· extracellular region · cytoplasm · lysosome · endosome · endoplasmic reticulum · endoplasmic reticulum membrane · plasma membrane · endosome membrane · integral component of membrane · basolateral plasma membrane · apical plasma membrane · early phagosome
· endolysosome membrane
生物过程
· toll-like receptor signaling pathway
· response to molecule of bacterial origin · MyD88-dependent toll-like receptor signaling pathway · inflammatory response · I-kappaB phosphorylation · insulin receptor signaling pathway · positive regulation of gene expression · maintenance of gastrointestinal epithelium · negative regulation of NF-kappaB transcription factor activity · tumor necrosis factor production · negative regulation of interleukin-6 production · negative regulation of interleukin-8 production · positive regulation of chemokine production · positive regulation of granulocyte macrophage colony-stimulating factor production · positive regulation of interferon-beta production · positive regulation of interleukin-10 production · positive regulation of interleukin-12 production · positive regulation of interleukin-18 production · positive regulation of interleukin-6 production · positive regulation of interleukin-8 production · positive regulation of tumor necrosis factor production · negative regulation of toll-like receptor signaling pathway · positive regulation of toll-like receptor signaling pathway · toll-like receptor 9 signaling pathway · positive regulation of NF-kappaB import into nucleus · defense response to bacterium · positive regulation of I-kappaB kinase/NF-kappaB signaling · positive regulation of JUN kinase activity · positive regulation of interferon-gamma biosynthetic process · innate immune response · positive regulation of interferon-alpha biosynthetic process · positive regulation of interferon-beta biosynthetic process · positive regulation of transcription from RNA polymerase II promoter · positive regulation of JNK cascade · regulation of cytokine secretion · positive regulation of inflammatory response · defense response to Gram-negative bacterium · positive regulation of NF-kappaB transcription factor activity · positive regulation of nitric-oxide synthase biosynthetic process
· negative regulation of calcium-transporting ATPase activity
TLR家族的受体在病原识别与先天免疫的激活中起着基础作用。TLRs are named for the high degree of conservation in structure and function seen between mammalian TLRs and the Drosophila transmembrane protein Toll. TLRs是呈現在細胞表面和胞內間室的跨膜蛋白，用以識別病原體呈現的病原相关分子模式（Pathogen-associated molecular patterns，PAMPs），然後啟動製造先天和获得性免疫所需的细胞因子的信號。 The various TLRs exhibit different patterns of expression. 这一基因通常表达于富含免疫细胞的组织，比如脾、淋巴结、骨髓等。研究指出，在小鼠和人中的TLR9受体可响应细菌DNA中的未甲基化的CpG寡脱氧核苷酸序列来激活先天免疫应答[2]。
There are new immunomodulatory treatments undergoing testing which involve the administration of artificial DNA oligonucleotides containing the CpG motif. CpG DNA has applications in treating allergies such as asthma,[3] immunostimulation against cancer,[4] immunostimulation against pathogens, and as adjuvants in vaccines.[5]
^Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw. Dec 2000, 11 (3): 362–71. PMID 11022119.
^Kline JN. Eat dirt: CpG DNA and immunomodulation of asthma. Proc Am Thorac Soc. July 2007, 4 (3): 283–8. PMC 2647631. PMID 17607014. doi:10.1513/pats.200701-019AW.
^Thompson JA, Kuzel T, Bukowski R, Masciari F, Schmalbach T. . Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). July 2004, 22 (14S) [2016-01-14]. （原始内容存档于2012-03-08）.
tlr9, toll样受体9, 英語, toll, like, receptor, 是由人类基因, 编码的蛋白质, 也被称为cd289, 分化簇289, cluster, differentiation, 是toll样受体, 家族的成员, toll, like, receptor, 9标识代号, cd289扩展标识遗传学, 605474, 鼠基因, 1932389, 同源基因, 68126, chembl, 5804, genecards, gene基因本体论描述分子功能, transmembrane, signa. Toll样受体9 英語 Toll like receptor 9 是由人类基因 TLR9 编码的蛋白质 1 也被称为CD289 分化簇289 cluster of differentiation 289 是Toll样受体 TLR 家族的成员 Toll like receptor 9标识代号TLR9 CD289扩展标识遗传学 605474 鼠基因 1932389 同源基因 68126 ChEMBL 5804 GeneCards TLR9 Gene基因本体论描述分子功能 transmembrane signaling receptor activity interleukin 1 receptor binding siRNA binding细胞成分 Golgi membrane extracellular region cytoplasm lysosome endosome endoplasmic reticulum endoplasmic reticulum membrane plasma membrane endosome membrane integral component of membrane basolateral plasma membrane apical plasma membrane early phagosome endolysosome membrane生物过程 toll like receptor signaling pathway response to molecule of bacterial origin MyD88 dependent toll like