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维基百科

PTEN (基因)

十二月 03, 2023

磷酸酯酶与张力蛋白同源物（英語：Phosphatase and tensin homolog，简称为PTEN）是一种在人体中由PTEN基因编码的蛋白质[2]。该基因的突变是多种癌症进展过程的环节之一。

磷酸酯酶与张力蛋白同源物
人PTEN的晶体结构图。N-端磷酸酯酶结构域以蓝色表示而C-端C2结构域以红色表示[1]。
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 PTEN; 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
扩展标识 遗传学：601728 鼠基因：109583 同源基因：265 GeneCards: PTEN Gene
EC編號 3.1.3.16, 3.1.3.48, 3.1.3.67
直系同源体
物种 人类 小鼠
Entrez 5728 19211
Ensembl ENSG00000171862 ENSMUSG00000013663
UniProt P60484 O08586
mRNA序列 NM_000314 NM_008960
蛋白序列 NP_000305 NP_032986
基因位置 Chr 10:
89.62 – 89.73 Mb		 Chr 19:
32.76 – 32.83 Mb
PubMed查询 [1] [2]

PTEN通过其磷酸酯酶蛋白产物而行使一种抑癌基因的作用。这一磷酸酯酶参与了细胞周期的调节，阻止细胞过快地生长与分裂[3]。其为癌微RNAMIRN21的靶之一。

该基因被鉴定为一种肿瘤抑制物，在多种癌症中往往处于变异状态。该基因编码的蛋白质是一种磷脂酰肌醇-3,4,5-三磷酸3-磷酸酯酶。该蛋白同时含有一张力蛋白样结构域及一催化结构域，这与双特异性蛋白酪氨酸磷酸酶很相似。但与大部分蛋白质酪氨酸磷酸酶不同的是，该蛋白偏好脱去磷酸肌醇底物上的磷酸。该蛋白负性调控胞内磷脂酰肌醇-3,4,5-三磷酸的水平，并通过负性调控Akt/PKB信号通道发挥抑癌基因的作用[4]。

參考文献 编辑

  1. ^ PDB 1d5r；Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. October 1999, 99 (3): 323–34. PMID 10555148. doi:10.1016/S0092-8674(00)81663-3. 
  2. ^ Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. April 1997, 15 (4): 356–62. PMID 9090379. doi:10.1038/ng0497-356. 
  3. ^ Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med. Sci. Monit. October 2004, 10 (10): RA235–41 [2013-05-25]. PMID 15448614. （原始内容于2012-02-14）. 
  4. ^ Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1). （原始内容于2010-03-07）. 

深入阅读 编辑

  • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997, 275 (5308): 1943–1947. PMID 9072974. doi:10.1126/science.275.5308.1943. 
  • Simpson L, Parsons R. PTEN: life as a tumor suppressor. Exp Cell Res. 2001, 264 (1): 29–41. PMID 11237521. doi:10.1006/excr.2000.5130. 
  • Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit. 2004, 10 (10): RA235–41. PMID 15448614. 
  • Eng C. PTEN: one gene, many syndromes. Hum Mutat. 2003, 22 (3): 183–98. PMID 12938083. doi:10.1002/humu.10257. 
  • Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 2005, 19 (17): 2054–65. PMC 1199575  . PMID 16107612. doi:10.1101/gad.1308805. 
  • Leslie NR, Downes CP. PTEN function: how normal cells control it and tumour cells lose it. Biochem J. 2004, 382 (Pt 1): 1–11. PMC 1133909  . PMID 15193142. doi:10.1042/BJ20040825. 
  • Pilarski R, Eng C. Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome. J Med Genet. 2004, 41 (5): 323–6. PMC 1735782  . PMID 15121767. doi:10.1136/jmg.2004.018036. 
  • Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004, 22 (14): 2954–63. PMID 15254063. doi:10.1200/JCO.2004.02.141. 
  • Waite KA, Eng C. Protean PTEN: Form and Function. Am J Hum Genet. 2002, 70 (4): 829–44. PMC 379112  . PMID 11875759. doi:10.1086/340026. 
  • Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C. Germline PTEN Promoter Mutations and Deletions in Cowden/Bannayan-Riley-Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway. Am J Hum Genet. 2003, 73 (2): 404–11. PMC 1180378  . PMID 12844284. doi:10.1086/377109. 
  • Ji S-P, Zhang Y, Cleemput JV, Jiang W, Liao M, Li L, Wan Q, Backstrom JR, Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nature Medicine. 2006, 12 (3): 324–9. PMID 16474401. doi:10.1038/nm1349. 

