995, 23 (14): 2593–9. ISSN 0305-1048. PMC 307079. PMID 7651819. doi:10.1093/nar/23.14.2593.引文使用过时参数coauthors (帮助)
^Voit, R; Grummt I. Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13631–6. ISSN 0027-8424. PMC 61092. PMID 11698641. doi:10.1073/pnas.231071698.引文使用过时参数coauthors (帮助)
^Zhai, W; Comai L. Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53. Mol. Cell. Biol. (UNITED STATES). August 2000, 20 (16): 5930–8. ISSN 0270-7306. PMC 86070. PMID 10913176. doi:10.1128/MCB.20.16.5930-5938.2000.引文使用过时参数coauthors (帮助)
^Hannan, K M; Hannan R D, Smith S D, Jefferson L S, Lun M, Rothblum L I. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene (ENGLAND). October 2000, 19 (43): 4988–99. ISSN 0950-9232. PMID 11042686. doi:10.1038/sj.onc.1203875.引文使用过时参数coauthors (帮助)
^Lin, Chih-Yin; Tuan JoAnn, Scalia Pierluigi, Bui Tiffany, Comai Lucio. The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr. Biol. (England). Dec 2002, 12 (24): 2142–6. ISSN 0960-9822. PMID 12498690. doi:10.1016/S0960-9822(02)01389-1.引文使用过时参数coauthors (帮助)
延伸阅读编辑
Chan EK, Imai H, Hamel JC, Tan EM. Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. J. Exp. Med. 1991, 174 (5): 1239–44. PMC 2119007. PMID 1940801. doi:10.1084/jem.174.5.1239.
Jantzen HM, Admon A, Bell SP, Tjian R. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature. 1990, 344 (6269): 830–6. PMID 2330041. doi:10.1038/344830a0.
Bell SP, Learned RM, Jantzen HM, Tjian R. Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Science. 1988, 241 (4870): 1192–7. PMID 3413483. doi:10.1126/science.3413483.
Voit R, Kuhn A, Sander EE, Grummt I. Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. Nucleic Acids Res. 1995, 23 (14): 2593–9. PMC 307079. PMID 7651819. doi:10.1093/nar/23.14.2593.
Hempel WM; Cavanaugh AH; Hannan RD; et al. The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. Mol. Cell. Biol. 1996, 16 (2): 557–63. PMC 231034. PMID 8552083.已忽略未知参数|author-separator= (帮助)
Hanada K; Song CZ; Yamamoto K; et al. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. EMBO J. 1996, 15 (9): 2217–26. PMC 450146. PMID 8641287.已忽略未知参数|author-separator= (帮助)
Pluta AF, Earnshaw WC. Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. J. Biol. Chem. 1996, 271 (31): 18767–74. PMID 8702533. doi:10.1074/jbc.271.31.18767.
Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB. ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. Chromosoma. 1998, 106 (8): 493–502. PMID 9426281. doi:10.1007/s004120050271.
Voit R, Hoffmann M, Grummt I. Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J. 1999, 18 (7): 1891–9. PMC 1171274. PMID 10202152. doi:10.1093/emboj/18.7.1891.
Liu CJ, Wang H, Lengyel P. The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription. EMBO J. 1999, 18 (10): 2845–54. PMC 1171365. PMID 10329630. doi:10.1093/emboj/18.10.2845.
Hannan KM; Hannan RD; Smith SD; et al. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene. 2000, 19 (43): 4988–99. PMID 11042686. doi:10.1038/sj.onc.1203875.已忽略未知参数|author-separator= (帮助)
Kalousek I, Krízková P. Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF. Cell. Mol. Biol. (Noisy-le-grand). 2001, 46 (7): 1163–71. PMID 11075946.
Pelletier G; Stefanovsky VY; Faubladier M; et al. Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol. Cell. 2002, 6 (5): 1059–66. PMID 11106745. doi:10.1016/S1097-2765(00)00104-0.已忽略未知参数|author-separator= (帮助)
Miller G; Panov KI; Friedrich JK; et al. hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. EMBO J. 2001, 20 (6): 1373–82. PMC 145519. PMID 11250903. doi:10.1093/emboj/20.6.1373.已忽略未知参数|author-separator= (帮助)
Seither P, Iben S, Thiry M, Grummt I. PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. Biol. Chem. 2002, 382 (8): 1163–70. PMID 11592397. doi:10.1515/BC.2001.146.
Voit R, Grummt I. Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc. Natl. Acad. Sci. U.S.A. 2002, 98 (24): 13631–6. PMC 61092. PMID 11698641. doi:10.1073/pnas.231071698.