receptor signaling pathway inflammatory response I kappaB phosphorylation insulin receptor signaling pathway positive regulation of gene expression maintenance of gastrointestinal epithelium negative regulation of NF kappaB transcription factor activity tumor necrosis factor production negative regulation of interleukin 6 production negative regulation of interleukin 8 production positive regulation of chemokine production positive regulation of granulocyte macrophage colony stimulating factor production positive regulation of interferon beta production positive regulation of interleukin 10 production positive regulation of interleukin 12 production positive regulation of interleukin 18 production positive regulation of interleukin 6 production positive regulation of interleukin 8 production positive regulation of tumor necrosis factor production negative regulation of toll like receptor signaling pathway positive regulation of toll like receptor signaling pathway toll like receptor 9 signaling pathway positive regulation of NF kappaB import into nucleus defense response to bacterium positive regulation of I kappaB kinase NF kappaB signaling positive regulation of JUN kinase activity positive regulation of interferon gamma biosynthetic process innate immune response positive regulation of interferon alpha biosynthetic process positive regulation of interferon beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade regulation of cytokine secretion positive regulation of inflammatory response defense response to Gram negative bacterium positive regulation of NF kappaB transcription factor activity positive regulation of nitric oxide synthase biosynthetic process negative regulation of calcium transporting ATPase activitySources Amigo QuickGO直系同源体物种人类小鼠Entrez5410681897EnsemblENSG00000239732ENSMUSG00000045322UniProtQ9NR96Q9EQU3mRNA序列NM 017442NM 031178蛋白序列NP 059138NP 112455基因位置Chr 3 52 22 52 23 MbChr 9 106 22 106 23 MbPubMed查询 1 2 查论编 目录 1 功能 2 临床意义 3 蛋白质相互作用 4 参考文献 5 延伸阅读 6 外部链接功能 编辑TLR家族的受体在病原识别与先天免疫的激活中起着基础作用 TLRs are named for the high degree of conservation in structure and function seen between mammalian TLRs and the Drosophila transmembrane protein Toll TLRs是呈現在細胞表面和胞內間室的跨膜蛋白 用以識別病原體呈現的病原相关分子模式 Pathogen associated molecular patterns PAMPs 然後啟動製造先天和获得性免疫所需的细胞因子的信號 The various TLRs exhibit different patterns of expression 这一基因通常表达于富含免疫细胞的组织 比如脾 淋巴结 骨髓等 研究指出 在小鼠和人中的TLR9受体可响应细菌DNA中的未甲基化的CpG寡脱氧核苷酸序列来激活先天免疫应答 2 TLR9可以识别DNA分子中的未甲基化的CpG序列 CpG位点在脊椎动物非常稀少 1 但在细菌或病毒基因组中很丰富 TLR9在免疫系统的多种细胞中有表达 如B淋巴细胞 单核细胞 自然杀伤细胞 NK 和浆细胞样树突状细胞 TLR9表达于细胞内 是核内体的组分之一 其功能为当细菌或病毒感染时结合其DNA上的富CpG基序来改变免疫系统的状态 TLR9的信号会导致细胞启动炎症反应 并分泌相关细胞因子 如I型干扰素和IL 12等 临床意义 编辑There are new immunomodulatory treatments undergoing testing which involve the administration of artificial DNA oligonucleotides containing the CpG motif CpG DNA has applications in treating allergies such as asthma 3 immunostimulation against cancer 4 immunostimulation against pathogens and as adjuvants in vaccines 5 蛋白质相互作用 编辑TLR9 可以与RNF216交互作用发生 6 它可以被CpG寡脱氧核苷酸激活 如阿托莫德 英语 Agatolimod 参考文献 编辑 Du X Poltorak A Wei Y Beutler B Three novel mammalian toll like receptors gene structure expression and evolution Eur Cytokine Netw Dec 2000 11 3 362 71 PMID 11022119 Entrez Gene TLR9 toll like receptor 9 Kline JN Eat dirt CpG DNA and immunomodulation of asthma Proc Am Thorac Soc July 2007 4 3 283 8 PMC 2647631 PMID 17607014 doi 10 1513 pats 200701 019AW Thompson JA Kuzel T Bukowski R Masciari F Schmalbach T Phase Ib trial of a targeted TLR9 CpG immunomodulator CPG 7909 in advanced renal cell carcinoma RCC Journal of Clinical Oncology 2004 ASCO Annual Meeting Proceedings Post Meeting Edition July 2004 22 14S 2016 01 14 原始内容存档于2012 03 08 Klinman DM Adjuvant activity of CpG oligodeoxynucleotides Int Rev Immunol 2006 25 3 4 135 54 PMID 16818369 doi 10 1080 08830180600743057 Chuang TH Ulevitch RJ Triad3A an E3 ubiquitin protein ligase regulating Toll like receptors Nat Immunol May 2004 5 5 495 502 PMID 15107846 doi 10 1038 ni1066 延伸阅读 编辑Lien E Ingalls RR Toll like receptors Crit Care Med 2002 30 1 Suppl S1 11 PMID 11782555 doi 10 1097 00003246 200201001 00001 Kaisho T Akira S Toll like receptors as adjuvant receptors Biochim Biophys Acta 2002 1589 1 1 13 PMID 11909637 doi 10 1016 S0167 4889 01 00182 3 外部链接 编辑醫學主題詞表 MeSH TLR9 protein humanTLR9引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 取自 https zh wikipedia org w index php title TLR9 amp oldid 54488577, 维基百科，wiki，书籍，书籍，图书馆，