外部链接 编辑

  • GeneReviews/NCBI/NIH/UW entry on PTEN Hamartoma Tumor Syndrome (PHTS)（页面存档备份，存于互联网档案馆）
  • 醫學主題詞表（MeSH）：PTEN+Protein
  • Template:UMichOPM
  • PTEN Gene - phosphatase and tensin homolog. GeneCards. The Weizmann Institute of Science. [2009-03-12]. （原始内容于2007-10-08）. 
  • . Alzforum: AlzGene. Alzheimer Research Forum. [2009-03-12]. （原始内容存档于2009-02-10）. 

PTEN (基因)引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

Template:蛋白酪氨酸磷酸酶类

十二月 03, 2023
pten, 基因, 磷酸酯酶与张力蛋白同源物, 英語, phosphatase, tensin, homolog, 简称为pten, 是一种在人体中由pten基因编码的蛋白质, 该基因的突变是多种癌症进展过程的环节之一, 磷酸酯酶与张力蛋白同源物人pten的晶体结构图, 端磷酸酯酶结构域以蓝色表示而c, 端c2结构域以红色表示, 有效结构pdb, 直系同源检索, pdbe, rcsbpdb查询代码列表1d5r, 2kyl标识代号pten, 10q23del, cws1, glm2, mham, mmac1, pte. 磷酸酯酶与张力蛋白同源物 英語 Phosphatase and tensin homolog 简称为PTEN 是一种在人体中由PTEN基因编码的蛋白质 2 该基因的突变是多种癌症进展过程的环节之一 磷酸酯酶与张力蛋白同源物人PTEN的晶体结构图 N 端磷酸酯酶结构域以蓝色表示而C 端C2结构域以红色表示 1 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表1D5R 2KYL标识代号PTEN 10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 TEP1扩展标识遗传学 601728 鼠基因 109583 同源基因 265 GeneCards PTEN GeneEC編號3 1 3 16 3 1 3 48 3 1 3 67基因本体论描述分子功能 magnesium ion binding phosphatidylinositol 3 phosphatase activity phosphoprotein phosphatase activity protein serine threonine phosphatase activity protein tyrosine phosphatase activity protein binding protein tyrosine serine threonine phosphatase activity lipid binding anaphase promoting complex binding phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity enzyme binding protein kinase binding PDZ domain binding inositol 1 3 4 5 tetrakisphosphate 3 phosphatase activity phosphatidylinositol 3 4 bisphosphate 3 phosphatase activity细胞成分 nucleus cytoplasm cytosol plasma membrane internal side of plasma membrane PML body myelin sheath adaxonal region cell projection neuron projection Schmidt Lanterman incisure生物过程 regulation of cyclin dependent protein serine threonine kinase activity angiogenesis negative regulation of protein phosphorylation regulation of B cell apoptotic process protein dephosphorylation phospholipid metabolic process phosphatidylinositol biosynthetic process apoptotic process induction of apoptosis activation of mitotic anaphase promoting complex activity epidermal growth factor receptor signaling pathway neuron neuron synaptic transmission synapse assembly central nervous system development heart development learning or memory locomotory behavior cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway regulation of neuron projection development negative regulation of phosphatidylinositol 3 kinase cascade cell migration dentate gyrus development central nervous system neuron axonogenesis negative regulation of cell migration negative regulation of myelination regulation of protein stability negative regulation of cyclin dependent protein serine threonine kinase activity involved in G1 S central nervous system myelin maintenance regulation of cellular component size regulation of myeloid cell apoptotic process multicellular organismal