· cytosol · plasma membrane · membrane · integral component of membrane · axon · dendritic spine · cell body · postsynaptic membrane
· extracellular exosome
生物过程
· xenobiotic metabolic process
· synaptic transmission · female pregnancy · learning · short-term memory · estrogen metabolic process · response to organic cyclic compound · cellular response to phosphate starvation · methylation · response to lipopolysaccharide · developmental process · negative regulation of renal sodium excretion · neurotransmitter catabolic process · neurotransmitter biosynthetic process · dopamine catabolic process · response to drug · small molecule metabolic process · negative regulation of dopamine metabolic process · response to pain · multicellular organismal reproductive process · negative regulation of smooth muscle cell proliferation · positive regulation of homocysteine metabolic process
^Figure 11-4 in: Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. 2007. ISBN 0-443-06911-5.
^Grossman MH, Emanuel BS, Budarf ML. Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1-q11.2. Genomics. April 1992, 12 (4): 822–5. PMID 1572656. doi:10.1016/0888-7543(92)90316-K.
^Tai CH, Wu RM. Catechol-O-methyltransferase and Parkinson's disease. Acta Med. Okayama. February 2002, 56 (1): 1–6. PMID 11873938.
^Axelrod J. O-Methylation of Epinephrine and Other Catechols in vitro and in vivo. Science. August 1957, 126 (3270): 400–1. PMID 13467217. doi:10.1126/science.126.3270.400.
^H. M. Ruottinen & U. K. Rinne. COMT inhibition in the treatment of Parkinson's disease. Journal of neurology. 1998 November, 245 (11 Suppl 3): P25–P34. PMID 9808337.请检查|date=中的日期值 (帮助)
^Goetz CG. Influence of COMT inhibition on levodopa pharmacology and therapy.. Neurology. 1998, 50 (5 Suppl 5): S26–30. PMID 9591519.
^Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR. Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience. 2003, 116 (1): 127–37. PMID 12535946. doi:10.1016/S0306-4522(02)00556-0.
^Karoum F, Chrapusta SJ, Egan MF. 3-Methoxytyramine is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple T. Journal of Neurochemistry. 2002, 63 (3): 972–9. PMID 7914228. doi:10.1046/j.1471-4159.1994.63030972.x.
^Bonifácio MJ, Palma PN, Almeida L, Soares-da-Silva P. Catechol-O-methyltransferase and its inhibitors in Parkinson's disease. CNS Drug Rev. 2007, 13 (3): 352–79. PMID 17894650. doi:10.1111/j.1527-3458.2007.00020.x.
深入閱讀编辑
Wichers M, Aguilera M, Kenis G, Krabbendam L, Myin-Germeys I, Jacobs N, Peeters F, Derom C, Vlietinck R, Mengelers R, Delespaul P, van Os J. The Catechol-O-Methyl Transferase Val158Met Polymorphism and Experience of Reward in the Flow of Daily Life. Neuropsychopharmacology. 2008, 33 ((2008) 33, 3030–3036): 3030–6. PMID 17687265. doi:10.1038/sj.npp.1301520.http://www.nature.com/npp/journal/v33/n13/full/1301520a.html
Trendelenburg U. The interaction of transport mechanisms and intracellular enzymes in metabolizing systems. J. Neural Transm. Suppl. 1991, 32: 3–18. PMID 2089098. doi:10.1007/978-3-7091-9113-2_1.
Tai CH, Wu RM. Catechol-O-methyltransferase and Parkinson's disease. Acta Med. Okayama. 2002, 56 (1): 1–6. PMID 11873938.
Zhu BT. On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis. Histol. Histopathol. 2003, 17 (4): 1283–91. PMID 12371153.
Oroszi G, Goldman D. Alcoholism: genes and mechanisms. Pharmacogenomics. 2005, 5 (8): 1037–48. PMID 15584875. doi:10.1517/14622416.5.8.1037.
Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L. Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biol. Psychiatry. 2005, 57 (2): 139–44. PMID 15652872. doi:10.1016/j.biopsych.2004.10.018.
Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol. Psychiatry. 2006, 60 (2): 141–51. PMID 16476412. doi:10.1016/j.biopsych.2005.10.024.
Diaz-Asper CM, Weinberger DR, Goldberg TE. Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics. NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics. 2006, 3 (1): 97–105. PMC 3593358. PMID 16490416. doi:10.1016/j.nurx.2005.12.010.
Craddock N, Owen MJ, O'Donovan MC. The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Mol. Psychiatry. 2006, 11 (5): 446–58. PMID 16505837. doi:10.1038/sj.mp.4001808.
Frank MJ, Moustafa AA, Haughey HM, Curran T, Hutchison KE. Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning. Proc Natl Acad Sci USA. 2007, 104 (41): 16311–6. PMC 2042203. PMID 17913879. doi:10.1073/pnas.0706111104.
儿茶酚, 甲基转移酶, 兒茶酚, 甲基轉移酶, comt, 是分解兒茶酚胺, 如多巴胺, 腎上腺素和去甲腎上腺素, 的幾種酶之一, 在人體, 兒茶酚, 甲基轉移酶由comt基因編碼, 鑒於在一些疾病中兒茶酚胺的調節受損, 數種藥物以comt為標靶, 調整其活性來控制兒茶酚胺的濃度, 兒茶酚, 甲基轉移酶catechol, methyltransferasecomt和3, dinitrocatechol, 深藍, 以及s, 腺苷甲硫氨酸, 結合, 來自pdb, 3bwm, 有效结构pdb, 直系同源检索, pdbe,. 兒茶酚 O 甲基轉移酶 COMT EC 2 1 1 6 是分解兒茶酚胺 如多巴胺 腎上腺素和去甲腎上腺素 的幾種酶之一 在人體 兒茶酚 O 甲基轉移酶由COMT基因編碼 2 鑒於在一些疾病中兒茶酚胺的調節受損 數種藥物以COMT為標靶 調整其活性來控制兒茶酚胺的濃度 3 兒茶酚 O 甲基轉移酶Catechol O methyltransferaseCOMT和3 5 dinitrocatechol 深藍 以及S 腺苷甲硫氨酸 黃 結合 來自PDB 3BWM 有效结构PDB 直系同源检索 PDBe RCSBPDB查询代码列表3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE标识代号COMT HEL S 98n扩展标识遗传学 116790 鼠基因 88470 同源基因 30982 ChEMBL 2023 GeneCards COMT GeneEC編號2 1 1 6基因本体论描述分子功能 magnesium ion binding protein binding O methyltransferase activity catechol O methyltransferase activity细胞成分 mitochondrion cytosol plasma membrane membrane integral component of membrane axon dendritic spine cell body postsynaptic membrane extracellular exosome生物过程 xenobiotic metabolic process synaptic transmission female pregnancy learning short term memory estrogen metabolic process response to organic cyclic compound cellular response to phosphate starvation methylation response to lipopolysaccharide developmental process negative regulation of renal sodium excretion neurotransmitter catabolic process neurotransmitter biosynthetic process dopamine catabolic process response to drug small molecule metabolic process negative regulation of dopamine metabolic process response to pain multicellular organismal reproductive process negative regulation of smooth muscle cell proliferation positive regulation of homocysteine metabolic process regulation of sensory perception of painSources Amigo