· positive regulation of transcription via serum response element binding · negative regulation of cysteine-type endopeptidase activity involved in apoptotic process · positive regulation of transcription from RNA polymerase II promoter · smooth muscle cell differentiation
· negative regulation of apoptotic signaling pathway
^Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.
^Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem. Aug 2002, 277 (32): 28853–60. PMID 12019265. doi:10.1074/jbc.M203190200.
^Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J Biol Chem. Apr 2004, 279 (17): 17578–86. PMID 14970199. doi:10.1074/jbc.M400961200.
Nakajima D, Okazaki N, Yamakawa H; et al. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.. DNA Res. 2003, 9 (3): 99–106. PMID 12168954. doi:10.1093/dnares/9.3.99. 引文格式1维护：显式使用等标签 (link)
Dunham I, Shimizu N, Roe BA; et al. The DNA sequence of human chromosome 22.. Nature. 1999, 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031. 引文格式1维护：显式使用等标签 (link)
Nagase T, Kikuno R, Ishikawa KI; et al. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.. DNA Res. 2000, 7 (1): 65–73. PMID 10718198. doi:10.1093/dnares/7.1.65. 引文格式1维护：显式使用等标签 (link)
Mercher T, Coniat MB, Monni R; et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia.. Proc. Natl. Acad. Sci. U.S.A. 2001, 98 (10): 5776–9. PMC 33289. PMID 11344311. doi:10.1073/pnas.101001498. 引文格式1维护：显式使用等标签 (link)
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Wang DZ, Li S, Hockemeyer D; et al. Potentiation of serum response factor activity by a family of myocardin-related transcription factors.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (23): 14855–60. PMC 137508. PMID 12397177. doi:10.1073/pnas.222561499. 引文格式1维护：显式使用等标签 (link)
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 引文格式1维护：显式使用等标签 (link)
Cen B, Selvaraj A, Burgess RC; et al. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes.. Mol. Cell. Biol. 2003, 23 (18): 6597–608. PMC 193697. PMID 12944485. doi:10.1128/MCB.23.18.6597-6608.2003. 引文格式1维护：显式使用等标签 (link)
Selvaraj A, Prywes R. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.. J. Biol. Chem. 2004, 278 (43): 41977–87. PMID 14565952. doi:10.1074/jbc.M305679200.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 引文格式1维护：显式使用等标签 (link)
Beausoleil SA, Jedrychowski M, Schwartz D; et al. Large-scale characterization of HeLa cell nuclear phosphoproteins.. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (33): 12130–5. PMC 514446. PMID 15302935. doi:10.1073/pnas.0404720101. 引文格式1维护：显式使用等标签 (link)
Selvaraj A, Prywes R. Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent.. BMC Mol. Biol. 2005, 5: 13. PMC 516031. PMID 15329155. doi:10.1186/1471-2199-5-13.
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Hsiao HH, Yang MY, Liu YC; et al. RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.. Am. J. Hematol. 2005, 79 (1): 43–5. PMID 15849773. doi:10.1002/ajh.20298. 引文格式1维护：显式使用等标签 (link)
Nakagawa K, Kuzumaki N. Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification.. Genes Cells. 2005, 10 (8): 835–50. PMID 16098147. doi:10.1111/j.1365-2443.2005.00880.x.
Template:Gene-22-stub
一月 01, 1970
mkl1, megakaryoblastic, leukemia, 巨核细胞白血病, 是一种由人类基因, 编码的蛋白质, megakaryoblastic, leukemia, translocation, 1巨核细胞白血病, 易位, 1rendering, based, 2kvu, 有效结构, 直系同源检索, pdbe, rcsb, pdb查询代码列表, 2kvu, 2kw9标识代号, bsac, mrtf, a扩展标识遗传学, 606078, 鼠基因, 2384495, 同源基因, 32487, genecar. MKL megakaryoblastic leukemia 1 巨核细胞白血病 是一种由人类基因 MKL1 编码的蛋白质 1 2 3 4 Megakaryoblastic leukemia translocation 1巨核细胞白血病 易位 1Rendering based on PDB 2KVU 有效结构 PDB 直系同源检索 PDBe RCSB PDB查询代码列表 2KVU 2KW9标识代号MKL1 BSAC MAL MRTF A扩展标识遗传学 606078 鼠基因 2384495 同源基因 32487 GeneCards MKL1 Gene基因本体论描述 分子功能 transcription regulatory region sequence specific DNA binding sequence specific DNA binding transcription factor activity transcription coactivator activity actin binding actin monomer binding protein binding leucine zipper domain binding 细胞成分 nucleus nucleolus cytoplasm 生物过程 transcription DNA templated positive regulation of transcription via serum response element binding negative regulation of cysteine type endopeptidase activity involved in apoptotic process positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation negative regulation of apoptotic signaling pathway Sources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez57591223701EnsemblENSG00000196588ENSMUSG00000042292UniProtQ969V6Q8K4J6mRNA序列NM 001282660NM 001082536蛋白序列NP 001269589NP 001076005基因位置Chr 22 40 81 41 03 MbChr 15 81 01 81 19 MbPubMed查询 