Stefanovsky VY; Pelletier G; Hannan R; et al. An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Mol. Cell. 2002, 8 (5): 1063–73. PMID 11741541. doi:10.1016/S1097-2765(01)00384-7.已忽略未知参数|author-separator= (帮助)
Andersen JS; Lyon CE; Fox AH; et al. Directed proteomic analysis of the human nucleolus. Curr. Biol. 2002, 12 (1): 1–11. PMID 11790298. doi:10.1016/S0960-9822(01)00650-9.已忽略未知参数|author-separator= (帮助)
Dühr S; Torres-Montaner A; Astola A; et al. Molecular analysis of the 5' region of human ribosomal transcription factor UBF. DNA Seq. 2002, 12 (4): 267–72. PMID 11916260. doi:10.3109/10425170109025001.已忽略未知参数|author-separator= (帮助)
十二月 11, 2023
ubtf, 核仁转录因子1, nucleolar, transcription, factor, 又叫上游结合转录因子, upstream, binding, transcription, factor, 缩写, 或上游结合因子1, upstream, binding, factor, 缩写ubf1, 是一种由人类基因, 所编码的蛋白质, upstream, binding, transcription, factor, polymerase, irna聚合酶i上游结合因子pdb, rendering, based. 核仁转录因子1 Nucleolar transcription factor 1 又叫上游结合转录因子 Upstream binding transcription factor 缩写UBTF 或上游结合因子1 Upstream binding factor 1 缩写UBF1 是一种由人类基因UBTF 所编码的蛋白质 1 2 Upstream binding transcription factor RNA polymerase IRNA聚合酶I上游结合因子PDB rendering based on 1k99 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1K99 1L8Y 1L8Z 2HDZ标识代号UBTF NOR 90 UBF UBF 1 UBF1扩展标识遗传学 600673 鼠基因 98512 同源基因 7970 GeneCards UBTF Gene基因本体论描述分子功能 DNA binding protein binding细胞成分 nucleoplasm nucleolus cytoplasm生物过程 blastocyst growth regulation of transcription from RNA polymerase I promoter transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription embryo implantation gene expression positive regulation of transcription from RNA polymerase I promoterSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez734321429EnsemblENSG00000108312ENSMUSG00000020923UniProtP17480A2AWT5mRNA序列NM 001076683NM 001044383蛋白序列NP 001070151NP 001037848基因位置Chr 17 42 28 42 3 MbChr 11 102 3 102 32 MbPubMed查询 1 2 查论编 目录 1 功能 2 相互作用 3 参考文献 4 延伸阅读功能 编辑UBTF是18S 5 8S和28S的核糖体RNA的转录所必须的转录因子 和SL1因子 一个四聚体 包括一个TATA结合蛋白和3个转录辅助因子TAF1 英语 TAF1 共同起作用 在人体中存在94和97kD的两种UBF多肽链 UBF是一种核仁磷酸化蛋白 nucleolar phosphoprotein 同时具有DNA结合结构域和反式激活结构域 通过HMG盒结合到人rRNA启动子的核心与上游部位 2 相互作用 编辑UBTF已知能与酪蛋白激酶2a亚基 英语 Casein kinase 2 alpha 1 3 TAF1C 4 5 视网膜母细胞瘤蛋白 6 和TAF1 7 进行交互作用 参考文献 编辑 Matera AG Wu W Imai H O Keefe CL Chan EK Molecular cloning of the RNA polymerase I transcription factor hUBF NOR 90 UBTF gene and localization to 17q21 3 by fluorescence in situ hybridization and radiation hybrid mapping Genomics May 1997 41 1 135 8 PMID 9126496 doi 10 1006 geno 1997 4647 2 0 2 1 Entrez Gene UBTF upstream binding transcription factor RNA polymerase I Voit R Kuhn A Sander E E Grummt I Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF Nucleic Acids Res ENGLAND July 1995 23 14 2593 9 ISSN 0305 1048 PMC 307079 nbsp PMID 7651819 doi 10 1093 nar 23 14 2593 引文使用过时参数coauthors 帮助 Voit R Grummt I Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription Proc Natl Acad Sci U S A United States November 2001 98 24 13631 6 ISSN 0027 8424 PMC 61092 nbsp PMID 11698641 doi 10 1073 pnas 231071698 引文使用过时参数coauthors 帮助 Zhai W Comai L Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53 Mol Cell Biol UNITED STATES August 2000 20 16 5930 8 ISSN 0270 7306 PMC 86070 nbsp PMID 10913176 doi 10 1128 MCB 20 16 5930 5938 2000 引文使用过时参数coauthors 帮助 Hannan K M Hannan R D Smith S D Jefferson L S Lun M Rothblum L I Rb and p130 regulate RNA polymerase I transcription Rb disrupts the interaction between UBF and SL 1 Oncogene ENGLAND October 2000 19 43 4988 99 ISSN 0950 9232 PMID 11042686 doi 10 1038 sj onc 1203875 引文使用过时参数coauthors 帮助 Lin Chih Yin Tuan JoAnn Scalia Pierluigi Bui Tiffany Comai Lucio The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF Curr Biol England Dec 2002 12 24 2142 6 ISSN 0960 9822 PMID 12498690 doi 10 1016 S0960 9822 02 01389 1 引文使用过时参数coauthors 帮助 延伸阅读 编辑Chan EK Imai H Hamel JC Tan EM Human autoantibody to RNA polymerase I transcription factor hUBF Molecular identity