QuickGORNA表达模式更多表达数据直系同源体物种人类小鼠Entrez131212846EnsemblENSG00000093010ENSMUSG00000000326UniProtP21964O88587mRNA序列NM 000754NM 001111062蛋白序列NP 000745NP 001104532基因位置Chr 22 19 94 19 97 MbChr 16 18 41 18 43 MbPubMed查询 1 2 查论编catechol O methyltransferase命名系统命名缩写识别码EC編號 2 1 1 6CAS号 9012 25 3数据库IntEnz IntEnz浏览BRENDA 英语 BRENDA BRENDA入口ExPASy 英语 ExPASy NiceZyme浏览KEGG KEGG入口MetaCyc 英语 MetaCyc 代谢路径PRIAM 英语 PRIAM enzyme specific profiles 概述PDB RCSB PDB PDBj PDBe PDBsum基因本体 AmiGO EGO搜索PMC 相关文献PubMed 相关文献正腎上腺素的分解 COMT以綠色盒子表示 1 COMT在1957年由生物化學家 朱利叶斯 阿克塞尔罗德發現 4 目录 1 功能 2 命名 3 COMT抑制劑 4 參見 5 額外圖片 6 參考資料 7 深入閱讀 8 外部連結功能 编辑兒茶酚 O 甲基轉移酶參與了儿茶酚胺神经递质 多巴胺 肾上腺素以及去甲肾上腺素 的去活性化 它在兒茶酚胺上加入由 S 腺苷甲硫氨酸 SAM 給予的甲基 具有鄰苯二酚結構的物質都是COMT的基質 如兒茶酚雌激素以及含有鄰苯二酚的黃酮類化合物 L 多巴 兒茶酚胺的前驅物 是COMT重要的基質 COMT抑制劑如恩他卡朋 使L 多巴不被COMT分解為3 O 甲基多巴 3 OMD 剩下芳香族L 氨基酸脫羧酶 DACC 途徑 同時增加其半衰期 5 6 延長L 多巴藥物時效 由COMT催化的反應包含 多巴胺 3 Methoxytyramine DOPAC 英语 DOPAC HVA 高香草酸 去甲肾上腺素 去甲變腎上腺素 肾上腺素 變腎上腺素 Dihydroxyphenylethylene glycol DOPEG Methoxyhydroxyphenylglycol 英语 Methoxyhydroxyphenylglycol MOPEG 3 4 Dihydroxymandelic acid DOMA Vanillylmandelic acid 英语 Vanillylmandelic acid VMA 在腦部 依賴COMT的多巴胺降解於低多巴胺轉運體 DAT 表現的區域特別重要 如前額葉皮質 7 8 命名 编辑COMT是編碼這個酶的基因的名字 名字中的O意指氧 不是ortho 英语 arene substitution patterns COMT抑制劑 编辑COMT抑制劑包括托卡朋 英语 tolcapone 以及恩他卡朋 常被用於治療帕金森氏症 9 參見 编辑多巴胺 L 多巴 O 甲基轉移酶 英语 O methyltransferase 帕金森氏症 思覺失調症額外圖片 编辑 nbsp 參考資料 编辑 Figure 11 4 in Rod Flower Humphrey P Rang Maureen M Dale Ritter James M Rang amp Dale s pharmacology Edinburgh Churchill Livingstone 2007 ISBN 0 443 06911 5 Grossman MH Emanuel BS Budarf ML Chromosomal mapping of the human catechol O methyltransferase gene to 22q11 1 q11 2 Genomics April 1992 12 4 822 5 PMID 1572656 doi 10 1016 0888 7543 92 90316 K Tai CH Wu RM Catechol O methyltransferase and Parkinson s disease Acta Med Okayama February 2002 56 1 1 6 PMID 11873938 Axelrod J O Methylation of Epinephrine and Other Catechols in vitro and in vivo Science August 1957 126 3270 400 1 PMID 13467217 doi 10 1126 science 126 3270 400 H M Ruottinen amp U K Rinne COMT inhibition in the treatment of Parkinson s disease Journal of neurology 1998 November 245 11 Suppl 3 P25 P34 PMID 9808337 请检查 date 中的日期值 帮助 Goetz CG Influence of COMT inhibition on levodopa pharmacology and therapy Neurology 1998 50 5 Suppl 5 S26 30 PMID 9591519 Matsumoto M Weickert CS Akil M Lipska BK Hyde TM Herman MM Kleinman JE Weinberger DR Catechol O methyltransferase mRNA expression in human and rat brain evidence for a role in cortical neuronal function Neuroscience 2003 116 1 127 37 PMID 12535946 doi 10 1016 S0306 4522 02 00556 0 Karoum F Chrapusta SJ Egan MF 3 Methoxytyramine is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex Nucleus Accumbens and