1 2 查论编 此基因编码的蛋白能与转录因子心肌素 英語 myocardin 一种调控平滑肌细胞分化的关键转录因子 相互作用 此蛋白主要存在于细胞核中 帮助信号从细胞质到细胞核的转导 在一个特异的染色体易位中 此基因会与1号染色体上的RNA结合基序蛋白15基因融合 这一易位与急性巨核细胞白血病相关 4 参考文献 编辑 Ma Z Morris SW Valentine V Li M Herbrick JA Cui X Bouman D Li Y Mehta PK Nizetic D Kaneko Y Chan GC Chan LC Squire J Scherer SW Hitzler JK Fusion of two novel genes RBM15 and MKL1 in the t 1 22 p13 q13 of acute megakaryoblastic leukemia Nat Genet Jun 2001 28 3 220 1 PMID 11431691 doi 10 1038 90054 Sasazuki T Sawada T Sakon S Kitamura T Kishi T Okazaki T Katano M Tanaka M Watanabe M Yagita H Okumura K Nakano H Identification of a novel transcriptional activator BSAC by a functional cloning to inhibit tumor necrosis factor induced cell death J Biol Chem Aug 2002 277 32 28853 60 PMID 12019265 doi 10 1074 jbc M203190200 Du KL Chen M Li J Lepore JJ Mericko P Parmacek MS Megakaryoblastic leukemia factor 1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells J Biol Chem Apr 2004 279 17 17578 86 PMID 14970199 doi 10 1074 jbc M400961200 4 0 4 1 Entrez Gene MKL1 megakaryoblastic leukemia translocation 1 延伸阅读 编辑Nakajima D Okazaki N Yamakawa H et al Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Res 2003 9 3 99 106 PMID 12168954 doi 10 1093 dnares 9 3 99 引文格式1维护 显式使用等标签 link Dunham I Shimizu N Roe BA et al The DNA sequence of human chromosome 22 Nature 1999 402 6761 489 95 PMID 10591208 doi 10 1038 990031 引文格式1维护 显式使用等标签 link Nagase T Kikuno R Ishikawa KI et al Prediction of the coding sequences of unidentified human genes XVI The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro DNA Res 2000 7 1 65 73 PMID 10718198 doi 10 1093 dnares 7 1 65 引文格式1维护 显式使用等标签 link Mercher T Coniat MB Monni R et al Involvement of a human gene related to the Drosophila spen gene in the recurrent t 1 22 translocation of acute megakaryocytic leukemia Proc Natl Acad Sci U S A 2001 98 10 5776 9 PMC 33289 nbsp PMID 11344311 doi 10 1073 pnas 101001498 引文格式1维护 显式使用等标签 link Wang D Chang PS Wang Z et al Activation of cardiac gene expression by myocardin a transcriptional cofactor for serum response factor Cell 2001 105 7 851 62 PMID 11439182 doi 10 1016 S0092 8674 01 00404 4 引文格式1维护 显式使用等标签 link Wang DZ Li S Hockemeyer D et al Potentiation of serum response factor activity by a family of myocardin related transcription factors Proc Natl Acad Sci U S A 2003 99 23 14855 60 PMC 137508 nbsp PMID 12397177 doi 10 1073 pnas 222561499 引文格式1维护 显式使用等标签 link Strausberg RL Feingold EA Grouse LH et al Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 2003 99 26 16899 903 PMC 139241 nbsp PMID 12477932 doi 10 1073 pnas 242603899 引文格式1维护 显式使用等标签 link Cen B Selvaraj A Burgess RC et al Megakaryoblastic leukemia 1 a potent transcriptional coactivator for serum response factor SRF is required for serum induction of SRF target genes Mol Cell Biol 2003 23 18 6597 608 PMC 193697 nbsp PMID 12944485 doi 10 1128 MCB 23 18 6597 6608 2003 引文格式1维护 显式使用等标签 link Selvaraj A Prywes R Megakaryoblastic leukemia 1 2 a transcriptional co activator of serum response factor is required for skeletal myogenic differentiation J Biol Chem 2004 278 43 41977 87 PMID 14565952 doi 10 1074 jbc M305679200 Ota T Suzuki Y Nishikawa T et al Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 2004 36 1 40 5 PMID 14702039 doi 10 1038 ng1285 引文格式1维护 显式使用等标签 link Beausoleil SA Jedrychowski M Schwartz D et al Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 2004 101 33 12130 5 PMC 514446 nbsp PMID 15302935 doi 10 1073 pnas 0404720101 引文格式1维护 显式使用等标签 link Selvaraj A Prywes R Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent BMC Mol Biol 2005 5 13 PMC 516031 nbsp PMID 15329155 doi 10 1186 1471 2199 5 13 Collins JE Wright CL Edwards CA et al A genome annotation driven approach to cloning the human ORFeome Genome Biol 2005 5 10 R84 PMC 545604 nbsp PMID 15461802 doi 10 1186 gb 2004 5 10 r84 引文格式1维护 显式使用等标签 link Gerhard DS Wagner L Feingold EA et al The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 2004 14 10B 2121 7 PMC 528928 nbsp PMID 15489334 doi 10 1101 gr 2596504 引文格式1维护 显式使用等标签 link Hsiao HH Yang MY Liu YC et al RBM15 MKL1 OTT MAL fusion transcript in an adult acute myeloid leukemia patient Am J Hematol 2005 79 1 43 5 PMID 15849773 doi 10 1002 ajh 20298 引文格式1维护 显式使用等标签 link Nakagawa K Kuzumaki N Transcriptional activity of megakaryoblastic leukemia 1 MKL1 is repressed by SUMO modification Genes Cells 2005 10 8 835 50 PMID 16098147 doi 10 1111 j 1365 2443 2005 00880 x Template Gene 22 stub 取自 https zh wikipedia org w index php title MKL1 amp oldid 68257139, 维基百科，wiki，书籍，书籍，图书馆，
