• antigen binding • signal transducer activity • 血浆蛋白结合 • tumor necrosis factor-activated receptor activity • 酶结合 • 泛素蛋白连接酶结合 • protein domain specific binding • signaling receptor activity
細胞組分
• 細胞質 • integral component of membrane • 細胞內膜結合細胞器 • 膜 • 细胞膜 • integral component of plasma membrane • 細胞外區域 • cell surface • CD40 receptor complex • 外排體 • external side of plasma membrane • 細胞外空間 • neuronal cell body • varicosity
生物學過程
• positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • positive regulation of interleukin-12 production • Akt/PKB信号通路 • positive regulation of protein kinase C signaling • immune system process • cellular calcium ion homeostasis • tumor necrosis factor-mediated signaling pathway • immune response-regulating cell surface receptor signaling pathway • platelet activation • multicellular organism development • B cell activation • positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regulation of endothelial cell apoptotic process • regulation of cell population proliferation • positive regulation of B cell proliferation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • 免疫反应 • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • positive regulation of isotype switching to IgG isotypes • cellular response to lipopolysaccharide • positive regulation of transcription by RNA polymerase II • defense response to protozoan • response to bacterium • response to nutrient levels • response to cobalamin • response to interferon-gamma • cellular response to erythropoietin • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to peptide • inflammatory response • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • protein-containing complex assembly
CD40在T細胞相關的免疫和發炎反應具有重要功能，諸如免疫球蛋白類型轉換、記憶B細胞發育，以及生發中心形成[6][8]。 B細胞上也有CD40存在，並會與輔助T細胞上的CD40L結合。CD40和CD40L的橋接可以活化B細胞，降低B細胞接觸到抗原的反應閾值，使其更容易釋放抗體。另外也可以促進B細胞的增殖、同型粘連（homotypic adhesion）、抗體類型轉換。在表面蛋白的表達方面，可以刺激MHC class II（英语：MHC class II）、CD23（英语：CD23）、CD25（英语：CD25）（IL-12R）、CD69（英语：CD69）、CD44等分子的表達，也會使淋巴球功能性抗原1（LFA-1）的轉為高親合態。在細胞週期方面，則會從間期進入S期，開始進行DNA和RNA的複製及合成CD40L[6]。 有研究也發現，要活化β澱粉樣蛋白（英语：Amyloid beta）的微膠細胞也需要CD40和CD40L的連結，因此可能也與阿茲海默症的病生理學相關[9]。
^Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology. 1998, 16: 111–35. PMID 9597126. doi:10.1146/annurev.immunol.16.1.111.
^Giunta, Brian; Rezai-Zadeh, Kavon; Tan, Jun. Impact of the CD40-CD40L Dyad in Alzheimers Disease. CNS & Neurological Disorders - Drug Targets. 2010-04-01, 9 (2): 149–155. doi:10.2174/187152710791012099（英语）.
^McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T. Crystallographic analysis of CD40 recognition and signaling by human TRAF2. Proceedings of the National Academy of Sciences of the United States of America. July 1999, 96 (15): 8408–13. Bibcode:1999PNAS...96.8408M. PMC 17529. PMID 10411888. doi:10.1073/pnas.96.15.8408.
^ 11.011.111.211.3Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proceedings of the National Academy of Sciences of the United States of America. February 1999, 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. PMC 15446. PMID 9990007. doi:10.1073/pnas.96.4.1234.
^Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. February 1997, 385 (6616): 540–4. PMID 9020361. S2CID 4366355. doi:10.1038/385540a0.
^Hu HM, O'Rourke K, Boguski MS, Dixit VM. A novel RING finger protein interacts with the cytoplasmic domain of CD40. The Journal of Biological Chemistry. December 1994, 269 (48): 30069–72. PMID 7527023.
^Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR. Molecular basis for CD40 signaling mediated by TRAF3. Proceedings of the National Academy of Sciences of the United States of America. September 2000, 97 (19): 10395–9. Bibcode:2000PNAS...9710395N. PMC 27035. PMID 10984535. doi:10.1073/pnas.97.19.10395.
