• positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • 脫氧核糖核酸複製 • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • 細胞增殖 • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • 基因調節 • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • 肌肉肥大 • Akt/PKB信号通路 • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • 訊息傳遞 • positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • 白细胞介素-1β产生的负调控 • 腫瘤壞死因子產生的負調控 • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation
^ 2.02.12.2GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017
^ 3.03.13.2GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, May 2017
^Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.
^Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.
^Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.
^Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.
延伸阅读
Butler AA, Yakar S, LeRoith D. Insulin-like growth factor-I: compartmentalization within the somatotropic axis?. News Physiol. Sci. 2002, 17: 82–5. PMID 11909998.
Maccario M, Tassone F, Grottoli S, Rossetto R, Gauna C, Ghigo E. Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity. Ann. Endocrinol. (Paris). 2002, 63 (2 Pt 1): 140–4. PMID 11994678.
Camacho-Hübner C, Woods KA, Clark AJ, Savage MO. Insulin-like growth factor (IGF)-I gene deletion. Reviews in endocrine & metabolic disorders. 2003, 3 (4): 357–61. PMID 12424437. doi:10.1023/A:1020957809082.
Dantzer B, Swanson EM. Mediation of vertebrate life histories via insulin-like growth factor-1. Biological Reviews. 2012, 87 (2): 414–429. PMID 21981025. doi:10.1111/j.1469-185X.2011.00204.x.
Trojan LA, Kopinski P, Wei MX, Ly A, Glogowska A, Czarny J, Shevelev A, Przewlocki R, Henin D, Trojan J. IGF-I: from diagnostic to triple-helix gene therapy of solid tumors. Acta Biochim. Pol. 2004, 49 (4): 979–90. PMID 12545204.
Winn N, Paul A, Musaró A, Rosenthal N. Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease. Cold Spring Harb. Symp. Quant. Biol. 2003, 67: 507–18. PMID 12858577. doi:10.1101/sqb.2002.67.507.
Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 2005, 24 (3): 435–44. PMID 14604834. doi:10.1161/01.ATV.0000105902.89459.09.
Trejo JL, Carro E, Garcia-Galloway E, Torres-Aleman I. Role of insulin-like growth factor I signaling in neurodegenerative diseases. J. Mol. Med. 2004, 82 (3): 156–62. PMID 14647921. doi:10.1007/s00109-003-0499-7.
Rabinovsky ED. The multifunctional role of IGF-1 in peripheral nerve regeneration. Neurol. Res. 2004, 26 (2): 204–10. PMID 15072640. doi:10.1179/016164104225013851.
Rincon M, Muzumdar R, Atzmon G, Barzilai N. The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech. Ageing Dev. 2005, 125 (6): 397–403. PMID 15272501. doi:10.1016/j.mad.2004.03.006.
Conti E, Carrozza C, Capoluongo E, Volpe M, Crea F, Zuppi C, Andreotti F. Insulin-like growth factor-1 as a vascular protective factor. Circulation. 2005, 110 (15): 2260–5. PMID 15477425. doi:10.1161/01.CIR.0000144309.87183.FB.
Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int. Rev. Cytol. International Review of Cytology. 2005, 243: 215–85. ISBN 9780123646477. PMID 15797461. doi:10.1016/S0074-7696(05)43004-1.
Sandhu MS. Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology. Endocrine development. Endocrine Development. 2005, 9: 44–54. ISBN 3-8055-7926-8. PMID 15879687. doi:10.1159/000085755.
Ye P, D'Ercole AJ. Insulin-like growth factor actions during development of neural stem cells and progenitors in the central nervous system. J. Neurosci. Res. 2006, 83 (1): 1–6. PMID 16294334. doi:10.1002/jnr.20688.
Gómez JM. The role of insulin-like growth factor I components in the regulation of vitamin D. Current pharmaceutical biotechnology. 2006, 7 (2): 125–32. PMID 16724947. doi:10.2174/138920106776597621.
Federico G, Street ME, Maghnie M, Caruso-Nicoletti M, Loche S, Bertelloni S, Cianfarani S. Assessment of serum IGF-I concentrations in the diagnosis of isolated childhood-onset GH deficiency: a proposal of the Italian Society for Pediatric Endocrinology and Diabetes (SIEDP/ISPED). J. Endocrinol. Invest. 2006, 29 (8): 732–7. PMID 17033263. doi:10.1007/bf03344184.