response to stress social behavior peptidyl tyrosine dephosphorylation maternal behavior negative regulation of apoptotic process protein kinase B signaling cascade endothelial cell migration inositol phosphate metabolic process small molecule metabolic process innate immune response locomotor rhythm negative regulation of cell size negative regulation of organ growth inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation neurotrophin TRK receptor signaling pathway phosphatidylinositol mediated signaling cardiac muscle tissue development forebrain morphogenesis brain morphogenesis negative regulation of epithelial cell proliferation negative regulation of axonogenesis protein stabilization T cell receptor signaling pathway positive regulation of sequence specific DNA binding transcription factor activity negative regulation of focal adhesion assembly negative regulation of protein kinase B signaling cascade rhythmic synaptic transmission canonical Wnt receptor signaling pathway synapse maturation prepulse inhibition male mating behavior long term synaptic potentiation prostate gland growth dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis negative regulation of ribosome biogenesis negative regulation of cell aging negative regulation of excitatory postsynaptic membrane potential presynaptic membrane assembly postsynaptic density assembly positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process negative regulation of G1 S transition of mitotic cell cycle positive regulation of excitatory postsynaptic membrane potential negative regulation of synaptic vesicle clusteringSources Amigo QuickGO直系同源体物种人类小鼠Entrez572819211EnsemblENSG00000171862ENSMUSG00000013663UniProtP60484O08586mRNA序列NM 000314NM 008960蛋白序列NP 000305NP 032986基因位置Chr 10 89 62 89 73 MbChr 19 32 76 32 83 MbPubMed查询 1 2 查论编PTEN通过其磷酸酯酶蛋白产物而行使一种抑癌基因的作用 这一磷酸酯酶参与了细胞周期的调节 阻止细胞过快地生长与分裂 3 其为癌微RNAMIRN21的靶之一 该基因被鉴定为一种肿瘤抑制物 在多种癌症中往往处于变异状态 该基因编码的蛋白质是一种磷脂酰肌醇 3 4 5 三磷酸3 磷酸酯酶 该蛋白同时含有一张力蛋白样结构域及一催化结构域 这与双特异性蛋白酪氨酸磷酸酶很相似 但与大部分蛋白质酪氨酸磷酸酶不同的是 该蛋白偏好脱去磷酸肌醇底物上的磷酸 该蛋白负性调控胞内磷脂酰肌醇 3 4 5 三磷酸的水平 并通过负性调控Akt PKB信号通道发挥抑癌基因的作用 4 參考文献 编辑 PDB 1d5r Lee JO Yang H Georgescu MM Di Cristofano A Maehama T Shi Y Dixon JE Pandolfi P Pavletich NP Crystal structure of the PTEN tumor suppressor implications for its phosphoinositide phosphatase activity and membrane association Cell October 1999 99 3 323 34 PMID 10555148 doi 10 1016 S0092 8674 00 81663 3 Steck PA Pershouse MA Jasser SA Yung WK Lin H Ligon AH Langford LA Baumgard ML Hattier T Davis T Frye C Hu R Swedlund B Teng DH Tavtigian SV Identification of a candidate tumour suppressor gene MMAC1 at chromosome 10q23 3 that is mutated in multiple advanced cancers Nat Genet April 1997 15 4 356 62 PMID 9090379 doi 10 1038 ng0497 356 Chu EC Tarnawski AS PTEN regulatory functions in tumor suppression and cell biology Med Sci Monit October 2004 10 10 RA235 41 2013 05 25 PMID 15448614 原始内容存档于2012 02 14 Entrez Gene PTEN phosphatase and tensin homolog mutated in multiple advanced