^ 15.015.1Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. The EMBO Journal. December 1997, 16 (23): 6914–25. PMC 1170295. PMID 9384571. doi:10.1093/emboj/16.23.6914.
^Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proceedings of the National Academy of Sciences of the United States of America. September 1996, 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I. PMC 38446. PMID 8790348. doi:10.1073/pnas.93.18.9437.
^Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. The Journal of Biological Chemistry. June 2000, 275 (24): 18586–93. PMID 10764746. doi:10.1074/jbc.M000531200.
^Sharma S, Pavlasova GM, Seda V, Cerna KA, Vojackova E, Filip D, Ondrisova L, Sandova V, Kostalova L, Zeni PF, Borsky M, Oppelt J, Liskova K, Kren L, Janikova A, Pospisilova S, Fernandes SM, Shehata M, Rassenti LZ, Jaeger U, Doubek M, Davids MS, Brown JR, Mayer J, Kipps TJ, Mraz M. miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: an Axis Affected by BCR inhibitors. Blood. December 2020. PMID 33171493. doi:10.1182/blood.2020005627.
^Vonderheide RH. The Immune Revolution: A Case for Priming, Not Checkpoint. Cancer Cell. April 2018, 33 (4): 563–569. PMC 5898647. PMID 29634944. doi:10.1016/j.ccell.2018.03.008.
外部連結
Human CD40 genome location and CD40 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
PDBe-KB （页面存档备份，存于互联网档案馆） provides an overview of all the structure information available in the PDB for Human Tumor necrosis factor receptor superfamily member 5 (CD40)
延伸閱讀
Parham P. The Immune System 2nd. Garland Science. 2004: 169–173. ISBN 978-0-8153-4093-5. 含有內容需登入查看的頁面 (link)
Wang JH, Zhang YW, Zhang P, Deng BQ, Ding S, Wang ZK, Wu T, Wang J. CD40 ligand as a potential biomarker for atherosclerotic instability. Neurological Research. September 2013, 35 (7): 693–700. PMC 3770830. PMID 23561892. doi:10.1179/1743132813Y.0000000190.
Banchereau J, Bazan F, Blanchard D, Brière F, Galizzi JP, van Kooten C, Liu YJ, Rousset F, Saeland S. The CD40 antigen and its ligand. Annual Review of Immunology. 1994, 12: 881–922. PMID 7516669. doi:10.1146/annurev.iy.12.040194.004313.
van Kooten C, Banchereau J. CD40-CD40 ligand. Journal of Leukocyte Biology. January 2000, 67 (1): 2–17. PMID 10647992. S2CID 35592719. doi:10.1002/jlb.67.1.2.
Schattner EJ. CD40 ligand in CLL pathogenesis and therapy. Leukemia & Lymphoma. May 2000, 37 (5–6): 461–72. PMID 11042507. S2CID 39398949. doi:10.3109/10428190009058499.
Bhushan A, Covey LR. CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunologic Research. 2002, 24 (3): 311–24. PMID 11817328. S2CID 19537892. doi:10.1385/IR:24:3:311.
Cheng G, Schoenberger SP. CD40 signaling and autoimmunity. Signal Transduction Pathways in Autoimmunity. Current Directions in Autoimmunity 5. 2002: 51–61. ISBN 978-3-8055-7308-5. PMID 11826760. doi:10.1159/000060547.
Dallman C, Johnson PW, Packham G. Differential regulation of cell survival by CD40. Apoptosis. January 2003, 8 (1): 45–53. PMID 12510151. S2CID 22461134. doi:10.1023/A:1021696902187.
O'Sullivan B, Thomas R. Recent advances on the role of CD40 and dendritic cells in immunity and tolerance. Current Opinion in Hematology. July 2003, 10 (4): 272–8. PMID 12799532. S2CID 43043879. doi:10.1097/00062752-200307000-00004.
Benveniste EN, Nguyen VT, Wesemann DR. Molecular regulation of CD40 gene expression in macrophages and microglia. Brain, Behavior, and Immunity. January 2004, 18 (1): 7–12. PMID 14651941. S2CID 8081107. doi:10.1016/j.bbi.2003.09.001.