Zakula Z, Koricanac G, Putnikovic B, Markovic L, Isenovic ER. Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. Med. Hypotheses. 2007, 69 (2): 302–6. PMID 17289286. doi:10.1016/j.mehy.2006.11.045.
Trojan J, Cloix JF, Ardourel MY, Chatel M, Anthony DD. Insulin-like growth factor type I biology and targeting in malignant gliomas. Neuroscience. 2007, 145 (3): 795–811. PMID 17320297. doi:10.1016/j.neuroscience.2007.01.021.
Venkatasubramanian G, Chittiprol S, Neelakantachar N, Naveen MN, Thirthall J, Gangadhar BN, Shetty KT. Insulin and insulin-like growth factor-1 abnormalities in antipsychotic-naive schizophrenia. Am J Psychiatry. October 2007, 164 (10): 1557–60. PMID 17898347. doi:10.1176/appi.ajp.2007.07020233.
IGF-1 （页面存档备份，存于互联网档案馆） recombinant GFP labeled at Protean Ltd. （页面存档备份，存于互联网档案馆）
六月 05, 2023
胰岛素样生长因子1, 英語, insulin, like, growth, factor, 也被称为生长调节素c, somatomedin, 是一个由人类基因, igf1, 编码的蛋白质, 在1970年代, 1也曾经被称为, 酸硫化, 英语, sulfation, 因子, 並認為其作用为, 不受抑制的胰岛样活力, nonsuppressible, insulin, like, activity, nsila, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1b9g, 1gzr, 1gzy, 1g. 胰岛素样生长因子1 英語 Insulin like growth factor 1 IGF 1 也被称为生长调节素C somatomedin C 是一个由人类基因 IGF1 编码的蛋白质 6 7 在1970年代 IGF 1也曾经被称为 酸硫化 英语 sulfation 因子 8 並認為其作用为 不受抑制的胰岛样活力 nonsuppressible insulin like activity NSILA 胰岛素样生长因子1已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1B9G 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSR 2GF1 3GF1 3LRI 1BQT 4XSS識別號别名IGF1 IGF I IGF1A IGFI MGF insulin like growth factor 1 IGF外部IDOMIM 147440 MGI 96432 HomoloGene 515 GeneCards IGF1相關疾病growth delay due to insulin like growth factor type 1 deficiency 1 基因位置 人类 染色体12號染色體 2 基因座12q23 2起始102 395 874 bp 2 终止102 481 744 bp 2 基因位置 小鼠 染色体小鼠10号染色体 3 基因座10 C1 10 43 7 cM起始87 694 127 bp 3 终止87 772 904 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 hormone activity insulin receptor binding 生長因子活性 integrin binding 血浆蛋白结合 insulin like growth factor receptor binding細胞組分 細胞外區域 exocytic vesicle insulin like growth factor binding protein complex platelet alpha granule lumen insulin like growth factor ternary complex alphav beta3 integrin IGF 1 IGF1R complex 细胞膜 細胞外空間生物學過程 positive regulation of transcription regulatory region DNA binding skeletal system development positive regulation of glucose import muscle organ development positive regulation of Ras protein signal transduction response to heat positive regulation of cardiac muscle hypertrophy positive regulation of smooth muscle cell migration 脫氧核糖核酸複製 positive regulation of insulin like growth factor receptor signaling pathway phosphatidylinositol 3 kinase signaling positive regulation of DNA binding Ras protein signal transduction 細胞增殖 positive regulation of mitotic nuclear division positive regulation of trophectodermal cell proliferation positive regulation of glycogen biosynthetic process positive regulation of fibroblast proliferation ERK1 and ERK2 cascade negative regulation of extrinsic apoptotic signaling pathway cell activation negative regulation of oocyte development positive regulation of transcription DNA templated bone mineralization involved in bone maturation positive regulation of peptidyl tyrosine phosphorylation positive regulation of MAPK cascade proteoglycan biosynthetic process positive regulation of activated T cell proliferation positive regulation of epithelial cell proliferation negative regulation of release of cytochrome c from mitochondria protein stabilization myotube cell development positive regulation of DNA replication myoblast proliferation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration positive regulation of protein secretion positive regulation of glycoprotein