cancers 1 原始内容存档于2010 03 07 深入阅读 编辑Li J Yen C Liaw D Podsypanina K Bose S Wang SI Puc J Miliaresis C Rodgers L McCombie R Bigner SH Giovanella BC Ittmann M Tycko B Hibshoosh H Wigler MH Parsons R PTEN a putative protein tyrosine phosphatase gene mutated in human brain breast and prostate cancer Science 1997 275 5308 1943 1947 PMID 9072974 doi 10 1126 science 275 5308 1943 Simpson L Parsons R PTEN life as a tumor suppressor Exp Cell Res 2001 264 1 29 41 PMID 11237521 doi 10 1006 excr 2000 5130 Chu EC Tarnawski AS PTEN regulatory functions in tumor suppression and cell biology Med Sci Monit 2004 10 10 RA235 41 PMID 15448614 Eng C PTEN one gene many syndromes Hum Mutat 2003 22 3 183 98 PMID 12938083 doi 10 1002 humu 10257 Hamada K Sasaki T Koni PA Natsui M Kishimoto H Sasaki J Yajima N Horie Y Hasegawa G Naito M Miyazaki J Suda T Itoh H Nakao K Mak TW Nakano T Suzuki A The PTEN PI3K pathway governs normal vascular development and tumor angiogenesis Genes Dev 2005 19 17 2054 65 PMC 1199575 nbsp PMID 16107612 doi 10 1101 gad 1308805 Leslie NR Downes CP PTEN function how normal cells control it and tumour cells lose it Biochem J 2004 382 Pt 1 1 11 PMC 1133909 nbsp PMID 15193142 doi 10 1042 BJ20040825 Pilarski R Eng C Will the real Cowden syndrome please stand up again Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome J Med Genet 2004 41 5 323 6 PMC 1735782 nbsp PMID 15121767 doi 10 1136 jmg 2004 018036 Sansal I Sellers WR The biology and clinical relevance of the PTEN tumor suppressor pathway J Clin Oncol 2004 22 14 2954 63 PMID 15254063 doi 10 1200 JCO 2004 02 141 Waite KA Eng C Protean PTEN Form and Function Am J Hum Genet 2002 70 4 829 44 PMC 379112 nbsp PMID 11875759 doi 10 1086 340026 Zhou XP Waite KA Pilarski R Hampel H Fernandez MJ Bos C Dasouki M Feldman GL Greenberg LA Ivanovich J Matloff E Patterson A Pierpont ME Russo D Nassif NT Eng C Germline PTEN Promoter Mutations and Deletions in Cowden Bannayan Riley Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol 3 Kinase Akt Pathway Am J Hum Genet 2003 73 2 404 11 PMC 1180378 nbsp PMID 12844284 doi 10 1086 377109 Ji S P Zhang Y Cleemput JV Jiang W Liao M Li L Wan Q Backstrom JR Zhang X Disruption of PTEN coupling with 5 HT2C receptors suppresses behavioral responses induced by drugs of abuse Nature Medicine 2006 12 3 324 9 PMID 16474401 doi 10 1038 nm1349 外部链接 编辑GeneReviews NCBI NIH UW entry on PTEN Hamartoma Tumor Syndrome PHTS 页面存档备份 存于互联网档案馆 醫學主題詞表 MeSH PTEN Protein Template UMichOPM PTEN Gene phosphatase and tensin homolog GeneCards The Weizmann Institute of Science 2009 03 12 原始内容存档于2007 10 08 Gene overview of all published AD association studies for PTEN Alzforum AlzGene Alzheimer Research Forum 2009 03 12 原始内容存档于2009 02 10 Research shows gene defect s role in autism like behaviorPTEN 基因 引用了美国国家医学图书馆提供的資料 这些資料属于公共领域 Template 蛋白酪氨酸磷酸酶类 取自 https zh wikipedia org w index php title PTEN 基因 amp oldid 73840251, 维基百科，wiki，书籍，书籍，图书馆，

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