Xu Y, Song G. The role of CD40-CD154 interaction in cell immunoregulation. Journal of Biomedical Science. 2005, 11 (4): 426–38. PMID 15153777. S2CID 202658036. doi:10.1159/000077892.
Contin C, Couzi L, Moreau JF, Déchanet-Merville J, Merville P. [Immune dysfuntion of uremic patients: potential role for the soluble form of CD40]. Nephrologie. 2004, 25 (4): 119–26. PMID 15291139.
一月 26, 2023
cd40, 分化簇40, cluster, differentiation, 簡稱, 是一種分布於抗原呈递细胞, 的協同刺激因子暨蛋白受體, 與輔助型t細胞上的cd154, 英语, cd154, 英语, 結合後, 抗原呈递细胞會活化, 並產生一系列下游反應, 已知的結構pdb直系同源搜索, pdbe, rcsbpdbid列表1czz, 1d00, 1fll, 1lb6, 3qd6, 5dmj, 5ihl, 5dmi識別號别名, bp50, cdw40, tnfrsf5, protein, molecule外部ido. 分化簇40 Cluster of differentiation 40 簡稱CD40 是一種分布於抗原呈递细胞 APC 的協同刺激因子暨蛋白受體 CD40與輔助型T細胞上的CD154 英语 CD154 CD40L 英语 CD40L 結合後 抗原呈递细胞會活化 並產生一系列下游反應 6 CD40已知的結構PDB直系同源搜索 PDBe RCSBPDBID列表1CZZ 1D00 1FLL 1LB6 3QD6 5DMJ 5IHL 5DMI識別號别名CD40 Bp50 CDW40 TNFRSF5 p50 CD40 protein CD40 molecule外部IDOMIM 109535 MGI 88336 HomoloGene 954 GeneCards CD40相關疾病類風濕性關節炎 第三型高IgM症候群 1 基因位置 人类 染色体20號染色體 2 基因座20q13 12起始46 118 271 bp 2 终止46 129 863 bp 2 基因位置 小鼠 染色体小鼠2号染色体 3 基因座2 H3 2 85 38 cM起始164 897 547 bp 3 终止164 914 868 bp 3 RNA表达模式查阅更多表达数据基因本體分子功能 antigen binding signal transducer activity 血浆蛋白结合 tumor necrosis factor activated receptor activity 酶结合 泛素蛋白连接酶结合 protein domain specific binding signaling receptor activity細胞組分 細胞質 integral component of membrane 細胞內膜結合細胞器 膜 细胞膜 integral component of plasma membrane 細胞外區域 cell surface CD40 receptor complex 外排體 external side of plasma membrane 細胞外空間 neuronal cell body varicosity生物學過程 positive regulation of protein phosphorylation positive regulation of MAP kinase activity positive regulation of interleukin 12 production Akt PKB信号通路 positive regulation of protein kinase C signaling immune system process cellular calcium ion homeostasis tumor necrosis factor mediated signaling pathway immune response regulating cell surface receptor signaling pathway platelet activation multicellular organism development B cell activation positive regulation of GTPase activity response to lipopolysaccharide B cell proliferation cellular response to mechanical stimulus positive regulation of endothelial cell apoptotic process regulation of cell population proliferation positive regulation of B cell proliferation positive regulation of NF kappaB transcription factor activity defense response to virus 免疫反应 regulation of immune response positive regulation of I kappaB kinase NF kappaB signaling apoptotic signaling pathway positive regulation of isotype switching to IgG isotypes cellular response to lipopolysaccharide positive regulation of transcription by RNA polymerase II defense response to protozoan response to bacterium response to nutrient levels response to cobalamin response to interferon gamma cellular response to erythropoietin cellular response to interleukin 1 