biosynthetic process 基因調節 phosphatidylinositol mediated signaling positive regulation of smooth muscle cell proliferation 肌肉肥大 Akt PKB信号通路 regulation of multicellular organism growth positive regulation of cell migration platelet degranulation positive regulation of calcineurin NFAT signaling cascade positive regulation of phosphatidylinositol 3 kinase signaling myoblast differentiation glycolate metabolic process positive regulation of glycolytic process negative regulation of smooth muscle cell apoptotic process 訊息傳遞 positive regulation of transcription by RNA polymerase II positive regulation of cell growth involved in cardiac muscle cell development positive regulation of cell population proliferation positive regulation of osteoblast differentiation activation of protein kinase B activity insulin like growth factor receptor signaling pathway negative regulation of apoptotic process positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity positive regulation of gene expression negative regulation of gene expression cellular response to amyloid beta positive regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process 白细胞介素 1b产生的负调控 腫瘤壞死因子產生的負調控 negative regulation of neuroinflammatory response negative regulation of amyloid beta formationSources Amigo QuickGO直系同源物種人類小鼠Entrez347916000EnsemblENSG00000017427ENSMUSG00000020053UniProtP05019P05017mRNA 序列NM 000618 NM 001111283 NM 001111284 NM 001111285NM 001111274 NM 001111275 NM 001111276 NM 010512 NM 184052 NM 001314010蛋白序列NP 000609 NP 001104753 NP 001104754 NP 001104755NP 001104744 NP 001104745 NP 001104746 NP 001300939 NP 034642基因位置 UCSC Chr 12 102 4 102 48 MbChr 10 87 69 87 77 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠IGF 1是一个在三级结构上与胰岛素类似的激素 在儿童成长发育中有重要作用 并持续在成人的合成代谢中起作用 一种人工合成的IGF 1类似物 美卡舍明 英语 mecasermin 用于治疗发育停滞 9 IGF 1蛋白由一个肽链构成 包括70个氨基酸残基和三个分子内二硫键 分子量为7 649道尔顿 10 已经发现 垂体前部的生长激素 GH 分泌受到GH释放激素 GHRH 和生长抑素的调节 GHRH和生长抑素之间的相互作用引起搏动性GH分泌 在青春期最高 GH诱导肝脏中胰岛素样生长因子1的产生 并调节许多其他组织中IGF 1的旁分泌 IGF 1是GH的合成代谢和促有丝分裂活性的介体 参考文献 编辑 與胰岛素样生长因子1相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000017427 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000020053 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Hoppener JW de Pagter Holthuizen P Geurts van Kessel AH Jansen M Kittur SD Antonarakis SE Lips CJ Sussenbach JS The human gene encoding insulin like growth factor I is located on chromosome 12 Hum Genet 1985 69 2 157 60 PMID 2982726 doi 10 1007 BF00293288 Jansen M van Schaik FM Ricker AT Bullock B Woods DE Gabbay KH Nussbaum AL Sussenbach JS Van den Brande JL Sequence of cDNA encoding human insulin like growth factor I precursor Nature 1983 306 5943 609 11 PMID 6358902 doi 10 1038 306609a0 Salmon WD Daughaday WH A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro J Lab Clin Med 1957 49 6 825 36 PMID 13429201 Keating GM Mecasermin BioDrugs 2008 22 3 177 88 PMID 18481900 doi 10 2165 00063030 200822030 00004 Rinderknecht E Humbel RE The amino acid sequence of human insulin like growth factor I and its structural homology with proinsulin J Biol Chem 1978 253 8 2769 2776 PMID 632300 延伸阅读 编辑Butler AA Yakar S LeRoith D Insulin like growth factor I compartmentalization within the somatotropic axis News Physiol Sci 2002 17 82 5 PMID 11909998 Maccario M Tassone F Grottoli S Rossetto R Gauna C Ghigo E Neuroendocrine and metabolic determinants of the adaptation of GH IGF I axis to obesity Ann Endocrinol Paris 2002 63 2 Pt 1 140 4 PMID 11994678 Camacho Hubner C Woods KA Clark AJ Savage MO Insulin like growth factor IGF I gene deletion Reviews in endocrine amp metabolic disorders 2003 3 4 357 61 PMID 12424437 doi 10 1023 A 1020957809082 Dantzer