of nucleolus organizer region autoantigen NOR 90 and ribosomal RNA transcription upstream binding factor J Exp Med 1991 174 5 1239 44 PMC 2119007 nbsp PMID 1940801 doi 10 1084 jem 174 5 1239 Jantzen HM Admon A Bell SP Tjian R Nucleolar transcription factor hUBF contains a DNA binding motif with homology to HMG proteins Nature 1990 344 6269 830 6 PMID 2330041 doi 10 1038 344830a0 Bell SP Learned RM Jantzen HM Tjian R Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis Science 1988 241 4870 1192 7 PMID 3413483 doi 10 1126 science 3413483 Voit R Kuhn A Sander EE Grummt I Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF Nucleic Acids Res 1995 23 14 2593 9 PMC 307079 nbsp PMID 7651819 doi 10 1093 nar 23 14 2593 Hempel WM Cavanaugh AH Hannan RD et al The species specific RNA polymerase I transcription factor SL 1 binds to upstream binding factor Mol Cell Biol 1996 16 2 557 63 PMC 231034 nbsp PMID 8552083 已忽略未知参数 author separator 帮助 Hanada K Song CZ Yamamoto K et al RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription EMBO J 1996 15 9 2217 26 PMC 450146 nbsp PMID 8641287 已忽略未知参数 author separator 帮助 Pluta AF Earnshaw WC Specific interaction between human kinetochore protein CENP C and a nucleolar transcriptional regulator J Biol Chem 1996 271 31 18767 74 PMID 8702533 doi 10 1074 jbc 271 31 18767 Whitehead CM Winkfein RJ Fritzler MJ Rattner JB ASE 1 a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes Chromosoma 1998 106 8 493 502 PMID 9426281 doi 10 1007 s004120050271 Voit R Hoffmann M Grummt I Phosphorylation by G1 specific cdk cyclin complexes activates the nucleolar transcription factor UBF EMBO J 1999 18 7 1891 9 PMC 1171274 nbsp PMID 10202152 doi 10 1093 emboj 18 7 1891 Liu CJ Wang H Lengyel P The interferon inducible nucleolar p204 protein binds the ribosomal RNA specific UBF1 transcription factor and inhibits ribosomal RNA transcription EMBO J 1999 18 10 2845 54 PMC 1171365 nbsp PMID 10329630 doi 10 1093 emboj 18 10 2845 Hannan KM Hannan RD Smith SD et al Rb and p130 regulate RNA polymerase I transcription Rb disrupts the interaction between UBF and SL 1 Oncogene 2000 19 43 4988 99 PMID 11042686 doi 10 1038 sj onc 1203875 已忽略未知参数 author separator 帮助 Kalousek I Krizkova P Lymphocyte mitogenic transformation is accompanied by phosphorylation of the nucleolar transcription factor UBF Cell Mol Biol Noisy le grand 2001 46 7 1163 71 PMID 11075946 Pelletier G Stefanovsky VY Faubladier M et al Competitive recruitment of CBP and Rb HDAC regulates UBF acetylation and ribosomal transcription Mol Cell 2002 6 5 1059 66 PMID 11106745 doi 10 1016 S1097 2765 00 00104 0 已忽略未知参数 author separator 帮助 Miller G Panov KI Friedrich JK et al hRRN3 is essential in the SL1 mediated recruitment of RNA Polymerase I to rRNA gene promoters EMBO J 2001 20 6 1373 82 PMC 145519 nbsp PMID 11250903 doi 10 1093 emboj 20 6 1373 已忽略未知参数 author separator 帮助 Seither P Iben S Thiry M Grummt I PAF67 a novel protein that is associated with the initiation competent form of RNA polymerase I Biol Chem 2002 382 8 1163 70 PMID 11592397 doi 10 1515 BC 2001 146 Voit R Grummt I Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription Proc Natl Acad Sci U S A 2002 98 24 13631 6 PMC 61092 nbsp PMID 11698641 doi 10 1073 pnas 231071698 Stefanovsky VY Pelletier G Hannan R et al An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF Mol Cell 2002 8 5 1063 73 PMID 11741541 doi 10 1016 S1097 2765 01 00384 7 已忽略未知参数 author separator 帮助 Andersen JS Lyon CE Fox AH et al Directed proteomic analysis of the human nucleolus Curr Biol 2002 12 1 1 11 PMID 11790298 doi 10 1016 S0960 9822 01 00650 9 已忽略未知参数 author separator 帮助 Duhr S Torres Montaner A Astola A et al Molecular analysis of the 5 region of human ribosomal transcription factor UBF DNA Seq 2002 12 4 267 72 PMID 11916260 doi 10 3109 10425170109025001 已忽略未知参数 author separator 帮助 取自 https zh wikipedia org w index php title UBTF amp oldid 69717839, 维基百科，wiki，书籍，书籍，图书馆，
