• cellular triglyceride homeostasis • positive regulation of MHC class II biosynthetic process • DNA synthesis involved in DNA repair • positive regulation of protein phosphorylation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • rhythmic process • single strand break repair • muscle organ development • histone H3-K9 deacetylation • negative regulation of cellular response to testosterone stimulus • regulation of peroxisome proliferator activated receptor signaling pathway • cellular response to DNA damage stimulus • regulation of bile acid biosynthetic process • 脫氧核糖核酸複製 • negative regulation of TOR signaling • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of glucose metabolic process • rDNA heterochromatin assembly • negative regulation of DNA damage response, signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • 昼夜节律 • positive regulation of cellular senescence • 精子发生 • intrinsic apoptotic signaling pathway in response to DNA damage • cellular response to ionizing radiation • negative regulation of helicase activity • cholesterol homeostasis • response to leptin • cellular response to hypoxia • triglyceride mobilization • negative regulation of prostaglandin biosynthetic process • proteasome-mediated ubiquitin-dependent protein catabolic process • 细胞凋亡 • peptidyl-lysine deacetylation • negative regulation of fat cell differentiation • negative regulation of peptidyl-lysine acetylation • regulation of transcription, DNA-templated • positive regulation of adaptive immune response • stress-induced premature senescence • negative regulation of androgen receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of gene expression • transcription, DNA-templated • negative regulation of cAMP-dependent protein kinase activity • pyrimidine dimer repair by nucleotide-excision repair • response to insulin • histone H3-K9 modification • positive regulation of macroautophagy • positive regulation of cholesterol efflux • protein ubiquitination • negative regulation of cell growth • positive regulation of macrophage apoptotic process • rRNA processing • regulation of brown fat cell differentiation • negative regulation of phosphorylation • viral process • DNA修復 • negative regulation of neuron death • positive regulation of histone H3-K9 methylation • negative regulation of histone H3-K14 acetylation • negative regulation of protein kinase B signaling • 细胞分化 • ovulation from ovarian follicle • regulation of protein serine/threonine kinase activity • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • protein ADP-ribosylation • leptin-mediated signaling pathway • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • chromatin organization • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • protein deacetylation • fatty acid homeostasis • protein destabilization • regulation of mitotic cell cycle • positive regulation of cAMP-dependent protein kinase activity • white fat cell differentiation • positive regulation of insulin receptor signaling pathway • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • peptidyl-lysine acetylation • response to hydrogen peroxide • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of histone H4-K16 acetylation • positive regulation of endothelial cell proliferation • regulation of smooth muscle cell apoptotic process • behavioral response to starvation • cellular glucose homeostasis • cellular response to starvation • cellular response to tumor necrosis factor • positive regulation of DNA repair • multicellular organism development • regulation of cell population proliferation • positive regulation of cell population proliferation • regulation of endodeoxyribonuclease activity • regulation of cellular response to heat • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • UV-damage excision repair • histone deacetylation • positive regulation of transcription by RNA polymerase II • 血管新生 • macrophage cytokine production • regulation of lipid storage • positive regulation of adipose tissue development • macrophage differentiation • transcription by RNA polymerase II • positive regulation of smooth muscle cell differentiation • negative regulation of histone H3-K9 trimethylation • positive regulation of apoptotic process • cellular response to hydrogen peroxide • histone H3 deacetylation • negative regulation of protein acetylation • regulation of apoptotic process • cellular response to leukemia inhibitory factor • positive regulation of angiogenesis • transforming growth factor beta receptor signaling pathway • positive regulation of blood vessel endothelial cell migration • negative regulation of cellular senescence
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000096717 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000020063 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Frye, R. A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochemical and Biophysical Research Communications. 1999-06-24, 260 (1): 273–279 [2021-11-10]. ISSN 0006-291X. PMID 10381378. doi:10.1006/bbrc.1999.0897. （原始内容于2021-11-10）.
sirt1, 英語, sirtuin, 也被称为, 依赖性去乙酰化酶sirtuin, 英語, dependent, deacetylase, sirtuin, 是人类基因组中由基因编码的蛋白, 人的基因位于10号染色体上, 的功能是去除蛋白质上的乙酰基团, 去乙酰化, 的去乙酰化功能在一些生物学过程中有发挥一定的作用, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表4i5i, 4if6, 4ig9, 4kxq, 4zzh, 4zzi, 4zzj, 5btr識別號别名, sir2l1, sir2,. SIRT1 英語 Sirtuin 1 也被称为 NAD 依赖性去乙酰化酶Sirtuin 1 英語 NAD dependent deacetylase sirtuin 1 是人类基因组中由SIRT1基因编码的蛋白 人的SIRT1基因位于10号染色体上 SIRT1的功能是去除蛋白质上的乙酰基团 去乙酰化 SIRT1的去乙酰化功能在一些生物学过程中有发挥一定的作用 6 7 8 SIRT1已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTR識別號别名SIRT1 SIR2L1 SIR2 hSIR2 SIR2alpha Sirtuin 1外部IDOMIM 604479 MGI 2135607 HomoloGene 56556 GeneCards SIRT1為以下藥物的標靶SRT1720 1 基因位置 人类 染色体10號染色體 2 基因座10q21 3起始67 884 656 bp 2 终止67 918 390 bp 2 基因位置 小鼠 染色体小鼠10号染色体 3 基因座10 10 B4起始63 154 784 bp 3 终止63 217 483 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 transcription corepressor activity protein domain specific binding core promoter sequence specific DNA binding protein C terminus binding keratin filament binding 转录因子结合 金屬離子結合 HLH domain binding 酶结合 protein deacetylase activity histone binding 血浆蛋白结合 NAD dependent histone deacetylase activity NAD dependent protein deacetylase activity histone deacetylase activity p53 binding mitogen activated protein kinase binding deacetylase activity bHLH transcription factor