B Swanson EM Mediation of vertebrate life histories via insulin like growth factor 1 Biological Reviews 2012 87 2 414 429 PMID 21981025 doi 10 1111 j 1469 185X 2011 00204 x Trojan LA Kopinski P Wei MX Ly A Glogowska A Czarny J Shevelev A Przewlocki R Henin D Trojan J IGF I from diagnostic to triple helix gene therapy of solid tumors Acta Biochim Pol 2004 49 4 979 90 PMID 12545204 Winn N Paul A Musaro A Rosenthal N Insulin like growth factor isoforms in skeletal muscle aging regeneration and disease Cold Spring Harb Symp Quant Biol 2003 67 507 18 PMID 12858577 doi 10 1101 sqb 2002 67 507 Delafontaine P Song YH Li Y Expression regulation and function of IGF 1 IGF 1R and IGF 1 binding proteins in blood vessels Arterioscler Thromb Vasc Biol 2005 24 3 435 44 PMID 14604834 doi 10 1161 01 ATV 0000105902 89459 09 Trejo JL Carro E Garcia Galloway E Torres Aleman I Role of insulin like growth factor I signaling in neurodegenerative diseases J Mol Med 2004 82 3 156 62 PMID 14647921 doi 10 1007 s00109 003 0499 7 Rabinovsky ED The multifunctional role of IGF 1 in peripheral nerve regeneration Neurol Res 2004 26 2 204 10 PMID 15072640 doi 10 1179 016164104225013851 Rincon M Muzumdar R Atzmon G Barzilai N The paradox of the insulin IGF 1 signaling pathway in longevity Mech Ageing Dev 2005 125 6 397 403 PMID 15272501 doi 10 1016 j mad 2004 03 006 Conti E Carrozza C Capoluongo E Volpe M Crea F Zuppi C Andreotti F Insulin like growth factor 1 as a vascular protective factor Circulation 2005 110 15 2260 5 PMID 15477425 doi 10 1161 01 CIR 0000144309 87183 FB Wood AW Duan C Bern HA Insulin like growth factor signaling in fish Int Rev Cytol International Review of Cytology 2005 243 215 85 ISBN 9780123646477 PMID 15797461 doi 10 1016 S0074 7696 05 43004 1 Sandhu MS Insulin like growth factor I and risk of type 2 diabetes and coronary heart disease molecular epidemiology Endocrine development Endocrine Development 2005 9 44 54 ISBN 3 8055 7926 8 PMID 15879687 doi 10 1159 000085755 Ye P D Ercole AJ Insulin like growth factor actions during development of neural stem cells and progenitors in the central nervous system J Neurosci Res 2006 83 1 1 6 PMID 16294334 doi 10 1002 jnr 20688 Gomez JM The role of insulin like growth factor I components in the regulation of vitamin D Current pharmaceutical biotechnology 2006 7 2 125 32 PMID 16724947 doi 10 2174 138920106776597621 Federico G Street ME Maghnie M Caruso Nicoletti M Loche S Bertelloni S Cianfarani S Assessment of serum IGF I concentrations in the diagnosis of isolated childhood onset GH deficiency a proposal of the Italian Society for Pediatric Endocrinology and Diabetes SIEDP ISPED J Endocrinol Invest 2006 29 8 732 7 PMID 17033263 doi 10 1007 bf03344184 Zakula Z Koricanac G Putnikovic B Markovic L Isenovic ER Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes Med Hypotheses 2007 69 2 302 6 PMID 17289286 doi 10 1016 j mehy 2006 11 045 Trojan J Cloix JF Ardourel MY Chatel M Anthony DD Insulin like growth factor type I biology and targeting in malignant gliomas Neuroscience 2007 145 3 795 811 PMID 17320297 doi 10 1016 j neuroscience 2007 01 021 Venkatasubramanian G Chittiprol S Neelakantachar N Naveen MN Thirthall J Gangadhar BN Shetty KT Insulin and insulin like growth factor 1 abnormalities in antipsychotic naive schizophrenia Am J Psychiatry October 2007 164 10 1557 60 PMID 17898347 doi 10 1176 appi ajp 2007 07020233 外部链接 编辑醫學主題詞表 MeSH Insulin Like Growth Factor I IGF 1 页面存档备份 存于互联网档案馆 at Lab Tests Online IGF 1 页面存档备份 存于互联网档案馆 recombinant GFP labeled at Protean Ltd 页面存档备份 存于互联网档案馆 取自 https zh wikipedia org w index php title 胰岛素样生长因子1 amp oldid 75643816, 维基百科，wiki，书籍，书籍，图书馆，