cellular response to tumor necrosis factor response to peptide inflammatory response positive regulation of tyrosine phosphorylation of STAT protein positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis protein containing complex assemblySources Amigo QuickGO直系同源物種人類小鼠Entrez95821939EnsemblENSG00000101017ENSMUSG00000017652UniProtP25942P27512mRNA 序列NM 001250 NM 001302753 NM 152854 NM 001322421 NM 001322422 NM 001362758NM 011611 NM 170702 NM 170703 NM 170704蛋白序列NP 001241 NP 001289682 NP 001309350 NP 001309351 NP 690593 NP 001349687NP 035741 NP 733803 NP 733804 NP 733805基因位置 UCSC Chr 20 46 12 46 13 MbChr 2 164 9 164 91 MbPubMed 查找 4 5 維基數據檢視 編輯人類檢視 編輯小鼠CD40缺失會造成第三型高IgM症候群 英语 Hyper IgM syndrome type 3 Hyper IgM syndrome type 3 6 目录 1 結構及表達 2 功能 3 交互作用 4 臨床應用 5 參考文獻 6 外部連結 7 延伸閱讀結構及表達 编辑CD40屬於腫瘤壞死因子受體 英语 TNF receptor 超家族 英语 TNF receptor superfamily TNF receptor superfamily 的一員 6 含有AT鉤 英语 AT hook 構型的轉譯因子AKNA 英语 AKNA 可以協同調控CD40及其配體 7 功能 编辑CD40在T細胞相關的免疫和發炎反應具有重要功能 諸如免疫球蛋白類型轉換 記憶B細胞發育 以及生發中心形成 6 8 B細胞上也有CD40存在 並會與輔助T細胞上的CD40L結合 CD40和CD40L的橋接可以活化B細胞 降低B細胞接觸到抗原的反應閾值 使其更容易釋放抗體 另外也可以促進B細胞的增殖 同型粘連 homotypic adhesion 抗體類型轉換 在表面蛋白的表達方面 可以刺激MHC class II 英语 MHC class II CD23 英语 CD23 CD25 英语 CD25 IL 12R CD69 英语 CD69 CD44等分子的表達 也會使淋巴球功能性抗原1 LFA 1 的轉為高親合態 在細胞週期方面 則會從間期進入S期 開始進行DNA和RNA的複製及合成CD40L 6 有研究也發現 要活化b澱粉樣蛋白 英语 Amyloid beta 的微膠細胞也需要CD40和CD40L的連結 因此可能也與阿茲海默症的病生理學相關 9 CD40 CD40L反應在免疫上的角色 6 相關 不相關一般免疫 T細胞啟動 priming 決定周邊免疫球蛋白的濃度 周邊淋巴器官及次級淋巴器官的淋巴球比例體液免疫 胸腺依賴性抗原 Thymus dependent antigen 的初級抗體反應 胸腺依賴性抗原 Thymus dependent antigen 的次級抗體反應及免疫球蛋白類型轉換 記憶B細胞及生發中心的發育 李斯特菌的廓清 對抗多醣體的抗體反應自體免疫 膠原蛋白引起的關節炎 狼瘡性腎炎 實驗性自體免疫腦炎 Experimental allergic encephalomyelitis 胞殺作用及移植 急性或慢性移植物對抗宿主疾病 GVHD 異體移植的胞殺作用 抗病毒的胞殺反應抗癌細胞的胞殺反應T細胞選汰 T細胞的胸腺選汰交互作用 编辑CD40可以與TRAF2 英语 TRAF2 10 11 12 TRAF3 英语 TRAF3 11 13 14 15 TRAF6 英语 TRAF6 11 15 TRAF5 英语 TRAF5 11 16 TTRAP 英语 TTRAP 17 產生交互作用 TRAF4家族的蛋白質雖不會直接與CD40作用 但可以間接增加CD40的作用 18 臨床應用 编辑CD40為癌症免疫疗法的潛在標的 目前已經開發出針對該蛋白的刺激性单克隆抗体 以活化樹突細胞刺激抗癌T細胞的途徑 且已有相關論文發表 現有多項臨床研究正在進行 19 參考文獻 编辑 與CD40相關的疾病 在維基數據上查看 編輯參考 2 0 2 1 2 2 GRCh38 Ensembl release 89 ENSG00000101017 Ensembl May 2017 3 0 3 1 3 2 GRCm38 Ensembl release 89 ENSMUSG00000017652 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine 6 0 6 1 6 2 6 3 6 4 6 5 Laman Jon D Claassen Eric Noelle Randolph J Functions of CD40 and Its Ligand gp39 CD40L Critical Reviews in Immunology 2017 37 2 6 371 420 2021 05 26 ISSN 1040 8401 doi 10 1615 CritRevImmunol v37 i2 6 100 原始内容存档于2021 05 26 英语 Siddiqa A Sims Mourtada J C Guzman Rojas L Rangel R Guret C Madrid Marina V Sun Y Martinez Valdez H Regulation of CD40 and CD40 ligand by the AT hook transcription factor AKNA Nature 2001 03 15 410 6826 383 387 2021 05 26 ISSN 0028 0836 PMID 11268217 doi 10 1038 35066602 原始内容存档于2021 05 26 Grewal IS Flavell RA CD40 and CD154 in cell mediated immunity Annual Review of Immunology 1998 16 111 35 PMID 