Striatum by a Simple T Journal of Neurochemistry 2002 63 3 972 9 PMID 7914228 doi 10 1046 j 1471 4159 1994 63030972 x Bonifacio MJ Palma PN Almeida L Soares da Silva P Catechol O methyltransferase and its inhibitors in Parkinson s disease CNS Drug Rev 2007 13 3 352 79 PMID 17894650 doi 10 1111 j 1527 3458 2007 00020 x 深入閱讀 编辑Wichers M Aguilera M Kenis G Krabbendam L Myin Germeys I Jacobs N Peeters F Derom C Vlietinck R Mengelers R Delespaul P van Os J The Catechol O Methyl Transferase Val158Met Polymorphism and Experience of Reward in the Flow of Daily Life Neuropsychopharmacology 2008 33 2008 33 3030 3036 3030 6 PMID 17687265 doi 10 1038 sj npp 1301520 http www nature com npp journal v33 n13 full 1301520a html Trendelenburg U The interaction of transport mechanisms and intracellular enzymes in metabolizing systems J Neural Transm Suppl 1991 32 3 18 PMID 2089098 doi 10 1007 978 3 7091 9113 2 1 Tai CH Wu RM Catechol O methyltransferase and Parkinson s disease Acta Med Okayama 2002 56 1 1 6 PMID 11873938 Zhu BT On the mechanism of homocysteine pathophysiology and pathogenesis a unifying hypothesis Histol Histopathol 2003 17 4 1283 91 PMID 12371153 Oroszi G Goldman D Alcoholism genes and mechanisms Pharmacogenomics 2005 5 8 1037 48 PMID 15584875 doi 10 1517 14622416 5 8 1037 Fan JB Zhang CS Gu NF Li XW Sun WW Wang HY Feng GY St Clair D He L Catechol O methyltransferase gene Val Met functional polymorphism and risk of schizophrenia a large scale association study plus meta analysis Biol Psychiatry 2005 57 2 139 44 PMID 15652872 doi 10 1016 j biopsych 2004 10 018 Tunbridge EM Harrison PJ Weinberger DR Catechol o methyltransferase cognition and psychosis Val158Met and beyond Biol Psychiatry 2006 60 2 141 51 PMID 16476412 doi 10 1016 j biopsych 2005 10 024 Diaz Asper CM Weinberger DR Goldberg TE Catechol O methyltransferase polymorphisms and some implications for cognitive therapeutics NeuroRx the journal of the American Society for Experimental NeuroTherapeutics 2006 3 1 97 105 PMC 3593358 nbsp PMID 16490416 doi 10 1016 j nurx 2005 12 010 Craddock N Owen MJ O Donovan MC The catechol O methyl transferase COMT gene as a candidate for psychiatric phenotypes evidence and lessons Mol Psychiatry 2006 11 5 446 58 PMID 16505837 doi 10 1038 sj mp 4001808 Frank MJ Moustafa AA Haughey HM Curran T Hutchison KE Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning Proc Natl Acad Sci USA 2007 104 41 16311 6 PMC 2042203 nbsp PMID 17913879 doi 10 1073 pnas 0706111104 外部連結 编辑维基共享资源中相关的多媒体资源 儿茶酚 O 甲基转移酶醫學主題詞表 MeSH Catechol O Methyltransferase nbsp 分子生物學主题 nbsp 藥理學主题 取自 https zh wikipedia org w index php title 儿茶酚 O 甲基转移酶 amp oldid 74885016, 维基百科，wiki，书籍，书籍，图书馆，