binding NAD binding 相同蛋白质结合 NAD ADP ribosyltransferase activity 水解酶活性 NAD dependent histone deacetylase activity H3 K9 specific DNA binding transcription activator activity RNA polymerase II specific細胞組分 細胞質 nuclear envelope rDNA heterochromatin chromatin silencing complex 線粒體 细胞核 ESC E Z complex 核仁 染色质 核质 PML body 內膜 细胞质基质生物學過程 cellular triglyceride homeostasis positive regulation of MHC class II biosynthetic process DNA synthesis involved in DNA repair positive regulation of protein phosphorylation positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway rhythmic process single strand break repair muscle organ development histone H3 K9 deacetylation negative regulation of cellular response to testosterone stimulus regulation of peroxisome proliferator activated receptor signaling pathway cellular response to DNA damage stimulus regulation of bile acid biosynthetic process 脫氧核糖核酸複製 negative regulation of TOR signaling positive regulation of cysteine type endopeptidase activity involved in apoptotic process regulation of glucose metabolic process rDNA heterochromatin assembly negative regulation of DNA damage response signal transduction by p53 class mediator DNA methylation dependent heterochromatin assembly 昼夜节律 positive regulation of cellular senescence 精子发生 intrinsic apoptotic signaling pathway in response to DNA damage cellular response to ionizing radiation negative regulation of helicase activity cholesterol homeostasis response to leptin cellular response to hypoxia triglyceride mobilization negative regulation of prostaglandin biosynthetic process proteasome mediated ubiquitin dependent protein catabolic process 细胞凋亡 peptidyl lysine deacetylation negative regulation of fat cell differentiation negative regulation of peptidyl lysine acetylation regulation of transcription DNA templated positive regulation of adaptive immune response stress induced premature senescence negative regulation of androgen receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway response to oxidative stress negative regulation of DNA binding transcription factor activity negative regulation of gene expression transcription DNA templated negative regulation of cAMP dependent protein kinase activity pyrimidine dimer repair by nucleotide excision repair response to insulin histone H3 K9 modification positive regulation of macroautophagy positive regulation of cholesterol efflux protein ubiquitination negative regulation of cell growth positive regulation of macrophage apoptotic process rRNA processing regulation of brown fat cell differentiation negative regulation of phosphorylation viral process DNA修復 negative regulation of neuron death positive regulation of histone H3 K9 methylation negative regulation of histone H3 K14 acetylation negative regulation of protein kinase B signaling 细胞分化 ovulation from ovarian follicle regulation of protein serine threonine kinase activity negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein ADP ribosylation leptin mediated signaling pathway negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II chromatin organization negative regulation of I kappaB kinase NF kappaB signaling circadian regulation of gene expression protein deacetylation fatty acid homeostasis protein destabilization regulation of mitotic cell cycle positive regulation of cAMP dependent protein kinase activity white fat cell differentiation positive regulation of insulin receptor signaling pathway negative regulation of transcription DNA templated negative regulation of NF kappaB transcription factor activity peptidyl lysine acetylation response to hydrogen peroxide intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of histone H4 K16 acetylation positive regulation of endothelial cell proliferation regulation of smooth muscle cell apoptotic process behavioral response to starvation cellular glucose homeostasis cellular response to starvation cellular response to tumor necrosis factor positive regulation of DNA repair multicellular organism development regulation of cell population proliferation positive regulation of cell population proliferation regulation of endodeoxyribonuclease activity regulation of cellular response to heat positive regulation of phosphatidylinositol 3 kinase signaling negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway UV damage excision repair histone deacetylation positive regulation of transcription by RNA polymerase II 血管新生 macrophage cytokine production regulation of lipid storage positive regulation of adipose tissue development macrophage differentiation transcription by RNA polymerase II positive regulation of smooth muscle cell differentiation negative regulation of histone H3 K9 trimethylation positive regulation of apoptotic process cellular response to hydrogen peroxide histone H3 deacetylation negative regulation of protein acetylation regulation of apoptotic process cellular response to leukemia inhibitory factor positive regulation of angiogenesis transforming growth factor beta receptor signaling pathway positive regulation of blood vessel endothelial cell migration negative regulation of cellular senescenceSources Amigo QuickGO直系同源物種人類小鼠Entrez2341193759EnsemblENSG00000096717ENSMUSG00000020063UniProtQ96EB6Q923E4mRNA 序列NM 001142498 NM 001314049 NM 012238NM 001159589 NM 001159590 NM 019812蛋白序列NP 001135970 NP 001300978 NP 036370NP 001153061 NP 062786基因位置 UCSC Chr 10 67 88 67 92 MbChr 10 63 15 63 22 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠参考文献 编辑 對SIRT1起作用的藥物 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000096717 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000020063 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Frye R A Characterization of five human cDNAs with homology to the yeast SIR2 gene Sir2 like proteins sirtuins metabolize NAD and may have protein ADP ribosyltransferase activity Biochemical and Biophysical Research Communications 1999 06 24 260 1 273 279 2021 11 10 ISSN 0006 291X PMID 10381378 doi 10 1006 bbrc 1999 0897 原始内容存档于2021 11 10 SIRT1 sirtuin 1 Homo sapiens human Gene NCBI www ncbi nlm nih gov 2021 11 10 原始内容存档于2021 11 10 Template UCSC genome browser外部链接 编辑Corante weblog by Derek Lowe about sir2 and SIRT1 research 这是一篇與生物化學相關的小作品 你可以通过编辑或修订扩充其内容 查论编 取自 https zh wikipedia org w index php title SIRT1 amp oldid 70569939, 维基百科，wiki，书籍，书籍，图书馆，