9597126 doi 10 1146 annurev immunol 16 1 111 Giunta Brian Rezai Zadeh Kavon Tan Jun Impact of the CD40 CD40L Dyad in Alzheimers Disease CNS amp Neurological Disorders Drug Targets 2010 04 01 9 2 149 155 doi 10 2174 187152710791012099 英语 McWhirter SM Pullen SS Holton JM Crute JJ Kehry MR Alber T Crystallographic analysis of CD40 recognition and signaling by human TRAF2 Proceedings of the National Academy of Sciences of the United States of America July 1999 96 15 8408 13 Bibcode 1999PNAS 96 8408M PMC 17529 PMID 10411888 doi 10 1073 pnas 96 15 8408 11 0 11 1 11 2 11 3 Tsukamoto N Kobayashi N Azuma S Yamamoto T Inoue J Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 Proceedings of the National Academy of Sciences of the United States of America February 1999 96 4 1234 9 Bibcode 1999PNAS 96 1234T PMC 15446 PMID 9990007 doi 10 1073 pnas 96 4 1234 Malinin NL Boldin MP Kovalenko AV Wallach D MAP3K related kinase involved in NF kappaB induction by TNF CD95 and IL 1 Nature February 1997 385 6616 540 4 PMID 9020361 S2CID 4366355 doi 10 1038 385540a0 Hu HM O Rourke K Boguski MS Dixit VM A novel RING finger protein interacts with the cytoplasmic domain of CD40 The Journal of Biological Chemistry December 1994 269 48 30069 72 PMID 7527023 Ni CZ Welsh K Leo E Chiou CK Wu H Reed JC Ely KR Molecular basis for CD40 signaling mediated by TRAF3 Proceedings of the National Academy of Sciences of the United States of America September 2000 97 19 10395 9 Bibcode 2000PNAS 9710395N PMC 27035 PMID 10984535 doi 10 1073 pnas 97 19 10395 15 0 15 1 Roy N Deveraux QL Takahashi R Salvesen GS Reed JC The c IAP 1 and c IAP 2 proteins are direct inhibitors of specific caspases The EMBO Journal December 1997 16 23 6914 25 PMC 1170295 PMID 9384571 doi 10 1093 emboj 16 23 6914 Ishida TK Tojo T Aoki T Kobayashi N Ohishi T Watanabe T Yamamoto T Inoue J TRAF5 a novel tumor necrosis factor receptor associated factor family protein mediates CD40 signaling Proceedings of the National Academy of Sciences of the United States of America September 1996 93 18 9437 42 Bibcode 1996PNAS 93 9437I PMC 38446 PMID 8790348 doi 10 1073 pnas 93 18 9437 Pype S Declercq W Ibrahimi A Michiels C Van Rietschoten JG Dewulf N de Boer M Vandenabeele P Huylebroeck D Remacle JE TTRAP a novel protein that associates with CD40 tumor necrosis factor TNF receptor 75 and TNF receptor associated factors TRAFs and that inhibits nuclear factor kappa B activation The Journal of Biological Chemistry June 2000 275 24 18586 93 PMID 10764746 doi 10 1074 jbc M000531200 Sharma S Pavlasova GM Seda V Cerna KA Vojackova E Filip D Ondrisova L Sandova V Kostalova L Zeni PF Borsky M Oppelt J Liskova K Kren L Janikova A Pospisilova S Fernandes SM Shehata M Rassenti LZ Jaeger U Doubek M Davids MS Brown JR Mayer J Kipps TJ Mraz M miR 29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4 an Axis Affected by BCR inhibitors Blood December 2020 PMID 33171493 doi 10 1182 blood 2020005627 Vonderheide RH The Immune Revolution A Case for Priming Not Checkpoint Cancer Cell April 2018 33 4 563 569 PMC 5898647 PMID 29634944 doi 10 1016 j ccell 2018 03 008 外部連結 编辑Human CD40 genome location and CD40 gene details page in the UCSC Genome Browser 英语 UCSC Genome Browser PDBe KB 页面存档备份 存于互联网档案馆 provides an overview of all the structure information available in the PDB for Human Tumor necrosis factor receptor superfamily member 5 CD40 延伸閱讀 编辑Parham P The Immune System 2nd Garland Science 2004 169 173 ISBN 978 0 8153 4093 5 含有內容需登入查看的頁面 link Wang JH Zhang YW Zhang P Deng BQ Ding S Wang ZK Wu T Wang J CD40 ligand as a potential biomarker for atherosclerotic instability Neurological Research September 2013 35 7 693 700 PMC 3770830 PMID 23561892 doi 10 1179 1743132813Y 0000000190 Banchereau J Bazan F Blanchard D Briere F Galizzi JP van Kooten C Liu YJ Rousset F Saeland S The CD40 antigen and its ligand Annual Review of Immunology 1994 12 881 922 PMID 7516669 doi 10 1146 annurev iy 12 040194 004313 van Kooten C Banchereau J CD40 CD40 ligand Journal of Leukocyte Biology January 2000 67 1 2 17 PMID 10647992 S2CID 35592719 doi 10 1002 jlb 67 1 2 Schattner EJ CD40 ligand in CLL pathogenesis and therapy Leukemia amp Lymphoma May 2000 37 5 6 461 72 PMID 11042507 S2CID 39398949 doi 10 3109 10428190009058499 Bhushan A Covey LR CD40 CD40L interactions in X linked and non X linked hyper IgM syndromes Immunologic Research 2002 24 3 311 24 PMID 11817328 S2CID 19537892 doi 10 1385 IR 24 3 311 Cheng G Schoenberger SP CD40 signaling and autoimmunity Signal Transduction Pathways in Autoimmunity Current Directions in Autoimmunity 5 2002 51 61 ISBN 978 3 8055 7308 5 PMID 11826760 doi 10 1159 000060547 Dallman C Johnson PW Packham G Differential regulation of cell survival by CD40 Apoptosis January 2003 8 1 45 53 PMID 12510151 S2CID 22461134 doi 10 1023 A 1021696902187 O Sullivan B Thomas R Recent advances on the role of CD40 and dendritic cells in immunity and tolerance Current Opinion in Hematology July 2003 10 4 272 8 PMID 12799532 S2CID 43043879 doi 10 1097 00062752 200307000 00004 Benveniste EN Nguyen VT Wesemann DR Molecular regulation of CD40 gene expression in macrophages and microglia Brain Behavior and Immunity January 2004 18 1 7 12 PMID 14651941 S2CID 8081107 doi 10 1016 j bbi 2003 09 001 Xu Y Song G The role of CD40 CD154 interaction in cell immunoregulation Journal of Biomedical Science 2005 11 4 426 38 PMID 15153777 S2CID 202658036 doi 10 1159 000077892 Contin C Couzi L Moreau JF Dechanet Merville J Merville P Immune dysfuntion of uremic patients potential role for the soluble form of CD40 Nephrologie 2004 25 4 119 26 PMID 15291139 取自 https zh wikipedia org w index php title CD40 amp oldid 71574716, 维基百科，wiki，书籍，书籍，图书馆，
